Genetics in Headache - International Association for the Study of Pain
... aura than in migraine without aura. Although genetic factors are also involved in other headaches, such as tension-type headache and cluster headache, gene discoveries in these headache types, unlike in migraine, are essentially lacking. To identify genetic factors that confer susceptibility to migr ...
... aura than in migraine without aura. Although genetic factors are also involved in other headaches, such as tension-type headache and cluster headache, gene discoveries in these headache types, unlike in migraine, are essentially lacking. To identify genetic factors that confer susceptibility to migr ...
J Biol Chem, v 275, pp 12237-12242
... cloned so far (3). Co-expression studies have established two physiological roles of  subunits in high voltage-activated Ca2⫹ channels: they dramatically increase ␣1 expression at the plasma membrane, and they alter the biophysical properties of the channel currents. In general,  subunits have lit ...
... cloned so far (3). Co-expression studies have established two physiological roles of  subunits in high voltage-activated Ca2⫹ channels: they dramatically increase ␣1 expression at the plasma membrane, and they alter the biophysical properties of the channel currents. In general,  subunits have lit ...
Identifying Factors that Control Mechanoreceptor Neuron
... TRNs detect gentle touch to the body in a manner dependent on the expression of mec-3. In TRNs, combined action of mec-3 and unc-86 activates various other mec genes (mec-1, 2, 4, 7, 8, 9, 10, 12, 14, 15, 17, 18) (Chalfie and Au, 1989) and the alr-1 gene (Topalidou et al., 2011), which define TRN fa ...
... TRNs detect gentle touch to the body in a manner dependent on the expression of mec-3. In TRNs, combined action of mec-3 and unc-86 activates various other mec genes (mec-1, 2, 4, 7, 8, 9, 10, 12, 14, 15, 17, 18) (Chalfie and Au, 1989) and the alr-1 gene (Topalidou et al., 2011), which define TRN fa ...
EAWAG news 56e: Genomic Islands and Horizontal Gene Transfer
... happening to the chromosomal DNA. Or is it? Bacterial chromosomes are now known to harbor what is called “genomic islands”, regions which can cut themselves out of the chromosome, in some cases travel to other bacterial cells and reinsert into the recipient’s chromosome. Their function? Very often, ...
... happening to the chromosomal DNA. Or is it? Bacterial chromosomes are now known to harbor what is called “genomic islands”, regions which can cut themselves out of the chromosome, in some cases travel to other bacterial cells and reinsert into the recipient’s chromosome. Their function? Very often, ...
Document
... toxicity(毒物) and single nucleotide polymorphisms(單一多型核甘 酸). They have been used more broadly as well to study Arabidopsis thaliana(阿拉伯芥 ), rat, yeast(酵母 ) and Escherichia coli(下痢性大腸桿菌 ) genomes(基因組), mouse models and others. The evolution of microarrays is to use the information gleaned(蒐集) from gen ...
... toxicity(毒物) and single nucleotide polymorphisms(單一多型核甘 酸). They have been used more broadly as well to study Arabidopsis thaliana(阿拉伯芥 ), rat, yeast(酵母 ) and Escherichia coli(下痢性大腸桿菌 ) genomes(基因組), mouse models and others. The evolution of microarrays is to use the information gleaned(蒐集) from gen ...
IOSR Journal of Computer Engineering (IOSR-JCE)
... hidden in SAGE data. Subsets of genes are interdependent with each other. Identifies set of related genes with similar samples yields tree like structure, makes identification of functional groups very difficult. B.W. Futscher et al[8], focuses on optimal search based subset selection methods becaus ...
... hidden in SAGE data. Subsets of genes are interdependent with each other. Identifies set of related genes with similar samples yields tree like structure, makes identification of functional groups very difficult. B.W. Futscher et al[8], focuses on optimal search based subset selection methods becaus ...
TheraGuide 5-FU
... • Use of pharmacogenetics in understanding patient susceptibility to 5-FU/capecitabine toxicity ...
... • Use of pharmacogenetics in understanding patient susceptibility to 5-FU/capecitabine toxicity ...
Molecular Pathology Studies of Mesothelioma in VDC-exposed F344/N Rats
... • Programmatic effort to add value to the NTP Technical Reports by providing molecular data ...
