Bioinfo primer - part 6/6
... (chromosomes, genomes, cells, etc). We can now analyse how they work together to produce the complexity of the organisms. • The function of the genome is – Metabolism: metabolic pathways convert chemical energy derived from food into useful work in the cell. – Regulation: regulatory pathways are bio ...
... (chromosomes, genomes, cells, etc). We can now analyse how they work together to produce the complexity of the organisms. • The function of the genome is – Metabolism: metabolic pathways convert chemical energy derived from food into useful work in the cell. – Regulation: regulatory pathways are bio ...
doc - VCU Secrets of the Sequence
... for snapping at something, tearing food and walking away all at the same time Stomatopod: shows further evolution with powerful appendages used for defense and attack. 2. How do the genes that create segments in arthropods correlate to humans? Homeotic genes called HOX genes that are found in all ...
... for snapping at something, tearing food and walking away all at the same time Stomatopod: shows further evolution with powerful appendages used for defense and attack. 2. How do the genes that create segments in arthropods correlate to humans? Homeotic genes called HOX genes that are found in all ...
Two distinct tumor suppressor loci within chromosome 11p15
... Chromosome 11p15 has attracted considerable attention because of the biological importance of this region to human disease. Apart from being an important tumor suppressor locus showing loss of heterozygosity (LOH) in several adult and childhood cancers, 11p15 has been shown by linkage analysis to ha ...
... Chromosome 11p15 has attracted considerable attention because of the biological importance of this region to human disease. Apart from being an important tumor suppressor locus showing loss of heterozygosity (LOH) in several adult and childhood cancers, 11p15 has been shown by linkage analysis to ha ...
Next generation sequencing
... map to date of human genetic variation as a tool for medical research September 2008 Announcement of the 250th peer-reviewed publication enabled by 454 Sequencing October 2008 Release of Genome Sequencer FLX Titanium Series reagents, featuring 1 million reads at 400 base pairs in length ...
... map to date of human genetic variation as a tool for medical research September 2008 Announcement of the 250th peer-reviewed publication enabled by 454 Sequencing October 2008 Release of Genome Sequencer FLX Titanium Series reagents, featuring 1 million reads at 400 base pairs in length ...
Methylation of the Factor IX Gene is the Main Source of Mutations
... GA and CT substitutions can be understood if to analyze the sequences in which this mutation occurs. It appears that 157 of CT and 147 of GA substitutions (82.6% and 59.3%, respectively) occur in sequence 5'-CpG-3'. This sequence is known as one of two main sites of enzymatic methylation in the ...
... GA and CT substitutions can be understood if to analyze the sequences in which this mutation occurs. It appears that 157 of CT and 147 of GA substitutions (82.6% and 59.3%, respectively) occur in sequence 5'-CpG-3'. This sequence is known as one of two main sites of enzymatic methylation in the ...
a zebrafish study Chiara Cianciolo Cosentino PhD
... CAMTA proteins: CAMTAs: calmodulin-binding transcription activators ...
... CAMTA proteins: CAMTAs: calmodulin-binding transcription activators ...
组蛋白甲基化
... The Set1 H3K4 methyltransferase binds to the serine 5 phosphorylated CTD of RNAPII, the initiating form of polymerase situated at the transcription start site (TSS). In contrast, the Set2 H3K36 methyltransferase binds to the serine 2 phosphorylated CTD of RNAPII, the transcriptional elongating form ...
... The Set1 H3K4 methyltransferase binds to the serine 5 phosphorylated CTD of RNAPII, the initiating form of polymerase situated at the transcription start site (TSS). In contrast, the Set2 H3K36 methyltransferase binds to the serine 2 phosphorylated CTD of RNAPII, the transcriptional elongating form ...
Synthetic lethal analysis of Caenorhabditis elegans posterior
... Attempted assembling matrix with only RNAi -led to variable, inconsistent results** Examined RNAi-treated progeny for % embryonic lethality -converted % lethality to % survival to calculate significance of the interaction ...
... Attempted assembling matrix with only RNAi -led to variable, inconsistent results** Examined RNAi-treated progeny for % embryonic lethality -converted % lethality to % survival to calculate significance of the interaction ...
(VHL) for families - Cancer Council Australia
... instructs them to work normally. Genes are the working units of DNA. VHL is a disease that results from an error, or a mutation, in a gene called the VHL gene. Genes come in pairs and a child inherits one gene from each parent. The mutation may be transmitted from a parent to a child following a dom ...
... instructs them to work normally. Genes are the working units of DNA. VHL is a disease that results from an error, or a mutation, in a gene called the VHL gene. Genes come in pairs and a child inherits one gene from each parent. The mutation may be transmitted from a parent to a child following a dom ...
Improving bone properties and fracture susceptibility: experimental
... exercise). Because fractures are caused by a number of different factors, reducing fracture incidence requires a multifactorial approach to unraveling the underlying biology of bone metabolism, in order to discover new ways to improve bone properties and prevent fractures. We have taken such an appr ...
... exercise). Because fractures are caused by a number of different factors, reducing fracture incidence requires a multifactorial approach to unraveling the underlying biology of bone metabolism, in order to discover new ways to improve bone properties and prevent fractures. We have taken such an appr ...
