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Year 10 CB3 - Bedford Free School
Year 10 CB3 - Bedford Free School

... Normal distribution – when many individuals have a middle for a feature with fewer individuals having greater or lesser values. This sort of data forms a bell shape on charts and graphs. Phenotype – the characteristics produced by a certain set of alleles. Polymers – a long-chained molecule made by ...
Genomics * Reading What we Can*t See
Genomics * Reading What we Can*t See

No Slide Title
No Slide Title

... A key distinctive feature of prokaryotic genomes are that they are organized into operons, clusters of co-regulated genes • Definition: groups of adjacent, co-expressed and co-regulated genes that encode functionally interacting proteins) • Genes within operons are close together in the genome and c ...
Huntington`s disease: Understanding a mutation - LENS
Huntington`s disease: Understanding a mutation - LENS

1 - life.illinois.edu
1 - life.illinois.edu

... [Revertants could be isolated by plating a pool of rII phage on K12 (λ+); only revertants will be able to form plaques. This is a selection. Looking for wild type plaques on B would require a lot more work since most of the plaques would be r type and wild type plaques would be exceedingly rare)] b. ...
The Humanized Fly - Barbara J. Culliton
The Humanized Fly - Barbara J. Culliton

... The number of Drosophila genes that correspond to genes associated with human  neurodegenerative diseases is quite astonishing. Flies were known to have a gene called  "Notch," which is associated with multi­infarct dementia—a kind of dementia that occurs  when lots of little blood vessels in the br ...
Lecture 10 Biol302 Spring 2011
Lecture 10 Biol302 Spring 2011

... two filaments to allow oxygen to enter the cell.  Sperm enter through the micropyle at the anterior end. ...
Leukaemia Section -Y / Y loss in leukemia in Oncology and Haematology
Leukaemia Section -Y / Y loss in leukemia in Oncology and Haematology

... - No significant difference was demonstrated between MDS patients and the control group in the unique study with statistical analysis. ...
BIOL 321 Lecture 7_pwpt
BIOL 321 Lecture 7_pwpt

... Chloroplast genomes can be transferred from one tree to the other across the graft junction Figure 1A from Stegemann et al., 2012, PNAS 109:2434 ...
Mamm_Genome yTrx1-2 + refs
Mamm_Genome yTrx1-2 + refs

... site WYGPC, where the Cys32 changing to tyrosine abolishes the enzymatic activity (Tagaya et al. 1989). Furthermore, a one-base deletion would initiate a frameshift resulting in a different C-terminus of the protein that has been found to be necessary for protein-protein interaction (Eklund et al. 1 ...
BIOL 321 Lecture 7_students
BIOL 321 Lecture 7_students

... 1.  A Sport was defined as, A spontaneous change or mutation in a part of a plant that created a feature not previously known within the species, their sexual hybrids and descendants . 2.  Sports were notoriously difficult to maintain and would often be unstable 3.  The first reproducible and stable ...
RNAi - University of Maryland, College Park
RNAi - University of Maryland, College Park

... A lot of research is currently being conducted investigating the use of RNAi as a future cancer therapeutic. Results from in vitro and in vivo animal studies look promising. This method is appealing due to the specificity of RNAi in silencing target genes without affecting other genes. As more genes ...
Biology Chapter 11-5 - Wayne County Public Schools
Biology Chapter 11-5 - Wayne County Public Schools

...  Morgan and his friends found that the fruit fly had 4 linkage groups (genes that were inherited together).  The linkage groups assorted independently but all the genes were inherited together. ...
20.1 Structural Genomics Determines the DNA Sequences of Entire
20.1 Structural Genomics Determines the DNA Sequences of Entire

... • A site in the genome where individual members of a species differ in a single base pair • Haplotype: the specific set of SNPs and other genetic variants observed on a chromosome • Linkage disequilibrium • Tag SNPs • Genome-wide association studies ...
Exploring Heredity Graphic Organizer
Exploring Heredity Graphic Organizer

... The fact that we get our genes from them is call heredity. The type of gene is always on the same chromosomes. But the type may be different. Ex. Eye color for dad may be blue, but for mom may be brown. So, for each trait we have get, two genes through the process of reproduction. ...
Genetics
Genetics

