Strict Liability in the Manufacture of
... manufactured products. 11 One reason for this different treatment is the interaction which occurs between the body of the patient and the drug's chemical compound. When a drug is ingested, the response of an individual patient is difficult to predict. Every effect and each adverse reaction is unique ...
... manufactured products. 11 One reason for this different treatment is the interaction which occurs between the body of the patient and the drug's chemical compound. When a drug is ingested, the response of an individual patient is difficult to predict. Every effect and each adverse reaction is unique ...
Adva-27a Publication
... efflux transporters, such as P-glycoprotein (P-gp) (2, 12). Several strategies have emerged to design and synthesize analogs of etoposide or podophyllotoxin with improved pharmaceutical and clinical activities (13, 31). These include glycosylated etoposide derivatives, such as teniposide, phosphoryl ...
... efflux transporters, such as P-glycoprotein (P-gp) (2, 12). Several strategies have emerged to design and synthesize analogs of etoposide or podophyllotoxin with improved pharmaceutical and clinical activities (13, 31). These include glycosylated etoposide derivatives, such as teniposide, phosphoryl ...
Effects of Losartan on Blood Pressure, Plasma Renin
... contain 135-165 mEq sodium and 70-90 mEq potassium per 24 hours. The purpose of the diet was to standardize sodium intake to aid in interpretation of changes in PRA, Ang II concentration, and blood pressure. However, we did not attempt to assure that subjects were truly in "balance" on the diet befo ...
... contain 135-165 mEq sodium and 70-90 mEq potassium per 24 hours. The purpose of the diet was to standardize sodium intake to aid in interpretation of changes in PRA, Ang II concentration, and blood pressure. However, we did not attempt to assure that subjects were truly in "balance" on the diet befo ...
Brother Can You Spare a Drug - Scholarly Commons at Hofstra Law
... Global epidemiological studies are equally alarming. World Health Organization (WHO) studies indicate that since 1981, more than 220,000 cases of AIDS have been reported from 153 countries. However, because of underreporting in many developing countries due to the lack of diagnostic equipment and he ...
... Global epidemiological studies are equally alarming. World Health Organization (WHO) studies indicate that since 1981, more than 220,000 cases of AIDS have been reported from 153 countries. However, because of underreporting in many developing countries due to the lack of diagnostic equipment and he ...
Antiemetic Guidelines for Adult Patients Receiving Chemotherapy
... adult patients. They are not intended to address nausea and vomiting in palliative care. These guidelines are intended to provide a framework to support clinical practice, they can not cover every clinical situation and good common clinical sense and clinical experience will be required when approac ...
... adult patients. They are not intended to address nausea and vomiting in palliative care. These guidelines are intended to provide a framework to support clinical practice, they can not cover every clinical situation and good common clinical sense and clinical experience will be required when approac ...
Polyamine transporter selective compounds as anticancer agents
... pertains. Although methods and materials similar or equivalent to those described herein can be used in the practice or testing of the present invention, suitable methods and materials are described below. Any publications, patent applications, patents, or other references mentioned herein are incor ...
... pertains. Although methods and materials similar or equivalent to those described herein can be used in the practice or testing of the present invention, suitable methods and materials are described below. Any publications, patent applications, patents, or other references mentioned herein are incor ...
Gadolinium anaphylaxis
... • Patients taking beta-blockers have more severe or treatmentrefractory anaphylaxis ...
... • Patients taking beta-blockers have more severe or treatmentrefractory anaphylaxis ...
... to that of placebo. In controlled pediatric clinical trials, the incidence of treatment-related headache, sedation and nervousness, which were rarely reported events, was similar to that of placebo. CONTRAINDICATIONS: LORATADINE (CLARITIN*) products are contraindicated in patients who have shown hyp ...
CELL MODEL SYSTEMS IN CHARACTERIZING α2
... neurotransmitter release, pain, alertness and cognitive processes. Therefore, potentially these receptors could be involved in the therapy or pathogenesis of many serious human diseases, such as hypertension, coronary heart disease, obesity, diabetes, chronic pain states as well as neuropsychiatric ...
... neurotransmitter release, pain, alertness and cognitive processes. Therefore, potentially these receptors could be involved in the therapy or pathogenesis of many serious human diseases, such as hypertension, coronary heart disease, obesity, diabetes, chronic pain states as well as neuropsychiatric ...
radiation therapy oncology group rtog 0813 seamless phase i/ii
... series, with 5-year survival rates ranging from 10-30%.5-6 This is partially due to lower rates of tumor eradication and resultant higher rates of local failures with RT, and partially due to less rigorous staging and selection of less fit patients for RT treatment, when compared to surgically treat ...
