Guidance - Scottish Medicines Consortium
... It is common for SMC to receive late notification of medicines that are predicted to reach the UK market within the next calendar year. Depending on when notification is received, it might be feasible to list the medicine in the main report but there may be insufficient time to develop a detailed mo ...
... It is common for SMC to receive late notification of medicines that are predicted to reach the UK market within the next calendar year. Depending on when notification is received, it might be feasible to list the medicine in the main report but there may be insufficient time to develop a detailed mo ...
highlights of prescribing information
... Picato® gel or ingenol mebutate. The effects of ingenol mebutate on fertility have not been evaluated. Ingenol mebutate was negative in the Ames test, in vitro mouse lymphoma assay, and in vivo rat micronucleus test, but positive in the Syrian hamster embryo (SHE) cell transformation assay. 14 CLINI ...
... Picato® gel or ingenol mebutate. The effects of ingenol mebutate on fertility have not been evaluated. Ingenol mebutate was negative in the Ames test, in vitro mouse lymphoma assay, and in vivo rat micronucleus test, but positive in the Syrian hamster embryo (SHE) cell transformation assay. 14 CLINI ...
Shire Richwood Inc.
... Alkalinizing agents Gastrointestinal alkalinizing agents (sodium bicarbonate, etc.) increase absorption of amphetamines. Urinary alkalinizing agents (acetazolamide, some thiazides) increase the concentration of the non-ionized species of the amphetamine molecule, thereby decreasing urinary excretion ...
... Alkalinizing agents Gastrointestinal alkalinizing agents (sodium bicarbonate, etc.) increase absorption of amphetamines. Urinary alkalinizing agents (acetazolamide, some thiazides) increase the concentration of the non-ionized species of the amphetamine molecule, thereby decreasing urinary excretion ...
Levodopa
... loses its selectivity. By, thus, decreasing the metabolism of dopamine, selegiline has been found to increase dopamine levels in the brain. Therefore, it enhances the actions of levodopa when these drugs are administered together. Selegiline substantially reduces the required dose of levodopa. Unlik ...
... loses its selectivity. By, thus, decreasing the metabolism of dopamine, selegiline has been found to increase dopamine levels in the brain. Therefore, it enhances the actions of levodopa when these drugs are administered together. Selegiline substantially reduces the required dose of levodopa. Unlik ...
Beclomethasone/formoterol versus budesonide/formoterol combination therapy in asthma
... (FEV1) 50–80% of predicted normal values were eligible to take part in the study. All patients were previously treated with ICS at a daily dose f1,000 mg of BDP-equivalent and had asthma symptoms not adequately controlled. The lack of adequate control can be defined as: presence of daily asthma symp ...
... (FEV1) 50–80% of predicted normal values were eligible to take part in the study. All patients were previously treated with ICS at a daily dose f1,000 mg of BDP-equivalent and had asthma symptoms not adequately controlled. The lack of adequate control can be defined as: presence of daily asthma symp ...
CANINE HYPERADRENOCORTICISM (CUSHING`S SYNDROME
... There are several radiographic changes that characterize some dogs with Cushing's syndrome. These include: (1) soft tissue mineralization, that can involve skin, muscles, lungs, and blood vessels, (2) hepatomegaly and pendulous abdomen, and (3) osteoporosis, especially involving the vertebrae. Appro ...
... There are several radiographic changes that characterize some dogs with Cushing's syndrome. These include: (1) soft tissue mineralization, that can involve skin, muscles, lungs, and blood vessels, (2) hepatomegaly and pendulous abdomen, and (3) osteoporosis, especially involving the vertebrae. Appro ...
Chapter 7 The Use of Animals in Testing
... designed so that what is measured provides useful and sufficiently accurate information. Statistical methods allow a scientist to estimate the minimum number of test animals from which conclusions can be drawn to estimate the reliability of any conclusions. Statistical analysis can help reduce the n ...
... designed so that what is measured provides useful and sufficiently accurate information. Statistical methods allow a scientist to estimate the minimum number of test animals from which conclusions can be drawn to estimate the reliability of any conclusions. Statistical analysis can help reduce the n ...
Cardiovascular Drugs - Cardiovascular Nursing Education Associates
... Maintenance dose: 75 mg daily for up to 12 months following stent placement; at least 1 month and preferably up to 1 year for medically treated UA/NSTEMI. Discontinue at least 5 days prior to CABG whenever possible ...
... Maintenance dose: 75 mg daily for up to 12 months following stent placement; at least 1 month and preferably up to 1 year for medically treated UA/NSTEMI. Discontinue at least 5 days prior to CABG whenever possible ...
