FORMULATION AND EVALUATION OF OXICONAZOLE NITRATE
... Objective: The aim of the present study was to formulate and evaluate nanoemulsion-based gel of oxiconazole nitrate (OXZ) for the treatment of vaginal infection. Methods: The solubility of Oxiconazole nitrate in various oils, surfactant and co-surfactant, were done to identify the components of the ...
... Objective: The aim of the present study was to formulate and evaluate nanoemulsion-based gel of oxiconazole nitrate (OXZ) for the treatment of vaginal infection. Methods: The solubility of Oxiconazole nitrate in various oils, surfactant and co-surfactant, were done to identify the components of the ...
formulation and delivery strategies
... The formulation and handling of biopharmaceutical drugs poses unique challenges that are not often experienced with small molecules. One of the key challenges is overcoming the instability of the biologic, which is caused by aggregation, deamidation, isomerization, hydrolysis, oxidation and denatura ...
... The formulation and handling of biopharmaceutical drugs poses unique challenges that are not often experienced with small molecules. One of the key challenges is overcoming the instability of the biologic, which is caused by aggregation, deamidation, isomerization, hydrolysis, oxidation and denatura ...
Managing Overfill during Preparation and Delivery of Intravenous
... neonates receiving amounts of trace elements that were greater than intended. Trace elements are chemicals that the body requires in only minute amounts, including, for example, zinc, selenium, and manganese. In the incident reported to ISMP Canada, the healthcare organization had responded to a sho ...
... neonates receiving amounts of trace elements that were greater than intended. Trace elements are chemicals that the body requires in only minute amounts, including, for example, zinc, selenium, and manganese. In the incident reported to ISMP Canada, the healthcare organization had responded to a sho ...
Rilpivirine: a new non-nucleoside reverse transcriptase inhibitor
... A Phase IIa randomized, double-blind, placebo-controlled, multiple-dose escalation trial randomized 47 HIV-1 seropositive, antiretroviral-naive adult males to receive one of four doses of rilpivirine monotherapy (25, 50, 100 or 150 mg daily) or placebo for 7 days, after which subjects commenced stan ...
... A Phase IIa randomized, double-blind, placebo-controlled, multiple-dose escalation trial randomized 47 HIV-1 seropositive, antiretroviral-naive adult males to receive one of four doses of rilpivirine monotherapy (25, 50, 100 or 150 mg daily) or placebo for 7 days, after which subjects commenced stan ...
Histopathological evaluation of gastro protective effect of Berberis
... the gastric mucosa by disrupting the gastric epithelial linings. It reduced the height of villi inside the luminal mucosa. In the glandular region there was connective tissue proliferation and also infiltration of cells was observed. However similar infiltration of cells was present on muscularis mu ...
... the gastric mucosa by disrupting the gastric epithelial linings. It reduced the height of villi inside the luminal mucosa. In the glandular region there was connective tissue proliferation and also infiltration of cells was observed. However similar infiltration of cells was present on muscularis mu ...
Title: Embryotoxicity of Orally Administered Misoprostol to Pregnant
... vehicle treated control fetuses (Figs. 2-5). Histological studies of fetuses recovered from vehicle control group showed well developed brain, eye and heart. Within the brain, diencephalon, lateral, third and fourth ventricles pinna were found well develop (Fig. 6A). Moreover, well developed medulla ...
... vehicle treated control fetuses (Figs. 2-5). Histological studies of fetuses recovered from vehicle control group showed well developed brain, eye and heart. Within the brain, diencephalon, lateral, third and fourth ventricles pinna were found well develop (Fig. 6A). Moreover, well developed medulla ...
... to complete the study. SAS statistical package, version 6.06 was used to perform the statistical analysis. The primary efficacy analysis was on all patients who received at least one dose of study drug (all-patients-treated approach) and who completed both treatment periods (n=45). A per-protocol an ...
Title: Directly observable behavioral effects of lorcaserin in rats
... present in the test cage) and allowed to habituate for 15 min. Experiments were conducted at the same time each test day (14:00 h) by an independent observer blind to the treatment. Behavior was assessed after injection of vehicle, followed by injection of increasing doses of drug administered i.p. ...
... present in the test cage) and allowed to habituate for 15 min. Experiments were conducted at the same time each test day (14:00 h) by an independent observer blind to the treatment. Behavior was assessed after injection of vehicle, followed by injection of increasing doses of drug administered i.p. ...
