Gamma-butyrolactone (GBL) - World Health Organization
... GBL directly into the thalami or hippocampi of rhesus monkeys were without effect on EEG activity reinforcing the belief that the biological activity of GBL is principally attributable to its conversion to GHB 27. Human studies Apparently there have been no reported double-blind placebo controlled h ...
... GBL directly into the thalami or hippocampi of rhesus monkeys were without effect on EEG activity reinforcing the belief that the biological activity of GBL is principally attributable to its conversion to GHB 27. Human studies Apparently there have been no reported double-blind placebo controlled h ...
Codeine and its Alternates for Pain and Cough Relief
... codeine, arranged according to animal and method, have been summarized in Table 27, yielding a wide range of effective doses, from 0.3 to 100 mg per kg. The variation is related mainly to the method, but this has varied in detail, even when it was said to be the same, in respect of the stimulus used ...
... codeine, arranged according to animal and method, have been summarized in Table 27, yielding a wide range of effective doses, from 0.3 to 100 mg per kg. The variation is related mainly to the method, but this has varied in detail, even when it was said to be the same, in respect of the stimulus used ...
Chemical structure of albuterol sulfate.
... (cAMP) from adenosine triphosphate (ATP). The cAMP thus formed mediates the cellular responses. In vitro studies and in vivo pharmacologic studies have demonstrated that albuterol has a preferential effect on β2-adrenergic receptors compared with isoproterenol. While it is recognized that β2-adrener ...
... (cAMP) from adenosine triphosphate (ATP). The cAMP thus formed mediates the cellular responses. In vitro studies and in vivo pharmacologic studies have demonstrated that albuterol has a preferential effect on β2-adrenergic receptors compared with isoproterenol. While it is recognized that β2-adrener ...
diazepam interaction on methadone-induced - HAL
... three injections of 1 mL of air into the chamber and the ambient temperature was noted. The spirogram was recorded and stored on a computer with an acquisition data card (PCI-DAS 1000, Dipsi, Chatillon, France) using respiratory acquisition software (Acquis1 Software, CNRS, Gif-sur-Yvette, France) ...
... three injections of 1 mL of air into the chamber and the ambient temperature was noted. The spirogram was recorded and stored on a computer with an acquisition data card (PCI-DAS 1000, Dipsi, Chatillon, France) using respiratory acquisition software (Acquis1 Software, CNRS, Gif-sur-Yvette, France) ...
ibogaine: a review
... August 1993: FDA Advisory Panel meeting, chaired by Medical Review Officer Curtis Wright, is held to formally consider Investigational New Drug Application filed by Dr. Deborah Mash, Professor of Neurology at the University of Miami School of Medicine. Approval is given for human trials. The approve ...
... August 1993: FDA Advisory Panel meeting, chaired by Medical Review Officer Curtis Wright, is held to formally consider Investigational New Drug Application filed by Dr. Deborah Mash, Professor of Neurology at the University of Miami School of Medicine. Approval is given for human trials. The approve ...
RNA-Induced Silencing Complex-Bound Small Interfering RNA Is a
... Lipids, Burnaby, BC, Canada), and monomethoxypolyethyleneglycol1,2-dimyristoylglycerol (NOF Corporation, Tokyo, Japan) at a 60:38:2 M ratio, respectively. In Vivo Studies. All experimental animal procedures adhered to a protocol approved by the Institutional Animal Care and Use Committee and were co ...
... Lipids, Burnaby, BC, Canada), and monomethoxypolyethyleneglycol1,2-dimyristoylglycerol (NOF Corporation, Tokyo, Japan) at a 60:38:2 M ratio, respectively. In Vivo Studies. All experimental animal procedures adhered to a protocol approved by the Institutional Animal Care and Use Committee and were co ...
Evaluation of different mycobacterial species for drug discovery and
... used for anti-Tb drug high-throughput screening (HTS), and to use this model to identify a novel candidate anti-tubercular drug and its cognate cellular target. A sensitive growth inhibition assay was set up with a GFP-labelled Tb vaccine strain, M. bovis BCG, using standard first and second line an ...
... used for anti-Tb drug high-throughput screening (HTS), and to use this model to identify a novel candidate anti-tubercular drug and its cognate cellular target. A sensitive growth inhibition assay was set up with a GFP-labelled Tb vaccine strain, M. bovis BCG, using standard first and second line an ...
elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil fumarate
... Extent of Protein Binding of [14C]EVG in Rats, Dogs, Monkeys, and Humans and to Purified Human Proteins (Mean ± SD, n = 3) .....................................................46 Distribution of [14C]EVG within Rat, Dog, Monkey, and Human Blood .......................47 Protein Binding for COBI in M ...
