A Review on Mouth Dissolving Film
... mouth dissolving film have led to wider acceptability of this dosage form by paediatric as well as geriatric patients. They also impart unique product differentiation, thus enabling use as line extensions for existing commercial products. This novel drug delivery system can also be beneficial for me ...
... mouth dissolving film have led to wider acceptability of this dosage form by paediatric as well as geriatric patients. They also impart unique product differentiation, thus enabling use as line extensions for existing commercial products. This novel drug delivery system can also be beneficial for me ...
Apixaban in patients with Atrial Fibrillation: A Systematic Review
... systemic embolism by 5- fold, it is a major global public health problem. Stroke is associated with greatest mortality and morbidity in patients with AF. Strokes associated with AF are especially large and disabling, and consequently primary prevention is paramount. Antithrombotic therapy is the mai ...
... systemic embolism by 5- fold, it is a major global public health problem. Stroke is associated with greatest mortality and morbidity in patients with AF. Strokes associated with AF are especially large and disabling, and consequently primary prevention is paramount. Antithrombotic therapy is the mai ...
Antisense therapy in oncology: new hope for an old idea?
... In a phase I study,6 the pharmacokinetics, toxicity, and therapeutic activity of an antisense oligonucleotide targeting the mRNA of BCL2 was assessed. 21 patients with BCL2-positive relapsed non-Hodgkin’s lymphoma were given a 14-day subcutaneous infusion of an 18-mer phosphorothioate oligonucleotid ...
... In a phase I study,6 the pharmacokinetics, toxicity, and therapeutic activity of an antisense oligonucleotide targeting the mRNA of BCL2 was assessed. 21 patients with BCL2-positive relapsed non-Hodgkin’s lymphoma were given a 14-day subcutaneous infusion of an 18-mer phosphorothioate oligonucleotid ...
Sound-Alike/Look-Alike Drugs for Hospital
... Fatal errors have occurred, often due to name similarity, when patients were erroneously given Vincristine intravenously, but at the higher Vinblastine dose. Similar names and some similar strengths have contributed to medication errors. This may represent significant overdose, leading to serious ad ...
... Fatal errors have occurred, often due to name similarity, when patients were erroneously given Vincristine intravenously, but at the higher Vinblastine dose. Similar names and some similar strengths have contributed to medication errors. This may represent significant overdose, leading to serious ad ...
Date Of Origin
... There is no evidence that branded medications, statin or non-statin, are safer or more effective than generic treatment options at optimized doses. Generics are available for statins, fibrates, and omega-3-acids. ...
... There is no evidence that branded medications, statin or non-statin, are safer or more effective than generic treatment options at optimized doses. Generics are available for statins, fibrates, and omega-3-acids. ...
MINI REVIEW - “What Is The Safety Of Fluoroquinolones For... Dorothy Koech
... The fluoroquinolone class of antimicrobials has been in clinical use for over 17 years now [14]. For a long time quinolones had not been approved for use in children, primarily because of concerns they could cause irreversible damage to growing cartilage in weight bearing joints, concerns resulting ...
... The fluoroquinolone class of antimicrobials has been in clinical use for over 17 years now [14]. For a long time quinolones had not been approved for use in children, primarily because of concerns they could cause irreversible damage to growing cartilage in weight bearing joints, concerns resulting ...
INTRAVENOUS INFUSION (not for IV Bolus Injection)
... The white to off-white cake will dissolve completely. Mix gently until a clear solution is obtained. Visually inspect the reconstituted solution for particulate matter or discoloration during reconstitution and prior to infusion. Do not use if the solution is cloudy or has precipitated. The reconsti ...
... The white to off-white cake will dissolve completely. Mix gently until a clear solution is obtained. Visually inspect the reconstituted solution for particulate matter or discoloration during reconstitution and prior to infusion. Do not use if the solution is cloudy or has precipitated. The reconsti ...
DMID 01-553 FQ EBA Study Results
... • Different doses can be evaluated to define dose for phase 2b & 3 trials • PK can be compared to bactericidal activity • Short term toxicity in humans with TB can be evaluated ...
... • Different doses can be evaluated to define dose for phase 2b & 3 trials • PK can be compared to bactericidal activity • Short term toxicity in humans with TB can be evaluated ...
Afeksin
... may be considered after two weeks if there is no response. If no improvement is observed within 10 weeks, treatment with fluoxetine should be reconsidered. If a good therapeutic response has been obtained, treatment can be continued at a dosage adjusted on an individual basis. While there are no sys ...
