John Salamone: Dopamine, Motivation and Schizophrenia
... antipsychotics based upon their mesolimbic actions; perhaps antipsychotic effects are due to actions on other systems (e.g. mesocortical DA). • They are related; the core antipsychotic effect could be directly dependent upon the fundamental motivational effects of D2 antagonists, which can be studie ...
... antipsychotics based upon their mesolimbic actions; perhaps antipsychotic effects are due to actions on other systems (e.g. mesocortical DA). • They are related; the core antipsychotic effect could be directly dependent upon the fundamental motivational effects of D2 antagonists, which can be studie ...
07.14.04 HI PA Program Web - himed
... ALLEGRA fexofenadine) for conditions other than chronic urticaria and angioedema ALLEGRA-D (fexofenadine with decongestant) CLARITIN and CLARITIN-D (loratadine Federal Legend) CLARINEX (desloratidine) CLARITIN/ALEVERT OTC (loratadine OTC) for ages 21 through 60 ZYRTEC (cetirizine) for conditions oth ...
... ALLEGRA fexofenadine) for conditions other than chronic urticaria and angioedema ALLEGRA-D (fexofenadine with decongestant) CLARITIN and CLARITIN-D (loratadine Federal Legend) CLARINEX (desloratidine) CLARITIN/ALEVERT OTC (loratadine OTC) for ages 21 through 60 ZYRTEC (cetirizine) for conditions oth ...
Preparation and Characterisation of Mucoadhesive Nasal Gel of
... single dose formulation was however, effective in overcoming nausea and other gastrointestinal disturbances associated with venlafaxine [3]. After oral administration, venlafaxine undergoes extensive presystemic metabolism in the liver. Based on the mass balance studies, it was found that about 92% ...
... single dose formulation was however, effective in overcoming nausea and other gastrointestinal disturbances associated with venlafaxine [3]. After oral administration, venlafaxine undergoes extensive presystemic metabolism in the liver. Based on the mass balance studies, it was found that about 92% ...
Imipramine Hydrochloride Imipramine Pamoate
... average dosages and may obtain satisfactory improvement with 25-50 mg of doxepin daily. The manufacturers state that appropriate dosage in geriatric patients should be selected with caution, usually initiating therapy at the low end of the dosage range since decreased hepatic, renal, or cardiac func ...
... average dosages and may obtain satisfactory improvement with 25-50 mg of doxepin daily. The manufacturers state that appropriate dosage in geriatric patients should be selected with caution, usually initiating therapy at the low end of the dosage range since decreased hepatic, renal, or cardiac func ...
Antipsychotic Drugs - Pharmacological Reviews
... shows that the selectivity is low and had been overestimated previously owing to overestimation of the Ki at the D2 receptor when determined in competition versus [3H]spiperone. Problems with the use of high-affinity ligands can also be seen in the in vivo scanning techniques. For example, some of t ...
... shows that the selectivity is low and had been overestimated previously owing to overestimation of the Ki at the D2 receptor when determined in competition versus [3H]spiperone. Problems with the use of high-affinity ligands can also be seen in the in vivo scanning techniques. For example, some of t ...
Front Matter
... those who were afflicted. That rice diets were the key to understanding the cause of the disease should have been evident from the study conducted in 1873 by van Leent, a Dutch naval surgeon who traced the high mortality from beriberi among Indian crews to their rice diet.4 Simply by putting them on ...
... those who were afflicted. That rice diets were the key to understanding the cause of the disease should have been evident from the study conducted in 1873 by van Leent, a Dutch naval surgeon who traced the high mortality from beriberi among Indian crews to their rice diet.4 Simply by putting them on ...
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)
... myoclonic epilepsy, arecommon. Partial epilepsy may arise from any disease of the cerebral cortex, congenital or acquired, and frequently generalize. Partial seizures signify the presence of focal cerebral pathology. Secondary generalized epilepsy may arise from spread of partialseizures due to stru ...
... myoclonic epilepsy, arecommon. Partial epilepsy may arise from any disease of the cerebral cortex, congenital or acquired, and frequently generalize. Partial seizures signify the presence of focal cerebral pathology. Secondary generalized epilepsy may arise from spread of partialseizures due to stru ...
our guide to drug detox.
... program, as well as the use of detox medications to help reduce the effects of withdrawal. Some people do attempt detox at home, although it’s important to understand that withdrawal symptoms for various drugs can be dangerous. It’s also more difficult to detox at home if you are experiencing other ...
... program, as well as the use of detox medications to help reduce the effects of withdrawal. Some people do attempt detox at home, although it’s important to understand that withdrawal symptoms for various drugs can be dangerous. It’s also more difficult to detox at home if you are experiencing other ...
