lab_july26_delong - C-MORE
... Automa tic training of gene finding parameters for new bac terial genomes using only genomic DNA as an i nput (optionally, pre-learned parame ters from r elated organism can be used) ...
... Automa tic training of gene finding parameters for new bac terial genomes using only genomic DNA as an i nput (optionally, pre-learned parame ters from r elated organism can be used) ...
Separating derived from ancestral features of mouse and human
... almost as many protein-coding genes as humans [13–15]. Nevertheless, the reduction of the human gene count from an initial 32 000 in the draft human genome publication [3] to its current level of approx. 19 000 shows the many inherent difficulties in gene predictions as well as the great progress th ...
... almost as many protein-coding genes as humans [13–15]. Nevertheless, the reduction of the human gene count from an initial 32 000 in the draft human genome publication [3] to its current level of approx. 19 000 shows the many inherent difficulties in gene predictions as well as the great progress th ...
Chromosomal Theory of Inheritance
... for treating disorders traceable to a single defective gene Vectors are used for delivery of genes into specific types of cells (example = bone marrow) Gene therapy raises ethical questions, such as whether human germ-line cells should be treated to correct the defect in future generations ...
... for treating disorders traceable to a single defective gene Vectors are used for delivery of genes into specific types of cells (example = bone marrow) Gene therapy raises ethical questions, such as whether human germ-line cells should be treated to correct the defect in future generations ...
Is there a link between DNA and Obesity?
... People with the high risk variant are likely to be attracted to high calorie and sugary foods. This is because the FTO gene works with the DRD2 gene, which alters how the dopamine system in the brain works, to send dopamine signals to boost cravings when people see high calorie or sugary foods. The ...
... People with the high risk variant are likely to be attracted to high calorie and sugary foods. This is because the FTO gene works with the DRD2 gene, which alters how the dopamine system in the brain works, to send dopamine signals to boost cravings when people see high calorie or sugary foods. The ...
The mystery of the tallest giants is revealed
... children are born normally and begin to grow abnormally even before they are one year old. They develop large pituitary adenomas which do not respond well to traditional therapies. They secrete phenomenal quantities of growth hormone as well as prolactin". Genetic studies have shown that these "litt ...
... children are born normally and begin to grow abnormally even before they are one year old. They develop large pituitary adenomas which do not respond well to traditional therapies. They secrete phenomenal quantities of growth hormone as well as prolactin". Genetic studies have shown that these "litt ...
ppt for
... we constructed a gene co-expression network based on a widespread survey of gene expression in the human brain. We identified modules associated with specific cell types and processes. By integrating known rare mutations and the results of an ASD genome-wide association study (GWAS), we identified t ...
... we constructed a gene co-expression network based on a widespread survey of gene expression in the human brain. We identified modules associated with specific cell types and processes. By integrating known rare mutations and the results of an ASD genome-wide association study (GWAS), we identified t ...
Brock Genetic Exchange in Bacteria
... Plasmid DNA must replicate each time cell divides or it will be lost ...
... Plasmid DNA must replicate each time cell divides or it will be lost ...
Untitled
... Betamax and VHS video, two different DNA reading methods battled it out for dominance in the early 1980s. In the end, the simpler technique pioneered by British scientist Fred Sanger won out over the alternative protocol developed by US researchers. Fred’s method revolutionised genetics over the fol ...
... Betamax and VHS video, two different DNA reading methods battled it out for dominance in the early 1980s. In the end, the simpler technique pioneered by British scientist Fred Sanger won out over the alternative protocol developed by US researchers. Fred’s method revolutionised genetics over the fol ...
The Pax and large Maf families of genes in mammalian eye development Vertebrate eye development is dependent on the coordinated action of thousands of genes. A specific group of over one hundred of regulatory genes is both responsible for ocular cell
... pituitary and retinal development identified a “gene cassette” comprised of members of Pax/Six/Eya/Dach families. Pax3 in combination with Six1, Eya2 and Dach2 was shown to regulate vertebrate muscle development (see Relaix and Buckingham, 1999). Pax6/Six6/Eya1‐ 3/Dach1‐2 were shown to regulate pr ...
... pituitary and retinal development identified a “gene cassette” comprised of members of Pax/Six/Eya/Dach families. Pax3 in combination with Six1, Eya2 and Dach2 was shown to regulate vertebrate muscle development (see Relaix and Buckingham, 1999). Pax6/Six6/Eya1‐ 3/Dach1‐2 were shown to regulate pr ...
Bio1A Unit 2-7 Gene Expression Pt 1 Notes File
... • Mutants are almost always “loss of function” whatever you mutated doesn’t work. There are far more ways for things to go wrong than right. The alternative is a “gain of function” mutation. • Think of mutations in terms of an enzyme. ...
... • Mutants are almost always “loss of function” whatever you mutated doesn’t work. There are far more ways for things to go wrong than right. The alternative is a “gain of function” mutation. • Think of mutations in terms of an enzyme. ...
