Medical Applications and Toxicities of Gallium Compounds
... non-Hodgkin’s lymphoma and bladder cancer. At least 4 separate clinical trials have demonstrated the anti-lymphoma activity of gallium nitrate administered as a single agent [24-27], while 3 additional trials have used it in combination with other antineoplastic agents to improve treatment outcome [ ...
... non-Hodgkin’s lymphoma and bladder cancer. At least 4 separate clinical trials have demonstrated the anti-lymphoma activity of gallium nitrate administered as a single agent [24-27], while 3 additional trials have used it in combination with other antineoplastic agents to improve treatment outcome [ ...
XIFAXAN (rifaximin) Tablets, 550 mg NDA 21-361
... studied to date, including IBS. Following repeat dosing of rifaximin 550 mg TID, mean steadystate AUCtau was 16.0 ng⋅h/mL and mean steady-state maximum concentration (Cmax) was 4.22 ng/mL in IBS patients, consistent with concentrations observed in healthy volunteers.64,65 In vitro, rifaximin does no ...
... studied to date, including IBS. Following repeat dosing of rifaximin 550 mg TID, mean steadystate AUCtau was 16.0 ng⋅h/mL and mean steady-state maximum concentration (Cmax) was 4.22 ng/mL in IBS patients, consistent with concentrations observed in healthy volunteers.64,65 In vitro, rifaximin does no ...
CARBIDOPA AND LEVODOPA EXTENDED-RELEASE
... Carbidopa does not decrease adverse reactions due to central effects of levodopa. By permitting more levodopa to reach the brain, particularly when nausea and vomiting is not a dose-limiting factor, certain adverse central nervous system (CNS) effects, e.g., dyskinesias, will occur at lower dosages ...
... Carbidopa does not decrease adverse reactions due to central effects of levodopa. By permitting more levodopa to reach the brain, particularly when nausea and vomiting is not a dose-limiting factor, certain adverse central nervous system (CNS) effects, e.g., dyskinesias, will occur at lower dosages ...
Administration of resveratrol: What formulation
... family of nicotinamide adenine dinucleotide-dependent deacetylases), resulting in improved cellular stress resistance and longevity [8–10,13]. Resveratrol can also regulate the expression of hormonedependent genes such as the oncosuppressor BRCA1 in breast cells, due to its structural similarity to ...
... family of nicotinamide adenine dinucleotide-dependent deacetylases), resulting in improved cellular stress resistance and longevity [8–10,13]. Resveratrol can also regulate the expression of hormonedependent genes such as the oncosuppressor BRCA1 in breast cells, due to its structural similarity to ...
Scientific Opinion on safety evaluation of Ephedra
... Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the evaluation of Ephedra species in accordance with Article 8 (2) of Regulation (EC) No 1925/2006 on the addition of vitamins and minerals and of certain other substances to foods. This request was t ...
... Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the evaluation of Ephedra species in accordance with Article 8 (2) of Regulation (EC) No 1925/2006 on the addition of vitamins and minerals and of certain other substances to foods. This request was t ...
ziprasidone - PsychSearch
... 1.3.1.A.1.b Schizophrenia 1) For SCHIZOPHRENIA the initial daily dose is 20 milligrams (mg) twice daily with food. In some patients daily dosage may be adjusted up to 80 mg twice daily. Adjustments, if indicated, should occur at intervals of not less than 2 days. Efficacy in short-term clinical tria ...
... 1.3.1.A.1.b Schizophrenia 1) For SCHIZOPHRENIA the initial daily dose is 20 milligrams (mg) twice daily with food. In some patients daily dosage may be adjusted up to 80 mg twice daily. Adjustments, if indicated, should occur at intervals of not less than 2 days. Efficacy in short-term clinical tria ...
Extract from the Clinical Evaluation Report for Sofosbuvir
... hepatocellular carcinoma (HCC). 4 CHC infection leads to approximately 10,000 deaths per year in the US 5 and has surpassed human immunodeficiency virus (HIV) as a cause of death. 6 0F ...
... hepatocellular carcinoma (HCC). 4 CHC infection leads to approximately 10,000 deaths per year in the US 5 and has surpassed human immunodeficiency virus (HIV) as a cause of death. 6 0F ...
The in vitro stability and in vivo pharmacokinetics of curcumin
... curcumin against hydrolysis and biotransformation. Most importantly, nanoparticulate curcumin was comparatively more effective than native curcumin against different cancer cell lines under in vitro condition with time due to enhanced cellular uptake resulting in reduction of cell viability by induc ...
... curcumin against hydrolysis and biotransformation. Most importantly, nanoparticulate curcumin was comparatively more effective than native curcumin against different cancer cell lines under in vitro condition with time due to enhanced cellular uptake resulting in reduction of cell viability by induc ...
