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DNA Structure and Function
DNA Structure and Function

... 5. Adenine and guanine are called -------------- and thymine and cytosine are ----------------. By a purine binding to a pyrimidine, the diameter of the molecule remains the same. 6. DNA is a ---------------------, RNA is -----------------------------DNA Replication: 1. For cells to reproduce and mu ...
1) Regulation of Gene expression 2) Genomes 3
1) Regulation of Gene expression 2) Genomes 3

... •  Genetic manipulation is an unnatural interference in nature •  Genetically altered foods are unsafe to eat •  Genetically altered crop plants are dangerous to the environment •  The complexity of the biological world makes it impossible to predict all potential environmental effects of transgenic ...
Why genes are regulated?
Why genes are regulated?

... A diffusible trans-acting factor bound to cis-acting targeting site(s) is: ...
9/18/08 Transcript I
9/18/08 Transcript I

... There are different TAFs in different cells. So these TAFs complexes were isolated from cell type. If you look at a different cell type, the complexes that you isolated from the GTFs could be slightly different or very different. In vivo these factors are associated with additional proteins forming ...
Ch. 11 - Gene Action and protein synthesis
Ch. 11 - Gene Action and protein synthesis

... The modified mRNA exits the nucleus via the nuclear pores Once in the cytoplasm, it is able to attach to the smaller subunit of the ribosome at the 5’ end The mRNA is made up of triplets of nucleotides called codons The codons code for a particular amino ...
Sequencing and Phylogeny - World Health Organization
Sequencing and Phylogeny - World Health Organization

... K. S. Li1, Y. Guan1,2, J. Wang1,2, G. J. D. Smith1,2, K. M. Xu1,2, L. Duan1,2, A. P. Rahardjo3, P. Puthavathana4, C. Buranathai5, T. D. Nguyen6, A. T. S. Estoepangestie3, A. Chaisingh5, P. Auewarakul4, H. T. Long7, N. T. H. Hanh7, R. J. Webby8, L. L. M. Poon2, H. Chen1,2, K. F. Shortridge1,2, K. Y. ...
Micro chpt. 9 notes
Micro chpt. 9 notes

... a. The eukaryotic genome, which is contained within the cell nucleus, is the largest and typically a linear double-stranded DNA divided into separate units, or chromosomes (e.g. human genome is 3 billion base pairs on 23 chromosomes). Replication is by DNA Polymerase. The prokaryotic genome is loose ...
Assessment Schedule – 2005 Biology: Describe gene expression
Assessment Schedule – 2005 Biology: Describe gene expression

... one cat can only have two. This gene has multiple alleles, each with their own enzyme product. The • C allows intermediate substance intermediate substance is only to be formed. produced if the C allele for tyrosinase is present. Combinations • Dominant allele(s) allow the of any of the other allele ...
Lesson 6.2 Genetics
Lesson 6.2 Genetics

... • These can produce a dominantly active phenotype by: – reducing function below a level necessary to maintain a normal phenotype (familial hypercholesterolemia, LDL receptor) – acting as a “dominant negative” (Marfan Syndrome, fibrillin-1 or some forms of Ehlers-Danlos Syndrome, collagen) which prev ...
Data Mining in Ensembl with BioMart
Data Mining in Ensembl with BioMart

... multiple terms and put them into a table format. • Such as: mouse gene (IDs), chromosome and base pair position • No programming required! ...
Lecture ten
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... • proteins that bind sequences of DNA to control transcription in eukaryotes • can act as activators or repressors to transcription – activating TFs - proteins that recruit the RNA polymerase to a promoter region – repressing TFs – proteins that prevent t ...
Chapter 17: From Gene to Protein
Chapter 17: From Gene to Protein