CDISC Glossary
... alphabetically by first word according to the opinion of the Glossary Project ...
... alphabetically by first word according to the opinion of the Glossary Project ...
Page 1 of 22
... hematuria, headache, polyuria, and prostatitis. The overall incidence of application site reactions of any kind was 28% (10 subjects with 13 adverse reactions). No serious adverse reactions to ANDRODERM 2 mg/day and 4 mg/day were reported during the clinical trial. Table 2 shows the adverse reaction ...
... hematuria, headache, polyuria, and prostatitis. The overall incidence of application site reactions of any kind was 28% (10 subjects with 13 adverse reactions). No serious adverse reactions to ANDRODERM 2 mg/day and 4 mg/day were reported during the clinical trial. Table 2 shows the adverse reaction ...
Enhanced water solubility for enhanced oral drug delivery via the
... paclitaxel. High levels of this enzyme have been described in cancer cells, and one hypothesis speculates that this enzyme is involved in resistance to many anticancer drugs. The prodrug compounds were 6–100 times more soluble than paclitaxel. Moreover, the most active compound 18 was 65 times more ...
... paclitaxel. High levels of this enzyme have been described in cancer cells, and one hypothesis speculates that this enzyme is involved in resistance to many anticancer drugs. The prodrug compounds were 6–100 times more soluble than paclitaxel. Moreover, the most active compound 18 was 65 times more ...
Subuphine sublingual tablet ENG
... Administration of Subuphine is sublingual. The physician must advise the patient that the sublingual route is the only effective and safe route of administration for this medicinal product. The sublingual tablet is to be placed under the tongue until dissolved, which usually occurs within 5 to 10 m ...
... Administration of Subuphine is sublingual. The physician must advise the patient that the sublingual route is the only effective and safe route of administration for this medicinal product. The sublingual tablet is to be placed under the tongue until dissolved, which usually occurs within 5 to 10 m ...
general information brochure on orthostatic
... How does upright posture lead to these problems? When a healthy individual stands up, gravity causes about 10-15% of his or her blood to settle in the abdomen, legs, and arms. This pooling of blood means that less blood reaches the brain, the result of which can be a feeling of lightheadedness, see ...
... How does upright posture lead to these problems? When a healthy individual stands up, gravity causes about 10-15% of his or her blood to settle in the abdomen, legs, and arms. This pooling of blood means that less blood reaches the brain, the result of which can be a feeling of lightheadedness, see ...
Efavirenz Interference in Urine Screening Immunoassays for Tetrahydrocannabinol Nicholette M Oosthuizen
... interference has been attributed to EFV 8-glucuronide (EFV-8-G), one of two major urinary metabolites. The other major urinary metabolite, 8-hydroxy-EFV, and the parent drug do not interfere.1 Given the widespread inclusion of EFV in first-line antiretroviral therapy, the use of THC assays that are ...
... interference has been attributed to EFV 8-glucuronide (EFV-8-G), one of two major urinary metabolites. The other major urinary metabolite, 8-hydroxy-EFV, and the parent drug do not interfere.1 Given the widespread inclusion of EFV in first-line antiretroviral therapy, the use of THC assays that are ...
Phytosomes - Journal of Chemical and Pharmaceutical Research
... extracts of Ginkgo biloba, Grape seed, Green tea, Ginseng, etc. has been profitably used. Phytosomes have been refined for therapeutic uses like cardiovascular, anti-inflammatory, immunomodulator, anticancer, antidiabetic etc. or for preventive and health reasons. In the ever-expanding pharmaceutica ...
... extracts of Ginkgo biloba, Grape seed, Green tea, Ginseng, etc. has been profitably used. Phytosomes have been refined for therapeutic uses like cardiovascular, anti-inflammatory, immunomodulator, anticancer, antidiabetic etc. or for preventive and health reasons. In the ever-expanding pharmaceutica ...
IOSR Journal of Agriculture and Veterinary Science (IOSR-JAVS)
... evading trypanolytic action of drugs [19]. It has been shown in previous studies that different parts of the same plant could show varying levels of antitrypanosomal activity just as extracts of different parts of the same plant [14]; Igwe and Onabanjo, 1989). In this present study the extracts had ...
... evading trypanolytic action of drugs [19]. It has been shown in previous studies that different parts of the same plant could show varying levels of antitrypanosomal activity just as extracts of different parts of the same plant [14]; Igwe and Onabanjo, 1989). In this present study the extracts had ...
PRODUCT INFORMATION ZINNAT
... compared with that of the fasting state and tend to cancel the effect of enhanced absorption after food. In common with other antibiotics, cefuroxime axetil may affect the gut flora, leading to lower oestrogen reabsorption and reduced efficacy of combined oral contraceptives. It is recommended that ...
