New anti-tuberculosis drugs and regimens: 2015 update
... “retreatment” cases are clearly separated, 30 days of previous anti-TB treatment being the cut-off [17]. New TB cases (irrespective of HIV status) should be treated for the first 2 months (intensive phase) with isoniazid, rifampicin, pyrazinamide and ethambutol, followed by isoniazid and rifampicin ...
... “retreatment” cases are clearly separated, 30 days of previous anti-TB treatment being the cut-off [17]. New TB cases (irrespective of HIV status) should be treated for the first 2 months (intensive phase) with isoniazid, rifampicin, pyrazinamide and ethambutol, followed by isoniazid and rifampicin ...
Original article Anti-hepatitis B virus activity in vitro of combinations
... The HBV DNA levels from the positive control wells (without tetracycline or drug) were consistently >200fold that from negative controls (with tetracycline), a signal/noise ratio allowing differentiation of a range of effects on HBV DNA levels (data not shown). The average EC50 values for each indiv ...
... The HBV DNA levels from the positive control wells (without tetracycline or drug) were consistently >200fold that from negative controls (with tetracycline), a signal/noise ratio allowing differentiation of a range of effects on HBV DNA levels (data not shown). The average EC50 values for each indiv ...
An In VitroAlternative For Predicting Systemic Toxicity - In
... Most models focus on predicting organ specific toxicity BARRIER to SUCCESS Alternative approach is to identify a plasma concentration that results in general systemic toxicity ...
... Most models focus on predicting organ specific toxicity BARRIER to SUCCESS Alternative approach is to identify a plasma concentration that results in general systemic toxicity ...
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... sources. The use of DPI is not limited to developing countries such as Nigeria alone. A study in Sweden showed that most community pharmacists use DPI and standard reference books as sources of drug information especially for drug indication and adverse drug effects [12]. The findings of this study ...
... sources. The use of DPI is not limited to developing countries such as Nigeria alone. A study in Sweden showed that most community pharmacists use DPI and standard reference books as sources of drug information especially for drug indication and adverse drug effects [12]. The findings of this study ...
Asmanex® HFA (mometasone furoate)
... • The most common adverse reactions (≥ 3%) with Asmanex HFA use were nasopharyngitis, headache, sinusitis, bronchitis, and influenza. ...
... • The most common adverse reactions (≥ 3%) with Asmanex HFA use were nasopharyngitis, headache, sinusitis, bronchitis, and influenza. ...
The Problems and Challenges of Immunotherapy
... P-80 TNF receptor to treat sepsis were abandoned after this trial; however, when the same drug was used in rheumatoid arthritis, another inflammatory disease but one with greater chronicity as compared with severe sepsis, the results were astoundingly positive. ...
... P-80 TNF receptor to treat sepsis were abandoned after this trial; however, when the same drug was used in rheumatoid arthritis, another inflammatory disease but one with greater chronicity as compared with severe sepsis, the results were astoundingly positive. ...
ICH E10 - Duke People
... should draw on information from any part of the CTD (non-clinical and clinical) and other relevant information, such as other drug labels, scientific literature, and postmarketing experience. Identified risks that require further evaluation More detailed information should be included on the most im ...
... should draw on information from any part of the CTD (non-clinical and clinical) and other relevant information, such as other drug labels, scientific literature, and postmarketing experience. Identified risks that require further evaluation More detailed information should be included on the most im ...
EVALUATION OF ANTIEPILEPTIC AND NOOTROPIC EFFECTS OF
... About 50 million people worldwide have epilepsy, with almost 90% of these people being in developing countries. Epilepsy is more likely to occur in young children (or) people over the age of 65 years. It can occur at any time6, 7. According to WHO, about 450 million people in the entire world have s ...
... About 50 million people worldwide have epilepsy, with almost 90% of these people being in developing countries. Epilepsy is more likely to occur in young children (or) people over the age of 65 years. It can occur at any time6, 7. According to WHO, about 450 million people in the entire world have s ...
USE OF NATURAL GUMS IN FORMULATION OF CONTROL RELEASED THEOPHYLLINE... Research Article *CLEMENT JACKSON, MUSILIU ADEDOKUN AND EKAETTE AKPABIO
... Matrix tablets were prepared using blends of xanthan gum (XG) and Guar gum (GG). Theophyline was used as the model drug. Theophylline controlled release (CR) powder mixtures were prepared and evaluated for the angle of repose, bulk density, tapped density, compressibility index and hausners ratio. A ...