Extract from the Clinical Evaluation Report for Sofosbuvir
... develop serious morbidities ± mortality, that is, cirrhosis, end stage liver disease (ESLD), hepatocellular carcinoma (HCC).4 CHC infection leads to approximately 10,000 deaths per year in the US5 and has surpassed human immunodeficiency virus (HIV) as a cause of death.6 HCV is a single stranded rib ...
... develop serious morbidities ± mortality, that is, cirrhosis, end stage liver disease (ESLD), hepatocellular carcinoma (HCC).4 CHC infection leads to approximately 10,000 deaths per year in the US5 and has surpassed human immunodeficiency virus (HIV) as a cause of death.6 HCV is a single stranded rib ...
Review Biomedical applications of collagen
... 0.01–0.5 mm and made of biodegradable materials, such as prepared from telopeptide-free reconstituted collagen, demonstrated a slow release profile of incorporated drugs (Rubin et al., 1973). The drugs can be loaded into collagen membranes by hydrogen bonding, covalent bonding or simple entrapment. ...
... 0.01–0.5 mm and made of biodegradable materials, such as prepared from telopeptide-free reconstituted collagen, demonstrated a slow release profile of incorporated drugs (Rubin et al., 1973). The drugs can be loaded into collagen membranes by hydrogen bonding, covalent bonding or simple entrapment. ...
Download CV
... Slusher BS, Vornov JJ, Thomas AG, Hurn PD, Traystman RJ, Robinson MB, Britton P, Lu M, Tortella FC, Wozniak K, Yudkoff M, Jackson PF. “An inhibitor of NAAG hydrolysis prevents ischemic glutamate release and provides neuroprotection.” Nature Medicine, 1999, 5:1396-1402 Thomas AJ, Olkowski JH, Vornov ...
... Slusher BS, Vornov JJ, Thomas AG, Hurn PD, Traystman RJ, Robinson MB, Britton P, Lu M, Tortella FC, Wozniak K, Yudkoff M, Jackson PF. “An inhibitor of NAAG hydrolysis prevents ischemic glutamate release and provides neuroprotection.” Nature Medicine, 1999, 5:1396-1402 Thomas AJ, Olkowski JH, Vornov ...
The safety of hydroquinone
... kg)10 and 50% absorption,6 81 mg would be absorbed, resulting in a plasma concentration of 81 mg/3000 mL equaling 0.027 mg/mL, or 27 !g/mL. Deisinger, Hill, and English11 determined that common foodstuffs contain significant amounts of arbutin, which readily hydrolyzes in weak acid (such as can be f ...
... kg)10 and 50% absorption,6 81 mg would be absorbed, resulting in a plasma concentration of 81 mg/3000 mL equaling 0.027 mg/mL, or 27 !g/mL. Deisinger, Hill, and English11 determined that common foodstuffs contain significant amounts of arbutin, which readily hydrolyzes in weak acid (such as can be f ...
PDF - Cosmetic Ingredient Review
... Oral – Non-Human Repeated dose toxicity studies are summarized in Table 6. Undiluted glycerin caused a dose-dependent increase in the number of animals showing hyperemia, petechial hemorrhage, and erosions in the gastro-intestinal tract.30 In short-term feeding experiments, glycerin at 20% for 4 wee ...
... Oral – Non-Human Repeated dose toxicity studies are summarized in Table 6. Undiluted glycerin caused a dose-dependent increase in the number of animals showing hyperemia, petechial hemorrhage, and erosions in the gastro-intestinal tract.30 In short-term feeding experiments, glycerin at 20% for 4 wee ...
TAXUS® Liberté™
... TAXUS Stent compared to bare-metal stents have not been associated with an increased risk of cardiac death, myocardial infarction, or all-cause mortality. Additional data from longer-term follow-up in the randomized clinical trials on the TAXUS Stent and analyses of DES-related stent thrombosis are ...
... TAXUS Stent compared to bare-metal stents have not been associated with an increased risk of cardiac death, myocardial infarction, or all-cause mortality. Additional data from longer-term follow-up in the randomized clinical trials on the TAXUS Stent and analyses of DES-related stent thrombosis are ...
EVG/COBI/FTC/TAF [E/C/F/TAF] FDC
... TAF and TFV: Cytochrome P450 and UGT1A1 Inhibition.................................................53 ...
... TAF and TFV: Cytochrome P450 and UGT1A1 Inhibition.................................................53 ...
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... the appearance of tics (involuntary body movements) or the worsening of pre-existing tics or other movement disorders. While some early studies reported such effects, the effects were not seen in studies that included control subjects (children not treated with methylphenidate) and evaluation by med ...
... the appearance of tics (involuntary body movements) or the worsening of pre-existing tics or other movement disorders. While some early studies reported such effects, the effects were not seen in studies that included control subjects (children not treated with methylphenidate) and evaluation by med ...
الدراسات والأبحاث حول القات TI: Khat and blood glucose levels in man
... CP: SWITZERLAND AB: The present review deals with the considerable body of evidence gathered in the last ten years on the clinical and experimental pharmacology of Khat. Khat effects are generally agreed to be of amphetamine-like type. In particular, Khat ingestion, like amphetamine ingestion, produ ...
