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RNA Helicase Module in an Acetyltransferase That Modifies a
RNA Helicase Module in an Acetyltransferase That Modifies a

... 20 mM Hepes-KOH (pH 7.6) at 37 °C for 3 hours. The hydrolysate was fractionated using an Inertsil ODS-3 column, 250 × 2.1 mm (GL science, Japan). The solvent system consisted of 5 mM NH4OAc (pH 5.3) (A) and 60% acetonitrile (B), used as follows: 1-35% B in 0-35min., 35-99% B in 35-40min., 99% B in 4 ...
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... response: as sensor-activator, as adaptormediator or further downstream. With its numerous roles in the DNA damage response, meiotic recombination, class switch recombination and telomere maintenance, the MRN complex is expected to be regulated by many post-translational modifications. A novel, unex ...
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DNA: the Molecule of Heredity
DNA: the Molecule of Heredity

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RNA-Seq with the Tuxedo Suite - UC Davis Bioinformatics Core
RNA-Seq with the Tuxedo Suite - UC Davis Bioinformatics Core

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Control of notochord gene expression by Brachyury

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Pa I I, hl.  L.   Blasticidin-S: on... Cycloheximide  has been used widely  as  ...
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Mutation of a Ubiquitously Expressed Mouse Transmembrane

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Analysis of the LacI family of repressor proteins in non

... (1961) 318] proposed a model for gene regulation, which survives essentially unchanged in contemporary textbooks. It is a cogent depiction of how a set of 'structural' genes may be coordinately transcribed in response to environmental conditions and regulates metabolic events in the cell (Lewis, 200 ...
TCR CommentaryAccept
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... understanding of the organism in its biological context. Ideally, one would like to be able to predict the behaviour of that organism from its genetic composition. This requires knowledge about non-coding DNA sequences, such as those to which regulatory molecules attach to modulate gene expression. ...
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GENETICS TEST IV - Daytona State College
GENETICS TEST IV - Daytona State College

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Summer Internship project
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... (iii) Which metabolic pathways are they utilizing? According to our preliminary data, there is good correspondence between the amount of total RNA isolated and the abundance of living microorganisms in a sample. In contrast to relatively stable DNA that can persist in the environment for a long time ...
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... On July 18, the scientific community lost Professor in the Departments of Chemone of its most creative and influential istry, Biochemistry, and Biophysics and thinkers and experimentalists. Jonathan the Beckman Institute at the University of Widom, William Deering Professor of Illinois at Urbana-Cha ...
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Single-Molecule Experiments in Synthetic Biology: An

... expression of genes involved in phosphate metabolism.[7–9] The protein[9] consists of a regulatory phosphorylation domain in the N-terminal region (PhoB 1–127) and a DNAbinding domain in the C-terminal region (PhoB 128–229). Deletion experiments showed that PhoB 139–229 binds to double-stranded DNA ...
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Regulation of Nucleotide Excision Repair: UV-DDB

... interacts weakly with the TGD motif of XPC and, in the proximity of UV lesions, exerts a bimodal action. By transient contacts with the BHD1 motif of XPC, the DDB2 subunit facilitates a β-hairpin insertion that locally unwinds the DNA double helix. This direct function is required across the whole g ...
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What is a protein

... mRNA goes to ribosome in cytoplasm (proteins made here!) Exon is identified by the START codon (AUG) Intron is discarded tRNA reads each codon (three nucleotide set code for amino acid) and transfers the correct amino acid accordingly. 5. The amino acids are linked together in the codon order. 6. tR ...
PDF
PDF

... that revealed the genetic network regulating neuronal subtype specification in the E11.5 dorsal neural tube, and to introduce the populations used in the current study for the ChIP-Seq and RNASeq experiments, we show here the expression patterns of Ascl1 and Ptf1a and some of the HD factors that sp ...
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Transcriptional regulation

In molecular biology and genetics, transcriptional regulation is the means by which a cell regulates the conversion of DNA to RNA (transcription), thereby orchestrating gene activity. A single gene can be regulated in a range of ways, from altering the number of copies of RNA that are transcribed, to the temporal control of when the gene is transcribed. This control allows the cell or organism to respond to a variety of intra- and extracellular signals and thus mount a response. Some examples of this include producing the mRNA that encode enzymes to adapt to a change in a food source, producing the gene products involved in cell cycle specific activities, and producing the gene products responsible for cellular differentiation in higher eukaryotes.The regulation of transcription is a vital process in all living organisms. It is orchestrated by transcription factors and other proteins working in concert to finely tune the amount of RNA being produced through a variety of mechanisms. Prokaryotic organisms and eukaryotic organisms have very different strategies of accomplishing control over transcription, but some important features remain conserved between the two. Most importantly is the idea of combinatorial control, which is that any given gene is likely controlled by a specific combination of factors to control transcription. In a hypothetical example, the factors A and B might regulate a distinct set of genes from the combination of factors A and C. This combinatorial nature extends to complexes of far more than two proteins, and allows a very small subset (less than 10%) of the genome to control the transcriptional program of the entire cell.
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