... series, with 5-year survival rates ranging from 10-30%.5-6 This is partially due to lower rates of tumor eradication and resultant higher rates of local failures with RT, and partially due to less rigorous staging and selection of less fit patients for RT treatment, when compared to surgically treat ...
The following protocol information is provided solely ... research underlying the published report associated with ...
... therapy at an earlier time point in the adjuvant setting has the potential to prevent secondary seeding to the central nervous system. Biochemotherapy approaches also have the advantage of being delivered over a shorter treatment period than high dose Interferon (9 weeks versus 52 weeks) which may i ...
... therapy at an earlier time point in the adjuvant setting has the potential to prevent secondary seeding to the central nervous system. Biochemotherapy approaches also have the advantage of being delivered over a shorter treatment period than high dose Interferon (9 weeks versus 52 weeks) which may i ...
Transfer from Methadone To Buprenorphine
... buprenorphine dose. Both the doctor and the patient may be surprised to learn that it may take much longer than 36 hours to begin methadone withdrawal. Clonidine, anxiolytics, including benzodiazepines, non-steroidal anti-inflammatory agents may be used judiciously to assist the withdrawal process, ...
... buprenorphine dose. Both the doctor and the patient may be surprised to learn that it may take much longer than 36 hours to begin methadone withdrawal. Clonidine, anxiolytics, including benzodiazepines, non-steroidal anti-inflammatory agents may be used judiciously to assist the withdrawal process, ...
adrenaline acid tartrate injection
... Overdosage or inadvertent IV injection of usual subcutaneous doses of adrenaline may cause hypertension. Cerebrovascular or other haemorrhage and hemiplegia may result, especially in geriatric patients. Inadvertent IV injection of adrenaline has also been reported to have caused convulsions, metabol ...
... Overdosage or inadvertent IV injection of usual subcutaneous doses of adrenaline may cause hypertension. Cerebrovascular or other haemorrhage and hemiplegia may result, especially in geriatric patients. Inadvertent IV injection of adrenaline has also been reported to have caused convulsions, metabol ...
LoNgER DuRAtIoN. gREAtER RoI.
... hypersalivation. One of these calves also exhibited transient dyspnea, which may have been related to pneumonia. Swine In one field study, one out of 40 pigs treated with DRAXXIN at 2.5 mg/kg BW exhibited mild salivation that resolved in less than four hours. CLINICAL PHARMACOLOGY At physiological p ...
... hypersalivation. One of these calves also exhibited transient dyspnea, which may have been related to pneumonia. Swine In one field study, one out of 40 pigs treated with DRAXXIN at 2.5 mg/kg BW exhibited mild salivation that resolved in less than four hours. CLINICAL PHARMACOLOGY At physiological p ...
Anticholinergics for Overactive Bladder Therapy: Central Nervous
... The adverse events most commonly associated with the use of antimuscarinic OAB drugs are the expected side effects of anticholinergics, such as dry mouth and constipation. CNS adverse events were generally observed in fewer than 10% of patients in phase III clinical trials, and were highest in patie ...
... The adverse events most commonly associated with the use of antimuscarinic OAB drugs are the expected side effects of anticholinergics, such as dry mouth and constipation. CNS adverse events were generally observed in fewer than 10% of patients in phase III clinical trials, and were highest in patie ...
Bioequivalence Study of Two Loperamide Hydrochloride 2 mg
... values, the Wilcoxon Signed Rank Test for paired samples was used. In this study, the 90% confidence interval for the ratio of the AUC0-t, AUC0-∞ and Cmax were calculated to be between 0.8730-1.0181, 0.8852-0.9891 and 0.80230.9559 respectively. All of the values were within the acceptable bioequival ...
... values, the Wilcoxon Signed Rank Test for paired samples was used. In this study, the 90% confidence interval for the ratio of the AUC0-t, AUC0-∞ and Cmax were calculated to be between 0.8730-1.0181, 0.8852-0.9891 and 0.80230.9559 respectively. All of the values were within the acceptable bioequival ...
OE05 Protocol - MRC Clinical Trials Unit
... This document is intended to describe a trial developed on behalf of the National Cancer Research Institute (NCRI) Upper GI Cancer Group and to provide information about procedures for entering patients. It is not intended that the protocol be used as an aide-memoir or guide for the treatment of oth ...
