Bioinformatics
... association and then the orthologous gene in humans needs to be found to see if the study can be moved to humans o In other cases, a gene is first linked to the disease in humans but then an animal model is needed for further study (eg. to test different therapies). Again, there must be a known orth ...
... association and then the orthologous gene in humans needs to be found to see if the study can be moved to humans o In other cases, a gene is first linked to the disease in humans but then an animal model is needed for further study (eg. to test different therapies). Again, there must be a known orth ...
Mutations Handout
... ______18. Why are insertion and deletion mutations usually more serious than substitutions? A. they can be passed on to offspring B. they change every codon after the mutation C. they always cause some form of cancer D. they cause recessive traits to become dominant traits ______19. Why do some gen ...
... ______18. Why are insertion and deletion mutations usually more serious than substitutions? A. they can be passed on to offspring B. they change every codon after the mutation C. they always cause some form of cancer D. they cause recessive traits to become dominant traits ______19. Why do some gen ...
Drosophila-Lecture-3-handout
... sequence to another. They are considered selfish pieces of DNA that parasitize other replicating molecules. There are three modes of transposition, conservative (or cut and paste), replicative and retrotransposition. The P element uses cut-andpaste. The P element encodes an enzyme called transposase ...
... sequence to another. They are considered selfish pieces of DNA that parasitize other replicating molecules. There are three modes of transposition, conservative (or cut and paste), replicative and retrotransposition. The P element uses cut-andpaste. The P element encodes an enzyme called transposase ...
9/11
... •This DNA is ~2 meters long and 2 nm wide. •~3% directly codes for amino acids •~10% is genes •In a single human cell only about 5-10% of genes are expressed at a time. ...
... •This DNA is ~2 meters long and 2 nm wide. •~3% directly codes for amino acids •~10% is genes •In a single human cell only about 5-10% of genes are expressed at a time. ...
Divining Biological Pathway Knowledge from High
... • Load your experiment results using the Launch EGAN Wizard • Your data must be in the proper 3-column format – ID, statistic (e.g. fold-change), p-value (or qvalue/FDR estimate) ...
... • Load your experiment results using the Launch EGAN Wizard • Your data must be in the proper 3-column format – ID, statistic (e.g. fold-change), p-value (or qvalue/FDR estimate) ...
140322JessicaMcCready
... Jessica McCready and Charlotte Kuperwasser, Dynamic regulation of lipolysis in adipocytes during mammary gland development promotes angiogenesis and breast cancer. 2011 IRACDA National Conference, Houston, TX La’Kesha Francis, Jessica McCready and Charlotte Kuperwasser, Cellular retinoic acid bindin ...
... Jessica McCready and Charlotte Kuperwasser, Dynamic regulation of lipolysis in adipocytes during mammary gland development promotes angiogenesis and breast cancer. 2011 IRACDA National Conference, Houston, TX La’Kesha Francis, Jessica McCready and Charlotte Kuperwasser, Cellular retinoic acid bindin ...
Midterm 2 2012 KEY
... 17. A zebrafish mutant named floating head lacks a notochord. Explain why the researchers chose the name floating head for the gene involved. Genes are often named after the mutant phenotype. In this case, mutation of floating head leads to the absence of a notochord, which in turn, leads to the lac ...
... 17. A zebrafish mutant named floating head lacks a notochord. Explain why the researchers chose the name floating head for the gene involved. Genes are often named after the mutant phenotype. In this case, mutation of floating head leads to the absence of a notochord, which in turn, leads to the lac ...
Transcription of a genome
... complexity of an organism is not necessarily related to its genome size (C-value). Transcription of a genome Only 5% of human and mouse genomes are conserved – this includes nearly all protein coding genes and a substantial number of genes for non-coding RNAs The remaining 95% of the human and mouse ...
... complexity of an organism is not necessarily related to its genome size (C-value). Transcription of a genome Only 5% of human and mouse genomes are conserved – this includes nearly all protein coding genes and a substantial number of genes for non-coding RNAs The remaining 95% of the human and mouse ...
a pair-rule gene
... Responsible for directing structure formation of each segment • These genes are clustered on chromosome 3 in the ________ ___________ (also called Hom-C) in two regions• The _______________ complex• The ________________ complex- ...
