Quantitative Structure-Activity Relationship Modeling to Predict Drug-Drug Interactions
... to market more quickly and at a lesser cost. A data set of 6,532 drugs was obtained from DrugBank for which 292 QSAR descriptors were calculated. The multi-label support vector machines (SVM) method was used for classification and the K-means method was used to cluster the data. The model was valida ...
... to market more quickly and at a lesser cost. A data set of 6,532 drugs was obtained from DrugBank for which 292 QSAR descriptors were calculated. The multi-label support vector machines (SVM) method was used for classification and the K-means method was used to cluster the data. The model was valida ...
Prodrugs - ISpatula
... • Problem: - Epinephrine is poorly absorbed through eye tissues - Catechols are unstable • Solution: The increased lipophilicity relative to epinephnine allows the drug to move across the membrane of the eye easily and achieve higher ...
... • Problem: - Epinephrine is poorly absorbed through eye tissues - Catechols are unstable • Solution: The increased lipophilicity relative to epinephnine allows the drug to move across the membrane of the eye easily and achieve higher ...
FORMULATION AND EVALUATION OF FLUCONAZOLE TOPICAL GEL Research Article DOAA A. HELAL
... classes: systemic and superficial. Consequently, the major antifungal agents are classified into systemic and topical drugs7. Antifungal drugs are classified according to their chemical structure as: polyene antifungals, azole antifungals, allylamine antifungals, echinocandin antifungals and others8 ...
... classes: systemic and superficial. Consequently, the major antifungal agents are classified into systemic and topical drugs7. Antifungal drugs are classified according to their chemical structure as: polyene antifungals, azole antifungals, allylamine antifungals, echinocandin antifungals and others8 ...
Human Pregnane X Receptor - Clinical Cancer Research
... Results: The current study showed that paclitaxel, discodermolide, and an analogue of epothilone B, BMS-247550, induced CYP3A4 protein expression in HepG2 hepatoma cells. Transient transcription assays of a luciferase reporter in the presence and absence of a GAL4-steroid and xenobiotic receptor (SX ...
... Results: The current study showed that paclitaxel, discodermolide, and an analogue of epothilone B, BMS-247550, induced CYP3A4 protein expression in HepG2 hepatoma cells. Transient transcription assays of a luciferase reporter in the presence and absence of a GAL4-steroid and xenobiotic receptor (SX ...
Anthelmintic drugs
... And they may cause heart toxicity, so that they are only used in severe amebic infection and when metronidazole is no effect. ...
... And they may cause heart toxicity, so that they are only used in severe amebic infection and when metronidazole is no effect. ...
Jubilant HollisterStier, LLC 11/27/13
... standards of sanitization and disinfection in the controlled area. We are also aware of the unexplained increased levels of Unknown (b)(4) Impurities (b)(4) in (b)(4). We understand that you withdrew (b)(4) lots of (b)(4) from the market and expiry was reduced from (b)(4) to (b)(4) months in respons ...
... standards of sanitization and disinfection in the controlled area. We are also aware of the unexplained increased levels of Unknown (b)(4) Impurities (b)(4) in (b)(4). We understand that you withdrew (b)(4) lots of (b)(4) from the market and expiry was reduced from (b)(4) to (b)(4) months in respons ...
Syllabus of the International Chemistry Olympiad
... give micelles, how a hard coating can be made, and how fuel cells can produce electricity. In the practical problems microscale equipment will be used. The synthesis of some organic compounds, the use of thin-layer chromatography, the quantitative analysis using spectroscopic methods and the use of ...
... give micelles, how a hard coating can be made, and how fuel cells can produce electricity. In the practical problems microscale equipment will be used. The synthesis of some organic compounds, the use of thin-layer chromatography, the quantitative analysis using spectroscopic methods and the use of ...
Introduction to the newest anticonvulsants
... Barbara Lynne Phillips, M.D. Assistant Professor of Neurology WSU BSOM ...
... Barbara Lynne Phillips, M.D. Assistant Professor of Neurology WSU BSOM ...
Chapter 1 notes
... • Students will be able to… – Understand matter, its phases, and composition – Know the differences quantitative and qualitative expressions – Explain the if something is a substance or a mixture – Know the differences between homogeneous and heterogeneous mixtures ...
... • Students will be able to… – Understand matter, its phases, and composition – Know the differences quantitative and qualitative expressions – Explain the if something is a substance or a mixture – Know the differences between homogeneous and heterogeneous mixtures ...
Macrolide Antibiotics - Christchurch Drug Information Service
... Erythromycin’s oral availability is affected by food in different ways depending upon the formulation used (ie. decreased with the base forms and increased with the estolate form). A short half-life (1-1.5h) means dosing four times daily is generally required. Roxithromycin has good oral availabilit ...
