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C - Journal of Medical Microbiology
C - Journal of Medical Microbiology

... culture filtrate was distinctly inferior to the other, more purified antigens. PPD has been used in ELISA by several investigators (Tandon et al., 1980; Viljanen, Eskola and Tala, 1982; Zeiss et al., 1982; Kalish et al., 1983; Radin et al., 1983) with good results. It is notable that Kalish et al. ( ...
Powerpoint - International AIDS Society
Powerpoint - International AIDS Society

... All cases resolved, no IRIS related mortality Median time to onset: 6.6 weeks (Range 2-34) 33% had a previous diagnosis with the IRIS infection 39% required hospitalization for IRIS ...
Meningitis and Septicaemia What is meningococcal disease
Meningitis and Septicaemia What is meningococcal disease

... Both adults and children can carry meningococcal bacteria harmlessly in the back of the throat. Carriage of bacteria can help build natural immunity to infection. Around 10% of the general population will be carriers at any given time and nearly everyone becomes immune as a result of carrying these ...
STD & HIV Presentation 52013
STD & HIV Presentation 52013

... Jaundice, abdominal pain, loss of appetite, nausea, dark urine, fever, & extreme tiredness. Blood. Needle sharing or equipment with blood on it. No vaccine, just some treatment to fight the disease and slow liver disease. ...
Risk-management-plan summary
Risk-management-plan summary

... often followed by vomiting. Pertussis can be severe in infants and children, but in adults the symptoms tend to be mild and indistinguishable from those of other respiratory infections. However, infected adults can still transmit the disease to susceptible individuals. Pertussis is endemic worldwide ...
An autosomal dominant major gene confers predisposition to
An autosomal dominant major gene confers predisposition to

... a model-based linkage analysis. We assumed a simple dominant model, as previously described (12), with the frequency of the risk allele fixed at 0.05 and a relative risk (comparing homozygous “resistant” subjects and carriers of at least one copy of the risk allele) of 10. Model-based LOD scores wer ...
The evaluation of FASTPlaqueTB test for the rapid diagnosis of
The evaluation of FASTPlaqueTB test for the rapid diagnosis of

... methods have been considered as gold standard for the detection of M. tuberculosis. BACTEC 460 TB culture system has been recommended as a valuable system with its high sensitivity and shortened duration of time required for the detection of mycobacteria 10 to 14 days. Thus, BACTEC 460 TB culture sy ...
Infectious Diseases in Schools
Infectious Diseases in Schools

... total case count; watch for clustering. • Consider exclusion of symptomatic students until cleared by physician. ...
introduction
introduction

... People infected with the diphtheria bacteria, even if they don't have any symptoms, can infect others for up to 4 weeks. The incubation period (the time it takes for a person to become infected after being exposed) for diphtheria is 2 to 4 days, although it can range from 1 to 6 days. Pathogenesis. ...
Neutrophils in tuberculosis—first line of defence or booster of
Neutrophils in tuberculosis—first line of defence or booster of

... depletion significantly increased the frequency of mycobacteriaspecific, IFN-γ -producing T cells, suggesting a PMN suppressor function of acquired immunity to M. tuberculosis. Recently, Kimmey et al. (2015) showed a unique autophagyindependent role for autophagy protein 5 (ATG5) in PMNmediated path ...
A Confirmed Case of Middle East Respiratory Syndrome(MERS)
A Confirmed Case of Middle East Respiratory Syndrome(MERS)

... of the disease from one country to another. In addition, the KCDC noted that the patient is getting better, and although some of the family members of the patient are developing similar symptoms of the disease, all persons who might have had possible exposure, including the medical staffs, are being ...
Chapter 14: Principles of Disease and Epidemiology
Chapter 14: Principles of Disease and Epidemiology

... 2. Mutualism: Both organisms benefit from living together (+/+).  E. ...
Tuberculosis
Tuberculosis

... • For children and adolescents (<18 years old): - Isoniazid for 9 months ...
STI Overview - HIVAIDSUkraine
STI Overview - HIVAIDSUkraine

... “enzyme reverse transcriptase" of the virus before it enters a new WBC cell. “Protease inhibitor” also act to prevent the production of the virus in new cells. There are many uncomfortable side effects and therefore, it is critical to have the correct dose of these drugs. This is why a hospital stay ...
A5300/I2003 - IMPAACT Network
A5300/I2003 - IMPAACT Network

... • Cross-sectional, multi-country study of adult MDR-TB index cases (IC) and their HHC (Phoenix Feasibility study) • A HHC was defined as living in the same dwelling and sharing housekeeping arrangements as the IC, with exposure in the 6 months preceding the IC starting MDR-TB treatment. • High risk ...
written text - FailingsOrigin persistence and Failings of HIV/AIDS
written text - FailingsOrigin persistence and Failings of HIV/AIDS

