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The genetics of dystonia: new twists in an old tale
The genetics of dystonia: new twists in an old tale

... The diagnosis of dystonia is, fundamentally, clinical. It relies on the presence of repetitive or sustained abnormal postures (with or without tremor) and the recognition of specific features, such as a geste antagoniste or overflow and mirror movements. Geste antagoniste refers to a voluntary manoe ...
Pharmacologic Identification of the Lower Esophageal Sphincter
Pharmacologic Identification of the Lower Esophageal Sphincter

... distal strips being more sensitive. The gradient of threshold was much steeper for norepinephrine than for the other drugs. Maximal responses did not differ among levels for the choline esters or ganglionic stimulants, but showed proximal diminution for norepinephrine. These differences in threshold ...
Dilution and Concentration
Dilution and Concentration

... quantity of a solution or mixture of solids is inversely proportional to the percentage or ratio strength; that is, the percentage or ratio strength decreases as the quantity increases, and vice versa. In other words, if the amount of active ingredient remains the same and the volume gets larger, th ...
Nicotine and the Central Nervous System
Nicotine and the Central Nervous System

Simultaneous Quantitative Determination of Candesartan cilexetil
Simultaneous Quantitative Determination of Candesartan cilexetil

... carbonyl]oxy ]ethyl 2-etho xy-1-[[2'-(1H-tetrazo l-5-y l)[1,1'biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carbo xylate is an angiotensin II receptor antagonist, selective for AT1 receptors, with tight binding to and slow dissociation from the receptor (Figure 1). It has no agonist activity. It is rapi ...
Pharmacokinetic Interaction Between Prasugrel and Ritonavir
Pharmacokinetic Interaction Between Prasugrel and Ritonavir

... level 26 times that of observed without ritonavir, and the increase of midazolam’s Cmax to a level 6 times that observed without ritonavir. These results are in agreement with previous studies demonstrating that ritonavir is a very potent CYP3A inhibitor [11,18]. A previous study assessing the effec ...
Chestal ® Cough Monograph - Boiron USA for Health Care
Chestal ® Cough Monograph - Boiron USA for Health Care

... The formula for Chestal and Children’s Chestal combines several homeopathic medicines. These medicines are manufactured according to the Homeopathic Pharmacopoeia of the United States’ guidelines, using the highest standards of production and quality control. Indications for homeopathic medicines ha ...
HYDROPHILIC POLYMERS FOR DISSOLUTION ENHANCEMENT OF CELECOXIB  Research Article PROF.M.V.NAGABHUSHANAM
HYDROPHILIC POLYMERS FOR DISSOLUTION ENHANCEMENT OF CELECOXIB Research Article PROF.M.V.NAGABHUSHANAM

... (C),4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1Hpyrazol-1-yl] benzene sulfonamide, is a nonsteroidal antiinflammatory drug that exhibits anti-inflammatory, analgesic and anti-pyretic activities is used in the treatment of rheumatoid arthritis and osteoarthritis (1,2). Celecoxib is also used in the m ...
Riboflavin 0.1% (VibeX) for the treatment of keratoconus
Riboflavin 0.1% (VibeX) for the treatment of keratoconus

... achieving crosslinking of corneal collagen. Using this method, Wollensak et al. [17] demonstrated a marked positive effect of crosslinking on the biomechanical properties of both porcine and human corneal tissue: crosslinking was shown to increase the rigidity of human corneal tissue (expressed by Y ...
Tetracycline Phosphate Complex
Tetracycline Phosphate Complex

... have deteriorated has been associated with the development of a reversible Fanconi-type syndrome characterised by polyuria and polydipsia with nausea, glycosuria, aminoaciduria, hyperphosphaturia, hypokalaemia, and hyperuricaemia with acidosis and proteinuria; these effects have been attributed to t ...
HISTORY OF ANESIATHIA - International Society for the History
HISTORY OF ANESIATHIA - International Society for the History

... Emerging data in animalmodels have demonstrated accelerated neuronal apoptosis and long-term behavioural changes in rodents exposed in the neonatal period to anesthetic agents that act on N-methyl D-aspartic acid (NMDA) and ...
A Small Dose of ™ Caffeine
A Small Dose of ™ Caffeine

... A Small Dose of Caffeine – 2/16/04 ...