NIDA Research Report - MDMA
... deceptive reputation as a “safe” drug among its users. This illegal drug, which has both stimulant and psychedelic properties, is often taken for the feelings of well-being, stimulation, and the distortions in time and sensory perceptions that it produces. MDMA first became popular in the “rave” and ...
... deceptive reputation as a “safe” drug among its users. This illegal drug, which has both stimulant and psychedelic properties, is often taken for the feelings of well-being, stimulation, and the distortions in time and sensory perceptions that it produces. MDMA first became popular in the “rave” and ...
Low doses of esmolol and phenylephrine act as
... hours in the control group (9%) was similar to that found for acetated Ringer’s during laparoscopic cholecystectomy [2] and thyroid surgery [3]. However, even with the two treatment drugs, urinary excretion was still far below the 50% to 70% of the infused volume seen within 3 hours in unstressed vo ...
... hours in the control group (9%) was similar to that found for acetated Ringer’s during laparoscopic cholecystectomy [2] and thyroid surgery [3]. However, even with the two treatment drugs, urinary excretion was still far below the 50% to 70% of the infused volume seen within 3 hours in unstressed vo ...
Expert Opin. Ther. Pat. 2016, 27, 179–189
... required to maintain therapeutic concentrations at specific locations. This, in turn, leads to increased side effects, frequently related with the concomitant damage to commensal human microbiota. Hence, among the most common side effects are the ones that affect the gastrointestinal tract, namely, ...
... required to maintain therapeutic concentrations at specific locations. This, in turn, leads to increased side effects, frequently related with the concomitant damage to commensal human microbiota. Hence, among the most common side effects are the ones that affect the gastrointestinal tract, namely, ...
Injections
... Patients whose blood glucose levels are well controlled on a mixed-insulin dose need to maintain their individual routine when preparing and administering their insulin. Do not mix insulin with any other medications or diluents unless approved by the prescriber. Verify insulin doses with another nur ...
... Patients whose blood glucose levels are well controlled on a mixed-insulin dose need to maintain their individual routine when preparing and administering their insulin. Do not mix insulin with any other medications or diluents unless approved by the prescriber. Verify insulin doses with another nur ...
Spectrophotometric Determination of Lorsartan Potassium
... Analysis of formulation and recovery studies Three different brands of losartan potassium tablets were taken for analysis. They are covance-25 mg, losar-50 mg and repace-25 mg and the tablets were powdered gently in a glass mortar. The tablet powder equivalent to 10 mg of losartan potassium was weig ...
... Analysis of formulation and recovery studies Three different brands of losartan potassium tablets were taken for analysis. They are covance-25 mg, losar-50 mg and repace-25 mg and the tablets were powdered gently in a glass mortar. The tablet powder equivalent to 10 mg of losartan potassium was weig ...
section 1: treatment of depression
... This guidance should be considered as part of a stepped care approach in the management of depressive disorders. Antidepressants are not routinely recommended for persistent sub-threshold depressive symptoms or mild depression but can be considered in these categories where there is a past history o ...
... This guidance should be considered as part of a stepped care approach in the management of depressive disorders. Antidepressants are not routinely recommended for persistent sub-threshold depressive symptoms or mild depression but can be considered in these categories where there is a past history o ...
A SURVEY BASED STUDY IN CURRENT SCENARIO OF GENERIC AND... Research Article
... same active ingredients and are shown to work the same way in the body, they have the same risks and benefits as their brand name counterparts. Also, generic drugs have the same quality, strength, purity and stability as brand name drugs. It is seen that Generic Drugs work in the same way and in the ...
... same active ingredients and are shown to work the same way in the body, they have the same risks and benefits as their brand name counterparts. Also, generic drugs have the same quality, strength, purity and stability as brand name drugs. It is seen that Generic Drugs work in the same way and in the ...
4: Central nervous system - Gateshead Health NHS Foundation Trust
... pharmacodynamic interactions (serotonin syndrome, hypotension, drowsiness) and pharmacokinetic interactions (e.g. elevation of tricyclic plasma levels by some SSRIs). The serotonin syndrome may include restlessness, diaphoresis, tremor, shivering, myoclonus, confusion, convulsions and death. ...
... pharmacodynamic interactions (serotonin syndrome, hypotension, drowsiness) and pharmacokinetic interactions (e.g. elevation of tricyclic plasma levels by some SSRIs). The serotonin syndrome may include restlessness, diaphoresis, tremor, shivering, myoclonus, confusion, convulsions and death. ...
