Pharmacy history
... congress to pass the pure food and drug act in 1906. In Germany, new discoveries in organic chemistry were making ...
... congress to pass the pure food and drug act in 1906. In Germany, new discoveries in organic chemistry were making ...
Managing Medication Use
... systems often use rules to determine when pop-ups will occur. These pop-ups may contain clinical information about medication use, potential drug interactions, recommended monitoring, etc. ■■ Stop orders: Physician orders that are automatically terminated. The P&T committee may establish stop orders ...
... systems often use rules to determine when pop-ups will occur. These pop-ups may contain clinical information about medication use, potential drug interactions, recommended monitoring, etc. ■■ Stop orders: Physician orders that are automatically terminated. The P&T committee may establish stop orders ...
Highlights of PET studies on chiral radiotracers and drugs at
... animal species. It also enables the assessment of drug behavior in diseases where there are no animal models. This information is not available with other methods and places PET in a unique position to streamline the process of drug development and evaluation. PET has also found increased applicatio ...
... animal species. It also enables the assessment of drug behavior in diseases where there are no animal models. This information is not available with other methods and places PET in a unique position to streamline the process of drug development and evaluation. PET has also found increased applicatio ...
IMS LifeCycle Content, Sources, Updates
... • Historical data - records not updated - hence always showing original companies and initial pack info at launch IMS LifeCycle • 5/23/2017 ...
... • Historical data - records not updated - hence always showing original companies and initial pack info at launch IMS LifeCycle • 5/23/2017 ...
13th Lecture 1436
... A primary action of isoniazid is to inhibit the biosynthesis of mycolic acids, which are long, branched lipids that are attached to a unique polysaccharide, arabino galactan, to form part of the mycobacterial cell wall Mycolic acids are unique to mycobacteria, explaining the high degree of selec ...
... A primary action of isoniazid is to inhibit the biosynthesis of mycolic acids, which are long, branched lipids that are attached to a unique polysaccharide, arabino galactan, to form part of the mycobacterial cell wall Mycolic acids are unique to mycobacteria, explaining the high degree of selec ...
3_01_1
... • “With all the steps you’re talking about you’ve now made the process take ten times longer than it takes right now. The whole idea of doing it is to simplify matters. Writing a prescription down takes 15 seconds. To do all this other stuff is going to take 3 or 4 minutes.” – Potential for error: p ...
... • “With all the steps you’re talking about you’ve now made the process take ten times longer than it takes right now. The whole idea of doing it is to simplify matters. Writing a prescription down takes 15 seconds. To do all this other stuff is going to take 3 or 4 minutes.” – Potential for error: p ...
Stimulants - CAP Members
... sensation known as a “rush” or a “flash.” Abuse is often associated with a pattern of binge use —sporadically consuming large doses of stimulants over a short period of time. Heavy users may inject themselves every few hours, continuing until they have depleted their drug supply or reached a point o ...
... sensation known as a “rush” or a “flash.” Abuse is often associated with a pattern of binge use —sporadically consuming large doses of stimulants over a short period of time. Heavy users may inject themselves every few hours, continuing until they have depleted their drug supply or reached a point o ...
ABC multidrug transporters: structure, function and role in
... identified). Several ABC proteins are multidrug efflux pumps that not only protect the body from exogenous toxins, but also play an important role in the uptake and distribution of therapeutic drugs [5]. They can, therefore, profoundly affect drug therapy, and resistance to treatment by multiple dru ...
... identified). Several ABC proteins are multidrug efflux pumps that not only protect the body from exogenous toxins, but also play an important role in the uptake and distribution of therapeutic drugs [5]. They can, therefore, profoundly affect drug therapy, and resistance to treatment by multiple dru ...
Setor 11. Farmacologia Clínica, Farmacocinética
... Introduction: According to World Health Organization the infertility reaches 15% of active sex life population and 50 % of these cases are caused by male factor as primary factor or in association with female ones. About one-third of reproductive age people smoke cigarettes and it can also be involv ...
... Introduction: According to World Health Organization the infertility reaches 15% of active sex life population and 50 % of these cases are caused by male factor as primary factor or in association with female ones. About one-third of reproductive age people smoke cigarettes and it can also be involv ...
DEVELOPMENT AND VALIDATION OF DERIVATIVE SPECTROPHOTOMETRIC METHOD FOR
... in treatment of hypertension. The present communication deals with development of simple, sensitive, rapid and economical method for simultaneous estimation of atorvastatin calcium and amlodipine besylate in combined dosage form. The AT and AM stock solutions are prepared in (50:50 V/V) methanol: wa ...