... may form coordination bond with metal ion. Chelation causes drastic changes in biological properties of ligands as well as metal moiety and in many cases it causes synergistic effect of both metal ion and ligand [9, 10]. A number of drugs and potential pharmaceutical agents also contain metal-bindin ...
Insect repellents
Insect repellents

... Articles intended to be rubbed, poured, sprinkled, or sprayed on, introduced into, or otherwise applied to the human body...for cleansing, beautifying, promoting attractiveness, or altering the appearance. ...
- International Journal of Pharmaceutical Sciences and
- International Journal of Pharmaceutical Sciences and

... way of dosing medications, not only for special population groups with swallowing difficulties such as children and the elderly, but also for the general population, including the young generation. Today, medicated chewing gum meets the same high quality standards as tablets. ...
CAFFEINE - IDC
CAFFEINE - IDC

... problems including peptic ulcers, erosive esophagatis, and gastrointestinal reflux disease. However, it should be noted that caffeine is most likely not responsible for the internal disorders because both excessive amounts of caffeinated and de-caffeinated coffee have shown to cause the problems. Ca ...
EES Granules - Arbor Pharmaceuticals
EES Granules - Arbor Pharmaceuticals

...   Clostridium difficile associated diarrhea (CDAD) has been reported with use of nearly all antibacterial agents, including E.E.S., and may range in severity from mild diarrhea to fatal colitis. Treatment with antibacterial agents alters the normal flora of the colon leading to overgrowth of C. diff ...
Effects of Phentermine on Responding Maintained under Multiple
Effects of Phentermine on Responding Maintained under Multiple

... treatments can be developed that will decrease cocaine abuse in humans. One approach to assessing this possibility is to test potential treatments on behaviors associated with the abuse potential of cocaine (Woolverton and Kleven, 1991). A number of reports have shown that cocaine self-administratio ...
Effects of Phentermine on Responding Maintained under Multiple
Effects of Phentermine on Responding Maintained under Multiple

... treatments can be developed that will decrease cocaine abuse in humans. One approach to assessing this possibility is to test potential treatments on behaviors associated with the abuse potential of cocaine (Woolverton and Kleven, 1991). A number of reports have shown that cocaine self-administratio ...
Potential for methotrexate exposure through contamination during
Potential for methotrexate exposure through contamination during

... autoimmune disease use (Fig. 1). For rheumatoid arthritis outpatients, this could mean a weekly nurse or physician visit rather than patients’ relatives being able to assist those with disability who require help with parenteral low-dose weekly MTX administration. Although the dose of MTX that is us ...
Pharmacology and the Nursing Process, 4th ed
Pharmacology and the Nursing Process, 4th ed

... Lithium is the drug of choice for the treatment of mania It is thought to potentiate serotonergic neurotransmission  May be used with other medications to stabilize mood  Narrow therapeutic range: maintenance serum levels should range between 0.6 and 1.2 mEq/L  Monitor sodium levels ...
Selective inhibitor of LRRK2, a protein kinase
Selective inhibitor of LRRK2, a protein kinase

... the Leucine-rich repeat kinase-2 (LRRK2) gene were first linked to PD in 20042,3 and extensive genetic, cellular and biochemical studies suggest that it is a key driver of the disease. Among the genes associated with PD, such as parkin and PINK1, LRRK2 is ...
MARTINDALE - The Complete Drug Reference Danazol
MARTINDALE - The Complete Drug Reference Danazol

... and may be a useful alternative.13 Progestogens such as medroxyprogesterone acetate, dydrogesterone, or norethisterone acetate are also commonly used. They appear to be as effective as danazol in relieving pain symptoms13 and tend to be better tolerated.1,5 Combined oral contraceptives have been use ...
C 3  R
C 3 R

... recently created in our laboratory (20). All 20 mutants were expressed in E.coli BL21 with pET28+-vectors; the P450 quantification was done by CO difference spectrum. For the mutants Pro87, Asp87 and Ser87, the reduced CO difference spectra only showed a peak at 420 nm, suggesting that these amino a ...
Review of cough and cold medicines in children
Review of cough and cold medicines in children

... doubt part of a common public attitude of wanting a chemical remedy for every symptom, combined with active and sometimes entrepreneurial research and marketing of the drug manufacture and sales industry. The enormous attraction of self-medication – something you can do for yourself or other family ...
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Neuropharmacology

Neuropharmacology is the study of how drugs affect cellular function in the nervous system, and the neural mechanisms through which they influence behavior. There are two main branches of neuropharmacology: behavioral and molecular. Behavioral neuropharmacology focuses on the study of how drugs affect human behavior (neuropsychopharmacology), including the study of how drug dependence and addiction affect the human brain. Molecular neuropharmacology involves the study of neurons and their neurochemical interactions, with the overall goal of developing drugs that have beneficial effects on neurological function. Both of these fields are closely connected, since both are concerned with the interactions of neurotransmitters, neuropeptides, neurohormones, neuromodulators, enzymes, second messengers, co-transporters, ion channels, and receptor proteins in the central and peripheral nervous systems. Studying these interactions, researchers are developing drugs to treat many different neurological disorders, including pain, neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease, psychological disorders, addiction, and many others.
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