... Erythromycin’s oral availability is affected by food in different ways depending upon the formulation used (ie. decreased with the base forms and increased with the estolate form). A short half-life (1-1.5h) means dosing four times daily is generally required. Roxithromycin has good oral availabilit ...
TLC of Analgesics
... temperature. Because the invading organisms are more susceptible to high temperatures than your own uninfected cells, this increase in temperature serves as one of the body's methods of ridding itself of invading organisms. Thus, while taking an analgesic drug serves to reduce symptoms associated wi ...
... temperature. Because the invading organisms are more susceptible to high temperatures than your own uninfected cells, this increase in temperature serves as one of the body's methods of ridding itself of invading organisms. Thus, while taking an analgesic drug serves to reduce symptoms associated wi ...
PowerPoint
... substance such as dirt, kitty litter, or used coffee grounds; 2. Place the mixture in a container such as a sealed plastic bag 3. Throw the container in your household trash; 4. Scratch out all personal information on the prescription label of your empty pill bottle or empty medicine packaging to ma ...
... substance such as dirt, kitty litter, or used coffee grounds; 2. Place the mixture in a container such as a sealed plastic bag 3. Throw the container in your household trash; 4. Scratch out all personal information on the prescription label of your empty pill bottle or empty medicine packaging to ma ...
Prescription Drugs: Abuse and Addiction
... their psychoactive effects. This typically means taking doses higher than recommended or combining OTC medications with alcohol, or with illicit or prescription drugs. Either practice can have dangerous results, depending on the medications involved. Some contain aspirin or acetaminophen (e.g., Tyle ...
... their psychoactive effects. This typically means taking doses higher than recommended or combining OTC medications with alcohol, or with illicit or prescription drugs. Either practice can have dangerous results, depending on the medications involved. Some contain aspirin or acetaminophen (e.g., Tyle ...
From coercion to cohesion Treating drug dependence through
... not necessarily mean that treatment is compulsory or that it involves the deprivation of liberty of an individual: individuals still have a choice between accepting treatment, or facing imprisonment or other administrative sanctions. Treatment as an alternative to criminal justice sanctions represen ...
... not necessarily mean that treatment is compulsory or that it involves the deprivation of liberty of an individual: individuals still have a choice between accepting treatment, or facing imprisonment or other administrative sanctions. Treatment as an alternative to criminal justice sanctions represen ...
WHAT ARE INHALANTS? - Florida Alcohol and Drug Abuse
... females have been converging over the past 20 years. Although the use of inhalants rose steadily in the early 1990's, its use peaked in 1997 and has declined significantly since then. The Drug Abuse Warning Network (DAWN) emergency department data in 1994 reported that there were 1,511 reported ment ...
... females have been converging over the past 20 years. Although the use of inhalants rose steadily in the early 1990's, its use peaked in 1997 and has declined significantly since then. The Drug Abuse Warning Network (DAWN) emergency department data in 1994 reported that there were 1,511 reported ment ...
Expanded Access - Treatment Use of Drug or Biologic
... (1) Open Label Protocol Or Open Protocol IND These are usually uncontrolled studies, carried out to obtain additional safety data (Phase 3 studies). They are typically used when the controlled trial has ended and treatment is continued so that the subjects and the controls may continue to receive th ...
... (1) Open Label Protocol Or Open Protocol IND These are usually uncontrolled studies, carried out to obtain additional safety data (Phase 3 studies). They are typically used when the controlled trial has ended and treatment is continued so that the subjects and the controls may continue to receive th ...
Pharmacological Approaches to Stuttering
... Combinations of medications can be fatal None of these drugs were designed for stuttering or were approved by the FDA to treat stuttering Faulty theoretical justifications Poor empirical support Weak research designs provide weak positive ...
... Combinations of medications can be fatal None of these drugs were designed for stuttering or were approved by the FDA to treat stuttering Faulty theoretical justifications Poor empirical support Weak research designs provide weak positive ...
Polyscias balfouriana
... shows highly positive results for triterpenoids and gave good colour reactions for Salkowsky test and Liebermann burchard test. Adaptogenic activity The medicinal substances causing a state of non specifically increased resistance (SNIR) are named as Adaptogens or Athenktropics. [5] Adaptogens are t ...
... shows highly positive results for triterpenoids and gave good colour reactions for Salkowsky test and Liebermann burchard test. Adaptogenic activity The medicinal substances causing a state of non specifically increased resistance (SNIR) are named as Adaptogens or Athenktropics. [5] Adaptogens are t ...
endangered ayurvedic medicinal plant kutaki (picrorhiza kurroa)
... protective effect of P. Kurroa might be ascribable to its membrane-stabilizing property and/or antioxidant nature.[8] Apocynin and Cancer: Klees et al. reported that while apocynin itself is not effective, its derivatives inhibit migration of the breast cancer cell line MDAMB-435 at subtoxic concent ...
