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MDMA produces stimulant-like conditioned locomotor activity* I
MDMA produces stimulant-like conditioned locomotor activity* I

... Daily injection of MDMA 5 rog:kg also produced an unconditioned locomotor hyperactivity measured by an increase in photocell beam interruptions (see Fig. 1, lower right panel). As with AMPH and cocaine, repeated daily injection of this dose of MDMA produced a statistically significant conditioned lo ...
Antibacterials
Antibacterials

... administered orally and distributed throughout the tissues. Patients should be advised that it may tinge body fluids red. It is an inducer of the p450 system and so interacts with many other agents and can lead to hepatitis. Pyrazinamide is active only at acidic pH. After phagocytosis, the mycobacte ...
Therapy for Chronic and Acute Heart Failure
Therapy for Chronic and Acute Heart Failure

... level of cAMP a. ↑cAMP will lead to activation of Protein Kinase A in which will further i. ↑ Ca level in the cytoplasm by 1. ↑Ca entry through Ca channel 2. ↓Ca sequestration (taking up) into the Sarcoplasmic Reticulum 2. This will then ↑ cardiac output and improve cardiac efficiency ...
Better blood pressure control: how to combine drugs
Better blood pressure control: how to combine drugs

... Importance of good blood pressure control and the need for combination treatment to achieve targets One of the most important findings of the metaanalyses of the blood pressure lowering trials was the confirmation that patients randomized to more rather than less intensive treatment have a 20% lower ...
NIDA InfoFacts: Steroids (Anabolic-Androgenic)
NIDA InfoFacts: Steroids (Anabolic-Androgenic)

... The immediate effects of AAS in the brain are mediated by their binding to androgen (male sex hormone) and estrogen (female sex hormone) receptors on the surface of a cell. This AAS–receptor complex can then shuttle into the cell nucleus to influence patterns of gene expression. Because of this, the ...
The Most Dangerous Drug
The Most Dangerous Drug

... of the class of medicines known as non-steroidal anti-inflammatory drugs, or NSAIDs. The name Aspirin® was a trademark of Bayer, but they lost the patent in certain countries including the United States as part of the reparations demanded under the Treaty of Versailles at the end of World War I. (In ...
Beta-lactams_E
Beta-lactams_E

... BETA-LACTAM ANTIBIOTICS Assoc. Prof. Ivan Lambev e-mail: [email protected] www.medpharm-sofia.eu ...
General Anesthetics
General Anesthetics

... - Blockade of small inhibitory neurons (e.g Golgi type II cells) in several brain areas. - Progressive depression of the ascending pathways in the reticular activating system. At the cellular level - Depression of synaptic transmission (the main cellular effect). Neurons are hyperpolarized and their ...
Childhood ataxia with CNS hypomyelination/vanishing white matter
Childhood ataxia with CNS hypomyelination/vanishing white matter

... [7,18]. There is no gadolinium enhancement of the lesions on MRI. These FLAIR abnormalities may not be present in mild, relatively nonprogressive cases. Unlike many other leukodystrophies, in typical CACH/VWM patients cortical atrophy and ventricular dilation are typically absent, even in rather adv ...
ISMP Medication Safety Alert
ISMP Medication Safety Alert

... One of themost important ways toprevent medication errors is tolearn about problems that have occurred in other organizations and tousethat information toprevent similar problems at your practicesite. To promotesuch aprocess, thefollowing selected items fromtheJuly-September 2010 issues of theISMPMe ...
Misuse of Prescription Drugs
Misuse of Prescription Drugs

... medicines that contain decongestants, as combining these substances may cause blood pressure to become dangerously high or lead to irregular heart rhythms.25 ...
5-hydroxytryptamine1a-like receptor activation in the bed nucleus of
5-hydroxytryptamine1a-like receptor activation in the bed nucleus of

Substance abuse in pregnancy
Substance abuse in pregnancy

... Local Messages*UTHSCSA LIBRARIES OWN JOURNAL. CLICK LIBRARY HOLDINGS FOR VOLS OWNED* AbstractThe vascular placental pathology (VPP) is associated with many etiologies. Some are the consequence of a maternal genetic or acquired predisposition. Others are associated with a chronic maternal disease (hy ...
Daclatasvir - Daklinza - Bristol
Daclatasvir - Daklinza - Bristol

