In vivo resistance to CPT
... resistance was achieved after 25 passages in nude mice treated with several cycles of 27 mg/kg/dx5 CPT-11 every 21 days and was revertible after 15 passages without treatment. Cross-resistance existed to the topoisomerase I inhibitor topotecan, but not to cyclophosphamide and cisplatin. Common mecha ...
... resistance was achieved after 25 passages in nude mice treated with several cycles of 27 mg/kg/dx5 CPT-11 every 21 days and was revertible after 15 passages without treatment. Cross-resistance existed to the topoisomerase I inhibitor topotecan, but not to cyclophosphamide and cisplatin. Common mecha ...
1 - Testbankexam
... recombinational analysis is that two genes that are far apart on a chromosome will have a higher frequency of recombination than two genes that are close together. Thus, if recombination between the gene of interest and a marker is very low, then the gene is likely located near that marker gene. ...
... recombinational analysis is that two genes that are far apart on a chromosome will have a higher frequency of recombination than two genes that are close together. Thus, if recombination between the gene of interest and a marker is very low, then the gene is likely located near that marker gene. ...
Chapter 5: Of Microbes and Men Explain how, through host
... 4. Explain how Lamarck got an undeserved bad name. 5. Explain how, with about 25,000 protein recipes (genes), you can produce millions of different proteins. 6. Explain how retroviruses deviate from the "normal" pattern of how DNA and mRNA work in our cells. ...
... 4. Explain how Lamarck got an undeserved bad name. 5. Explain how, with about 25,000 protein recipes (genes), you can produce millions of different proteins. 6. Explain how retroviruses deviate from the "normal" pattern of how DNA and mRNA work in our cells. ...
level one science: biology
... explaining the link between a change in the genetic code and a change in phenotype. I can explain how a mutation can lead to a new allele by linking genotype and phenotype. I can discuss why mutations are only passed on if they occur in gametes. ...
... explaining the link between a change in the genetic code and a change in phenotype. I can explain how a mutation can lead to a new allele by linking genotype and phenotype. I can discuss why mutations are only passed on if they occur in gametes. ...
Document
... MeCP2 protein • 486 amino acids and 52kD. • An abundant mammalian chromosomal protein that binds to methylated CpG. • Ubiquitously expressed, more abundant in brain. • Can bind to single methyl-CpG pair (unlike MeCP1 which requires >10 methyl-CpGs to bind DNA) ...
... MeCP2 protein • 486 amino acids and 52kD. • An abundant mammalian chromosomal protein that binds to methylated CpG. • Ubiquitously expressed, more abundant in brain. • Can bind to single methyl-CpG pair (unlike MeCP1 which requires >10 methyl-CpGs to bind DNA) ...
Cell Evolution in Fast Motion - Max-Planck
... cally identical. They can actually differ in terms of the pattern of the organellar DNA sequences transferred to the nuclear genome. Another interesting consequence of this process arises from the random insertion of transferred organellar genes into the nuclear genome. It is conceivable that insert ...
... cally identical. They can actually differ in terms of the pattern of the organellar DNA sequences transferred to the nuclear genome. Another interesting consequence of this process arises from the random insertion of transferred organellar genes into the nuclear genome. It is conceivable that insert ...
notes (p.49-52)
... We can also ask how many mutations are found on the whole tree: this is the number of distinct mutations that will be seen in the sample of k individuals. The expected number is just µE(L) ⇡ 2Ne µ( + log k). The ratio between the number of distinct mutations, and the average number of mutations that ...
... We can also ask how many mutations are found on the whole tree: this is the number of distinct mutations that will be seen in the sample of k individuals. The expected number is just µE(L) ⇡ 2Ne µ( + log k). The ratio between the number of distinct mutations, and the average number of mutations that ...
Gregor Mendel (1822-1844) & the Foundations of Genetics
... • Chromosomes can be duplicated, portions can be translocated to a different chromosome or inverted on the same, or deleted • Usually has profound consequences - sterility or worse • Common, e.g. Down’s syndrome 1:700 births • Major mode of ‘instantaneous’ speciation in selffertilizing or inbreeding ...
... • Chromosomes can be duplicated, portions can be translocated to a different chromosome or inverted on the same, or deleted • Usually has profound consequences - sterility or worse • Common, e.g. Down’s syndrome 1:700 births • Major mode of ‘instantaneous’ speciation in selffertilizing or inbreeding ...
BB30055: Genes and genomes
... proteins (structural proteins and proteins involved in signal transduction and immune function) However, only 3 cases where a combination of 3 domain types shared by human & yeast proteins. e.g carbomyl-phosphate synthase (involved in the first 3 steps of de novo pyrimidine biosynthesis) has 7 domai ...
... proteins (structural proteins and proteins involved in signal transduction and immune function) However, only 3 cases where a combination of 3 domain types shared by human & yeast proteins. e.g carbomyl-phosphate synthase (involved in the first 3 steps of de novo pyrimidine biosynthesis) has 7 domai ...
Chapter 12 - Biotechnology
... • DNA is the genetic material of all living organisms and all organisms use the same genetic code. Genes from one kind of organism can be transcribed and translated when put into another kind of ...
... • DNA is the genetic material of all living organisms and all organisms use the same genetic code. Genes from one kind of organism can be transcribed and translated when put into another kind of ...
Microbial Genetics
... recombination In the same way that mutations can be beneficial, neutral or harmful, so is the recombination of incoming DNA New gene combinations are maintained if they provide the organism with a selective ...