... Several years ago I reported that the cumulative record of HIV testing shows that what is being detected by those tests is not an infectious agent. Details are in 3 articles in JSE (19 #4, 20 #1, 2) and further details and discussion are in the 2007 book, The Origin, Persistence and Failings of HIV/ ...
Text Version - Global Tuberculosis Institute
Text Version - Global Tuberculosis Institute

Ethical Aspects of Research Involving Human Subjects will be
Ethical Aspects of Research Involving Human Subjects will be

... Equipoise and choice of control  Does the selected control best establishes the value of the candidate intervention and has documented positive outcomes for the condition ? ...
lab 2: aseptic technique and transfer of microorganisms
lab 2: aseptic technique and transfer of microorganisms

... People infected with the diphtheria bacteria, even if they don't have any symptoms, can infect others for up to 4 weeks. The incubation period (the time it takes for a person to become infected after being exposed) for diphtheria is 2 to 4 days, although it can range from 1 to 6 days. Pathogenesis. ...
Challenges in Infectious Disease: Need for Imaging
Challenges in Infectious Disease: Need for Imaging

... • Does diagnosis and monitoring of infections in special situations (hard to get locations, difficult to grow bugs, e.g. M.tb.) merit the development and / or use of technologies, that may be different from those being developed currently? ...
BACTERIAL DISEASES (OTHER THAN MYCOPLASMA)
BACTERIAL DISEASES (OTHER THAN MYCOPLASMA)

... Salmonella are responsible for a number of diseases in humans. In addition to causing typhoid fever, infection can present as acute diarrhea or in more severe cases as septicemia, meningitis, reactive arthritis, osteomyelitis, and endocarditis. With respect to the gastroenteritis, the incubation per ...
spleen
spleen

... spleenic anurysm, TB, old infarct of SCA…etc.) -soft tissue shadow at upper lt. hypochonderial area -descending colonic gas shadows -obliteration of the psoas shadow ...
Scientific dogmas, paradoxes and mysteries of latent
Scientific dogmas, paradoxes and mysteries of latent

... the most important form of Mtb latency is that occurring between primary infection and the emergence of postprimary, usually infectious, pulmonary TB. The classical rationale of preventing emergence of active disease from a latent state involves administering a limited duration course of a single or ...
Collin-Jamal Smith The Role of Ferroportin in Macrophage
Collin-Jamal Smith The Role of Ferroportin in Macrophage

... responses. One role of macrophages in the reticuloendothelial system (spleen, liver, bone marrow, and other lymphoid tissues) is eryptosis, or the phagocytosis and elimination of senescent erythrocytes in circulation; a consequence of this is the elevation of intracellular iron (Fe2+) levels. The ir ...
Introduction
Introduction

... may remain positive for up to 20 years after the infection has been cured. • An assay that detects worm antigens with monoclonal antibodies is also available and can be used in conjunction with the intradermal skin test. ...
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Tuberculosis



Tuberculosis, MTB, or TB (short for tubercle bacillus), in the past also called phthisis, phthisis pulmonalis, or consumption, is a widespread, infectious disease caused by various strains of mycobacteria, usually Mycobacterium tuberculosis. Tuberculosis typically attacks the lungs, but can also affect other parts of the body. It is spread through the air when people who have an active TB infection cough, sneeze, or otherwise transmit respiratory fluids through the air. Most infections do not have symptoms, known as latent tuberculosis. About one in ten latent infections eventually progresses to active disease which, if left untreated, kills more than 50% of those so infected.The classic symptoms of active TB infection are a chronic cough with blood-tinged sputum, fever, night sweats, and weight loss (the last of these giving rise to the formerly common term for the disease, ""consumption""). Infection of other organs causes a wide range of symptoms. Diagnosis of active TB relies on radiology (commonly chest X-rays), as well as microscopic examination and microbiological culture of body fluids. Diagnosis of latent TB relies on the tuberculin skin test (TST) and/or blood tests. Treatment is difficult and requires administration of multiple antibiotics over a long period of time. Household, workplace and social contacts are also screened and treated if necessary. Antibiotic resistance is a growing problem in multiple drug-resistant tuberculosis (MDR-TB) infections. Prevention relies on early detection and treatment of cases and on screening programs and vaccination with the bacillus Calmette-Guérin vaccine.One-third of the world's population is thought to have been infected with M. tuberculosis, and new infections occur in about 1% of the population each year. In 2007, an estimated 13.7 million chronic cases were active globally, while in 2013, an estimated 9 million new cases occurred. In 2013 there were between 1.3 and 1.5 million associated deaths, most of which occurred in developing countries. The total number of tuberculosis cases has been decreasing since 2006, and new cases have decreased since 2002. The rate of tuberculosis in different areas varies across the globe; about 80% of the population in many Asian and African countries tests positive in tuberculin tests, while only 5–10% of the United States population tests positive. More people in the developing world contract tuberculosis because of a poor immune system, largely due to high rates of HIV infection and the corresponding development of AIDS.
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