Using SAS® for Modeling and Simulation in Drug Development – A Review and Assessment of Some Available Tools
... CLINICAL DATA SIMULATION In a typical clinical trial, there are hundreds of responses or observation made, both safety and efficacy, measured for each subject over the course of the study. These are collected, cleaned and subsequently analyzed to help establish safety and efficacy claims. There are ...
... CLINICAL DATA SIMULATION In a typical clinical trial, there are hundreds of responses or observation made, both safety and efficacy, measured for each subject over the course of the study. These are collected, cleaned and subsequently analyzed to help establish safety and efficacy claims. There are ...
Maximum Dosage Policy
... zoledronic acid (zoledronic acid, Reclast® and Zometa®) Most medications have a maximum dosage based upon body surface area or patient weight or a set maximal dosage independent of patient body size, and are proven when used according to labeled indications or when otherwise supported by published c ...
... zoledronic acid (zoledronic acid, Reclast® and Zometa®) Most medications have a maximum dosage based upon body surface area or patient weight or a set maximal dosage independent of patient body size, and are proven when used according to labeled indications or when otherwise supported by published c ...
TrialNet New Protocol –
... Preclinical studies have shown that ALS treatment of the NOD mouse (18) and BB rat (19) with recent onset T1D can induce remission, supporting proof of principle for such an approach in humans. The case for combination of ATG with other agents received support from follow-up studies in new-onset NOD ...
... Preclinical studies have shown that ALS treatment of the NOD mouse (18) and BB rat (19) with recent onset T1D can induce remission, supporting proof of principle for such an approach in humans. The case for combination of ATG with other agents received support from follow-up studies in new-onset NOD ...
Dabigatran instead of warfarin in AF
... if they have one or more of the following risk factors: o Aged 75 or over o Age 65 or over with either diabetes, coronary artery disease or hypertension o Previous CVA, TIA or systemic emboli o LV ejection fraction of <40% o Symptomatic heart failure (NYHA class 2 or worse= anyone with any limi ...
... if they have one or more of the following risk factors: o Aged 75 or over o Age 65 or over with either diabetes, coronary artery disease or hypertension o Previous CVA, TIA or systemic emboli o LV ejection fraction of <40% o Symptomatic heart failure (NYHA class 2 or worse= anyone with any limi ...
phytopharmacological aspects of chlorophytum borivilianum
... increase in average latent period when the animals received C. borivilianum root extract at a dose level of 800 mg/kg body weight/day orally in double distilled water at pre, peri and post initiation stages of carcinogenesis. A significant reduction in the frequency of chromosomal aberration and mic ...
... increase in average latent period when the animals received C. borivilianum root extract at a dose level of 800 mg/kg body weight/day orally in double distilled water at pre, peri and post initiation stages of carcinogenesis. A significant reduction in the frequency of chromosomal aberration and mic ...
FINASTERIDE (Propecia® / Proscar®) - EU
... scalp. DHT is known to be the main cause of hair loss and is formed when the enzyme 5-alpha reductase interacts with the male hormone testosterone. Research also shows that finasteride generate little side effects to human, although about 5% of the patients experienced a decrease in libido and sex d ...
... scalp. DHT is known to be the main cause of hair loss and is formed when the enzyme 5-alpha reductase interacts with the male hormone testosterone. Research also shows that finasteride generate little side effects to human, although about 5% of the patients experienced a decrease in libido and sex d ...
Prescribing Information - Mallinckrodt Pharmaceuticals
... use of other serotonergic drugs (including triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone, and St. John’s Wort) and with drugs that impair metabolism of serotonin (in particular, MAOIs, both those intended to treat psychiatric disorders and also others, such ...
... use of other serotonergic drugs (including triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone, and St. John’s Wort) and with drugs that impair metabolism of serotonin (in particular, MAOIs, both those intended to treat psychiatric disorders and also others, such ...
448-452 - Cairo University Scholars
... produced with Selenium combination with the same drug. However, the use of each antioxidant alone didn’t induce any considerable effect. Synergistic effect of antioxidants with specific antiparasitic drug may occur as a result of the ability of the antioxidant to improve the immune and general healt ...