... recombination In the same way that mutations can be beneficial, neutral or harmful, so is the recombination of incoming DNA New gene combinations are maintained if they provide the organism with a selective ...
Chapter 12 - Biotechnology
... • DNA is the genetic material of all living organisms and all organisms use the same genetic code. Genes from one kind of organism can be transcribed and translated when put into another kind of ...
... • DNA is the genetic material of all living organisms and all organisms use the same genetic code. Genes from one kind of organism can be transcribed and translated when put into another kind of ...
- human genetics
... a. The DNA h m the two DNA fingerprints almost certainly came from the same person. b. The DNA from the two DNA fmgerprints definitely came from two different people. c. The DNA from the two DNA fingerprints definitely came from the same person. d. The DNA repeats that formed the bands in each DNA f ...
... a. The DNA h m the two DNA fingerprints almost certainly came from the same person. b. The DNA from the two DNA fmgerprints definitely came from two different people. c. The DNA from the two DNA fingerprints definitely came from the same person. d. The DNA repeats that formed the bands in each DNA f ...
Document
... • Valuable for discovering function(s) of genes for which mutant strains were not previously available. • Generalizations: 1. Mice are often surprisingly unaffected by their deficiency. Many genes turn out not to be indispensable. 2. Most genes are pleiotropic; that is, they are expressed in differe ...
... • Valuable for discovering function(s) of genes for which mutant strains were not previously available. • Generalizations: 1. Mice are often surprisingly unaffected by their deficiency. Many genes turn out not to be indispensable. 2. Most genes are pleiotropic; that is, they are expressed in differe ...
Traditional Cancer Prevention Activities at Academic Cancer Centers
... promoting awareness that CT radiation exposure for head scans in children can be 200 to 6000 chest x-ray equivalents – National workshop held at University of Pittsburgh, Spring 2008 and white paper with recommendations for emergency room use of CT scans being developed Cell phones and brain tumors ...
... promoting awareness that CT radiation exposure for head scans in children can be 200 to 6000 chest x-ray equivalents – National workshop held at University of Pittsburgh, Spring 2008 and white paper with recommendations for emergency room use of CT scans being developed Cell phones and brain tumors ...
Plant Nuclear Genome Size Variation
... Chromosome numbers vary n = 2 to n = ~680 Euploid variation – polyploidy ~35% of vascular plants are neopolyploids All are paleopolyploids Aneuploid variation – gain or less of one or ...
... Chromosome numbers vary n = 2 to n = ~680 Euploid variation – polyploidy ~35% of vascular plants are neopolyploids All are paleopolyploids Aneuploid variation – gain or less of one or ...
The Importance of Prioritizing Cancer Prevention at Major Academic
... promoting awareness that CT radiation exposure for head scans in children can be 200 to 6000 chest x-ray equivalents – National workshop held at University of Pittsburgh, Spring 2008 and white paper with recommendations for emergency room use of CT scans being developed Cell phones and brain tumors ...
... promoting awareness that CT radiation exposure for head scans in children can be 200 to 6000 chest x-ray equivalents – National workshop held at University of Pittsburgh, Spring 2008 and white paper with recommendations for emergency room use of CT scans being developed Cell phones and brain tumors ...
Quiz 13 Name: 1. Suppose there are two alleles of a gene, called A
... 4. Disorders caused by recessive, sex-linked (X) alleles should be most commonly expressed in: A) male humans (XY) B) female humans (XX) 5. If we assume that in dogs long legs are dominant to short then, if a heterozygous long-legged dog mates with a homozygous short-legged dog, what is the probabil ...
... 4. Disorders caused by recessive, sex-linked (X) alleles should be most commonly expressed in: A) male humans (XY) B) female humans (XX) 5. If we assume that in dogs long legs are dominant to short then, if a heterozygous long-legged dog mates with a homozygous short-legged dog, what is the probabil ...
Oncogenomics
Oncogenomics is a relatively new sub-field of genomics that applies high throughput technologies to characterize genes associated with cancer. Oncogenomics is synonymous with ""cancer genomics"". Cancer is a genetic disease caused by accumulation of mutations to DNA leading to unrestrained cell proliferation and neoplasm formation. The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies. The success of targeted cancer therapies such as Gleevec, Herceptin, and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment.Besides understanding the underlying genetic mechanisms that initiates or drives cancer progression, one of the main goals of oncogenomics is to allow for the development of personalized cancer treatment. Cancer develops due to an accumulation of mutations in DNA. These mutations accumulate randomly, and thus, different DNA mutations and mutation combinations exist between different individuals with the same type of cancer. Thus, identifying and targeting specific mutations which have occurred in an individual patient may lead to increased efficacy of cancer therapy.The completion of the Human Genome Project has greatly facilitated the field of oncogenomics and has increased the abilities of researchers to find cancer causing genes. In addition, the sequencing technologies now available for sequence generation and data analysis have been applied to the study of oncogenomics. With the amount of research conducted on cancer genomes and the accumulation of databases documenting the mutational changes, it has been predicted that the most important cancer-causing mutations, rearrangements, and altered expression levels will be cataloged and well characterized within the next decade.Cancer research may look either on the genomic level at DNA mutations, the epigenetic level at methylation or histone modification changes, the transcription level at altered levels of gene expression, or the protein level at altered levels of protein abundance and function in cancer cells. Oncogenomics focuses on the genomic, epigenomic, and transcript level alterations in cancer.