View SPC - Veterinary Medicines Directorate
... Acepromazine is hypotensive. Particular care should therefore be taken in hypovolaemic animals; rehydration should precede acepromazine administration. In some dogs, particularly Boxers and other short-nosed breeds, spontaneous fainting or syncope may occur due to sinoatrial block caused by excessiv ...
... Acepromazine is hypotensive. Particular care should therefore be taken in hypovolaemic animals; rehydration should precede acepromazine administration. In some dogs, particularly Boxers and other short-nosed breeds, spontaneous fainting or syncope may occur due to sinoatrial block caused by excessiv ...
- Wiley Online Library
... disease patients, and demonstrated an increase in antiinflammatory factors (Tomé-Carneiro et al., 2013). Importantly, this study did not report any adverse side effects due to high levels of resveratrol, indicating that the rapid clearance rates or poor absorbance of this polyphenol may be beneficia ...
... disease patients, and demonstrated an increase in antiinflammatory factors (Tomé-Carneiro et al., 2013). Importantly, this study did not report any adverse side effects due to high levels of resveratrol, indicating that the rapid clearance rates or poor absorbance of this polyphenol may be beneficia ...
Pediatric Intensive Care Unit (PICU) Nurse`s Guide Intravenous Drip
... Systemic thromboses: 0.1-0.6 mg/kg/hour for 6 hours (some pts may require longer or shorter duration of therapy); initiate at 0.1 mg/kg/hour if no response after 6 hours, increase infusion by 0.1 mg/kg/hr to maximum of 0.5 mg/kg/hr; maintain fibrinogen > 100 mg/dl Aminocaproic Acid ...
... Systemic thromboses: 0.1-0.6 mg/kg/hour for 6 hours (some pts may require longer or shorter duration of therapy); initiate at 0.1 mg/kg/hour if no response after 6 hours, increase infusion by 0.1 mg/kg/hr to maximum of 0.5 mg/kg/hr; maintain fibrinogen > 100 mg/dl Aminocaproic Acid ...
An Advances in Natural and Applied Sciences Areca catechu (Arecaceae)
... of Areca catechu leaves in glucose-induced hyperglycemic mice was observed with a 400 mg.kg-1 dose (65.7% inhibition), while the standard drug, glibenclamide produced 71.4 % inhibitory activity at 10 mg.kg-1 dose (Table 1) under the experimental conditions of the present study. The present prelimina ...
... of Areca catechu leaves in glucose-induced hyperglycemic mice was observed with a 400 mg.kg-1 dose (65.7% inhibition), while the standard drug, glibenclamide produced 71.4 % inhibitory activity at 10 mg.kg-1 dose (Table 1) under the experimental conditions of the present study. The present prelimina ...
Viagra - Pfizer
... There was no impairment of fertility in rats given sildenafil for 36 days to females and 102 days to males at a dose producing an AUC value of more than 25 times the human male AUC. There is no information on the effects of sildenafil on semen production, sperm motility/morphology in patients suffer ...
... There was no impairment of fertility in rats given sildenafil for 36 days to females and 102 days to males at a dose producing an AUC value of more than 25 times the human male AUC. There is no information on the effects of sildenafil on semen production, sperm motility/morphology in patients suffer ...
NIH Public Access
... calculated CI scores using CompuSyn (38), and found that these drugs were synergistic in both cell lines (average CI scores were 0.34±0.19 for DDLS8817 and 0.63±0.17 for LPS141) (Fig. 2). In addition, the IGF1R small molecule inhibitor NVP-AEW541 appeared to be synergistic in combination with PD0332 ...
... calculated CI scores using CompuSyn (38), and found that these drugs were synergistic in both cell lines (average CI scores were 0.34±0.19 for DDLS8817 and 0.63±0.17 for LPS141) (Fig. 2). In addition, the IGF1R small molecule inhibitor NVP-AEW541 appeared to be synergistic in combination with PD0332 ...
... overall risk of corticosteroid-induced osteoporosis and fracture in severe asthmatics, by diminishing oral corticosteroid intake and allowing an increase in physical activity. Again, differences exist between the inhaled corticosteroids, and the pharmacodynamics of different actions of inhaled corti ...
DESTINY - UNC-CHAPEL HILL - CB# 7448, Morehead Planetarium
... Memory B cells — as the activated B cell reproduces, it will also make memory B cells; these memory B cells have antigen-binding regions that are identical to those of the original parent B cell. The memory B cells persist in the body and the next time the antigen is encountered, it will be recogniz ...
... Memory B cells — as the activated B cell reproduces, it will also make memory B cells; these memory B cells have antigen-binding regions that are identical to those of the original parent B cell. The memory B cells persist in the body and the next time the antigen is encountered, it will be recogniz ...