... 23. Describe the structure and functions of ribosomes. 24. Describe the process of translation (including initiation, elongation, and termination) and explain which enzymes, protein factors, and energy sources are needed for each stage. 25. Describe the significance of polyribosomes. 26. Explain wha ...
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... start site) and moves toward the terminator (which is downstream of the start site). The first nucleotide transcribed is numbered +1. Nucleotides upstream of the start site are assigned negative numbers. ...
Section 16.2
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Exam 2 Student Key
Exam 2 Student Key

... 5. (6 pts) Imagine there are twin sisters, Abby and Babs. They both inherited mutations in their DNA Polymerase III genes that make the enzyme slightly less efficient at proofreading. Abby gets three different cancers before age 60. Babs never gets cancer. Assume both sisters are accumulating mutati ...
Bio1A - Lec 19 slides File
Bio1A - Lec 19 slides File

... interaction can occur • The active site is where specific electrons movement (chemical reactions) occur between catalyst and reactants ...
Forum: Environmental Commission 2016 Issue: Eliminating Disease
Forum: Environmental Commission 2016 Issue: Eliminating Disease

... generations. This type of gene therapy would prevent inherited diseases from affecting newborns. Gene therapies have grown, and now include treatments for infection diseases, arthritis, and even cancer. However, the issue is that some scientists are concerned that these therapeutic genes may causes ...
DNA Structure and Function
DNA Structure and Function

... All living things are related. ...
Chapter 6 From DNA to Protein: How Cell Read the Genome
Chapter 6 From DNA to Protein: How Cell Read the Genome

... Signals in the sequence of a gene tell bacteria RNA polymerase where to start and stop transcription Bacterial RNA polymerase ...
RNA Polymerase II analysis in Drosophila Melanogaster
RNA Polymerase II analysis in Drosophila Melanogaster

... RNA Polymerase II analysis in Drosophila Melanogaster Aim Most of the differences in nucleotides between organisms are situated in noncoding DNA regions. These non coding regions affect the expression levels of genes thus making phenotypes depending more on differential expression rather than genes ...
INTERVENING SEQUENCES IN EUKARYOTES
INTERVENING SEQUENCES IN EUKARYOTES

... 3. Introns were “discovered” by the presence of R loops, single-stranded regions observed when DNA-mRNA hybrids (heteroduplexes) were visualized by electron microscopy. Observation of R-loops fit well with earlier observations that pre-mRNAs (hnRNAs) were far larger than predicted based on length of ...
TUMOR-SUPPRESSOR GENES
TUMOR-SUPPRESSOR GENES

... most amplified oncogenes are apparently normal on the basis of restriction endonuclease mapping. Gene amplification arises from a segment of DNA replicating more than once during a single cell cycle. There is evidence that there are preferred chromosomal positions for amplification of cellular genes ...
DNA replication proceeds in a semi conservative fashion, where the
DNA replication proceeds in a semi conservative fashion, where the

... The polypeptide chain is cleaved from the tRNA completing the synthesis of the polypeptide; The empty tRNA is released from the ribosome; The two ribosomal subunits dissociate from the mRNA chain. ...
Project : Operon Prediction - Bioinformatics at School of Informatics
Project : Operon Prediction - Bioinformatics at School of Informatics

... very strong intuition to understand the genome structure. Conserved gene neighborhoods reconstructed from many genomes by the Tiling Path Method can be used to predict the functions of uncharacterized genes and functional coupling between well-characterized genes in those genomes. Ultimately, We can ...
Mathematical Challenges from Genomics and Molecular Biology
Mathematical Challenges from Genomics and Molecular Biology

... progress has been made by a variety of methods. These range from numerical simulation of the physical forces exerted by the amino acids on one another to pattern recognition techniques which correlate motifs within the linear amino acid sequence with structural features of a protein. From Genes to P ...
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Promoter (genetics)



In genetics, a promoter is a region of DNA that initiates transcription of a particular gene. Promoters are located near the transcription start sites of genes, on the same strand and upstream on the DNA (towards the 5' region of the sense strand).Promoters can be about 100–1000 base pairs long.
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