... in treatment of hypertension. The present communication deals with development of simple, sensitive, rapid and economical method for simultaneous estimation of atorvastatin calcium and amlodipine besylate in combined dosage form. The AT and AM stock solutions are prepared in (50:50 V/V) methanol: wa ...
Common Drugs of Abuse
... which a baby can suffer from dependence and withdrawal symptoms after birth. Pregnancy-related issues are listed in the chart below for drugs where there is enough scientific evidence to connect the drug use to negative effects. However, most drugs could potentially harm an unborn baby. In the chart ...
... which a baby can suffer from dependence and withdrawal symptoms after birth. Pregnancy-related issues are listed in the chart below for drugs where there is enough scientific evidence to connect the drug use to negative effects. However, most drugs could potentially harm an unborn baby. In the chart ...
Straight Facts About Drugs and Drug Abuse
... major social concern. The widespread availability and use of drugs means that drug-related problems will impact all Canadians in one way or another. As a result, there is a need for accurate information about different types of drugs and their effects, how people use them, and how they can affect ou ...
... major social concern. The widespread availability and use of drugs means that drug-related problems will impact all Canadians in one way or another. As a result, there is a need for accurate information about different types of drugs and their effects, how people use them, and how they can affect ou ...
Antimicrobial Agents
... Drug interaction • Ciprofloxacin is a liver enzyme inhibitor and may cause life-threatening interaction with theophylline. ...
... Drug interaction • Ciprofloxacin is a liver enzyme inhibitor and may cause life-threatening interaction with theophylline. ...
High-dose antipsychotic medication
... All known antipsychotic drugs are antagonists at D2receptors, but their selectivity and potency vary considerably. By 'selectivity' is meant the 'cleanliness' of their pharmacology - what receptors other than D2 receptors the drug might block. 'Potency' is a complex property, reflecting the bioavail ...
... All known antipsychotic drugs are antagonists at D2receptors, but their selectivity and potency vary considerably. By 'selectivity' is meant the 'cleanliness' of their pharmacology - what receptors other than D2 receptors the drug might block. 'Potency' is a complex property, reflecting the bioavail ...
Average, population and individual bioequivalence
... recommended. On the other hand, for large therapeutic range drugs, such as oral antibiotics, antacids, antihistaminic agents and some analgesics, more flexible limits have been suggested.13 Literature shows that assessing bioequivalence for drugs with a high pharmacokinetic variability, such as vera ...
... recommended. On the other hand, for large therapeutic range drugs, such as oral antibiotics, antacids, antihistaminic agents and some analgesics, more flexible limits have been suggested.13 Literature shows that assessing bioequivalence for drugs with a high pharmacokinetic variability, such as vera ...
COTAZYM
... will transmit an infectious agent to humans has been reduced by the testing and inactivation of certain viruses during manufacturing, there is a theoretical risk for transmission of viral disease, including diseases caused by novel or unidentified viruses. The presence of porcine viruses that might ...
... will transmit an infectious agent to humans has been reduced by the testing and inactivation of certain viruses during manufacturing, there is a theoretical risk for transmission of viral disease, including diseases caused by novel or unidentified viruses. The presence of porcine viruses that might ...
Chemistry
... technological world rather than focusing on large quantities of factual material which may have only short term relevance. Experimental work is an important component and should underpin the teaching and learning of Chemistry. ...
... technological world rather than focusing on large quantities of factual material which may have only short term relevance. Experimental work is an important component and should underpin the teaching and learning of Chemistry. ...
Non-Clinical Investigation of the Dependence Potential of Medicinal
... Whether a medicinal product may cause a dependence syndrome or lead to drug abuse is also influenced by other factors, for instance clinical (e.g. the occurrence of side-effects), social (acceptability of use), economic (availability and costs), chemical (ease of synthesis) and pharmaceutical. As th ...
... Whether a medicinal product may cause a dependence syndrome or lead to drug abuse is also influenced by other factors, for instance clinical (e.g. the occurrence of side-effects), social (acceptability of use), economic (availability and costs), chemical (ease of synthesis) and pharmaceutical. As th ...
Presentation
... • RNA therapeutics as a platform is a revolutionary approach to discover new and important therapeutic agents for treating human diseases • RNA as a class of molecules plays a major role in the regulation of biological processes and in human diseases • Therapeutic approaches against RNA are generall ...
... • RNA therapeutics as a platform is a revolutionary approach to discover new and important therapeutic agents for treating human diseases • RNA as a class of molecules plays a major role in the regulation of biological processes and in human diseases • Therapeutic approaches against RNA are generall ...
Balancing the outcomes: reporting adverse events
... ITT methods should be routinely reported, and data for treatment actually received should be added, with an explanation as to why, if there are high rates of non-compliance. Treatment withdrawal after adverse events Adverse events resulting in withdrawals from treatment should also be adequately des ...
