Relationship between Type of Endorser and
... there was a correlation between different types of endorsers and specific product types (Friedman, 1977). Friedman identified three types of endorsers: celebrities, experts, and typical consumers. Using the literature about consumers’ perceived risks and the social influence theory, Friedman hypothe ...
... there was a correlation between different types of endorsers and specific product types (Friedman, 1977). Friedman identified three types of endorsers: celebrities, experts, and typical consumers. Using the literature about consumers’ perceived risks and the social influence theory, Friedman hypothe ...
TYLENOL® with Codeine
... The minimum effective analgesic concentration will vary widely among patients, especially among patients who have been previously treated with potent agonist opioids. The minimum effective analgesic concentration of codeine for any individual patient may increase over time due to an increase in pain ...
... The minimum effective analgesic concentration will vary widely among patients, especially among patients who have been previously treated with potent agonist opioids. The minimum effective analgesic concentration of codeine for any individual patient may increase over time due to an increase in pain ...
Our Commitment to Legalizing Marijuana for Adults
... The harms of marijuana use can also manifest in users’ quality of life. In one study, heavy marijuana users reported that the drug impaired several important measures of health and quality of life, including physical and mental health, cognitive abilities, social life, and career status. Marijuana ...
... The harms of marijuana use can also manifest in users’ quality of life. In one study, heavy marijuana users reported that the drug impaired several important measures of health and quality of life, including physical and mental health, cognitive abilities, social life, and career status. Marijuana ...
Evaluation of Kidney Function
... GFR is dependent on numerous factors, one of which is protein load. Bosch13 suggested that an appropriate comprehensive evaluation of renal function should include the measurement of “filtration capacity” of the kidney. This is similar in context to a cardiac stress test. The patient may have no hyp ...
... GFR is dependent on numerous factors, one of which is protein load. Bosch13 suggested that an appropriate comprehensive evaluation of renal function should include the measurement of “filtration capacity” of the kidney. This is similar in context to a cardiac stress test. The patient may have no hyp ...
D4/D5 The Miracle Drug It`s springtime. Imagine yourself walking
... infections, especially Pseudomonas aeruginosa. The antibiotics of this group are carcenicillin and ticarcillin. The fifth group of antibiotics within the penicillin class is the ureidopenicillins. The side chains of this group were further modified to increase the spectrum of activity to include add ...
... infections, especially Pseudomonas aeruginosa. The antibiotics of this group are carcenicillin and ticarcillin. The fifth group of antibiotics within the penicillin class is the ureidopenicillins. The side chains of this group were further modified to increase the spectrum of activity to include add ...
PANTOPRAZOLE SODIUM DELAYED-RELEASE
... Pantoprazole is metabolized mainly by CYP2C19 and to minor extents by CYPs 3A4, 2D6 and 2C9. In in vivo drug-drug interaction studies with CYP2C19 substrates (diazepam [also a CYP3A4 substrate] and phenytoin [also a CYP3A4 inducer]), nifedipine, midazolam, and clarithromycin (CYP3A4 substrates), met ...
... Pantoprazole is metabolized mainly by CYP2C19 and to minor extents by CYPs 3A4, 2D6 and 2C9. In in vivo drug-drug interaction studies with CYP2C19 substrates (diazepam [also a CYP3A4 substrate] and phenytoin [also a CYP3A4 inducer]), nifedipine, midazolam, and clarithromycin (CYP3A4 substrates), met ...
Fear Conditioning
... b. NPS does not affect acquisition of avoidance memory i. NPS does not affect avoidance if administered before training c. NPS reduces memory retrieval 8. NPSR KO → ↓ avoidance memory a. No effect of NPS on nociception 9. β–adrenergic antagonist inhibits NPS-enhanced avoidance memory a. propranolol ...
... b. NPS does not affect acquisition of avoidance memory i. NPS does not affect avoidance if administered before training c. NPS reduces memory retrieval 8. NPSR KO → ↓ avoidance memory a. No effect of NPS on nociception 9. β–adrenergic antagonist inhibits NPS-enhanced avoidance memory a. propranolol ...
Cannabis use and misuse
... for harm, with the goal of providing an informed and thoughtful understanding and appreciation of cannabis and its potential impact on adolescents. Cannabis throughout history By some accounts, cannabis first appeared approximately four thousand years ago in the Chinese culture as a plant grown for ...
... for harm, with the goal of providing an informed and thoughtful understanding and appreciation of cannabis and its potential impact on adolescents. Cannabis throughout history By some accounts, cannabis first appeared approximately four thousand years ago in the Chinese culture as a plant grown for ...
Diazepam - EWU Institutional Repository
... leads to a increased conductance to chloride ions, which produces membrane hyperpolarization, this induces a neuronal inhibition. The binding of benzodiazepines to the GABA-A receptor increases the affinity of gamma amino butyric acid (GABA) and its receptor, thereby increasing the opening frequency ...
... leads to a increased conductance to chloride ions, which produces membrane hyperpolarization, this induces a neuronal inhibition. The binding of benzodiazepines to the GABA-A receptor increases the affinity of gamma amino butyric acid (GABA) and its receptor, thereby increasing the opening frequency ...
catechol-o-methyltransferase activity: assay, distribution
... a sequential order reaction mechanism, i.e. SAM binds first to the enzyme then Mg2+ before the substrate is bound. The release of the molecules follows in the reverse order (Lotta et al. 1995). The reaction mechanism should be the same for both COMT isoforms. ...
