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Muscle Metabolic Adaptation to Exercise
Muscle Metabolic Adaptation to Exercise

... to maintain steady state condition. it includes: ...
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... 40. At time=_______ms, the muscle cell is in its latent period. a. 2 b. 18 c. 35 d. 120 e. 150 41. At time=60ms, calcium is actively being pumped into the sarcoplasmic reticulum a. True b. False 42. Which of the following is TRUE? a. Skeletal muscle fibers are formed from the embryonic fusion of myo ...
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... Caffeine inhibits phosphodiesterase (PDE), causing a build-up of cAMP levels and greater effect of NE on fatty acid lipolysis. PDE blunts lipolysis; therefore inhibiting PDE allows lipolysis to proceed at an accelerated rate. The end result is there are more fatty acids available for oxidation after ...
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ergogenic aids: boon or bane to mankind?
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... supplementation when otherwise deficient (vegans, vegetarians with low dairy intake) or during prolonged endurance exercise. Anecdotally reported to reduce sugar cravings. Research shows glutamine builds muscle when tested on those suffering from physical trauma such as burns or muscular wounds (kni ...
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Beta-Hydroxy beta-methylbutyric acid



Beta-Hydroxy beta-methylbutyric acid β-Hydroxy β-methylbutyric acid (HMB), or β-hydroxy β-methylbutyrate, is a metabolite of the essential amino acid leucine and is synthesized in the human body. Its part in protein synthesis was discovered by Steven L. Nissen at Iowa State University. It has been used in scientific studies to purportedly increase muscle mass and decrease muscle breakdown. Nissen held the original patent on the metabolite as a nutritional supplement. It was discovered in pigs and small quantities can also be found in grapefruit, alfalfa, and catfish. As a supplement it is usually sold as the calcium salt calcium beta-hydroxy-beta-methylbutyrate.Research published in the Journal of Applied Physiology has shown that HMB may have an effect on increasing muscle weight and strength. A review in Nutrition & Metabolism provides an in depth and objective analysis of HMB research.The same study lists as HMB's proposed mechanisms of action the following: Increased sarcolemmal integrity via conversion to HMG-CoA Enhanced protein synthesis via the mTOR pathway Depression of protein degradation through inhibition of the ubiquitin pathwayThe human body produces about 0.2-0.4 grams per day. Standard doses in research studies have been 1.5 to 3.0 grams per day, usually divided into two doses. Toxicity at these doses is unlikely, as the no-observed-adverse-event-level (NOAEL) in rats is between 2.48 to 2.83 g/kg BW per day, roughly equivalent to 70 to 100 g/day in humans.
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