MUTATIONS
... Environmental damage Mistakes when DNA is copied Non-disjunction-failure of chromosomes to separate properly during Meiosis. ...
... Environmental damage Mistakes when DNA is copied Non-disjunction-failure of chromosomes to separate properly during Meiosis. ...
Chapter 12
... sequences • The polymerase chain reaction (PCR) can be used to quickly clone a very large number of DNA copies for analysis – DNA sample mixed with DNA polymerase, nucleotide monomers, other ingredients – Mixture exposed to cycles of heating to separate the DNA strands – During each cycle, DNA repli ...
... sequences • The polymerase chain reaction (PCR) can be used to quickly clone a very large number of DNA copies for analysis – DNA sample mixed with DNA polymerase, nucleotide monomers, other ingredients – Mixture exposed to cycles of heating to separate the DNA strands – During each cycle, DNA repli ...
Supplementary Information (doc 28K)
... siRNA (Cy). After 24 hours cells were incubated in the presence or absence of hypoxic condition (1%O2, 5%CO2 atmosphere or CoCl2 treatment) for 12 hours. HIF-1 mRNA expression was evaluated by RT-PCR whereas HIF-1 protein level and activity was detected by western blot and ELISA, respectively, as ...
... siRNA (Cy). After 24 hours cells were incubated in the presence or absence of hypoxic condition (1%O2, 5%CO2 atmosphere or CoCl2 treatment) for 12 hours. HIF-1 mRNA expression was evaluated by RT-PCR whereas HIF-1 protein level and activity was detected by western blot and ELISA, respectively, as ...
William’s syndrome: gene expression is related to ORIGINAL ARTICLE
... As an approach toward understanding the role of the deleted genes in WS, we have characterized WS subjects according to genetic, social/ emotional, neurocognitive, neurophysiological and neuroanatomical features. Previous work from this laboratory also used molecular cytogenetic, microsatellite and ...
... As an approach toward understanding the role of the deleted genes in WS, we have characterized WS subjects according to genetic, social/ emotional, neurocognitive, neurophysiological and neuroanatomical features. Previous work from this laboratory also used molecular cytogenetic, microsatellite and ...
Dominant Inheritance Recessive Inheritance X
... condition. Even within a family, some individuals may be affected by the same dominant condition in different ways. Some dominant conditions are known as "late onset disorders". In other words, they only affect individuals in adulthood. In some families, an isolated case of a dominant disorder may b ...
... condition. Even within a family, some individuals may be affected by the same dominant condition in different ways. Some dominant conditions are known as "late onset disorders". In other words, they only affect individuals in adulthood. In some families, an isolated case of a dominant disorder may b ...
JPBMS REVIEW ON Hereditary Disorders bstract РЦФСЖЧЕЦЛСР
... (CMT2). Recent studies, however, show that the pathologies of these two classes are frequently intermingled, due to the dependence and close cellular interaction of Schwann cells and neurons. Schwann cells are responsible for myelin formation, enwrapping neural axons with their plasma membranes in a ...
... (CMT2). Recent studies, however, show that the pathologies of these two classes are frequently intermingled, due to the dependence and close cellular interaction of Schwann cells and neurons. Schwann cells are responsible for myelin formation, enwrapping neural axons with their plasma membranes in a ...
file
... Finding 3’ UTRs elements associated with high/low transcript stability (in yeast) Entire genome ...
... Finding 3’ UTRs elements associated with high/low transcript stability (in yeast) Entire genome ...
Oncogenomics
Oncogenomics is a relatively new sub-field of genomics that applies high throughput technologies to characterize genes associated with cancer. Oncogenomics is synonymous with ""cancer genomics"". Cancer is a genetic disease caused by accumulation of mutations to DNA leading to unrestrained cell proliferation and neoplasm formation. The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies. The success of targeted cancer therapies such as Gleevec, Herceptin, and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment.Besides understanding the underlying genetic mechanisms that initiates or drives cancer progression, one of the main goals of oncogenomics is to allow for the development of personalized cancer treatment. Cancer develops due to an accumulation of mutations in DNA. These mutations accumulate randomly, and thus, different DNA mutations and mutation combinations exist between different individuals with the same type of cancer. Thus, identifying and targeting specific mutations which have occurred in an individual patient may lead to increased efficacy of cancer therapy.The completion of the Human Genome Project has greatly facilitated the field of oncogenomics and has increased the abilities of researchers to find cancer causing genes. In addition, the sequencing technologies now available for sequence generation and data analysis have been applied to the study of oncogenomics. With the amount of research conducted on cancer genomes and the accumulation of databases documenting the mutational changes, it has been predicted that the most important cancer-causing mutations, rearrangements, and altered expression levels will be cataloged and well characterized within the next decade.Cancer research may look either on the genomic level at DNA mutations, the epigenetic level at methylation or histone modification changes, the transcription level at altered levels of gene expression, or the protein level at altered levels of protein abundance and function in cancer cells. Oncogenomics focuses on the genomic, epigenomic, and transcript level alterations in cancer.