... Responsible for directing structure formation of each segment • These genes are clustered on chromosome 3 in the ________ ___________ (also called Hom-C) in two regions• The _______________ complex• The ________________ complex- ...
Recombination and Genetic Engineering
... There are two major groups of enzymes that carry out sitespecific recombination reactions; one group - known as the tyrosine recombinase family - consists of over 140 proteins. These proteins are 300-400 amino acids in size, they contain two conserved structural domains, and they carry out recombina ...
... There are two major groups of enzymes that carry out sitespecific recombination reactions; one group - known as the tyrosine recombinase family - consists of over 140 proteins. These proteins are 300-400 amino acids in size, they contain two conserved structural domains, and they carry out recombina ...
BioMart: The linked dataset
... Worked Example – Demonstrating the Linked Dataset BioMart can federate (join together) databases, in this example we will join two different datasets, Ensembl genes and RGD (the Rat Genome Database) to identify all Ensembl genes involved in carbohydrate metabolism in rat. First, we will limit our se ...
... Worked Example – Demonstrating the Linked Dataset BioMart can federate (join together) databases, in this example we will join two different datasets, Ensembl genes and RGD (the Rat Genome Database) to identify all Ensembl genes involved in carbohydrate metabolism in rat. First, we will limit our se ...
Douglas Bishop, Ph.D. Dr. Bishop`s group focuses on the
... Douglas Bishop, Ph.D. Dr. Bishop's group focuses on the mechanisms cell use to repair broken DNA molecules. DNA breaks occur during normal cell growth, during meiosis, the special cell divisions that gives rise to gametes, and when cells are exposed to radiation. DNA repair is relevant to cancer in ...
... Douglas Bishop, Ph.D. Dr. Bishop's group focuses on the mechanisms cell use to repair broken DNA molecules. DNA breaks occur during normal cell growth, during meiosis, the special cell divisions that gives rise to gametes, and when cells are exposed to radiation. DNA repair is relevant to cancer in ...
Cystic Fibrosis Transmembrane Conductance Regulator
... was performed on the patients, following PCR amplification of 17 CFTR exons, by denaturing gradient gel electrophoresis (DGGE) and direct genomic sequencing. Surprisingly, the delta F508 mutation was not detected in any of the patients. Instead multiplex amplification of exons 11, 14b, and 17b enabl ...
... was performed on the patients, following PCR amplification of 17 CFTR exons, by denaturing gradient gel electrophoresis (DGGE) and direct genomic sequencing. Surprisingly, the delta F508 mutation was not detected in any of the patients. Instead multiplex amplification of exons 11, 14b, and 17b enabl ...
Leukaemia Section del(13q) in myeloid malignancies Atlas of Genetics and Cytogenetics
... E2F factor who becoms active and whose target genes encode proteins (c-myc, dihydrofolate reductase, thymidine kinase, and DNA polymerase alpha, cdk kinases) necessary for progression of the cell cycle from G1 to S-phase. The protein pRb is also involved in the process of cell differentiation (high ...
... E2F factor who becoms active and whose target genes encode proteins (c-myc, dihydrofolate reductase, thymidine kinase, and DNA polymerase alpha, cdk kinases) necessary for progression of the cell cycle from G1 to S-phase. The protein pRb is also involved in the process of cell differentiation (high ...
ppt - Chair of Computational Biology
... These clusters, or CpG islands, are targets for proteins that bind to unmethylated CpGs and initiate gene transcription. In contrast, methylated CpGs are generally associated with silent DNA, can block methylation-sensitive proteins and can be easily mutated. The loss of normal DNA methylation patte ...
... These clusters, or CpG islands, are targets for proteins that bind to unmethylated CpGs and initiate gene transcription. In contrast, methylated CpGs are generally associated with silent DNA, can block methylation-sensitive proteins and can be easily mutated. The loss of normal DNA methylation patte ...