Population Genetics 5: Mutation pressure Mutation pressure
... • if island has non-equilibrium GC content mutation pressure will cause it to evolve to a new equilibrium. • process of evolution to a new GC equilibrium is called mutational amelioration • amelioration is much slower than in our model above because 4 states (ACGT) • because mutation pressure is ...
... • if island has non-equilibrium GC content mutation pressure will cause it to evolve to a new equilibrium. • process of evolution to a new GC equilibrium is called mutational amelioration • amelioration is much slower than in our model above because 4 states (ACGT) • because mutation pressure is ...
Cancer Risk Factors in Ontario | Tobacco Use
... • Tobacco smoke may induce cancer through several mechanisms when ingested (either directly through tobacco smoke or indirectly by dissolving in saliva): 23 ◦ Tobacco carcinogens can form DNA adducts, which can lead to DNA damage. ◦ Nicotine and tobacco-specific nitrosamines (e.g., 4-[methylnitros ...
... • Tobacco smoke may induce cancer through several mechanisms when ingested (either directly through tobacco smoke or indirectly by dissolving in saliva): 23 ◦ Tobacco carcinogens can form DNA adducts, which can lead to DNA damage. ◦ Nicotine and tobacco-specific nitrosamines (e.g., 4-[methylnitros ...
Slide 1
... Project revealed that most of the human genome does not consist of genes Results of the Human Genome Project indicate that – humans have about 20,000 genes in 3.2 billion nucleotide pairs, – only 1.5% of the DNA codes for proteins, tRNAs, or rRNAs, and – the remaining 98.5% of the DNA is noncoding ...
... Project revealed that most of the human genome does not consist of genes Results of the Human Genome Project indicate that – humans have about 20,000 genes in 3.2 billion nucleotide pairs, – only 1.5% of the DNA codes for proteins, tRNAs, or rRNAs, and – the remaining 98.5% of the DNA is noncoding ...
Solid Tumour Section Angiomatoid fibrous histiocytoma (AFH) Atlas of Genetics and Cytogenetics
... (translocated in liposarcoma), and then called FUS, contains an RNA-recognition motif and is a component of nuclear riboprotein complexes. Lack of FUS in mice causes lethality into neonatal period, it influences lymphocyte development in a non-cell-intrinsic manner, it has an intrinsic role in the p ...
... (translocated in liposarcoma), and then called FUS, contains an RNA-recognition motif and is a component of nuclear riboprotein complexes. Lack of FUS in mice causes lethality into neonatal period, it influences lymphocyte development in a non-cell-intrinsic manner, it has an intrinsic role in the p ...
4.Genetechnology2
... an important part of gene technology There are three main methods for obtaining genes • Synthesising the gene using an automated gene machine – this method can be used if the amino sequence of the protein gene product is known; the DNA sequence of the gene can be determined by working backwards usin ...
... an important part of gene technology There are three main methods for obtaining genes • Synthesising the gene using an automated gene machine – this method can be used if the amino sequence of the protein gene product is known; the DNA sequence of the gene can be determined by working backwards usin ...
lecture 03 - phylogenetics - Cal State LA
... process by which we infer the evolutionary history of a group based on the traits we see today - the best phylogenetic tree is the one which requires the fewest changes in traits (characters) to account for modern character states in surviving lineages - i.e., assumes that the minimum number of chan ...
... process by which we infer the evolutionary history of a group based on the traits we see today - the best phylogenetic tree is the one which requires the fewest changes in traits (characters) to account for modern character states in surviving lineages - i.e., assumes that the minimum number of chan ...
Estimation of spontaneous genome-wide mutation rate
... relative to a value of 1 for wild type. Estimating U, h and especially s is the primary goal of empirical studies. I will concentrate on two approaches for estimating mutational parameters. One, the so-called mutation accumulation (MA) approach, uses controlled designs where mutations are allowed to ...
... relative to a value of 1 for wild type. Estimating U, h and especially s is the primary goal of empirical studies. I will concentrate on two approaches for estimating mutational parameters. One, the so-called mutation accumulation (MA) approach, uses controlled designs where mutations are allowed to ...
1 - Gene Ontology Consortium
... decreased. (1) When a non-IEA, non-ND annotation is added to a gene with an existing IEA annotation for that aspect, the IEA annotation is removed. In some cases, because of one-to-many INTERPRO-to-GO mappings for a single domain, more than one IEA annotation can be replaced by a single non-IEA, non ...
... decreased. (1) When a non-IEA, non-ND annotation is added to a gene with an existing IEA annotation for that aspect, the IEA annotation is removed. In some cases, because of one-to-many INTERPRO-to-GO mappings for a single domain, more than one IEA annotation can be replaced by a single non-IEA, non ...
