Paediatric Public Assessment Report
... an un-sterile product to be stored for a period of more than a week with a label which also states it to be a parenteral product. This proposed variation has not provided any new information compared to the previous variation submitted to the Swedish MPA and based on the submitted information the co ...
... an un-sterile product to be stored for a period of more than a week with a label which also states it to be a parenteral product. This proposed variation has not provided any new information compared to the previous variation submitted to the Swedish MPA and based on the submitted information the co ...
revlimid - Celgene
... Angioedema and serious dermatologic reactions including Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) have been reported as rare cases from post-marketing experience. These events have the potential to be fatal. REVLIMID® discontinuation should be considered if skin rash ≥ Grad ...
... Angioedema and serious dermatologic reactions including Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) have been reported as rare cases from post-marketing experience. These events have the potential to be fatal. REVLIMID® discontinuation should be considered if skin rash ≥ Grad ...
Pharmacotherapy of Autism Spectrum Disorders: A Small Piece of
... Only 1 randomized trial included Phase 1: 7 days glutathione lotion or placebo lotion followed by 3 days of of oral DMSA Phase 2: 3 days of oral DMSA or placebo followed by 11 days off, cycle repeated up to 6 times NO effect on ASD symtpoms ...
... Only 1 randomized trial included Phase 1: 7 days glutathione lotion or placebo lotion followed by 3 days of of oral DMSA Phase 2: 3 days of oral DMSA or placebo followed by 11 days off, cycle repeated up to 6 times NO effect on ASD symtpoms ...
HYPERSENSITIVITY TO LOCAL ANAESTHETICS – 6 FACTS AND
... allergy to LA is in fact exceptional. Skin tests for LA allergy, including skin-prick tests (SPT) and intradermal (ID) tests, have poor sensitivity and specificity. True LA allergy, when appropriate, has to be confirmed by challenge. Provocation challenge is safe and well tolerated. Since the discov ...
... allergy to LA is in fact exceptional. Skin tests for LA allergy, including skin-prick tests (SPT) and intradermal (ID) tests, have poor sensitivity and specificity. True LA allergy, when appropriate, has to be confirmed by challenge. Provocation challenge is safe and well tolerated. Since the discov ...
The use of clozapine plasma levels in optimising therapy
... Centorrino et al (1995) found that there was no association between the degree of leucopenia caused by clozapine and clozapine or norclo zapine plasma levels. Clozapine serum levels are difficult to predict from the dose given and there are many factors which influence the serum level obtained. Shor ...
... Centorrino et al (1995) found that there was no association between the degree of leucopenia caused by clozapine and clozapine or norclo zapine plasma levels. Clozapine serum levels are difficult to predict from the dose given and there are many factors which influence the serum level obtained. Shor ...
The Expanding Role of Microsomal Enzyme Induction, and Its
... short of the number required to support the known specific reactions of the drug hydroxylation system. An alternative possibility is that there are different binding proteins for each compound or class of compound, and that these binding proteins in turn react with only one of the known forms of cyt ...
... short of the number required to support the known specific reactions of the drug hydroxylation system. An alternative possibility is that there are different binding proteins for each compound or class of compound, and that these binding proteins in turn react with only one of the known forms of cyt ...
IOPIDINE ® Solution
... Overdose is unlikely with topical ocular instillation, as the volume of exposure is limited by the capacity of the cul-de-sac. The small volume packaging and unique design of the DROPTAINER7 limit the potential for accidental overdosage by ingestion. Signs of toxicity of apraclonidine in animals inc ...
... Overdose is unlikely with topical ocular instillation, as the volume of exposure is limited by the capacity of the cul-de-sac. The small volume packaging and unique design of the DROPTAINER7 limit the potential for accidental overdosage by ingestion. Signs of toxicity of apraclonidine in animals inc ...
Chronic WIN55,212-2 elicits sustained and conditioned increases in
... 30 consecutive days of testing. Furthermore, there was no difference between pre- and post-injection ICSS thresholds during the first 5 consecutive days of the baseline phase. However, postinjection ICSS thresholds were increased after each WIN55,212-2 injection during the testing phase. This effect ...
... 30 consecutive days of testing. Furthermore, there was no difference between pre- and post-injection ICSS thresholds during the first 5 consecutive days of the baseline phase. However, postinjection ICSS thresholds were increased after each WIN55,212-2 injection during the testing phase. This effect ...
Development of an enzyme-linked immunosorbent assay and a beta
... for 4 h at 1008C. The mixture was then titrated to a final pH of 3 with 30% (v/v) NaOH, and the product and the nonhydrolyzed ATL were analyzed by MS (IMI TAMI Institute for Research and Development). The results showed full conversion of ATL to ATL-acid. The final concentration of the sample was 20 m ...
