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Fibroblast growth factors as regulators of central nervous system
Fibroblast growth factors as regulators of central nervous system

... Streit et al. (195) have also shown that FGFs, produced by organizer precursor cells at the posterior margin, can initiate and promote neural tissue development through a BMP-independent mechanism. Therefore, FGF-mediated neural induction occurs via two distinct mechanisms in chick epiblastic cells: ...
15 UPK 3_1_  - Asian Journal Of Advanced Basic Sciences
15 UPK 3_1_ - Asian Journal Of Advanced Basic Sciences

... exceptions in which angiogenesis occurs under tight regulation found in the female reproductive system and during wound healing. In pathological situations, however, angiogenesis may be turned on, which contribute to the onset and progression of most severe human pathologies characterized by high mo ...
Cannabinoids in the Treatment of Epilepsy
Cannabinoids in the Treatment of Epilepsy

... Cannabis has been used medicinally for millennia and was used in the treatment of epilepsy as early as 1800 b.c.e. in Sumeria.5 Victorian-era neurologists used Indian hemp to treat epilepsy and reported dramatic success.5,6 The use of cannabis therapy for the treatment of epilepsy diminished with th ...
Supplemental Digital Content
Supplemental Digital Content

... Postmarketing surveillance refers to analysis of data accumulated typically for the purpose of detecting adverse effects after a medicinal product has been given a marketing authorization by a regulatory body [35,36]. The term normally refers to the processes of signal detection and signal evaluatio ...
Alcohol - Robbinsville Schools
Alcohol - Robbinsville Schools

... # 9: The public knows enough about the effects of alcohol use; further research is not necessary. ...
Low potential of dobutamine and dopexamine to block intestinal
Low potential of dobutamine and dopexamine to block intestinal

... motility in the gut. This low potency in suppressing intestinal propulsion favors the use of dobutamine and dopexamine in critically ill patients, although this recommendation is only based on their effects on intestinal motility and does not take their effects on gut perfusion into account. Milder ...
Buprenorphine for Treating Opioid-Dependent Pregnant Women: Behavioral Pharmacology in Action
Buprenorphine for Treating Opioid-Dependent Pregnant Women: Behavioral Pharmacology in Action

... - US in midst of heroin epidemic that was peaking at this time and would last through much of 1950s - Other false hopes with opioids brought to US market diacetylmorphine (a.k.a. heroin in late 1890s) meperidine (a.k.a. Demerol in early 1940s) •  Conclusion of Isbell & Vogel (1949): “The results lea ...
Synthetic Drugs - Ohio Crime Prevention Association
Synthetic Drugs - Ohio Crime Prevention Association

... police station and impaled himself through the thigh on a spike. Rescue crews had to cut away part of the fence before the victim was rushed to surgery with part of the spike still in his leg. On April 4, a man wearing only sneakers ran amuck through Fort Lauderdale traffic trying to get struck by a ...
Intravenous Infusions
Intravenous Infusions

... been associated with either static or decreased SVR. Static or decreased SVR associated with low or moderate increments in cardiac output is believed to be a reflection of differential effects on specific vascular beds with increased resistance in peripheral beds (e.g., femoral) and concomitant decr ...
Neurological Assessment Tips
Neurological Assessment Tips

Predicting Drug Metabolism - Cambridge Repository
Predicting Drug Metabolism - Cambridge Repository

... forms are expressed predominantly in the liver, but also in a whole variety of other organs at lower expression levels (Figure 1). Hence liver, or liver-derived in vitro systems are often the most convenient, interesting and important experimental model systems for metabolism studies, e.g. when cons ...
Muscle Relaxants
Muscle Relaxants

... Muscle relaxants must not be given without adequate dosage of analgesic and hypnotic drugs Inappropriately given : a patient is paralyzed but not anesthetized ...
Self-Study - NurseCe4Less.com
Self-Study - NurseCe4Less.com

... been associated with either static or decreased SVR. Static or decreased SVR associated with low or moderate increments in cardiac output is believed to be a reflection of differential effects on specific vascular beds with increased resistance in peripheral beds (e.g., femoral) and concomitant decr ...
What is oseltamivir (Tamiflu  )? What is influenza? Why is influenza a
What is oseltamivir (Tamiflu )? What is influenza? Why is influenza a

... necessary viral enzyme called neuraminidase. This enzyme is required by the virus to multiply, spread from cell to cell and, eventually, spread to other susceptible individuals. Oseltamivir is a pill. Zanamivir is available as a powder that is inhaled; this may be difficult for some LTCF residents. ...
Effects of a 5‐HT3 antagonist, ondansetron, on fasting and
Effects of a 5‐HT3 antagonist, ondansetron, on fasting and