... This document is intended to describe a trial developed on behalf of the National Cancer Research Institute (NCRI) Upper GI Cancer Group and to provide information about procedures for entering patients. It is not intended that the protocol be used as an aide-memoir or guide for the treatment of oth ...
nasal dosage forms and devices for intranasal drug delivery
... metered-dose spray pumps, but inexpensive single-dose pipettes produced by “blow-fill-seal” technique are still common for OTC products like decongestants and saline. An advantage is that preservatives are not required. In addition, due to inadequate clinical efficacy of spray pumps in patients with ...
... metered-dose spray pumps, but inexpensive single-dose pipettes produced by “blow-fill-seal” technique are still common for OTC products like decongestants and saline. An advantage is that preservatives are not required. In addition, due to inadequate clinical efficacy of spray pumps in patients with ...
HIGHLIGHTS OF PRESCRIBING INFORMATION •
... Clostridium difficile associated diarrhea (CDAD) has been reported with use of nearly all antibacterial agents, including AMOXIL, and may range in severity from mild diarrhea to fatal colitis. Treatment with antibacterial agents alters the normal flora of the colon leading to overgrowth of C. diffic ...
... Clostridium difficile associated diarrhea (CDAD) has been reported with use of nearly all antibacterial agents, including AMOXIL, and may range in severity from mild diarrhea to fatal colitis. Treatment with antibacterial agents alters the normal flora of the colon leading to overgrowth of C. diffic ...
Demerol (meperidine hydrochloride)
... In chronic overdosage, which may occur in patients or addicts who are tolerant to its depressant effects, DEMEROL may produce tremors, muscle twitches, dilated pupils, hyperactive reflexes and convulsions. These excitatory symptoms are due to the accumulation of normeperidine. Acute overdosage is li ...
... In chronic overdosage, which may occur in patients or addicts who are tolerant to its depressant effects, DEMEROL may produce tremors, muscle twitches, dilated pupils, hyperactive reflexes and convulsions. These excitatory symptoms are due to the accumulation of normeperidine. Acute overdosage is li ...
Multi compartment models (Delayed distribution models)
... • Ideally a true pharmacokinetic model should be the one with a rate constant for each tissue undergoing equilibrium. • Therefore best approach is to pool together tissues on the basis of similarity in their distribution characteristics. • The drug disposition occurs by first order. • Multi-compart ...
... • Ideally a true pharmacokinetic model should be the one with a rate constant for each tissue undergoing equilibrium. • Therefore best approach is to pool together tissues on the basis of similarity in their distribution characteristics. • The drug disposition occurs by first order. • Multi-compart ...
Experimental animal studies on analgesic and anti
... Results: In acetic acid induced writhing model, effect of ASP was better than the control. In the hot plate model, maximum effect was observed at 60 min at a dose of 300 mg/kg, which was higher than the control. In formalin-induced paw licking model, ASP completely abolished the early phase at 150 a ...
... Results: In acetic acid induced writhing model, effect of ASP was better than the control. In the hot plate model, maximum effect was observed at 60 min at a dose of 300 mg/kg, which was higher than the control. In formalin-induced paw licking model, ASP completely abolished the early phase at 150 a ...
In vivo imaging of dopamine and serotonin release Udo de
... (SPM) 99 was used for spatial normalization of the RAC image. A summation of the first 10 RAC frames was normalized to the SPM [15O]-H2O template, giving 68 horizontal planes. The normalization parameters were thereafter used to normalize the other frames of the RAC scan. A predetermined standard re ...
... (SPM) 99 was used for spatial normalization of the RAC image. A summation of the first 10 RAC frames was normalized to the SPM [15O]-H2O template, giving 68 horizontal planes. The normalization parameters were thereafter used to normalize the other frames of the RAC scan. A predetermined standard re ...
Rubidium Rb 82 Generator
... a maximum volume per infusion of 100 mL and a cumulative volume not to exceed 200 mL. These performance characteristics reflect the conditions of use under which the drug development clinical trials were conducted. Adequate data from clinical trials to determine precise localization of myocardial in ...
... a maximum volume per infusion of 100 mL and a cumulative volume not to exceed 200 mL. These performance characteristics reflect the conditions of use under which the drug development clinical trials were conducted. Adequate data from clinical trials to determine precise localization of myocardial in ...