... Matrix tablets were prepared using blends of xanthan gum (XG) and Guar gum (GG). Theophyline was used as the model drug. Theophylline controlled release (CR) powder mixtures were prepared and evaluated for the angle of repose, bulk density, tapped density, compressibility index and hausners ratio. A ...
PRODUCT MONOGRAPH PRECEDEX™ Dexmedetomidine
... In situations where other vasodilators or negative chronotropic agents are administered, coadministration of Precedex™ could have an additive pharmacodynamic effect and should be administered with caution. Transient Hypertension: Transient hypertension has been observed during the loading dose and ...
... In situations where other vasodilators or negative chronotropic agents are administered, coadministration of Precedex™ could have an additive pharmacodynamic effect and should be administered with caution. Transient Hypertension: Transient hypertension has been observed during the loading dose and ...
Impedance technology reveals correlations between cytotoxicity and
... The study of drug-like or absorption, distribution, metabolism, excretion and toxicity (ADMET) properties of new chemicals early in drug discovery has gained significant importance over the last decade due to the high rate of late drug failures during clinical trials (Hamid et al, 2004), in addition ...
... The study of drug-like or absorption, distribution, metabolism, excretion and toxicity (ADMET) properties of new chemicals early in drug discovery has gained significant importance over the last decade due to the high rate of late drug failures during clinical trials (Hamid et al, 2004), in addition ...
A NEW TOPICAL FLUCONAZOLE MICROSPONGE LOADED HYDROGEL: PREPARATION AND CHARACTERIZATION Research Article
... determined with rotation viscometer by using small sample adapter, S18 spindle for dispersed phase at the rate of 50 rpm at 25˚C. The results showed that the apparent viscosities of the Eu RS100 solution was 4.8 cp compared to 17.6 cps for the EC containing solution. This result is in full accordanc ...
... determined with rotation viscometer by using small sample adapter, S18 spindle for dispersed phase at the rate of 50 rpm at 25˚C. The results showed that the apparent viscosities of the Eu RS100 solution was 4.8 cp compared to 17.6 cps for the EC containing solution. This result is in full accordanc ...
prescribing information
... Serious, life-threatening, or fatal respiratory depression may occur. Monitor closely, especially upon initiation or following a dose increase. Instruct patients to swallow HYSINGLA ER whole to avoid exposure to a potentially fatal dose of hydrocodone. (5.2) Accidental ingestion of HYSINGLA ER, ...
... Serious, life-threatening, or fatal respiratory depression may occur. Monitor closely, especially upon initiation or following a dose increase. Instruct patients to swallow HYSINGLA ER whole to avoid exposure to a potentially fatal dose of hydrocodone. (5.2) Accidental ingestion of HYSINGLA ER, ...
Benzodiazepine Metabolism and Pharmacokinetics
... age.1 Benzodiazepine core chemical structure is composed of diazepine fused to a benzene ring. Different benzodiazepines have different side chains, which determine their pharmacokinetic profile. Benzodiazepines are used for their anxiolytic, antiepileptic, muscle relaxant, and hypnotic effects. Apa ...
... age.1 Benzodiazepine core chemical structure is composed of diazepine fused to a benzene ring. Different benzodiazepines have different side chains, which determine their pharmacokinetic profile. Benzodiazepines are used for their anxiolytic, antiepileptic, muscle relaxant, and hypnotic effects. Apa ...
Lidocaine Hydrochloride and Epinephrine
... unintended fetal intracranial injection of local anesthetic solution have been reported following intended paracervical or pudendal block or both. Babies so affected present with unexplained neonatal depression at birth, which correlates with high local anesthetic serum levels, and often manifest se ...
... unintended fetal intracranial injection of local anesthetic solution have been reported following intended paracervical or pudendal block or both. Babies so affected present with unexplained neonatal depression at birth, which correlates with high local anesthetic serum levels, and often manifest se ...
Approaches to Drug Dosing in Renal Dysfunction
... 50% of patients with diminished renal function are not having their doses adjusted appropriately (according to the study authors) A. True B. False ...