... Extent of Protein Binding of [14C]EVG in Rats, Dogs, Monkeys, and Humans and to Purified Human Proteins (Mean ± SD, n = 3) .....................................................46 Distribution of [14C]EVG within Rat, Dog, Monkey, and Human Blood .......................47 Protein Binding for COBI in M ...
$doc.title
... effect on eyes, liver, kidneys or bone marrow. Based on clinical trials in which high doses of melatonin (200 mg: 50 mg 4 x day) were administered orally to patients with metastatic cutaneous malignant melanoma, Robinson and coworkers (1995) reported that, while melatonin lacked significant therapeu ...
... effect on eyes, liver, kidneys or bone marrow. Based on clinical trials in which high doses of melatonin (200 mg: 50 mg 4 x day) were administered orally to patients with metastatic cutaneous malignant melanoma, Robinson and coworkers (1995) reported that, while melatonin lacked significant therapeu ...
SEVOFLURANE
... and/or medications administered.Nausea, vomiting, and delirium have been observed in the postoperative period, common sequelae of surgery and general anesthesia, which may be due to inhalational anesthetic, other agents administered intra-operatively or post-operatively, and to the patient's respons ...
... and/or medications administered.Nausea, vomiting, and delirium have been observed in the postoperative period, common sequelae of surgery and general anesthesia, which may be due to inhalational anesthetic, other agents administered intra-operatively or post-operatively, and to the patient's respons ...
Morphine Sulfate Extended-Release Tablets Page 1 of 22
... Use of higher starting doses in patients who are not opioid tolerant may cause fatal respiratory depression. Conversion from Other Oral Morphine to Morphine Sulfate Extended-Release Tablets Patients receiving other oral morphine formulations may be converted to morphine sulfate extendedrelease table ...
... Use of higher starting doses in patients who are not opioid tolerant may cause fatal respiratory depression. Conversion from Other Oral Morphine to Morphine Sulfate Extended-Release Tablets Patients receiving other oral morphine formulations may be converted to morphine sulfate extendedrelease table ...
... preparations. In addition, tramadol and paracetamol were found to reduce the severity of pain and photophobia associated with moderate-to-severe migraine headache [97]. Intra-operative studies showed tramadol did not antagonise the hypnotic effects of volatile inhalational agents (such as isoflurane ...
biaxin pm
... form of drug allergy, particularly to structurally related-drugs. If an allergic reaction to clarithromycin occurs, administration of the drug should be discontinued. Serious hypersensitivity reactions may require epinephrine, antihistamines, or corticosteroids. See WARNINGS AND PRECAUTIONS, Immune, ...
... form of drug allergy, particularly to structurally related-drugs. If an allergic reaction to clarithromycin occurs, administration of the drug should be discontinued. Serious hypersensitivity reactions may require epinephrine, antihistamines, or corticosteroids. See WARNINGS AND PRECAUTIONS, Immune, ...
Timolol Metabolism in Human Liver Microsomes Is Mediated
... activities of CYP1A1/2 (ethoxyresorufin O-deethylation), CYP2A6 (coumarin 7-hydroxylation), CYP2C9 (tolbutamide hydroxylation), CYP2D6 (dextromethorphan O-demethylation), CYP2E1 (chlorzoxazone 6-hydroxylation), and CYP3A4/5 (midazolam 1⬘-hydroxylation) have been described previously in detail in an ...
... activities of CYP1A1/2 (ethoxyresorufin O-deethylation), CYP2A6 (coumarin 7-hydroxylation), CYP2C9 (tolbutamide hydroxylation), CYP2D6 (dextromethorphan O-demethylation), CYP2E1 (chlorzoxazone 6-hydroxylation), and CYP3A4/5 (midazolam 1⬘-hydroxylation) have been described previously in detail in an ...
biaxin pm
... form of drug allergy, particularly to structurally related-drugs. If an allergic reaction to clarithromycin occurs, administration of the drug should be discontinued. Serious hypersensitivity reactions may require epinephrine, antihistamines, or corticosteroids. See WARNINGS AND PRECAUTIONS, Immune, ...
... form of drug allergy, particularly to structurally related-drugs. If an allergic reaction to clarithromycin occurs, administration of the drug should be discontinued. Serious hypersensitivity reactions may require epinephrine, antihistamines, or corticosteroids. See WARNINGS AND PRECAUTIONS, Immune, ...
Losartan Potassium
... ER. Published evidence for the efficacy of losartan potassium in other special patient groups is scant, as are long term efficacy data. Results from double-blind trials involving a total of >2800 patients with hypertension who received losartan potassium indicate that the drug is very well tolerated ...
... ER. Published evidence for the efficacy of losartan potassium in other special patient groups is scant, as are long term efficacy data. Results from double-blind trials involving a total of >2800 patients with hypertension who received losartan potassium indicate that the drug is very well tolerated ...