... may be considered after two weeks if there is no response. If no improvement is observed within 10 weeks, treatment with fluoxetine should be reconsidered. If a good therapeutic response has been obtained, treatment can be continued at a dosage adjusted on an individual basis. While there are no sys ...
use
... •Results are mixed. One study showed no benefit •Jacobson et al. J Clin Oncol 2001;19:2739-2745 n=85; cohosh product NOT DESCRIBED •Munoz and Pluchino. Maturitas 2003;44:S59-S65. N=136; cohosh 20mg/d Menofem® for 12 months. •Table 4 ...
... •Results are mixed. One study showed no benefit •Jacobson et al. J Clin Oncol 2001;19:2739-2745 n=85; cohosh product NOT DESCRIBED •Munoz and Pluchino. Maturitas 2003;44:S59-S65. N=136; cohosh 20mg/d Menofem® for 12 months. •Table 4 ...
FORMULATION AND EVALUATION OF GASTRO RETENTIVE IN
... : Mean percent dissolved at each time point for the reference and test dissolution profiles The two dissolution profiles are considered similar or closeness between two ...
... : Mean percent dissolved at each time point for the reference and test dissolution profiles The two dissolution profiles are considered similar or closeness between two ...
Young Innovators 2009
... Metabolized primarily by hepatic CYP3A4 and UGT1A9; both parent drug and metabolites undergo biliary excretion1. Subject to GI solubility-limited absorption as evidenced by less than proportional increase in exposure (AUC) with escalating doses; a plateau is reached at 600 mg BID2. Associated with h ...
... Metabolized primarily by hepatic CYP3A4 and UGT1A9; both parent drug and metabolites undergo biliary excretion1. Subject to GI solubility-limited absorption as evidenced by less than proportional increase in exposure (AUC) with escalating doses; a plateau is reached at 600 mg BID2. Associated with h ...
CARDOXIN doctor leaflet
... adjunct in myocardial imaging must be weighed against the risk to the patient. Comparable reactions to exercise-induced stress may occur. Therefore dipyridamolethallium scanning should be performed with continuous ECG monitoring of the patient. When myocardial imaging is performed with intravenous C ...
... adjunct in myocardial imaging must be weighed against the risk to the patient. Comparable reactions to exercise-induced stress may occur. Therefore dipyridamolethallium scanning should be performed with continuous ECG monitoring of the patient. When myocardial imaging is performed with intravenous C ...
- Wiley Online Library
... is reported to act preferentially at mu receptors.33Stimulation of sigma receptors causes central nervous stimulation and psychotomimetic effects. The significance and distribution of opiate receptors in the horse remains to be determined. Roger studied the effects of morphine (0.5 or 1 mg/kg IV) on ...
... is reported to act preferentially at mu receptors.33Stimulation of sigma receptors causes central nervous stimulation and psychotomimetic effects. The significance and distribution of opiate receptors in the horse remains to be determined. Roger studied the effects of morphine (0.5 or 1 mg/kg IV) on ...
CUBICIN ® Product Monograph - Sunovion Pharmaceuticals
... swallowing, truncal erythema and pulmonary eosinophilia) have been reported with CUBICIN® use. If an allergic reaction occurs, administration of CUBICIN® should be discontinued and appropriate therapy should be initiated. Persisting or Relapsing Staphylococcus aureus Infection Patients with persisti ...
... swallowing, truncal erythema and pulmonary eosinophilia) have been reported with CUBICIN® use. If an allergic reaction occurs, administration of CUBICIN® should be discontinued and appropriate therapy should be initiated. Persisting or Relapsing Staphylococcus aureus Infection Patients with persisti ...
Role of nanotechnology in targeted drug delivery and imaging: T
... uptake are particularly valuable to therapeutics that are not taken up easily by cells and require facilitation by fusion, endocytosis, or other processes to access their cellular active sites [55]. Active targeting can also enhance the distribution of nanomedicine within the tumor interstitium [4]. ...
... uptake are particularly valuable to therapeutics that are not taken up easily by cells and require facilitation by fusion, endocytosis, or other processes to access their cellular active sites [55]. Active targeting can also enhance the distribution of nanomedicine within the tumor interstitium [4]. ...
![Propranolol Tabs BP 10 mg [saw]](http://s1.studyres.com/store/data/007844755_1-24becc6cbee99ead17fa7f3a408832e3-300x300.png)
Propranolol Tabs BP 10 mg [saw]
... Dysrhythmias, thyrotoxicosis: the minimum effective dosage based on 0.25 - 0.5 mg/kg body weight three or four times daily. Migraine: children under the age of 12 may be given 20 mg two or three times daily. Older children may be given adult dosage. Elderly No specific dosage recommendations. Howeve ...
