Tox21 Phase III: The S1500 Genes High Throughput Transcriptomics Project Progress Report
... numbers of substances using toxicogenomic technologies. Workshop sponsored by DNTP & DERT of NIEHS with the following goals to: • Address the need for identifying environmentally responsive genes in humans, rats, mice, zebrafish, and C. elegans for use in toxicological studies of large numbers of su ...
... numbers of substances using toxicogenomic technologies. Workshop sponsored by DNTP & DERT of NIEHS with the following goals to: • Address the need for identifying environmentally responsive genes in humans, rats, mice, zebrafish, and C. elegans for use in toxicological studies of large numbers of su ...
Leukaemia Section Plasma cell leukemia (PCL) Atlas of Genetics and Cytogenetics
... Chromosomal changes are detectable by conventional cytogenetic techniques or by FISH; in addition, comparative genomic hybridization showed to be a useful tool in PCL, allowing assessment of regions showing copy number changes. ...
... Chromosomal changes are detectable by conventional cytogenetic techniques or by FISH; in addition, comparative genomic hybridization showed to be a useful tool in PCL, allowing assessment of regions showing copy number changes. ...
Introduction
... Multitude of existing SNP analysis tools and resources F-SNP provides a single web based resource to mine SNP disease associations Query and analysis by SNP, Gene, Disease ...
... Multitude of existing SNP analysis tools and resources F-SNP provides a single web based resource to mine SNP disease associations Query and analysis by SNP, Gene, Disease ...
13-3
... for which they code. Whether a mutation is negative or beneficial depends on how its DNA changes relative to the organism’s situation. Mutations are often thought of as negative, since they can disrupt the normal function of genes. However, without mutations, organisms could not evolve, because mutat ...
... for which they code. Whether a mutation is negative or beneficial depends on how its DNA changes relative to the organism’s situation. Mutations are often thought of as negative, since they can disrupt the normal function of genes. However, without mutations, organisms could not evolve, because mutat ...
7. 8. Brain Tumors
... - Prior radiation therapy - Loss of chromosome 22 (esp. 22q) NF2 gene merlin protein loss Grade II Higher rate of recurrence Grade III ...
... - Prior radiation therapy - Loss of chromosome 22 (esp. 22q) NF2 gene merlin protein loss Grade II Higher rate of recurrence Grade III ...
Bacterial Genomics
... 1. Genome-pairs with low levels of drift (i.e., more efficient selection) display a relatively narrow range of coding densities (usually 85-90%) 2. Most genome pairs displaying high levels of drift have coding densities that lie outside of the 85-90% range This occurs due to pseudogene formation in re ...
... 1. Genome-pairs with low levels of drift (i.e., more efficient selection) display a relatively narrow range of coding densities (usually 85-90%) 2. Most genome pairs displaying high levels of drift have coding densities that lie outside of the 85-90% range This occurs due to pseudogene formation in re ...
Abstract Rosa English
... caused by loss of motoneurons (MNs). Several ALS‐linked genes have been recently discovered. In the case of the RNA‐binding factor FUS, most in vitro studies rely on cell lines in which the mutated protein is overexpressed. Such systems do not recapitulate the complexity of the MN and ...
... caused by loss of motoneurons (MNs). Several ALS‐linked genes have been recently discovered. In the case of the RNA‐binding factor FUS, most in vitro studies rely on cell lines in which the mutated protein is overexpressed. Such systems do not recapitulate the complexity of the MN and ...
SPIS TREŚCI
... Sasidharan R and Gerstein M (2008) Genomics: protein fossils live on as RNA Nature 453: 729-31. ...
... Sasidharan R and Gerstein M (2008) Genomics: protein fossils live on as RNA Nature 453: 729-31. ...
The future role of molecular and cell biology in
... to infection may have a strong genetic basis, it is only with the advent of the molecular era that it has been possible to investigate this important possibility20*21. Until very recently studies in this field utilised the 'candidate gene' approach, that is research workers made an educated guess ab ...
... to infection may have a strong genetic basis, it is only with the advent of the molecular era that it has been possible to investigate this important possibility20*21. Until very recently studies in this field utilised the 'candidate gene' approach, that is research workers made an educated guess ab ...
Gene Section MMP9 (matrix metallopeptidase 9 (gelatinase B,
... binding of certain substrates, membrane activation, and some proteolytic activities. It also shows a series of three head-to-tail cysteine-rich repeats within its catalytic domain. These inserts resemble the collagenbinding type II repeats of fibronectin and are required to bind and cleave collagen ...
... binding of certain substrates, membrane activation, and some proteolytic activities. It also shows a series of three head-to-tail cysteine-rich repeats within its catalytic domain. These inserts resemble the collagenbinding type II repeats of fibronectin and are required to bind and cleave collagen ...
THE GENOME AND THE ORIGIN OF MAN
... Sasidharan R and Gerstein M (2008) Genomics: protein fossils live on as RNA Nature 453: 729-31. ...