Salvia Divinorum
... medical studies undertaken to examine the drug's physiological effects have focused only on short-term effects. However, information provided by abusers indicates that the negative longterm effects of Salvia Divinorum may be similar to those produced by other hallucinogens such as LSD (lysergic acid ...
... medical studies undertaken to examine the drug's physiological effects have focused only on short-term effects. However, information provided by abusers indicates that the negative longterm effects of Salvia Divinorum may be similar to those produced by other hallucinogens such as LSD (lysergic acid ...
Colloidal Submicron-Particle Curcumin Exhibits High Absorption
... is micronized but Meriva is not. This also affects their dispersibility in water. However, Theracurmin’s degradation efficacy in water has not been reported so far, although Meriva possesses a structure protecting it from degradation. Not only the size of the formulation and its absorption efficacy ...
... is micronized but Meriva is not. This also affects their dispersibility in water. However, Theracurmin’s degradation efficacy in water has not been reported so far, although Meriva possesses a structure protecting it from degradation. Not only the size of the formulation and its absorption efficacy ...
Vol 1 Pg 22 ACETAMINOPHEN PRODUCTS
... For products labeled for both adults and children <12 years of age, the bulleted text, “Give the child more than 5 doses in 24 hours” would be added in McNeil’s proposal. For products labeled only for children <12 years of age, the bulleted text, “Give the child more than 5 doses in 24 hours” would ...
... For products labeled for both adults and children <12 years of age, the bulleted text, “Give the child more than 5 doses in 24 hours” would be added in McNeil’s proposal. For products labeled only for children <12 years of age, the bulleted text, “Give the child more than 5 doses in 24 hours” would ...
Clopidogrel Markedly Increases the Plasma Concentrations of the
... CYP3A4 (Jaakkola et al., 2006a). Certain drugs and genetic factors can have a clinically significant effect on hepatic CYP2C8 activity (Backman et al., 2016), and therefore such factors can alter the exposure to pioglitazone (Deng et al., 2005; Jaakkola et al., 2005; Jaakkola et al., 2006b; Tornio e ...
... CYP3A4 (Jaakkola et al., 2006a). Certain drugs and genetic factors can have a clinically significant effect on hepatic CYP2C8 activity (Backman et al., 2016), and therefore such factors can alter the exposure to pioglitazone (Deng et al., 2005; Jaakkola et al., 2005; Jaakkola et al., 2006b; Tornio e ...
Medicinal Value of the Caterpillar Fungi Species
... mushroom that is only found in cohabitation with the larvae of an insect, and it is this unique growth parameter that has made it challenging to produce Cordyceps spp. in artificial cultivation. Further complicating this cultivation issue is the rarefied atmosphere, mineral-rich soil, and low temper ...
... mushroom that is only found in cohabitation with the larvae of an insect, and it is this unique growth parameter that has made it challenging to produce Cordyceps spp. in artificial cultivation. Further complicating this cultivation issue is the rarefied atmosphere, mineral-rich soil, and low temper ...
Clinical pharmacology and abuse potential of gamma‐hydroxybutyric acid (GHB)
... participated in 5 experimental sessions in the framework of a clinical trial. Drug conditions were a single oral dose of GHB (40 or 60 mg/kg), ethanol (0.7 g/kg), flunitrazepam (1.25 mg),and placebo. All active conditions induced positive effects related to their abuse potential. The administrat ...
... participated in 5 experimental sessions in the framework of a clinical trial. Drug conditions were a single oral dose of GHB (40 or 60 mg/kg), ethanol (0.7 g/kg), flunitrazepam (1.25 mg),and placebo. All active conditions induced positive effects related to their abuse potential. The administrat ...
DOVOBET® Gel
... ADVERSE REACTIONS Overview Studies on the Body In a safety pool of randomized, multi-centre prospective vehicle- and/or active controlled clinical trials in subjects with plaque psoriasis on non-scalp areas, patients applied study product once daily for up to 8 weeks. A total of 824 patients were tr ...
... ADVERSE REACTIONS Overview Studies on the Body In a safety pool of randomized, multi-centre prospective vehicle- and/or active controlled clinical trials in subjects with plaque psoriasis on non-scalp areas, patients applied study product once daily for up to 8 weeks. A total of 824 patients were tr ...
Untitled - DONA™, The Original Glucosamine Sulfate
... existing drug was classified as structure-modifying at the time of the recommendations/guidance above, all drugs currently approved for the treatment of osteoarthritis within the European Economic Area (EEA) may be classified as symptom-modifying, as long as they fulfill the requirements set forth i ...
... existing drug was classified as structure-modifying at the time of the recommendations/guidance above, all drugs currently approved for the treatment of osteoarthritis within the European Economic Area (EEA) may be classified as symptom-modifying, as long as they fulfill the requirements set forth i ...