... protective effect of P. Kurroa might be ascribable to its membrane-stabilizing property and/or antioxidant nature.[8] Apocynin and Cancer: Klees et al. reported that while apocynin itself is not effective, its derivatives inhibit migration of the breast cancer cell line MDAMB-435 at subtoxic concent ...
Herbal Plants Used as Diuretics: A comprehensive Review
... Medicinal herbs are the significant source as Diuretics. Mono and poly-herbal preparations have been used as diuretics. According to one estimate, more than 650 mono and poly-herbal preparations in the form of decoction, tincture, tablets and capsules from more than 75 plants are in clinical use. Th ...
... Medicinal herbs are the significant source as Diuretics. Mono and poly-herbal preparations have been used as diuretics. According to one estimate, more than 650 mono and poly-herbal preparations in the form of decoction, tincture, tablets and capsules from more than 75 plants are in clinical use. Th ...
Rapid determination of Ziprasidone and Buclizine Hydrochloride in
... 100 ml volumetric flask. Added about 80 ml of warm isopropyl alcohol (ZPD) and CHCl3 (BUCZ) and shaken well for about 20 minutes. The contents were diluted with isopropyl alcohol and chloroform upto the mark and mixed thoroughly. The solutions were filtered. The filtrates were evaporated to dryness. ...
... 100 ml volumetric flask. Added about 80 ml of warm isopropyl alcohol (ZPD) and CHCl3 (BUCZ) and shaken well for about 20 minutes. The contents were diluted with isopropyl alcohol and chloroform upto the mark and mixed thoroughly. The solutions were filtered. The filtrates were evaporated to dryness. ...
Quick Overview of Bioinformatics
... Remove errors Compare with database of ‘known function proteins’ • Provide transitive annotations ...
... Remove errors Compare with database of ‘known function proteins’ • Provide transitive annotations ...
THE KOREAN HERBAL PHARMACOPOEIA
... 5. When the contents or the potency in terms of units of the active ingredients, or the expiration date is specified in the official monographs of the Korean Pharmacopoeia, these statements should be shown on the immediate container or wrapping. 6. The names of drugs or chemicals followed by molecul ...
... 5. When the contents or the potency in terms of units of the active ingredients, or the expiration date is specified in the official monographs of the Korean Pharmacopoeia, these statements should be shown on the immediate container or wrapping. 6. The names of drugs or chemicals followed by molecul ...
Antiseizure Drugs
... CNS is accomplished without major disturbances in the normal electrical activity. • In fact antiseizure drugs inhibit sustained, high-frequency, repetitive firing much more effectively than low-frequency, nonrepetitive firing. ...
... CNS is accomplished without major disturbances in the normal electrical activity. • In fact antiseizure drugs inhibit sustained, high-frequency, repetitive firing much more effectively than low-frequency, nonrepetitive firing. ...
Drug discovery
In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which new candidate medications are discovered. Historically, drugs were discovered through identifying the active ingredient from traditional remedies or by serendipitous discovery. Later chemical libraries of synthetic small molecules, natural products or extracts were screened in intact cells or whole organisms to identify substances that have a desirable therapeutic effect in a process known as classical pharmacology. Since sequencing of the human genome which allowed rapid cloning and synthesis of large quantities of purified proteins, it has become common practice to use high throughput screening of large compounds libraries against isolated biological targets which are hypothesized to be disease modifying in a process known as reverse pharmacology. Hits from these screens are then tested in cells and then in animals for efficacy.Modern drug discovery involves the identification of screening hits, medicinal chemistry and optimization of those hits to increase the affinity, selectivity (to reduce the potential of side effects), efficacy/potency, metabolic stability (to increase the half-life), and oral bioavailability. Once a compound that fulfills all of these requirements has been identified, it will begin the process of drug development prior to clinical trials. One or more of these steps may, but not necessarily, involve computer-aided drug design. Modern drug discovery is thus usually a capital-intensive process that involves large investments by pharmaceutical industry corporations as well as national governments (who provide grants and loan guarantees). Despite advances in technology and understanding of biological systems, drug discovery is still a lengthy, ""expensive, difficult, and inefficient process"" with low rate of new therapeutic discovery. In 2010, the research and development cost of each new molecular entity (NME) was approximately US$1.8 billion. Drug discovery is done by pharmaceutical companies, with research assistance from universities. The ""final product"" of drug discovery is a patent on the potential drug. The drug requires very expensive Phase I, II and III clinical trials, and most of them fail. Small companies have a critical role, often then selling the rights to larger companies that have the resources to run the clinical trials.Discovering drugs that may be a commercial success, or a public health success, involves a complex interaction between investors, industry, academia, patent laws, regulatory exclusivity, marketing and the need to balance secrecy with communication. Meanwhile, for disorders whose rarity means that no large commercial success or public health effect can be expected, the orphan drug funding process ensures that people who experience those disorders can have some hope of pharmacotherapeutic advances.