... a sequential order reaction mechanism, i.e. SAM binds first to the enzyme then Mg2+ before the substrate is bound. The release of the molecules follows in the reverse order (Lotta et al. 1995). The reaction mechanism should be the same for both COMT isoforms. ...
Pain White Paper by Joseph Vaughan, M.D.
... which directly stimulate nociceptors, but it also causes the release of substance P. This is a key early feature which has both local effects (cutaneous blood vessel dilatation and resultant cutaneous erythema, pain production) and magnifying effects (SP, a chemoattractant for leukocytes, releases h ...
... which directly stimulate nociceptors, but it also causes the release of substance P. This is a key early feature which has both local effects (cutaneous blood vessel dilatation and resultant cutaneous erythema, pain production) and magnifying effects (SP, a chemoattractant for leukocytes, releases h ...
Over-the-Counter Sleep Aid Medications and Insomnia
... who had not received previous treatment for insomnia.15 This finding suggests drug tolerance, cross-drug tolerance, or that the efficacy of diphenhydramine is not as robust as other pharmamocologic treatments. Tolerance to the hypnotic effects of diphenhydramine was evident on both objective and sub ...
... who had not received previous treatment for insomnia.15 This finding suggests drug tolerance, cross-drug tolerance, or that the efficacy of diphenhydramine is not as robust as other pharmamocologic treatments. Tolerance to the hypnotic effects of diphenhydramine was evident on both objective and sub ...
Comparison of the Effects of Pilocarpine Solution and Tablet on
... 12 healthy volunteers (6 males and 6 females) in a predetermined order with wash-out period of at least two days and unstimulated whole saliva was collected before and after administration of each drug. Blood pressure and pulse rate was also measured and subjective effect and potential side effects ...
... 12 healthy volunteers (6 males and 6 females) in a predetermined order with wash-out period of at least two days and unstimulated whole saliva was collected before and after administration of each drug. Blood pressure and pulse rate was also measured and subjective effect and potential side effects ...
use of chick embryo in screening for teratogenicity
... In other cases, a risk benefit decision may be made based upon the result of in vitro testing (3). Many in vitro techniques have been evolved but till date no method has been able to replace whole animal testing, as the regulations in many cases require specific tests and the fear of litigation is a ...
... In other cases, a risk benefit decision may be made based upon the result of in vitro testing (3). Many in vitro techniques have been evolved but till date no method has been able to replace whole animal testing, as the regulations in many cases require specific tests and the fear of litigation is a ...
Yohimbine enhances the effect of sildenafil on erectile
... alkaloid whose aphrodisiac activity may be mediated through a combination of central nervous system effects and peripheral effects including blockade of pre- and postsynaptic a2-adrenergic receptors.5–7 Placebo-controlled studies have suggested the effectiveness of yohimbine in treating ED due to ps ...
... alkaloid whose aphrodisiac activity may be mediated through a combination of central nervous system effects and peripheral effects including blockade of pre- and postsynaptic a2-adrenergic receptors.5–7 Placebo-controlled studies have suggested the effectiveness of yohimbine in treating ED due to ps ...
Caffeine - The Personality Project
... locomotor activity. Only at doses not likely to be consumed by humans does caffeine cause release of dopamine in the nucleus accumbens; however, this dose is associated with non-specific activation in the brain and aversive effects such as anxiety Sturgess et al. (2010). Tolerance refers to an acqui ...
... locomotor activity. Only at doses not likely to be consumed by humans does caffeine cause release of dopamine in the nucleus accumbens; however, this dose is associated with non-specific activation in the brain and aversive effects such as anxiety Sturgess et al. (2010). Tolerance refers to an acqui ...
Mechanism of endothelial nitric oxide synthase
... evolved a stronger biological activity and a more complex structural diversity to adapt to the extreme marine environment, such as high salt, high pressure, low-nutrient and unstable temperature condition (Suleria et al., 2015). Therefore, marine natural products may become a novel pharmaceutical re ...
... evolved a stronger biological activity and a more complex structural diversity to adapt to the extreme marine environment, such as high salt, high pressure, low-nutrient and unstable temperature condition (Suleria et al., 2015). Therefore, marine natural products may become a novel pharmaceutical re ...
effect of piperine, a major component of black pepper, on the
... possible that the increased levels of domperidone observed in this study following its concurrent administration with piperine may result, at least in part, from inhibition of hepatic CYP3A4 enzymes by piperine. The drug export pump, P-glycoprotein is important for the absorption, distribution and e ...
... possible that the increased levels of domperidone observed in this study following its concurrent administration with piperine may result, at least in part, from inhibition of hepatic CYP3A4 enzymes by piperine. The drug export pump, P-glycoprotein is important for the absorption, distribution and e ...
BoNT_A Presentation UMass Dartmouth 081029
... intoxication with BoNTs, new small-molecule inhibitors of these toxins are critically needed. ...
... intoxication with BoNTs, new small-molecule inhibitors of these toxins are critically needed. ...