... • Programmatic effort to add value to the NTP Technical Reports by providing molecular data ...
Body maps on the human genome | SpringerLink
... most strongly in brain, heart, kidney, ovary, etc. respectively tend significantly to correspond to the anteroposterior order of those organs in the body. In particular, for anterior organs (e.g., brain), the gradient of their tailto-head gene distribution in the spermcell nucleus is increasing (see ...
... most strongly in brain, heart, kidney, ovary, etc. respectively tend significantly to correspond to the anteroposterior order of those organs in the body. In particular, for anterior organs (e.g., brain), the gradient of their tailto-head gene distribution in the spermcell nucleus is increasing (see ...
RESPIRATORY PATHOPHYSIOLOGY
... The primary lesion is usually in lung with bacteria surviving in dried form for months. . The infection begins with a primary lesion which causes necrosis, fibrosis and calcification. The infection than goes dormant for possible years. S&S: Vague with anorexia, malaise, fatique, weight loss. Later- ...
... The primary lesion is usually in lung with bacteria surviving in dried form for months. . The infection begins with a primary lesion which causes necrosis, fibrosis and calcification. The infection than goes dormant for possible years. S&S: Vague with anorexia, malaise, fatique, weight loss. Later- ...
Leukaemia Section t(2 14)(p13-16 32)
... domain between zinc fingers 1 and 2 and an acidic domain between 3 and 4. 835 amino acids; 91197 Da, alternative splicing: 6 isoforms, sharing a common Nterminus. Originally named EV19 human homolog BCL11A; high level of conservation across a wide range of species; highly homologous to another gene ...
... domain between zinc fingers 1 and 2 and an acidic domain between 3 and 4. 835 amino acids; 91197 Da, alternative splicing: 6 isoforms, sharing a common Nterminus. Originally named EV19 human homolog BCL11A; high level of conservation across a wide range of species; highly homologous to another gene ...
Resources of biomolecular data - Center for Biological Sequence
... Remember that prediction servers provide...well, predictions! ...
... Remember that prediction servers provide...well, predictions! ...
Promoter identification
... a well-defined sites. However, transcription of many protein-coding genes has been shown to begin at any one of multiple possible sites over an extended region 20–200 bp long. As a result, such genes give rise to mRNAs with multiple alternative 5’ ends. These are housekeeping genes, they do not cont ...
... a well-defined sites. However, transcription of many protein-coding genes has been shown to begin at any one of multiple possible sites over an extended region 20–200 bp long. As a result, such genes give rise to mRNAs with multiple alternative 5’ ends. These are housekeeping genes, they do not cont ...
- Wiley Online Library
... four families having -thalassemia major and carrier phenotype and a control group of 26 healthy individuals. In these two groups, we examined portions of the -globin gene locus control region HSs 1, 2, 3, and 4, which included the (CA)x(TA)y repeat motif, the (AT)xNy(AT)z repeat motif, the inverte ...
... four families having -thalassemia major and carrier phenotype and a control group of 26 healthy individuals. In these two groups, we examined portions of the -globin gene locus control region HSs 1, 2, 3, and 4, which included the (CA)x(TA)y repeat motif, the (AT)xNy(AT)z repeat motif, the inverte ...
View/Open
... biologically related to the query sequence at hand. BLAST is particularly rapid in its database searching because it minimizes the time spent on local alignments that have little chance of exceeding the threshold (S). This estimation is performed as follows. Firstly, allow a word pair to be a segmen ...
... biologically related to the query sequence at hand. BLAST is particularly rapid in its database searching because it minimizes the time spent on local alignments that have little chance of exceeding the threshold (S). This estimation is performed as follows. Firstly, allow a word pair to be a segmen ...
Report of the Second International Symposium on Molecular
... that children with cancer have a high incidence of malformation syndromes. Wilms tumour (WT) has been reported in association with more than 50 different clinical conditions and several abnormal constitutional karyotypes. High risk syndromes (> 20%) associated for WT include Denys-Drash syndrome ...
... that children with cancer have a high incidence of malformation syndromes. Wilms tumour (WT) has been reported in association with more than 50 different clinical conditions and several abnormal constitutional karyotypes. High risk syndromes (> 20%) associated for WT include Denys-Drash syndrome ...