... produced with Selenium combination with the same drug. However, the use of each antioxidant alone didn’t induce any considerable effect. Synergistic effect of antioxidants with specific antiparasitic drug may occur as a result of the ability of the antioxidant to improve the immune and general healt ...
Protecting Human Subjects in Clinical Trials
... healthcare professionals in the palliative care community that the action taken on March 30 would cause a shortage of 20 mg/ml morphine sulfate oral solution, the agency stated in a press release. This product is widely used to alleviate pain in terminally ill patients. The agency has determined tha ...
... healthcare professionals in the palliative care community that the action taken on March 30 would cause a shortage of 20 mg/ml morphine sulfate oral solution, the agency stated in a press release. This product is widely used to alleviate pain in terminally ill patients. The agency has determined tha ...
Smart Infusion Pumps Reduce Intravenous Medication - jppr
... smart pumps and found many soft– and hard–limit alerts that were not self-reported. A prospective randomised time–series trial to determine if smart pumps improve medication safety, identified 87 and 93 serious intravenous medication errors per 100 patients pump days pre- and postimplementation, res ...
... smart pumps and found many soft– and hard–limit alerts that were not self-reported. A prospective randomised time–series trial to determine if smart pumps improve medication safety, identified 87 and 93 serious intravenous medication errors per 100 patients pump days pre- and postimplementation, res ...
Marijuana Dosing Issues: Notes From the Literature
... through the pharynx and stomach lining. As a result, alcohol-based products are fast-acting (15-45 minutes) but not necessarily long-lasting.” –VICS ...
... through the pharynx and stomach lining. As a result, alcohol-based products are fast-acting (15-45 minutes) but not necessarily long-lasting.” –VICS ...
March 2012: Financial highlights of Financial highlights of the life
... Appoi nts Peter Klemm as CEO Following Series B Financing of USD 22.5 M Applied Proteomics Inc. (San Diego, CA. USA), powering the proteome to transform diagnostics, announced the appointment of veteran diagnostic developer, Peter Klemm, Ph.D., as chief executive officer. Applied Proteomics also ann ...
... Appoi nts Peter Klemm as CEO Following Series B Financing of USD 22.5 M Applied Proteomics Inc. (San Diego, CA. USA), powering the proteome to transform diagnostics, announced the appointment of veteran diagnostic developer, Peter Klemm, Ph.D., as chief executive officer. Applied Proteomics also ann ...
Administration of Corticosterone After the First Downshift Trial
... 11, the first postshift trial, half of the rats received a subcutaneous injection of corticosterone (3 mg/kg). To prepare corticosterone (Upjohn Laboratories, Kalamazoo, MI), ethanol 100% was diluted in 0.9% isotonic saline to a 5% ethanol concentration; corticosterone was then diluted in this vehic ...
... 11, the first postshift trial, half of the rats received a subcutaneous injection of corticosterone (3 mg/kg). To prepare corticosterone (Upjohn Laboratories, Kalamazoo, MI), ethanol 100% was diluted in 0.9% isotonic saline to a 5% ethanol concentration; corticosterone was then diluted in this vehic ...
Basic Principles of GMP - World Health Organization
... paediatric population but it does not address the problem of offlabel use. Children undergo various stages of physiological development. Moreover, they represent a wide spectrum of physiological and developmental stages from the newborns through adolescents, before they become adults. Each of th ...
... paediatric population but it does not address the problem of offlabel use. Children undergo various stages of physiological development. Moreover, they represent a wide spectrum of physiological and developmental stages from the newborns through adolescents, before they become adults. Each of th ...
WOMEN AND NEWBORN HEALTH SERVICE 9 ABNORMALITIES OF EARLY PREGNANCY 9.4
... patients in the single dose protocol will have side effects . The most common are stomatitis and conjunctivitis. Rare side effects include gastritis, enteritis, dermatitis, pneumonitis, alopecia, elevated liver enzymes, and bone marrow suppression. All of these side effects resolve as ...
... patients in the single dose protocol will have side effects . The most common are stomatitis and conjunctivitis. Rare side effects include gastritis, enteritis, dermatitis, pneumonitis, alopecia, elevated liver enzymes, and bone marrow suppression. All of these side effects resolve as ...
Attention Deficit/Hyperactivity Disorder: Case
... except transdermal MPH, which is only approved for children ages 6-17 years ...
... except transdermal MPH, which is only approved for children ages 6-17 years ...