... Sasidharan R and Gerstein M (2008) Genomics: protein fossils live on as RNA Nature 453: 729-31. ...
b. genetic engineering.
... survival rate and showed more abnormalities during development, suggesting that inbreeding had exposed harmful mutations which reduced fitness. ...
... survival rate and showed more abnormalities during development, suggesting that inbreeding had exposed harmful mutations which reduced fitness. ...
DNA chips: a new tool for genetic analysis and diagnostics
... of thousands of probes (without having to worry about handling and storing each probe), other companies and research laboratories have entered the race by proposing lower-cost or higher-yield alternatives (without photomasks). Protogene uses piezoelectric pipetting to successively deposit the four b ...
... of thousands of probes (without having to worry about handling and storing each probe), other companies and research laboratories have entered the race by proposing lower-cost or higher-yield alternatives (without photomasks). Protogene uses piezoelectric pipetting to successively deposit the four b ...
Somatic Cell Gene Mutations in Humans
... because they measure this common functional pathway. When these mutations occur in critical regions, they produce genotoxic disease. Most studies of human genotoxic diseases are concerned with genes involved in the disorder. Cancer research has become highly focused on the critical genes involved in ...
... because they measure this common functional pathway. When these mutations occur in critical regions, they produce genotoxic disease. Most studies of human genotoxic diseases are concerned with genes involved in the disorder. Cancer research has become highly focused on the critical genes involved in ...
What is a Gene?
... typical protein-coding genes by RNA polymerase II and produce transcripts of varying sizes, which are processed in much the same way as the protein-coding mRNAs, but are ultimately not translated or are untranslatable. These non-protein coding genes function through their transcripts in an as yet un ...
... typical protein-coding genes by RNA polymerase II and produce transcripts of varying sizes, which are processed in much the same way as the protein-coding mRNAs, but are ultimately not translated or are untranslatable. These non-protein coding genes function through their transcripts in an as yet un ...
X and Y Chromosomes
... Or, to put it more precisely, the heterozygous offspring of those two individuals can produce gametes with neither mutation. ...
... Or, to put it more precisely, the heterozygous offspring of those two individuals can produce gametes with neither mutation. ...
Genomic sequence analysis of a plant
... Dony Chacko Mathew1, Shou-Chen Lo1, Gincy Marina Mathew2, Kung-Hao Chang1 and Chieh-Chen Huang1* ...
... Dony Chacko Mathew1, Shou-Chen Lo1, Gincy Marina Mathew2, Kung-Hao Chang1 and Chieh-Chen Huang1* ...
lecture 21 notes
... 0.5 Infected, 0.5 Normal Wolbachia does better by killing some of the normal offspring, but this reduces the fitness of the insect population ...
... 0.5 Infected, 0.5 Normal Wolbachia does better by killing some of the normal offspring, but this reduces the fitness of the insect population ...
Gene Section FUT8 (fucosyltransferase 8 (alpha (1,6) fucosyltransferase))
... that exhibit growth retardation, lung emphysema and death during postnatal development (Wang et al., 2005). As has been clearly shown in studies using knockout mice, the lack of core fucosylation resulted in the biological activities of various proteins to be perturbed (Taniguchi et al., 2006; Takah ...
... that exhibit growth retardation, lung emphysema and death during postnatal development (Wang et al., 2005). As has been clearly shown in studies using knockout mice, the lack of core fucosylation resulted in the biological activities of various proteins to be perturbed (Taniguchi et al., 2006; Takah ...
Oncogenomics
Oncogenomics is a relatively new sub-field of genomics that applies high throughput technologies to characterize genes associated with cancer. Oncogenomics is synonymous with ""cancer genomics"". Cancer is a genetic disease caused by accumulation of mutations to DNA leading to unrestrained cell proliferation and neoplasm formation. The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies. The success of targeted cancer therapies such as Gleevec, Herceptin, and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment.Besides understanding the underlying genetic mechanisms that initiates or drives cancer progression, one of the main goals of oncogenomics is to allow for the development of personalized cancer treatment. Cancer develops due to an accumulation of mutations in DNA. These mutations accumulate randomly, and thus, different DNA mutations and mutation combinations exist between different individuals with the same type of cancer. Thus, identifying and targeting specific mutations which have occurred in an individual patient may lead to increased efficacy of cancer therapy.The completion of the Human Genome Project has greatly facilitated the field of oncogenomics and has increased the abilities of researchers to find cancer causing genes. In addition, the sequencing technologies now available for sequence generation and data analysis have been applied to the study of oncogenomics. With the amount of research conducted on cancer genomes and the accumulation of databases documenting the mutational changes, it has been predicted that the most important cancer-causing mutations, rearrangements, and altered expression levels will be cataloged and well characterized within the next decade.Cancer research may look either on the genomic level at DNA mutations, the epigenetic level at methylation or histone modification changes, the transcription level at altered levels of gene expression, or the protein level at altered levels of protein abundance and function in cancer cells. Oncogenomics focuses on the genomic, epigenomic, and transcript level alterations in cancer.