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Profile Documents Logout
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Plant Nuclear Genome Size Variation
Plant Nuclear Genome Size Variation

... Chromosome numbers vary n = 2 to n = ~680 Euploid variation – polyploidy ~35% of vascular plants are neopolyploids Most are likely paleopolyploids Aneuploid variation – gain or less of one or ...
Mutations - ScienceGeek.net Homepage
Mutations - ScienceGeek.net Homepage

... – Mutations that occur in germ cells (sperm, eggs) are passed on to offspring – Mutations in somatic (body) cells may be harmless, or may result in disease such as cancer ...
Ask the Expert Information Sheet
Ask the Expert Information Sheet

... The World Health Organization (WHO) provides an internationally recognized classification of brain tumours that is used by neuropathologists around the world to diagnose these diseases. Since the previous WHO update in 2007, there have been a number of significant advances in our understanding of th ...
Gene mutation
Gene mutation

GENETICS
GENETICS

... expressed. Some traits are recessive. They need 2 genes to be expressed. Hybrids look just like the pure ...
DNA Test Study Guide
DNA Test Study Guide

... 7. Describe transcription. Where does it take place? What are the steps? What is the purpose? Transcription is the process of changing DNA into mRNA. The end goal will be to make a protein to express that portion of DNA known as a gene. It takes place in the nucleus in eukaryotic organisms, and in t ...
Chapter 14
Chapter 14

... supply or nucleotide bases and a supply of four different chain-terminating tags  the chemical tags form complementary base pairs just like the nucleotide bases ...
Pharm 202 Computer Aided Drug Design
Pharm 202 Computer Aided Drug Design

... tools. Iterative determination of crystal structures for multiple target/compound complexes in parallel with assays, computational design and synthesis results in optimized leads with high binding affinities and low molecular weights. The combinatorial nature of FAST™ provides access to expansive ch ...
Chromosomes come in pairs
Chromosomes come in pairs

... sequences can be transposed -inserted on other chromosomes. Transposition events sometimes occur in plants, eg flax, during times of ecological stress. It is a quick way to disrupt the phenotype, giving rise to new morphologies and physiologies in ...
Aneuploidy vs. gene mutation hypothesis of cancer
Aneuploidy vs. gene mutation hypothesis of cancer

... (‘‘How many mutations does it take to make a tumor?’’), ‘‘There are no oncogenes or tumor suppressor genes that are activated or deleted from all cancers. Even tumors of a single organ rarely have uniform genetic alterations, although tumor types from one specific organ have a tendency to share muta ...
Orientamento In Rete
Orientamento In Rete

... – Mutations that occur in germ cells (sperm, eggs) are passed on to offspring – Mutations in somatic (body) cells may be harmless, or may result in disease such as cancer ...
insertion mutation
insertion mutation

... • Children born with this disorder cannot make an enzyme that is critical in breaking down fat and toxic substances in the brain. • The disease is terminal. Most will die before age ...
DNA
DNA

... • Each gene has a string of bases, the order of the bases gives the cell information about how to make each trait • DNA functions the same way for all organisms • Faulty or missing genes cause disease – Cystic fibrosis – Sickle cell anemia – Scientists hope to be able to treat genetic disorders some ...
Notes april 16 and 17 - Salmon River High School
Notes april 16 and 17 - Salmon River High School

... Answer: If transformation is successful, Recombinant the _________________DNA is integrated into one of the chromosomes of the cell. ...
Mitochondria are the - Charlin Manchester Terriers
Mitochondria are the - Charlin Manchester Terriers

... puppies has a greater genetic influence on them than the sire has, and those who just as adamantly insist that notion is biologically impossible. The sire and dam each contribute the same number of genes from their own DNA during mitosis, and those genes match up and form the new DNA helixes in each ...
Legal and Ethical Considerations
Legal and Ethical Considerations

... interventions regardless of DNR status ...
Personal genomics as a major focus of CSAIL research
Personal genomics as a major focus of CSAIL research

... Rank all probes by Alzheimer’s association 7000 probes increase methylation (repressed) Enriched in brain-specific enhancers Near motifs of brain-specific regulators ...
Classic Methods of Genetic Analysis
Classic Methods of Genetic Analysis

... Human Genetic Diseases ...
[pdf]
[pdf]

... tubules, and in these regions the cells underwent epithelial–mesenchymal transition before branching occurred. On the basis of tubule geometry and computer modelling, it is probable that branching is suppressed by the secretion of an inhibitory factor produced by the epithelial cells. Only at tubule ...
Evolution of genes and genomes
Evolution of genes and genomes

... Evolution of genes and genomes Molecular biology  Tools of molecular biology allow us to see evolution at a smaller scale  Genomics are the future of molecular biology field ...
Causes, Risk Factors, and Prevention What Are the Risk Factors for
Causes, Risk Factors, and Prevention What Are the Risk Factors for

Cell senescence questions
Cell senescence questions

... shortening telomeres make the cell know that it has undergone plenty of divisions) Senescence is a broader category. Rep. senescence is an example of cellular senescence. Cellular senescence refers to the cell response to any of many stimuli. (cell division/shortening telomeres is just one of these ...
Working at the University of Oxford
Working at the University of Oxford

... The successful candidate will aim to define the signalling pathways, which promote recombinational repair reactions in normal cells. These will of course be altered in cancer cells, leading to illegitimate repair of spontaneous DNA breaks and chromosomal aberrations. BRCA1 and 53BP1 are DNA damage r ...
presentation - Harlem Children Society
presentation - Harlem Children Society

... • The mice that test out positive for the gene will be followed to see if they develop melanoma. • The melanomas developed will be characterized and treated with the HGP75 optimized or HGP75 vaccine to suppress the melanoma. ...
DOCX - Cancer Australia
DOCX - Cancer Australia

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Oncogenomics



Oncogenomics is a relatively new sub-field of genomics that applies high throughput technologies to characterize genes associated with cancer. Oncogenomics is synonymous with ""cancer genomics"". Cancer is a genetic disease caused by accumulation of mutations to DNA leading to unrestrained cell proliferation and neoplasm formation. The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies. The success of targeted cancer therapies such as Gleevec, Herceptin, and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment.Besides understanding the underlying genetic mechanisms that initiates or drives cancer progression, one of the main goals of oncogenomics is to allow for the development of personalized cancer treatment. Cancer develops due to an accumulation of mutations in DNA. These mutations accumulate randomly, and thus, different DNA mutations and mutation combinations exist between different individuals with the same type of cancer. Thus, identifying and targeting specific mutations which have occurred in an individual patient may lead to increased efficacy of cancer therapy.The completion of the Human Genome Project has greatly facilitated the field of oncogenomics and has increased the abilities of researchers to find cancer causing genes. In addition, the sequencing technologies now available for sequence generation and data analysis have been applied to the study of oncogenomics. With the amount of research conducted on cancer genomes and the accumulation of databases documenting the mutational changes, it has been predicted that the most important cancer-causing mutations, rearrangements, and altered expression levels will be cataloged and well characterized within the next decade.Cancer research may look either on the genomic level at DNA mutations, the epigenetic level at methylation or histone modification changes, the transcription level at altered levels of gene expression, or the protein level at altered levels of protein abundance and function in cancer cells. Oncogenomics focuses on the genomic, epigenomic, and transcript level alterations in cancer.
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