... ITT methods should be routinely reported, and data for treatment actually received should be added, with an explanation as to why, if there are high rates of non-compliance. Treatment withdrawal after adverse events Adverse events resulting in withdrawals from treatment should also be adequately des ...
ANISOCHILUS CARNOSUS TETRA CHLORIDE –INDUCED HEPATOTOXICITY IN ALBINO RATS Full Proceeding Paper
... lining the biliary ducts of the liver synthesise the enzyme Alkaline phosphatase (ALP). Bile duct obstruction or diseases of the liver result in an elevated level of ALP in the plasma. The increased activity of alkaline phosphatase, may be due to de novo synthesis by liver cells and is a reliable ma ...
... lining the biliary ducts of the liver synthesise the enzyme Alkaline phosphatase (ALP). Bile duct obstruction or diseases of the liver result in an elevated level of ALP in the plasma. The increased activity of alkaline phosphatase, may be due to de novo synthesis by liver cells and is a reliable ma ...
Benzodiazepines
... depressants that are commonly known as tranquilizers, sedatives, or anxiolytics Due to the sedative effects they produce, they are often used as “date rape” drugs Approximately 2,000 benzodiazepines have been produced but only 15 are marketed in the U.S Schedule IV Twice as many women as men ...
... depressants that are commonly known as tranquilizers, sedatives, or anxiolytics Due to the sedative effects they produce, they are often used as “date rape” drugs Approximately 2,000 benzodiazepines have been produced but only 15 are marketed in the U.S Schedule IV Twice as many women as men ...
Slides generic guide - Gerontological Nursing Association
... Always need to use the lowest possible dose and review frequently Most patients need these medications only for short periods (few months) ...
... Always need to use the lowest possible dose and review frequently Most patients need these medications only for short periods (few months) ...
Prescribing Information
... buspirone, and St. John’s Wort [see Drug Interactions (7.1)]. Amphetamines and amphetamine derivatives are known to be metabolized, to some degree, by cytochrome P450 2D6 (CYP2D6) [see Clinical Pharmacology 12.3]. The potential for a pharmacokinetic interaction exists with the coadministration of CY ...
... buspirone, and St. John’s Wort [see Drug Interactions (7.1)]. Amphetamines and amphetamine derivatives are known to be metabolized, to some degree, by cytochrome P450 2D6 (CYP2D6) [see Clinical Pharmacology 12.3]. The potential for a pharmacokinetic interaction exists with the coadministration of CY ...
Drug discovery
In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which new candidate medications are discovered. Historically, drugs were discovered through identifying the active ingredient from traditional remedies or by serendipitous discovery. Later chemical libraries of synthetic small molecules, natural products or extracts were screened in intact cells or whole organisms to identify substances that have a desirable therapeutic effect in a process known as classical pharmacology. Since sequencing of the human genome which allowed rapid cloning and synthesis of large quantities of purified proteins, it has become common practice to use high throughput screening of large compounds libraries against isolated biological targets which are hypothesized to be disease modifying in a process known as reverse pharmacology. Hits from these screens are then tested in cells and then in animals for efficacy.Modern drug discovery involves the identification of screening hits, medicinal chemistry and optimization of those hits to increase the affinity, selectivity (to reduce the potential of side effects), efficacy/potency, metabolic stability (to increase the half-life), and oral bioavailability. Once a compound that fulfills all of these requirements has been identified, it will begin the process of drug development prior to clinical trials. One or more of these steps may, but not necessarily, involve computer-aided drug design. Modern drug discovery is thus usually a capital-intensive process that involves large investments by pharmaceutical industry corporations as well as national governments (who provide grants and loan guarantees). Despite advances in technology and understanding of biological systems, drug discovery is still a lengthy, ""expensive, difficult, and inefficient process"" with low rate of new therapeutic discovery. In 2010, the research and development cost of each new molecular entity (NME) was approximately US$1.8 billion. Drug discovery is done by pharmaceutical companies, with research assistance from universities. The ""final product"" of drug discovery is a patent on the potential drug. The drug requires very expensive Phase I, II and III clinical trials, and most of them fail. Small companies have a critical role, often then selling the rights to larger companies that have the resources to run the clinical trials.Discovering drugs that may be a commercial success, or a public health success, involves a complex interaction between investors, industry, academia, patent laws, regulatory exclusivity, marketing and the need to balance secrecy with communication. Meanwhile, for disorders whose rarity means that no large commercial success or public health effect can be expected, the orphan drug funding process ensures that people who experience those disorders can have some hope of pharmacotherapeutic advances.