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Unusual Pattern Detection in DNA Database Using KMP Algorithm
Unusual Pattern Detection in DNA Database Using KMP Algorithm

... damage at some point in time, or specific selective conditions. Genetic instability is defined by an increased rate at which cells acquire genetic abnormalities [Lengauer et al. (1998)l. That is, cells have a defect in specific repair genes which results in higher variability. Indeed, studies have s ...
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Glossary of Scientific Terms Used in this

... DNA (Deoxyribonucleic acid): “Engineer.” The genetic material of organisms, usually double-stranded; each unit of DNA is composed of three chemical elements-a nitrogenous base, a phosphate group, and a deoxyribose sugar molecule. This unit is called a nucleotide. DNA is present in all nucleated cell ...
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... be encrypted into DNA is first modified by a mutation correction code, the Hamming-code, to correct mutations within the DNA sequences. A header, containing the length of the original file, is produced and linked to the modified binary sequence. The composition of the header and the file is translat ...
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Same Genetic Mutation, Different Genetic Disease Phenotype

... colleagues studied 141 members of a family afflicted with isolated deafness (i.e., deafness was the only clinical finding in this family), which is caused by the DFNB26 gene. The researchers noticed that the disease was incompletely penetrant. While most individuals who were homozygous for the gene ...
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new hope in acute myeloid leukemia treatment

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File - NCEA Level 2 Biology

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...  Gene responsible for the disease resides on the X chromosome  X-linked traits can be dominant or recessive  Lack of transmission from father to son because dad passes his Y to the son.  Most X-linked traits are recessive so that heterozygous females do not exhibit the disease E. Fragile X Syndr ...
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Patient Informed Consent Form for Genetic Testing

... that genetic analysis will reveal unwanted information, for example about ancestry, parentage, other non-medical physical or personality traits, etc. The data may also reveal that you may be at risk for certain genetic diseases or if you are a carrier of disease-associated mutations. Also, predictio ...
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Severe Combined Immunodeficiency Genetic Testing
Severe Combined Immunodeficiency Genetic Testing

... the SCID-related genes, a mutation was found that has not been reported before. It is unclear if the mutation is the cause of the child’s signs and symptoms. Genetic testing of family members may provide more information. If all affected family members have the same mutation, then it is likely to be ...
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Frameshift mutation



A frameshift mutation (also called a framing error or a reading frame shift) is a genetic mutation caused by indels (insertions or deletions) of a number of nucleotides in a DNA sequence that is not divisible by three. Due to the triplet nature of gene expression by codons, the insertion or deletion can change the reading frame (the grouping of the codons), resulting in a completely different translation from the original. The earlier in the sequence the deletion or insertion occurs, the more altered the protein. A frameshift mutation is not the same as a single-nucleotide polymorphism in which a nucleotide is replaced, rather than inserted or deleted. A frameshift mutation will in general cause the reading of the codons after the mutation to code for different amino acids. The frameshift mutation will also alter the first stop codon (""UAA"", ""UGA"" or ""UAG"") encountered in the sequence. The polypeptide being created could be abnormally short or abnormally long, and will most likely not be functional.Frameshift mutations are apparent in severe genetic diseases such as Tay-Sachs disease and Cystic Fibrosis; they increase susceptibility to certain cancers and classes of familial hypercholesterolaemia; in 1997, a frameshift mutation was linked to resistance to infection by the HIV retrovirus. Frameshift mutations have been proposed as a source of biological novelty, as with the alleged creation of nylonase, however, this interpretation is controversial. A study by Negoro et al (2006) found that a frameshift mutation was unlikely to have been the cause and that rather a two amino acid substitution in the catalytic cleft of an ancestral esterase amplified Ald-hydrolytic activity.
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