Phospholipid Complex Technique for Superior Bioavailability of
... Phytoconstituents have been utilized as medicines for thousands of years, yet their application is limited owing to major hurdles like deficit lipid solubility, large molecular size and degradation in the gastric environment of gut. Recently, phospholipid-complex technique has unveiled in addressing ...
... Phytoconstituents have been utilized as medicines for thousands of years, yet their application is limited owing to major hurdles like deficit lipid solubility, large molecular size and degradation in the gastric environment of gut. Recently, phospholipid-complex technique has unveiled in addressing ...
Pharmacokinetics
... of action of drugs affecting these tissues. Drugs are distributed more slowly to less perfused tissues such as skeletal muscle and even more slowly to those with the lowest blood flow, such as skin, bone, and adipose tissue. Plasma Protein Binding Almost all drugs are reversibly bound to plasma prot ...
... of action of drugs affecting these tissues. Drugs are distributed more slowly to less perfused tissues such as skeletal muscle and even more slowly to those with the lowest blood flow, such as skin, bone, and adipose tissue. Plasma Protein Binding Almost all drugs are reversibly bound to plasma prot ...
Review of vancomycin-containing medicines started Information on
... Due to a growing problem of infections that are resistant to multiple antibiotics including vancomycin, it is considered of high relevance that the way this antibiotic is used in treating infections is re-assessed and that the product information for vancomycin-containing products is updated in ligh ...
... Due to a growing problem of infections that are resistant to multiple antibiotics including vancomycin, it is considered of high relevance that the way this antibiotic is used in treating infections is re-assessed and that the product information for vancomycin-containing products is updated in ligh ...
... The designs of the four relevant M100240 phase I/II studies with available PK data are summarized in Table I. Biomarkers (i.e., quantifiable surrogate markers measuring in vivo drug effect) for ACE and NEP activity were measured in study A only. In this study, subjects were on a fixed-sodium diet (7 ...
An Update on Analgesics for the Management of Acute
... action of acetylsalicylic acid (ASA) was discovered approximately 30 years ago.1 Clinical trials have shown repeatedly that, by themselves, NSAIDs are effective for the management of any level of dental pain, whether mild, moderate or severe.2-5 Optimal use of these drugs resides in understanding th ...
... action of acetylsalicylic acid (ASA) was discovered approximately 30 years ago.1 Clinical trials have shown repeatedly that, by themselves, NSAIDs are effective for the management of any level of dental pain, whether mild, moderate or severe.2-5 Optimal use of these drugs resides in understanding th ...
Nanomedicine Taxonomy
... In advance of the workshop, the CIHR has requested a briefing paper for workshop participants to define the range of nanoscience and nanotechnology that is currently being applied to health research. The CIHR is Canada's premier federal agency for health research. Its objective is to excel, accordin ...
... In advance of the workshop, the CIHR has requested a briefing paper for workshop participants to define the range of nanoscience and nanotechnology that is currently being applied to health research. The CIHR is Canada's premier federal agency for health research. Its objective is to excel, accordin ...
Factorial design Advantages of the factorial design Interaction plot
... A two-way design enables us to examine the joint (or interaction) effect of the independent variables on the dependent variable. An interaction means that the effect of one independent variable has on a dependent variable is not the same for all levels of the other independent variable. We cannot ge ...
... A two-way design enables us to examine the joint (or interaction) effect of the independent variables on the dependent variable. An interaction means that the effect of one independent variable has on a dependent variable is not the same for all levels of the other independent variable. We cannot ge ...
data sheet
... symptoms at every adjustment of dose, then at least every 6 months and at every visit. Tics and worsening of Tourette’s syndrome: Methylphenidate is associated with the onset or exacerbation of motor and verbal tics . Worsening of Tourette’s syndrome has also been reported. It is recommended that th ...
... symptoms at every adjustment of dose, then at least every 6 months and at every visit. Tics and worsening of Tourette’s syndrome: Methylphenidate is associated with the onset or exacerbation of motor and verbal tics . Worsening of Tourette’s syndrome has also been reported. It is recommended that th ...
Strategies after the failure of the first anti-tumor necrosis factor
... On the contrary, in another double blind RCT patients who had responded to infliximab 3 mg/kg, but had not achieved remission were randomized to receive either 3 mg/kg or 5 mg/kg for another 12 months. At the end of the 12 months, patients receiving both doses had similar disease activity scores, whi ...