... Dysrhythmias, thyrotoxicosis: the minimum effective dosage based on 0.25 - 0.5 mg/kg body weight three or four times daily. Migraine: children under the age of 12 may be given 20 mg two or three times daily. Older children may be given adult dosage. Elderly No specific dosage recommendations. Howeve ...
Management of Neonatal Opioid Withdrawal
... Results of urine testing are rapidly available; however, there is a high false negative rate given the rapid clearance of most drugs and the difficulty in obtaining sufficient urine from a newborn in the first day of life. Meconium testing offers the advantage of assessing drug exposure during the p ...
... Results of urine testing are rapidly available; however, there is a high false negative rate given the rapid clearance of most drugs and the difficulty in obtaining sufficient urine from a newborn in the first day of life. Meconium testing offers the advantage of assessing drug exposure during the p ...
IOSR Journal of Dental and Medical Sciences (JDMS)
... chloride currents in Xenopus oocytes expressing human GABAA receptor subunits α1, β2, γ2L, but direct activation of chloride flux occurred only at micromolar concentrations [21,22]. Ganaxolone have unique, noninteracting binding requirements on GABAA receptors distinct from those of benzodiazepines ...
... chloride currents in Xenopus oocytes expressing human GABAA receptor subunits α1, β2, γ2L, but direct activation of chloride flux occurred only at micromolar concentrations [21,22]. Ganaxolone have unique, noninteracting binding requirements on GABAA receptors distinct from those of benzodiazepines ...
- Wiley Online Library
... aspects, on the structural characteristics of the matrix polymer and its degradation and swelling, and on the microenvironmental pH changes inside the polymer matrix pores that are due to the degradation products. Prediction of the drug release profile using a model can obviously be very useful in th ...
... aspects, on the structural characteristics of the matrix polymer and its degradation and swelling, and on the microenvironmental pH changes inside the polymer matrix pores that are due to the degradation products. Prediction of the drug release profile using a model can obviously be very useful in th ...
Cephalexin Product Information Australia DRAFT
... Impaired Renal Function Cephalexin should be administered with caution in the presence of markedly impaired renal function. Careful clinical and laboratory studies should be made because safe dosage may be lower than that ...
... Impaired Renal Function Cephalexin should be administered with caution in the presence of markedly impaired renal function. Careful clinical and laboratory studies should be made because safe dosage may be lower than that ...
Pramipexole in the Management of Restless Legs Syndrome
... mentation. The shortest time to augmentation was 2 months. In contrast, Ferini-Strambi found an augmentation rate of only 8% in 60 patients followed for at least 6 months.17 These discrepant results may be due to the shorter duration of follow-up in their study. Studies of pergolide, however, repor ...
... mentation. The shortest time to augmentation was 2 months. In contrast, Ferini-Strambi found an augmentation rate of only 8% in 60 patients followed for at least 6 months.17 These discrepant results may be due to the shorter duration of follow-up in their study. Studies of pergolide, however, repor ...
Graphene Oxide for Biomedical Applications
... examined towards human neuroblastoma cells. The cytotoxicity of this GO was checked with SK-N-BE (2) and SH-SY5Y cell lines and found low concentration of GO gives minimal effects on healthy cells [42]. GO can be single layer and multilayer and the number of layers definitely changes its physico che ...
... examined towards human neuroblastoma cells. The cytotoxicity of this GO was checked with SK-N-BE (2) and SH-SY5Y cell lines and found low concentration of GO gives minimal effects on healthy cells [42]. GO can be single layer and multilayer and the number of layers definitely changes its physico che ...
Demystifying Analytical Approaches for Urine Drug Testing to
... adherence testing is evolving, and consensus regarding the specific content of a “comprehensive” or “standard” drug testing panel that meets needs of all pain management clinics does not currently exist. The best approach to drug testing for any application is to employ the test or tests that most c ...
... adherence testing is evolving, and consensus regarding the specific content of a “comprehensive” or “standard” drug testing panel that meets needs of all pain management clinics does not currently exist. The best approach to drug testing for any application is to employ the test or tests that most c ...
Antipsychotics (oral) BNF 4
... sexual & menstrual dysfunction. Document findings even if no side effects experienced. The following antipsychotics should be considered as first line treatment where appropriate; risperidone, olanzapine or quetiapine immediate release or any of the typical antipsychotics as listed in the table be ...
... sexual & menstrual dysfunction. Document findings even if no side effects experienced. The following antipsychotics should be considered as first line treatment where appropriate; risperidone, olanzapine or quetiapine immediate release or any of the typical antipsychotics as listed in the table be ...