Human genetics
... loss of retinoblastoma gene by interstitial deletion of the long arm of chromosome 13, i.e. 13q in which, the newborn carrying this deletion will develop retinoblastoma (Figures 6-4 A & B). Another gene is lost in deletion of short arm of chromosome 11, which results in development of Wilm‟s tumor w ...
... loss of retinoblastoma gene by interstitial deletion of the long arm of chromosome 13, i.e. 13q in which, the newborn carrying this deletion will develop retinoblastoma (Figures 6-4 A & B). Another gene is lost in deletion of short arm of chromosome 11, which results in development of Wilm‟s tumor w ...
Identifying Chromosomal Abnormalities Using Infinium
... – ~1% of their total of >2000 samples (~10% of “aberrant” samples) – Much higher than reported previously, likely owing to the new abilities to detect ...
... – ~1% of their total of >2000 samples (~10% of “aberrant” samples) – Much higher than reported previously, likely owing to the new abilities to detect ...
Poster - University of British Columbia
... 800 mcg BID by inhalation. After two rounds of linear amplification of the extracted RNA, the gene expression profiles were analyzed using the Affymetrix U133A microarray chip. Results: Using Principal Component Analysis, the effect of active smoking was found to be stronger than the effect of budes ...
... 800 mcg BID by inhalation. After two rounds of linear amplification of the extracted RNA, the gene expression profiles were analyzed using the Affymetrix U133A microarray chip. Results: Using Principal Component Analysis, the effect of active smoking was found to be stronger than the effect of budes ...
Evolution
... changes when they occur. In order to do this there must be enough variability in the information in the gene pool, or the ability to bring in new genes through genetic change (mutation), or through hybridization. Plants are more likely to use hybridization as a way to obtain new genes than animals a ...
... changes when they occur. In order to do this there must be enough variability in the information in the gene pool, or the ability to bring in new genes through genetic change (mutation), or through hybridization. Plants are more likely to use hybridization as a way to obtain new genes than animals a ...
Solid Tumour Section Soft tissue tumors: Alveolar rhabdomyosarcoma in Oncology and Haematology
... the trunk and head and neck. This tumor often presents as a painless mass, but in other cases, may be discovered from symptoms produced by compression of structures at the primary site. A substantial fraction of patients with ARMS (25-30%) will have metastatic disease at the time of diagnosis. ARMS ...
... the trunk and head and neck. This tumor often presents as a painless mass, but in other cases, may be discovered from symptoms produced by compression of structures at the primary site. A substantial fraction of patients with ARMS (25-30%) will have metastatic disease at the time of diagnosis. ARMS ...
Oncogenomics
Oncogenomics is a relatively new sub-field of genomics that applies high throughput technologies to characterize genes associated with cancer. Oncogenomics is synonymous with ""cancer genomics"". Cancer is a genetic disease caused by accumulation of mutations to DNA leading to unrestrained cell proliferation and neoplasm formation. The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies. The success of targeted cancer therapies such as Gleevec, Herceptin, and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment.Besides understanding the underlying genetic mechanisms that initiates or drives cancer progression, one of the main goals of oncogenomics is to allow for the development of personalized cancer treatment. Cancer develops due to an accumulation of mutations in DNA. These mutations accumulate randomly, and thus, different DNA mutations and mutation combinations exist between different individuals with the same type of cancer. Thus, identifying and targeting specific mutations which have occurred in an individual patient may lead to increased efficacy of cancer therapy.The completion of the Human Genome Project has greatly facilitated the field of oncogenomics and has increased the abilities of researchers to find cancer causing genes. In addition, the sequencing technologies now available for sequence generation and data analysis have been applied to the study of oncogenomics. With the amount of research conducted on cancer genomes and the accumulation of databases documenting the mutational changes, it has been predicted that the most important cancer-causing mutations, rearrangements, and altered expression levels will be cataloged and well characterized within the next decade.Cancer research may look either on the genomic level at DNA mutations, the epigenetic level at methylation or histone modification changes, the transcription level at altered levels of gene expression, or the protein level at altered levels of protein abundance and function in cancer cells. Oncogenomics focuses on the genomic, epigenomic, and transcript level alterations in cancer.