... (P < 0.0002) compared with the group of subjects who were not intubated. Conclusions The 5-HT3 receptor antagonism increased fasting small bowel water. This was associated with reduced fasting antroduodenal Motility Index which may explain the clinical benefit of such drugs. Aliment Pharmacol Ther 20 ...
Formulation and Evaluation of Trimetazidine Dihydrochloride
Formulation and Evaluation of Trimetazidine Dihydrochloride

... Similarity factor (f2) analysis: In vitro drug release profile of the marketed trimetzidine dihydrochloride sustained release tablets was compared with the drug release profile of test product under similar experimental conditions. The data obtained from this drug release studies was used to determi ...
Conserved regulators of cognitive aging: From worms to humans
Conserved regulators of cognitive aging: From worms to humans

... worms move to the training temperature that had been associated with food, or avoid a temperature associated with starvation, a behavior that is termed isothermal tracking (IT). This conditioning ...
Indinavir and Nelfinavir  inhibit proximal insulin receptor signalling and... inhibition:potential role of the NFkappa B pathway
Indinavir and Nelfinavir inhibit proximal insulin receptor signalling and... inhibition:potential role of the NFkappa B pathway

... observed in present study are unlikely to be due to cellular toxicity because in a previously reported study, indinavir was not toxic to cells even at concentrations of 100 µM [Germinario and Colby-Germinario, 2003]. Therefore, the range of indinavir used in the observation was in the range (0-100µM ...
September 2015 - State Pharmaceuticals Corporation of Sri Lanka
September 2015 - State Pharmaceuticals Corporation of Sri Lanka

The role of the quantity in the prosecution of drug offences
The role of the quantity in the prosecution of drug offences

... brought into play for drug traffickers but have no relevance for those who possess drugs without the intention of trafficking. Finally, on an international legal level, there is the question that traffickers may be subject to extradition proceedings and confiscation of assets in situations where use ...
Prolonged Effects of Cholinesterase Inhibition
Prolonged Effects of Cholinesterase Inhibition

... study of rCBF changes induced by eptastigmine: animals were injected with eptastigmine dissolved in saline at doses of 0.5, 1, or 3 mg kg-I by rapid i.v. infusion (20 s) or with an equivalent volume of saline (controls) in groups of 6, 5, 6, and 7 animals, respectively. rCBF was measured 20 min afte ...
Anticholinergics for Overactive Bladder
Anticholinergics for Overactive Bladder

... Dr. J. Yelland (Parkridge LTC), S. Knezacek (Pharmacist, Parkridge LTC), Juliet Sarjeant (SHR-Physio), Eliza Meggs (RN, NCA, Nurse Continence Advisor; Saskatoon), Ann Burton (SHR-RNSpecialist, Parkridge Centre) & the RxFiles Advisory Committee. Prepared by: K Mulherin PharmD Cand L. Regier BSP, BA, ...
BAOJ Pharmaceutical Sciences
BAOJ Pharmaceutical Sciences

... most widely studied enhancers of this group. Pyrrolidones have been used as permeation promoters for numerous molecules including hydrophilic (e.g. mannitol, 5-fluorouracil and sulphaguanidine) and lipophilic (betamethasone-17-benzoate, hydrocortisone and progesterone) permeants. As with many studie ...
key concepts in acute pain management
key concepts in acute pain management

... – Do not use celecoxib is history of anaphylaxis or severe cutaneous reaction ...
a novel approach using hydrotropic solubalization technique
a novel approach using hydrotropic solubalization technique

... Objective: Analysis of drug utilized the organic solvent which are costlier, toxic, and causing environment pollution. Hydrotropic solution may be a proper choice to preclude the use of organic solvents so that an attempt has been made to develop simple, accurate, novel, safe and precise spectrophot ...
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Neuropharmacology

Neuropharmacology is the study of how drugs affect cellular function in the nervous system, and the neural mechanisms through which they influence behavior. There are two main branches of neuropharmacology: behavioral and molecular. Behavioral neuropharmacology focuses on the study of how drugs affect human behavior (neuropsychopharmacology), including the study of how drug dependence and addiction affect the human brain. Molecular neuropharmacology involves the study of neurons and their neurochemical interactions, with the overall goal of developing drugs that have beneficial effects on neurological function. Both of these fields are closely connected, since both are concerned with the interactions of neurotransmitters, neuropeptides, neurohormones, neuromodulators, enzymes, second messengers, co-transporters, ion channels, and receptor proteins in the central and peripheral nervous systems. Studying these interactions, researchers are developing drugs to treat many different neurological disorders, including pain, neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease, psychological disorders, addiction, and many others.
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