... perforatum) ...
WHAT`S SMACK GOT TO DO WITH IT
WHAT`S SMACK GOT TO DO WITH IT

... won’t kill you, unless you are using other drugs at the same time, or you are in poor health. It is much less dangerous than withdrawal from drugs like alcohol or benzodiazepines. ...
phentermine HCl - Citius Pharmaceuticals
phentermine HCl - Citius Pharmaceuticals

... Suprenza is indicated only as short-term (a few weeks) monotherapy for the management of exogenous obesity. The safety and efficacy of combination therapy with Suprenza and any other drug products for weight loss including prescribed drugs, over-the-counter preparations, and herbal products, or sero ...
Chronic potassium iodide therapy caused remission in about half of
Chronic potassium iodide therapy caused remission in about half of

... attack and turn on the thyroid, producing hyperthyroidism. If the antibodies go away, the Graves’ disease goes into remission and thyroid function returns to normal. The antithyroid drugs Methimazole and Propylthiouracil are effective in controlling the hyperthyroidism in patients with Graves’ disea ...
The Truth about LSD
The Truth about LSD

... “I ended up homeless and on the streets living and sleeping in a cardboard box by [the train] Station, begging and struggling to find ways to get my next meal.” ...
Fentanyl Is Superior To Morphine
Fentanyl Is Superior To Morphine

Use of textile biomaterials for the topic treatment of chronic venous
Use of textile biomaterials for the topic treatment of chronic venous

... drugs in the dermatological area was not mentioned in the speciality literature. The topic of our research is the interface for several fields of activity, very important to the scientific research: fine organic synthesis, polymers science, pharmacology, biochemistry, textiles and dermatology [5, 6, ...
Protocol for Management of Suspected Anaphylactic Shock
Protocol for Management of Suspected Anaphylactic Shock

... concentration of epinephrine into the blood stream compared to other sites. If accessing the thigh muscle is problematic, and the person is older than 12 months of age, epinephrine can be administered in the ...
The Cambridge Crystallographic Data Centre (CCDC)
The Cambridge Crystallographic Data Centre (CCDC)

... molecule structures to help understand the affinity and solubility of drug molecules. This presentation, timed Paper ID: 2133840 to coincide with the 50th anniversary of the Cambridge Structural Database will demonstrate how we can efficiently analyse hydrated structures and use this information in ...
Practical Pharmacokinetics for the Bedside Clinician
Practical Pharmacokinetics for the Bedside Clinician

... discharge counseling. What considerations might you take into account? A. MA is giving up smoking and therefore will be more sensitive to the effects of caffeine B. MA may be at risk of stent thrombosis secondary to suboptimal therapy from the antiplatelets she has been prescribed C. Both of the abo ...
Phenobarbitone Elixir 15mg/5mL
Phenobarbitone Elixir 15mg/5mL

... Actions Phenobarbitone is a non selective central nervous system depressant with a long duration of action. The mechanism of action of the barbiturates is not completely known. They may act by enhancing and/or mimicking the synaptic action of gamma-aminobutyric acid (GABA). Barbiturates depress the ...
The Reta Trust Pharmacy Schedule of Benefits for 3
The Reta Trust Pharmacy Schedule of Benefits for 3

... Your covered services include certain medications that require the covered person go through a preauthorization or step therapy process. Preauthorization means that certain select medications will not be covered until one or more formulary alternatives or “first-line” drugs have been tried first. Pr ...
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Neuropharmacology

Neuropharmacology is the study of how drugs affect cellular function in the nervous system, and the neural mechanisms through which they influence behavior. There are two main branches of neuropharmacology: behavioral and molecular. Behavioral neuropharmacology focuses on the study of how drugs affect human behavior (neuropsychopharmacology), including the study of how drug dependence and addiction affect the human brain. Molecular neuropharmacology involves the study of neurons and their neurochemical interactions, with the overall goal of developing drugs that have beneficial effects on neurological function. Both of these fields are closely connected, since both are concerned with the interactions of neurotransmitters, neuropeptides, neurohormones, neuromodulators, enzymes, second messengers, co-transporters, ion channels, and receptor proteins in the central and peripheral nervous systems. Studying these interactions, researchers are developing drugs to treat many different neurological disorders, including pain, neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease, psychological disorders, addiction, and many others.
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