YYRR
... • What are two types of complications that form nonMendelian phenotype ratios? • Which are breaking Mendel’s Laws? • Which are actually still following Mendel’s laws? – How does each of them still follow Mendel’s Laws if they are producing non-Mendelian ratios? • What is Linkage? • How is genetic di ...
... • What are two types of complications that form nonMendelian phenotype ratios? • Which are breaking Mendel’s Laws? • Which are actually still following Mendel’s laws? – How does each of them still follow Mendel’s Laws if they are producing non-Mendelian ratios? • What is Linkage? • How is genetic di ...
Case report - HAL
... gene, encoding HNF1 (3). These mutations are inactivating and both alleles are mutated in tumors. Patients with an inherited mutation in one allele of HNF1 may develop maturity onset diabetes of the young type 3 (MODY3, OMIM#600496) and familial liver adenomatosis, when the second allele is inacti ...
... gene, encoding HNF1 (3). These mutations are inactivating and both alleles are mutated in tumors. Patients with an inherited mutation in one allele of HNF1 may develop maturity onset diabetes of the young type 3 (MODY3, OMIM#600496) and familial liver adenomatosis, when the second allele is inacti ...
DNA Damage and Repair - American Federation for Aging Research
... Our cells must have the ability to repair lesions in their DNA to survive. If the DNA of dividing cells is sufficiently damaged, the DNA cannot be properly copied, and the cells cannot divide. ...
... Our cells must have the ability to repair lesions in their DNA to survive. If the DNA of dividing cells is sufficiently damaged, the DNA cannot be properly copied, and the cells cannot divide. ...
DNA Damage and Repair - American Federation for Aging Research
... Our cells must have the ability to repair lesions in their DNA to survive. If the DNA of dividing cells is sufficiently damaged, the DNA cannot be properly copied, and the cells cannot divide. ...
... Our cells must have the ability to repair lesions in their DNA to survive. If the DNA of dividing cells is sufficiently damaged, the DNA cannot be properly copied, and the cells cannot divide. ...
S. cerevisiae
... Here they ChIP’d 6 TFs implicated in RP regulation in S. cerevisiae and/or C. albicans Ifh1-Fhl1 co-activators are conserved in Sc-Ca (>200 my) Required co-factors have evolved: Hmo1 and Rap1 required for Ifh1-Fhl1 binding in S. cerevisiae * Hmo1 is a ‘generalist’ in C. albicans In C. albicans, Cbf ...
... Here they ChIP’d 6 TFs implicated in RP regulation in S. cerevisiae and/or C. albicans Ifh1-Fhl1 co-activators are conserved in Sc-Ca (>200 my) Required co-factors have evolved: Hmo1 and Rap1 required for Ifh1-Fhl1 binding in S. cerevisiae * Hmo1 is a ‘generalist’ in C. albicans In C. albicans, Cbf ...
The genes on the X and Y chromosomes: Sex linkage inheritance
... Mitochondrial inheritance gives a recognizable matrilineal pedigree pattern Mitochondrial mutations are a significant cause of human genetic disease. The mitochondrial genome is small but highly mutable compared to nuclear DNA. The mutation rate of mtDNA is about 10 times higher than that of nucle ...
... Mitochondrial inheritance gives a recognizable matrilineal pedigree pattern Mitochondrial mutations are a significant cause of human genetic disease. The mitochondrial genome is small but highly mutable compared to nuclear DNA. The mutation rate of mtDNA is about 10 times higher than that of nucle ...
Oncogenomics
Oncogenomics is a relatively new sub-field of genomics that applies high throughput technologies to characterize genes associated with cancer. Oncogenomics is synonymous with ""cancer genomics"". Cancer is a genetic disease caused by accumulation of mutations to DNA leading to unrestrained cell proliferation and neoplasm formation. The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies. The success of targeted cancer therapies such as Gleevec, Herceptin, and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment.Besides understanding the underlying genetic mechanisms that initiates or drives cancer progression, one of the main goals of oncogenomics is to allow for the development of personalized cancer treatment. Cancer develops due to an accumulation of mutations in DNA. These mutations accumulate randomly, and thus, different DNA mutations and mutation combinations exist between different individuals with the same type of cancer. Thus, identifying and targeting specific mutations which have occurred in an individual patient may lead to increased efficacy of cancer therapy.The completion of the Human Genome Project has greatly facilitated the field of oncogenomics and has increased the abilities of researchers to find cancer causing genes. In addition, the sequencing technologies now available for sequence generation and data analysis have been applied to the study of oncogenomics. With the amount of research conducted on cancer genomes and the accumulation of databases documenting the mutational changes, it has been predicted that the most important cancer-causing mutations, rearrangements, and altered expression levels will be cataloged and well characterized within the next decade.Cancer research may look either on the genomic level at DNA mutations, the epigenetic level at methylation or histone modification changes, the transcription level at altered levels of gene expression, or the protein level at altered levels of protein abundance and function in cancer cells. Oncogenomics focuses on the genomic, epigenomic, and transcript level alterations in cancer.