... for 4 h at 1008C. The mixture was then titrated to a final pH of 3 with 30% (v/v) NaOH, and the product and the nonhydrolyzed ATL were analyzed by MS (IMI TAMI Institute for Research and Development). The results showed full conversion of ATL to ATL-acid. The final concentration of the sample was 20 m ...
A novel bivalent morphine/heroin vaccine that prevents relapse to
... nance of heroin abstinence is the high incidence of relapse to addictive drug consumption [1–6]. An alternative pharmacotherapy for both abstinence and prevention of relapse to heroin addiction is based on blocking heroin from reaching its opioid receptor target by using naltrexone and naloxone [7]. ...
... nance of heroin abstinence is the high incidence of relapse to addictive drug consumption [1–6]. An alternative pharmacotherapy for both abstinence and prevention of relapse to heroin addiction is based on blocking heroin from reaching its opioid receptor target by using naltrexone and naloxone [7]. ...
Primary Hypertension in Adults - Georgia Coastal Health District
... combination of standard therapy with SHAPP medications, or those who have intolerable side effects, or in those who have specific contraindications to other therapy. Verapamil 120mg sustained-release (SR) up to 480 mg/day. Dosage should be adjusted according to the client’s blood pressure response. ...
... combination of standard therapy with SHAPP medications, or those who have intolerable side effects, or in those who have specific contraindications to other therapy. Verapamil 120mg sustained-release (SR) up to 480 mg/day. Dosage should be adjusted according to the client’s blood pressure response. ...
Public Assessment Report Scientific discussion Oxcarbazepine CF
... of dosage units. The release and shelf-life requirements/limits are identical with the exception of the limits for water and total impurities, which can be accepted. The analytical methods have been adequately described and validated. Batch analyses data has been provided for two pilot-scale batches ...
... of dosage units. The release and shelf-life requirements/limits are identical with the exception of the limits for water and total impurities, which can be accepted. The analytical methods have been adequately described and validated. Batch analyses data has been provided for two pilot-scale batches ...
IN-VIVO SCREENING OF ANTI-INFLAMMATORY ACTIVITY IN METHANOLIC EXTRACT OF CORBICHONIA DECUMBENS
... Determination of anti-inflammatory activity Carrageenan Induced Hind Paw Oedema The anti-inflammatory activity of the extract was determined using carrageenan induced rat paw oedema assay [9]. Wister Albino rats of either sex weighing 150-200 grams were divided into five groups of six animals each. ...
... Determination of anti-inflammatory activity Carrageenan Induced Hind Paw Oedema The anti-inflammatory activity of the extract was determined using carrageenan induced rat paw oedema assay [9]. Wister Albino rats of either sex weighing 150-200 grams were divided into five groups of six animals each. ...
Promacta - Novartis Pharmaceuticals Corporation
... Discontinuation: The prescribing information for pegylated interferon and ribavirin include recommendations for antiviral treatment discontinuation for treatment futility. Refer to pegylated interferon and ribavirin prescribing information for discontinuation recommendations for antiviral treatment ...
... Discontinuation: The prescribing information for pegylated interferon and ribavirin include recommendations for antiviral treatment discontinuation for treatment futility. Refer to pegylated interferon and ribavirin prescribing information for discontinuation recommendations for antiviral treatment ...
Club des Chirurgiens Cardiaques 20
... the outcome gradient between DES and BMS, in order to provide the evidence that DES should replace BMS and be used in all cases The performance of BMS used in DES trials is perceived by many as exceedingly poor compared to their experience (EU > US) Per protocol angiography results in ± doubling of ...
... the outcome gradient between DES and BMS, in order to provide the evidence that DES should replace BMS and be used in all cases The performance of BMS used in DES trials is perceived by many as exceedingly poor compared to their experience (EU > US) Per protocol angiography results in ± doubling of ...
Anadol - Square Pharmaceuticals Ltd.
... Tramadol should be used with caution in patients with increased intracranial pressure or head injury and patients with acute abdominal conditions. Use in Pregnancy and Lactation Safe use of tramadol in pregnancy has not been established. Tramadol has been shown to cross the placenta. There are no ad ...
... Tramadol should be used with caution in patients with increased intracranial pressure or head injury and patients with acute abdominal conditions. Use in Pregnancy and Lactation Safe use of tramadol in pregnancy has not been established. Tramadol has been shown to cross the placenta. There are no ad ...
Immediate hypersensitivity to penicillins with negative skin tests
... previous reaction had been life-threatening. The drug challenge tests were done according to ENDA guidelines (4), under strict medical surveillance. Increasing doses (four or five), of the antibiotic to which the patients had positive specific IgE were administered each 30 min until the therapeutic ...