... compared with that of the fasting state and tend to cancel the effect of enhanced absorption after food. In common with other antibiotics, cefuroxime axetil may affect the gut flora, leading to lower oestrogen reabsorption and reduced efficacy of combined oral contraceptives. It is recommended that ...
Full Prescribing Information
... ABSTRAL (fentanyl) sublingual tablets are indicated for the management of breakthrough pain in cancer patients 18 years of age and older who are already receiving and who are tolerant to opioid therapy for their underlying persistent cancer pain. Patients considered opioid tolerant are those who are ...
... ABSTRAL (fentanyl) sublingual tablets are indicated for the management of breakthrough pain in cancer patients 18 years of age and older who are already receiving and who are tolerant to opioid therapy for their underlying persistent cancer pain. Patients considered opioid tolerant are those who are ...
Warfarin Safety for Nursing Homes
... It is classified as an anti coagulant It is an anticoagulant known as a vitamin K antagonist (VKA) ...
... It is classified as an anti coagulant It is an anticoagulant known as a vitamin K antagonist (VKA) ...
SOLUBILITY AND DISSOLUTION IMPROVEMENT OF KETOPROFEN BY SOLID DISPERSION IN POLYMER AND SURFACTANT USING SOLVENT EVAPORATION METHOD
... dissolution effeciency, thus it was subjected to further analysis including kinetic of drug release and DSC studies. Table 4 lists the regression parameters obtained after fitting various release kinetic ...
... dissolution effeciency, thus it was subjected to further analysis including kinetic of drug release and DSC studies. Table 4 lists the regression parameters obtained after fitting various release kinetic ...
Helicobacter pylori PYLERA® Capsules were designed to ease the burden of
... Your doctor has decided that PYLERA® Capsules plus omeprazole might be right for you. How to take PYLERA® Innovative 3-in-1 PYLERA® therapy • PYLERA® is specifically designed for the treatment of H. pylori infection and duodenal ulcer disease (active or history of within the past 5 years) • PYLER ...
... Your doctor has decided that PYLERA® Capsules plus omeprazole might be right for you. How to take PYLERA® Innovative 3-in-1 PYLERA® therapy • PYLERA® is specifically designed for the treatment of H. pylori infection and duodenal ulcer disease (active or history of within the past 5 years) • PYLER ...
Product Monograph Template - Standard
... density in both female and male patients. Tissue culture experiments indicate that approximately one-third of human breast cancers are prolactin dependent in vitro, a factor of potential importance if the prescription of these drugs is considered in a patient with previously detected breast cancer. ...
... density in both female and male patients. Tissue culture experiments indicate that approximately one-third of human breast cancers are prolactin dependent in vitro, a factor of potential importance if the prescription of these drugs is considered in a patient with previously detected breast cancer. ...
A status report on RNAi therapeutics Open Access Review
... (Alnylam Pharmaceuticals Inc., unpublished observations). In terms of pharmacology, the LNP experiments have fully validated the drug-like behavior of siRNAs. For all the LNP studies cited, there is a consistency of observations with respect to PD onset, which generally occurs within 24 hrs with pea ...
... (Alnylam Pharmaceuticals Inc., unpublished observations). In terms of pharmacology, the LNP experiments have fully validated the drug-like behavior of siRNAs. For all the LNP studies cited, there is a consistency of observations with respect to PD onset, which generally occurs within 24 hrs with pea ...
Asthma Treatment Guidelines Word V3
... Asthma is a chronic inflammatory respiratory disease. It can affect people of any age, but often starts in childhood. It is characterised by attacks (also known as exacerbations) of breathlessness and wheezing, with the severity and frequency of attacks varying from person to person. The attacks are ...
... Asthma is a chronic inflammatory respiratory disease. It can affect people of any age, but often starts in childhood. It is characterised by attacks (also known as exacerbations) of breathlessness and wheezing, with the severity and frequency of attacks varying from person to person. The attacks are ...
Treatment of Narcolepsy with Methamphetamine
... of experimental drug was prepared by our institutional pharmacy using conventional tablets of Desoxyn ® (Abbott Laboratories). Tablets were fractured and placed in unmarked, opaque gelatin capsules, surDesign and protocol rounded by powdered sucrose. Placebo capsules conThe study used a four-conditi ...
... of experimental drug was prepared by our institutional pharmacy using conventional tablets of Desoxyn ® (Abbott Laboratories). Tablets were fractured and placed in unmarked, opaque gelatin capsules, surDesign and protocol rounded by powdered sucrose. Placebo capsules conThe study used a four-conditi ...