Supergreens - Nutrigold Update Service
... Another exciting constituent in pre-sprouted barley is the enzyme superoxide dismutase (SOD), so called because it scavenges free radicals called superoxides and converts them into less potentially harmful compounds. There are various types of SOD enzymes bound to different minerals, such as mangane ...
... Another exciting constituent in pre-sprouted barley is the enzyme superoxide dismutase (SOD), so called because it scavenges free radicals called superoxides and converts them into less potentially harmful compounds. There are various types of SOD enzymes bound to different minerals, such as mangane ...
A-12 Models for gene activation
... concentration will increase until the saturation is reached. The morphogen m is assumed to have an activating influence on the g-production. It can bring the system over the threshold such that a permanent switch form low to high g occurs. The gene remains activated even after the morphogen is no lo ...
... concentration will increase until the saturation is reached. The morphogen m is assumed to have an activating influence on the g-production. It can bring the system over the threshold such that a permanent switch form low to high g occurs. The gene remains activated even after the morphogen is no lo ...
Title
... 30. The description of DNA as “beads on a string” refers to DNA that is: a. tightly condensed and looped b. in its raw from ...
... 30. The description of DNA as “beads on a string” refers to DNA that is: a. tightly condensed and looped b. in its raw from ...
Using Computer Simulation to Understand Mutation
... mutations in a detailed manner from parents to progeny through many generations. Mutations are modeled so as to have a continuous range of effects from lethal to beneficial and to vary in expression from fully dominant to fully recessive. Each mutation’s unique identifier encodes its genotypic fitne ...
... mutations in a detailed manner from parents to progeny through many generations. Mutations are modeled so as to have a continuous range of effects from lethal to beneficial and to vary in expression from fully dominant to fully recessive. Each mutation’s unique identifier encodes its genotypic fitne ...
§S0.1 Gene Prediction Methodology Gene structures were predicted
... histograms of gene prediction correlation coefficients are shown for predictions based on different level of protein similarity. ...
... histograms of gene prediction correlation coefficients are shown for predictions based on different level of protein similarity. ...
Normalization and analysis of cDNA microarrays using
... their log ratios by -1), there is no treatment effect among six arrays. From such a reversion, 15,266 t test or weighted t test statistics were obtained.There are 20 examples of such a balanced sign permutation.The pool of these 20 X 15,226 test statistics forms an estimate of the null distributio ...
... their log ratios by -1), there is no treatment effect among six arrays. From such a reversion, 15,266 t test or weighted t test statistics were obtained.There are 20 examples of such a balanced sign permutation.The pool of these 20 X 15,226 test statistics forms an estimate of the null distributio ...
Oncogenomics
Oncogenomics is a relatively new sub-field of genomics that applies high throughput technologies to characterize genes associated with cancer. Oncogenomics is synonymous with ""cancer genomics"". Cancer is a genetic disease caused by accumulation of mutations to DNA leading to unrestrained cell proliferation and neoplasm formation. The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies. The success of targeted cancer therapies such as Gleevec, Herceptin, and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment.Besides understanding the underlying genetic mechanisms that initiates or drives cancer progression, one of the main goals of oncogenomics is to allow for the development of personalized cancer treatment. Cancer develops due to an accumulation of mutations in DNA. These mutations accumulate randomly, and thus, different DNA mutations and mutation combinations exist between different individuals with the same type of cancer. Thus, identifying and targeting specific mutations which have occurred in an individual patient may lead to increased efficacy of cancer therapy.The completion of the Human Genome Project has greatly facilitated the field of oncogenomics and has increased the abilities of researchers to find cancer causing genes. In addition, the sequencing technologies now available for sequence generation and data analysis have been applied to the study of oncogenomics. With the amount of research conducted on cancer genomes and the accumulation of databases documenting the mutational changes, it has been predicted that the most important cancer-causing mutations, rearrangements, and altered expression levels will be cataloged and well characterized within the next decade.Cancer research may look either on the genomic level at DNA mutations, the epigenetic level at methylation or histone modification changes, the transcription level at altered levels of gene expression, or the protein level at altered levels of protein abundance and function in cancer cells. Oncogenomics focuses on the genomic, epigenomic, and transcript level alterations in cancer.