... previous reaction had been life-threatening. The drug challenge tests were done according to ENDA guidelines (4), under strict medical surveillance. Increasing doses (four or five), of the antibiotic to which the patients had positive specific IgE were administered each 30 min until the therapeutic ...
indiv_drugs_f12
... Difficult to overdose on cannabis Amount required to cause death very large Smoking too much - sleepiness Eating too much - nausea, vomiting ...
... Difficult to overdose on cannabis Amount required to cause death very large Smoking too much - sleepiness Eating too much - nausea, vomiting ...
Prescribing Information for SPIRIVA RESPIMAT
... Because clinical trials are conducted under widely varying conditions, the incidence of adverse reactions observed in the clinical trials of a drug cannot be directly compared to the incidences in the clinical trials of another drug and may not reflect the incidences observed in practice. Since the ...
... Because clinical trials are conducted under widely varying conditions, the incidence of adverse reactions observed in the clinical trials of a drug cannot be directly compared to the incidences in the clinical trials of another drug and may not reflect the incidences observed in practice. Since the ...
Intravenous Immunoglobulins In The Therapy Of Immune
... effective, although most studies have used 1 g/kg. IVIG is administered as an intravenous infusion over 6-12 hours. It should be started at a slow rate (0.01 ml/kg/min) and gradually increased every 30-60 minutes to a maintenance fluid rate (maximum 0.08 ml/kg/min). Excessively high rates should be ...
... effective, although most studies have used 1 g/kg. IVIG is administered as an intravenous infusion over 6-12 hours. It should be started at a slow rate (0.01 ml/kg/min) and gradually increased every 30-60 minutes to a maintenance fluid rate (maximum 0.08 ml/kg/min). Excessively high rates should be ...
testosterone cypionate injection, USP
... response and the appearance of adverse reactions. Various dosage regimens have been used to induce pubertal changes in hypogonadal males; some experts have advocated lower dosages initially, gradually increasing the dose as puberty progresses, with or without a decrease to maintenance levels. Other ...
... response and the appearance of adverse reactions. Various dosage regimens have been used to induce pubertal changes in hypogonadal males; some experts have advocated lower dosages initially, gradually increasing the dose as puberty progresses, with or without a decrease to maintenance levels. Other ...
Infusion reactions associated with use of biologic
... of granulocytes [16]. A proportion of bone marrow cells, including some CD34+ cells, express variable levels of CD52. Alemtuzumab binds to CD52 on the leukemic cells which leads to antibody-dependent cell mediated cytotoxicity. Alemtuzumab is indicated as a single agent for the treatment of B-cell c ...
... of granulocytes [16]. A proportion of bone marrow cells, including some CD34+ cells, express variable levels of CD52. Alemtuzumab binds to CD52 on the leukemic cells which leads to antibody-dependent cell mediated cytotoxicity. Alemtuzumab is indicated as a single agent for the treatment of B-cell c ...
Might stimulant drugs support moral agency in ADHD children? Steven Edward Hyman
... The data and analysis provided by Singh2 represent a much needed empirical foray into a set of concerns generally discussed at a rather sterile theoretical level. The underlying data are derived from interviews with children drawn from approximately 150 families in the US and UK who were being treat ...
... The data and analysis provided by Singh2 represent a much needed empirical foray into a set of concerns generally discussed at a rather sterile theoretical level. The underlying data are derived from interviews with children drawn from approximately 150 families in the US and UK who were being treat ...
The Effect of Overencapsulation on Disintegration and
... Although encapsulation resulted in a lag time of 2-3 min in disintegration compared with the unencapsulated tablets, the disintegration and dissolution of propranolol and rofecoxib were the same whether tablets were encapsulated in DBcaps capsules or standard gelatin capsules. It can thus be expecte ...
... Although encapsulation resulted in a lag time of 2-3 min in disintegration compared with the unencapsulated tablets, the disintegration and dissolution of propranolol and rofecoxib were the same whether tablets were encapsulated in DBcaps capsules or standard gelatin capsules. It can thus be expecte ...
Heart Failure - Derbyshire Medicines Management
... modification of the patient's treatment. Heart failure treatment, especially the combination of ACEi and MRA puts the patient at risk of acute decline in renal function and hyperkalaemia. In the event of intercurrent illness, especially diarrhoea and vomiting, all patients should be counselled to co ...
... modification of the patient's treatment. Heart failure treatment, especially the combination of ACEi and MRA puts the patient at risk of acute decline in renal function and hyperkalaemia. In the event of intercurrent illness, especially diarrhoea and vomiting, all patients should be counselled to co ...