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Behavioral Evolution and Altruism
Behavioral Evolution and Altruism

... •  Tame foxes also show differences in hormones, coat color patterns, and even in skull shape. ...
baby joe
baby joe

... mutations. Many of these mutations are in genes involved in somatic recombination. Somatic recombination occurs in the immunoglobulin (ig) genes in b cells and in the t cell receptor (tcr) genes in t cells. In each individual developing b or t cell, the dna composing the ig or tcr gene is physically ...
Epigenetics and Culture
Epigenetics and Culture

... • DNA contains nucleotides which code for amino acids which eventually make a protein • Together, all of the nucleotides needed to make that protein together are a gene • Genes can be turned on or off depending on what type of cell it is and what the needs of that cell are ...
Genetics and Evolution IB 201 06
Genetics and Evolution IB 201 06

... homeotic genes— genes whose products provide positional information in a multicellular embryo; these genes act within cells to select their developmental fate (selector genes); they regulate the overall body plan and determine the number, identity and pattern of body parts. Mutations in homeotic gen ...
Control (n=217)
Control (n=217)

... • The effect of gene dosage on increasing the severity of infertile phenotype and the underlying mechanism is yet to be explored at the functional level. • To understand that compromised DNA damage, DNA repair , apoptosis, immunological and detoxification pathways in the testicular cells may impair ...
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The Biotechnology Age: Issues and Impacts

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Eukaryotic Gene Expression Practice Problems Class Work 1

... 1. Explain the central dogma of cell biology. 2. What is gene expression? 3. Transcription is the process of copying a sequence of DNA into a complementary strand of RNA. Number the events of transcription in order: ______RNA polymerase attaches at the promoter sequence on DNA ______ The new RNA str ...
biochemistry and molecular biology
biochemistry and molecular biology

... An overview of applications of fractals and chaos in biosciences. The emphasis is on general understanding  of basic concepts (selfsimilarity, scaling, dimension, sensitivity to initial conditions, bifurcations, chaotic  data, control of chaos, etc.) and their applications (protein backbone, neurons ...
Eukaryotic Gene Expression Practice Problems Class Work 1
Eukaryotic Gene Expression Practice Problems Class Work 1

... 1. Explain the central dogma of cell biology. 2. What is gene expression? 3. Transcription is the process of copying a sequence of DNA into a complementary strand of RNA. Number the events of transcription in order: ______RNA polymerase attaches at the promoter sequence on DNA ______ The new RNA str ...
Transcriptome - Nematode bioinformatics. Analysis tools and data
Transcriptome - Nematode bioinformatics. Analysis tools and data

... select statistically meaningful genes/patterns. • Sensitivity and selectivity are inversely related - e.g. increased selection of true positives WILL result in more false positive and less false negatives. • False negatives are lost opportunities, false positives cost $’s and waste time. • A typical ...
EOC Review Unit 7_Genetics
EOC Review Unit 7_Genetics

... If the mutant cell is a body cell - contributes to the aging process or the development of many types of cancer.  If the mutant cell is a gamete (sex cell) – the changed DNA will be transmitted to the offspring ○ Can lead to genetic disorders.  gene mutation - affects a single gene  chromosomal m ...
Genetic disorders
Genetic disorders

... A clinically and genetically heterogeneous group of disorders that result from some defect in collagen synthesis or structure (other disorders resulting from mutations affecting collagen synthesis include osteogenesis imperfecta, Alport syndrome, epidermolysis bullosa) ...
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Original Article Genetic and epigenetic association studies suggest

... from breast cancer patients and healthy controls. The keywords used were: Gene, “XPO5”; Conditions, “Breast Cancer”; and the results were filtered by species to include only Homo sapiens. One experiment was identified that examined gene expression in breast tumor tissue (N=23), adjacent tissue (N=28 ...
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... 1) Select correct statements a) Accumulated CpG dinucleotides are present in the promoter region of gene b) Epigenetic modifications of genes can be a cause of tumor growth c) Metastable epialleles have identical gene expression d) Short noncoding RNAs are 20-30 nucleotides long 2) Which of the foll ...
Evolution of Duplicated Genomes
Evolution of Duplicated Genomes

... • Adams, KL and JF Wendel. 2005. Polyploidy and genome evolution in plants. Curr. Op. Plant Bio. 8:135-141 • Wendel JF. 2000. Genome evolution in polyploids. Plant Mol. ...
Honors Biology
Honors Biology

... 1. Summarize how restriction enzymes cut DNA. 2. Explain how restriction maps show the lengths of DNA fragments. 3. Describe the role of polymerases in copying DNA segments. 4. Outline the PCR process and explain why it is used. 5. Describe what a DNA fingerprint represents. 6. Summarize how DNA fin ...
Honors Biology Mid
Honors Biology Mid

... Summarize how restriction enzymes cut DNA. Explain how restriction maps show the lengths of DNA fragments. Describe the role of polymerases in copying DNA segments. Outline the PCR process and explain why it is used. Describe what a DNA fingerprint represents. Summarize how DNA fingerprints are used ...
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Practice exam (2010) key

... Through this process organelle genomes having different haplotypes sort into different cells. Over multiple generations this leads to homoplasmic cells. In the absence of selection the each of the initial haplotypes should be represented within the cell population. At this point the even a recessive ...
ppt - Phenotype RCN
ppt - Phenotype RCN

... living units: cells, tissues, organs, and organisms. For example, the gene product cytochrome c can be described by the molecular function term oxidoreductase activity, the biological process terms oxidative phosphorylation and induction of cell death, and the cellular component terms mitochondrial ...
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Oncogenomics



Oncogenomics is a relatively new sub-field of genomics that applies high throughput technologies to characterize genes associated with cancer. Oncogenomics is synonymous with ""cancer genomics"". Cancer is a genetic disease caused by accumulation of mutations to DNA leading to unrestrained cell proliferation and neoplasm formation. The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies. The success of targeted cancer therapies such as Gleevec, Herceptin, and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment.Besides understanding the underlying genetic mechanisms that initiates or drives cancer progression, one of the main goals of oncogenomics is to allow for the development of personalized cancer treatment. Cancer develops due to an accumulation of mutations in DNA. These mutations accumulate randomly, and thus, different DNA mutations and mutation combinations exist between different individuals with the same type of cancer. Thus, identifying and targeting specific mutations which have occurred in an individual patient may lead to increased efficacy of cancer therapy.The completion of the Human Genome Project has greatly facilitated the field of oncogenomics and has increased the abilities of researchers to find cancer causing genes. In addition, the sequencing technologies now available for sequence generation and data analysis have been applied to the study of oncogenomics. With the amount of research conducted on cancer genomes and the accumulation of databases documenting the mutational changes, it has been predicted that the most important cancer-causing mutations, rearrangements, and altered expression levels will be cataloged and well characterized within the next decade.Cancer research may look either on the genomic level at DNA mutations, the epigenetic level at methylation or histone modification changes, the transcription level at altered levels of gene expression, or the protein level at altered levels of protein abundance and function in cancer cells. Oncogenomics focuses on the genomic, epigenomic, and transcript level alterations in cancer.
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