... – Direct gene diagnosis is possible only if the mutant gene and its normal counterpart have been identified and cloned and their nucleotide sequences are known. ...
BioSc 231 Exam 2 2005
BioSc 231 Exam 2 2005

... A antigens on the cell surface B antigens on the cell surface both A and B antigens on the cell surface no surface antigens ...
Mansi`s Powerpoint
Mansi`s Powerpoint

... true muscle true gut nervous system tissue grade ...
Attenuated Familial Adenomatous Polyposis
Attenuated Familial Adenomatous Polyposis

... FAP). People with FAP or AFAP will have an increased number of adenomatous colon polyps during their lifetime and an increased risk of developing colorectal cancer [3]. An adenomatous polyp is a lump filled with the cells that make mucous and line the inside of a person's colon. Normally these cells ...
Types of mutation
Types of mutation

... genome that sit between genes, and usually they have no effect. When variations occur within genes, there is more often a consequence, but even then mutation only rarely causes death or disease. Mutation also generates new variations that can give an individual a survival ...
Sookie, a student in Genetics 200A, is a little too obsessed with
Sookie, a student in Genetics 200A, is a little too obsessed with

... there has been a lateral spread of heterochromatin outside of its normal boundaries, suggest a hypothesis (or two) for what might be the molecular cause of fission yeast vampirism. Many possible correct answers, in general, yeast vampirism is caused by the spread of silencing outside of its boundari ...
Focus Summer 2008 - the Royal College of Ophthalmologists
Focus Summer 2008 - the Royal College of Ophthalmologists

... of Rb in their offspring, but also with regard to their own increased risk of developing a non-ocular cancer in early adulthood. Emphasising the need to avoid known carcinogenic factors such as smoking, radiation, obesity and excess UV light is particularly important. As radiation is associated with ...
The Chromosomal Basis of Inheritance
The Chromosomal Basis of Inheritance

... size must be linked – look at the expected v/s observed ratios in the ...
Eukaryotic Genome: Organization, Regulation, and Evolution
Eukaryotic Genome: Organization, Regulation, and Evolution

... The coordinate regulation of clustered genes in eukaryotic cells is thought to involve changes in the chromatin structure that makes the entire group of genes either available or unavailable for transcription. ...
The origins of diversity in a simple model of evolution
The origins of diversity in a simple model of evolution

... • Also: genetic inference relies on this! • Theory or data interpretation is wrong • Inappropriate to apply theory? • Stochastic interpretation of evolution? ...
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Oncogenomics



Oncogenomics is a relatively new sub-field of genomics that applies high throughput technologies to characterize genes associated with cancer. Oncogenomics is synonymous with ""cancer genomics"". Cancer is a genetic disease caused by accumulation of mutations to DNA leading to unrestrained cell proliferation and neoplasm formation. The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies. The success of targeted cancer therapies such as Gleevec, Herceptin, and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment.Besides understanding the underlying genetic mechanisms that initiates or drives cancer progression, one of the main goals of oncogenomics is to allow for the development of personalized cancer treatment. Cancer develops due to an accumulation of mutations in DNA. These mutations accumulate randomly, and thus, different DNA mutations and mutation combinations exist between different individuals with the same type of cancer. Thus, identifying and targeting specific mutations which have occurred in an individual patient may lead to increased efficacy of cancer therapy.The completion of the Human Genome Project has greatly facilitated the field of oncogenomics and has increased the abilities of researchers to find cancer causing genes. In addition, the sequencing technologies now available for sequence generation and data analysis have been applied to the study of oncogenomics. With the amount of research conducted on cancer genomes and the accumulation of databases documenting the mutational changes, it has been predicted that the most important cancer-causing mutations, rearrangements, and altered expression levels will be cataloged and well characterized within the next decade.Cancer research may look either on the genomic level at DNA mutations, the epigenetic level at methylation or histone modification changes, the transcription level at altered levels of gene expression, or the protein level at altered levels of protein abundance and function in cancer cells. Oncogenomics focuses on the genomic, epigenomic, and transcript level alterations in cancer.
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