... 50% of patients with diminished renal function are not having their doses adjusted appropriately (according to the study authors) A. True B. False ...
O A
... epoxycyclohexan-2,3,4,5-tetrol (III-VI), a Diels-Alder adduct of 3-benzoyl-1-benzoyloxymethylcyclohexa-4,6dien-2,3-diol (VII), and a triacylated derivative of salicin (IX), in addition to (-)-zeylenol (II), and crotepoxide (VIII). Compounds II and VI demonstrated antifeedant activities against larva ...
... epoxycyclohexan-2,3,4,5-tetrol (III-VI), a Diels-Alder adduct of 3-benzoyl-1-benzoyloxymethylcyclohexa-4,6dien-2,3-diol (VII), and a triacylated derivative of salicin (IX), in addition to (-)-zeylenol (II), and crotepoxide (VIII). Compounds II and VI demonstrated antifeedant activities against larva ...
Important Information for Patients (Please read before treatment
... drug gains a license when it is safe, that means it will have side effects but that these are mild or occur infrequently. A drug will only be considered for a license if the drug company that makes it asks the licensing agency to do so. Because of the way Avastin works against cancer some ophthalmol ...
... drug gains a license when it is safe, that means it will have side effects but that these are mild or occur infrequently. A drug will only be considered for a license if the drug company that makes it asks the licensing agency to do so. Because of the way Avastin works against cancer some ophthalmol ...
Zantac - GSK Source
... acid secretion are estimated to be 36 to 94 ng/mL. Following a single oral dose of 150 mg, serum concentrations of ranitidine are in this range up to 12 hours. However, blood levels bear no consistent relationship to dose or degree of acid inhibition. Antisecretory Activity: 1. Effects on Acid Secre ...
... acid secretion are estimated to be 36 to 94 ng/mL. Following a single oral dose of 150 mg, serum concentrations of ranitidine are in this range up to 12 hours. However, blood levels bear no consistent relationship to dose or degree of acid inhibition. Antisecretory Activity: 1. Effects on Acid Secre ...
Immuneflu - BlueeyedCurse – A Holistic Health Resource for
... The Life Extension Foundation waged a multi-decade war against the FDA to get ribavirin approved in the United States. The FDA finally capitulated in the late 1990s and approved ribavirin as an adjuvant treatment for hepatitis C. A concern with using ribavirin is that it has been shown to cause ane ...
... The Life Extension Foundation waged a multi-decade war against the FDA to get ribavirin approved in the United States. The FDA finally capitulated in the late 1990s and approved ribavirin as an adjuvant treatment for hepatitis C. A concern with using ribavirin is that it has been shown to cause ane ...
Topographic pharmaco-EEG mapping of the effects of the South
... those of other classical serotonergic agents, such as psilocybin, and parenteral DMT [13, 14]. Ayahuasca was able to induce dose-dependent perceptual, cognitive and affective modifications, with a milder intensity and longer duration than those previously described for intravenous DMT [14], but with ...
... those of other classical serotonergic agents, such as psilocybin, and parenteral DMT [13, 14]. Ayahuasca was able to induce dose-dependent perceptual, cognitive and affective modifications, with a milder intensity and longer duration than those previously described for intravenous DMT [14], but with ...
The Oklahoma ITP Registry Newsletter
... my doctors and my parents were plenty concerned. That led to steroid treatment for the next seven months, including some hefty doses of prednisone up to 120 milligrams per day. Steroids are known far and wide for their rather nasty side effects, a trait with which I would whole heartedly agree. I ex ...
... my doctors and my parents were plenty concerned. That led to steroid treatment for the next seven months, including some hefty doses of prednisone up to 120 milligrams per day. Steroids are known far and wide for their rather nasty side effects, a trait with which I would whole heartedly agree. I ex ...
comparison of budesonide with oral prednisolone inhaled
... (be~az-agonists and theophylline) and anti-allergic as baseline therapy throughout the study but the had to be consLant. Topical be~az-agonists were pc11rniae111 for use as required, but a record of all concom was kept in case record forms and diary cards. who took additional steroids other than for ...
... (be~az-agonists and theophylline) and anti-allergic as baseline therapy throughout the study but the had to be consLant. Topical be~az-agonists were pc11rniae111 for use as required, but a record of all concom was kept in case record forms and diary cards. who took additional steroids other than for ...