... On the contrary, in another double blind RCT patients who had responded to infliximab 3 mg/kg, but had not achieved remission were randomized to receive either 3 mg/kg or 5 mg/kg for another 12 months. At the end of the 12 months, patients receiving both doses had similar disease activity scores, whi ...
The Development of Context-specific Operant Sensitization to d
... not occur (e.g., Rademacher, Napier, & Meredith, 2007). Previous research has shown that under some circumstances sensitization may also develop when subjects complete an operant task, as observed by Odum and Shahan (2004). In their experiment, sensitization to the rate-decreasing effects of d-amphe ...
... not occur (e.g., Rademacher, Napier, & Meredith, 2007). Previous research has shown that under some circumstances sensitization may also develop when subjects complete an operant task, as observed by Odum and Shahan (2004). In their experiment, sensitization to the rate-decreasing effects of d-amphe ...
Therapeutic options and challenges for substances of abuse
... cases.6,62 Controlled trials of disulfiram versus placebo have not demonstrated significant improvement over placebo,63,64 and meta-analyses have only shown slight improvement in drinking.65 A large Veterans Cooperative Study with over 600 subjects found, however, that disulfiram may be effective in ...
... cases.6,62 Controlled trials of disulfiram versus placebo have not demonstrated significant improvement over placebo,63,64 and meta-analyses have only shown slight improvement in drinking.65 A large Veterans Cooperative Study with over 600 subjects found, however, that disulfiram may be effective in ...
C11 Chemistry 151 Whitesell The Provisional Progress of
... discovered to regenerate muscle movement in crippled patients, the “miracle drug” had harmful side effects when taken in large doses. Therefore, prednisone was utilized as a corticosteroid in high doses at a short period of time, in order to decrease the risks of dangerous side effects. The FDA firs ...
... discovered to regenerate muscle movement in crippled patients, the “miracle drug” had harmful side effects when taken in large doses. Therefore, prednisone was utilized as a corticosteroid in high doses at a short period of time, in order to decrease the risks of dangerous side effects. The FDA firs ...
Principles of early drug discovery
... even closely related targets and often providing higher affinity. In contrast, small molecules are disadvantaged by the need to interact with the often more conserved active site of a target, while antibodies can be selected to bind to unique epitopes. This exquisite specificity is the basis for the ...
... even closely related targets and often providing higher affinity. In contrast, small molecules are disadvantaged by the need to interact with the often more conserved active site of a target, while antibodies can be selected to bind to unique epitopes. This exquisite specificity is the basis for the ...
Cardiovascular Drug Therapy in the Elderly
... and warfarin, bind extensively to albumin. Decreased binding of drugs such as warfarin to plasma albumin may result in increased free-drug concentrations, resulting in more intense drug effects.11 ...
... and warfarin, bind extensively to albumin. Decreased binding of drugs such as warfarin to plasma albumin may result in increased free-drug concentrations, resulting in more intense drug effects.11 ...
Public Assessment Report
... Statement of compliance with GCP and GLP is presented. 72 subjects were enrolled. One subject was withdrawn from the study for an AE before the second period. They were healthy subjects of either sex, 18-55 years old, BMI within the normal range, without alcohol or drug abuse, non-smokers or moderat ...
... Statement of compliance with GCP and GLP is presented. 72 subjects were enrolled. One subject was withdrawn from the study for an AE before the second period. They were healthy subjects of either sex, 18-55 years old, BMI within the normal range, without alcohol or drug abuse, non-smokers or moderat ...
Scandinavian Journal of Infectious Diseases
... Mexican study, Lopez-Merino et al. found fluoroquinolones comparable to tetracycline and doxycycline, and the MIC values for tetracyclines were higher than in Brucella strains isolated in Turkey [7]. In 4 studies from Turkey, MIC90 values of DOX were detected between 0.032 and 0.50 mg/ml [5,8 10]. ...
... Mexican study, Lopez-Merino et al. found fluoroquinolones comparable to tetracycline and doxycycline, and the MIC values for tetracyclines were higher than in Brucella strains isolated in Turkey [7]. In 4 studies from Turkey, MIC90 values of DOX were detected between 0.032 and 0.50 mg/ml [5,8 10]. ...
Product Monograph
... Pregnant Women: The safety of SALAGEN tablets has not been established in human pregnancy. There are no known human data for the effects of pilocarpine on fetal survival and development. Studies in animals have shown reproductive toxicity (see TOXICOLOGY). SALAGEN tablets should be used in pregnancy ...
... Pregnant Women: The safety of SALAGEN tablets has not been established in human pregnancy. There are no known human data for the effects of pilocarpine on fetal survival and development. Studies in animals have shown reproductive toxicity (see TOXICOLOGY). SALAGEN tablets should be used in pregnancy ...