... CP: SWITZERLAND AB: The present review deals with the considerable body of evidence gathered in the last ten years on the clinical and experimental pharmacology of Khat. Khat effects are generally agreed to be of amphetamine-like type. In particular, Khat ingestion, like amphetamine ingestion, produ ...
Dextromethorphan Pre
... suppression can be achieved by a number of different mechanisms. Behavioural studies in animals In preclinical rodent and monkey studies, dextromethorphan produces PCP-like stimulus effects in rats and partial substitution for PCP in monkeys. Dextrorphan produced full substitution for PCP in both ra ...
... suppression can be achieved by a number of different mechanisms. Behavioural studies in animals In preclinical rodent and monkey studies, dextromethorphan produces PCP-like stimulus effects in rats and partial substitution for PCP in monkeys. Dextrorphan produced full substitution for PCP in both ra ...
A Systematic Review of Modafinil: Potential
... γ-aminobutyric acid, and glutamate. It is a welltolerated medication with low propensity for abuse and is frequently used for off-label indications. The objective of this study was to systematically review the available evidence supporting the clinical use of modafinil. Data Sources: The search term ...
... γ-aminobutyric acid, and glutamate. It is a welltolerated medication with low propensity for abuse and is frequently used for off-label indications. The objective of this study was to systematically review the available evidence supporting the clinical use of modafinil. Data Sources: The search term ...
TRIAMTERENE and HYDROCHLOROTHIAZIDE TABLETS, USP
... and 1000 mg/kg/day, respectively. At these doses, which are multiples of the MRHD equal to 3000 for mice and 1000 for rats, based on body-weight, and equal to 282 for mice and 206 for rats, based on body-surface area, there was no evidence of harm to the fetus. There are, however, no adequate and we ...
... and 1000 mg/kg/day, respectively. At these doses, which are multiples of the MRHD equal to 3000 for mice and 1000 for rats, based on body-weight, and equal to 282 for mice and 206 for rats, based on body-surface area, there was no evidence of harm to the fetus. There are, however, no adequate and we ...
Applied Clinical Pharmacokinetics
... molecules to reach the systemic circulation. In order to be absorbed, the drug molecules must pass through several physiological barriers before reaching the vascular system. For example, when a medication is given orally, the drug dosage form must release drug molecules via dissolution, and the mol ...
... molecules to reach the systemic circulation. In order to be absorbed, the drug molecules must pass through several physiological barriers before reaching the vascular system. For example, when a medication is given orally, the drug dosage form must release drug molecules via dissolution, and the mol ...
Understanding your BOTOX treatment Answers to questions about BOTOX
... been reported hours to weeks after injection. Swallowing and breathing difficulties can be life threatening and there have been reports of death. The risk of symptoms is probably greatest in children treated for spasticity but symptoms can also occur in adults treated for spasticity and other condit ...
... been reported hours to weeks after injection. Swallowing and breathing difficulties can be life threatening and there have been reports of death. The risk of symptoms is probably greatest in children treated for spasticity but symptoms can also occur in adults treated for spasticity and other condit ...
GHB, GBL and 1,4-BD Addiction - Trimbos
... drugs of abuse, like ecstasy or cannabis [30]. Likewise, the number of information requests for GHB and GBL intoxication has risen steeply and ranks second after cannabis in 2011 and, especially, information requests by medical practitioners about GBL intoxication increased sharply from 5% in 2008 t ...
... drugs of abuse, like ecstasy or cannabis [30]. Likewise, the number of information requests for GHB and GBL intoxication has risen steeply and ranks second after cannabis in 2011 and, especially, information requests by medical practitioners about GBL intoxication increased sharply from 5% in 2008 t ...
Targeting Trace Mineral Bioavailability: The Case of Selenium
... plaques, inhibiting peroxidation of lipids, inhibiting platelet aggregation, modulate prostaglandin synthesis and affording protection against heavy metal toxicity. Recent reports suggest that dietary selenium supplementation may provide a safe and convenient method for increasing antioxidant protec ...
... plaques, inhibiting peroxidation of lipids, inhibiting platelet aggregation, modulate prostaglandin synthesis and affording protection against heavy metal toxicity. Recent reports suggest that dietary selenium supplementation may provide a safe and convenient method for increasing antioxidant protec ...
Hyaluronidase in Ophthalmology - The Journal of Applied Research
... duced from reference 5, with permission. purified hyaluronidase API extracted from an animal source usually contains less than 1% of the enzyme per milligram of total protein.5 The extract is often contaminated with proteases, immunoglobulin, and other elements, which can increase capillary permeabi ...
... duced from reference 5, with permission. purified hyaluronidase API extracted from an animal source usually contains less than 1% of the enzyme per milligram of total protein.5 The extract is often contaminated with proteases, immunoglobulin, and other elements, which can increase capillary permeabi ...