ROXICET™ Oxycodone 5 mg and Acetaminophen 325 mg Tablets
... effects of oxycodone include anxiolysis, euphoria and feelings of relaxation. These effects are mediated by receptors (notably µ and k) in the central nervous system for endogenous opioid-like compounds such as endorphins and enkephalins. Oxycodone produces respiratory depression through direct acti ...
... effects of oxycodone include anxiolysis, euphoria and feelings of relaxation. These effects are mediated by receptors (notably µ and k) in the central nervous system for endogenous opioid-like compounds such as endorphins and enkephalins. Oxycodone produces respiratory depression through direct acti ...
ANZCOR Guideline 11.5 – Medications in Adult Cardiac Arrest
... have not been able to control for the quality of cardiopulmonary resuscitation. Furthermore, most drug evaluations to date have been conducted before recent advances in post-cardiac arrest care including Targeted Temperature Management. Since most drug trials have, at most, demonstrated only short-t ...
... have not been able to control for the quality of cardiopulmonary resuscitation. Furthermore, most drug evaluations to date have been conducted before recent advances in post-cardiac arrest care including Targeted Temperature Management. Since most drug trials have, at most, demonstrated only short-t ...
PSUEDOMONAS AERUGINOSA INFECTIONS IN NIGERIA Original Article
... of the available drugs are becoming obsolete resulting from innate and/or acquired resistance. Drugs presently regarded as major antipseudomonas such as amikacin, imipenen and meropenem among others [9] are neither available in most of the health facilities nor affordable to majority of the populace ...
... of the available drugs are becoming obsolete resulting from innate and/or acquired resistance. Drugs presently regarded as major antipseudomonas such as amikacin, imipenen and meropenem among others [9] are neither available in most of the health facilities nor affordable to majority of the populace ...
Treating Chronic Pain
... NMDA receptor mechanisms are involved in the development of hyperalgesia/sensitization (as are opioid metabolites) NMDA receptor is also involved with opioid ...
... NMDA receptor mechanisms are involved in the development of hyperalgesia/sensitization (as are opioid metabolites) NMDA receptor is also involved with opioid ...
Drug interaction
A drug interaction is a situation in which a substance (usually another drug) affects the activity of a drug when both are administered together. This action can be synergistic (when the drug's effect is increased) or antagonistic (when the drug's effect is decreased) or a new effect can be produced that neither produces on its own. Typically, interactions between drugs come to mind (drug-drug interaction). However, interactions may also exist between drugs and foods (drug-food interactions), as well as drugs and medicinal plants or herbs (drug-plant interactions). People taking antidepressant drugs such as monoamine oxidase inhibitors should not take food containing tyramine as hypertensive crisis may occur (an example of a drug-food interaction). These interactions may occur out of accidental misuse or due to lack of knowledge about the active ingredients involved in the relevant substances.It is therefore easy to see the importance of these pharmacological interactions in the practice of medicine. If a patient is taking two drugs and one of them increases the effect of the other it is possible that an overdose may occur. The interaction of the two drugs may also increase the risk that side effects will occur. On the other hand, if the action of a drug is reduced it may cease to have any therapeutic use because of under dosage. Notwithstanding the above, on occasion these interactions may be sought in order to obtain an improved therapeutic effect. Examples of this include the use of codeine with paracetamol to increase its analgesic effect. Or the combination of clavulanic acid with amoxicillin in order to overcome bacterial resistance to the antibiotic. It should also be remembered that there are interactions that, from a theoretical standpoint, may occur but in clinical practice have no important repercussions.The pharmaceutical interactions that are of special interest to the practice of medicine are primarily those that have negative effects for an organism. The risk that a pharmacological interaction will appear increases as a function of the number of drugs administered to a patient at the same time.It is possible that an interaction will occur between a drug and another substance present in the organism (i.e. foods or alcohol). Or in certain specific situations a drug may even react with itself, such as occurs with dehydration. In other situations, the interaction does not involve any effect on the drug. In certain cases, the presence of a drug in an individual's blood may affect certain types of laboratory analysis (analytical interference).It is also possible for interactions to occur outside an organism before administration of the drugs has taken place. This can occur when two drugs are mixed, for example, in a saline solution prior to intravenous injection. Some classic examples of this type of interaction include that Thiopentone and Suxamethonium should not be placed in the same syringe and same is true for Benzylpenicillin and Heparin. These situations will all be discussed under the same heading due to their conceptual similarity.Drug interactions may be the result of various processes. These processes may include alterations in the pharmacokinetics of the drug, such as alterations in the absorption, distribution, metabolism, and excretion (ADME) of a drug. Alternatively, drug interactions may be the result of the pharmacodynamic properties of the drug, e.g. the co-administration of a receptor antagonist and an agonist for the same receptor.