women
... Takes 8-12 weeks to get therapeutic response Monitor CBC, platelets, renal & hepatic function ...
... Takes 8-12 weeks to get therapeutic response Monitor CBC, platelets, renal & hepatic function ...
TEMSIS
... Describe pharmacokinetics, pharmacodynamics, theories of drug action, drug-response relationship, factors altering drug responses, predictable drug responses, iatrogenic drug responses, and unpredictable adverse drug responses. Discuss considerations for storing drugs. List the components of a drug ...
... Describe pharmacokinetics, pharmacodynamics, theories of drug action, drug-response relationship, factors altering drug responses, predictable drug responses, iatrogenic drug responses, and unpredictable adverse drug responses. Discuss considerations for storing drugs. List the components of a drug ...
Lesson 2 Medical and Pharmacy Terminology
... drug products that minimizes microrganism contamination ...
... drug products that minimizes microrganism contamination ...
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
... •irritability, nervousness, restlessness •long-term intoxication can result in a schizophrenialike reaction ...
... •irritability, nervousness, restlessness •long-term intoxication can result in a schizophrenialike reaction ...
PowerPoint-esitys
... 1. multiple transporter proteins that transport the drug to the hepatocyte 2. drug metabolic enzymes 3. multiple transporter proteins that transport the drug/metabolite(s) from the hepatocyte ...
... 1. multiple transporter proteins that transport the drug to the hepatocyte 2. drug metabolic enzymes 3. multiple transporter proteins that transport the drug/metabolite(s) from the hepatocyte ...
Substance misuse
... regular excessive consumption of and/or dependence on – psychoactive substances, leading to social, psychological, physical or ...
... regular excessive consumption of and/or dependence on – psychoactive substances, leading to social, psychological, physical or ...
E7Step4
... Geriatric patients should be included in the Phase 3 database (and in Phase 2, at the sponsor's option) in meaningful numbers. The geriatric subpopulation should be represented sufficiently to permit the comparison of drug response in them to that of younger patients. For drugs used in diseases not ...
... Geriatric patients should be included in the Phase 3 database (and in Phase 2, at the sponsor's option) in meaningful numbers. The geriatric subpopulation should be represented sufficiently to permit the comparison of drug response in them to that of younger patients. For drugs used in diseases not ...
Form O IND
... An FDA approved IND indicates the FDA has determined that: (1) The patient or patients to be treated have a serious or immediately life-threatening disease or condition, and there is no comparable or satisfactory alternative therapy to diagnose, monitor, or treat the disease or condition; (2) The po ...
... An FDA approved IND indicates the FDA has determined that: (1) The patient or patients to be treated have a serious or immediately life-threatening disease or condition, and there is no comparable or satisfactory alternative therapy to diagnose, monitor, or treat the disease or condition; (2) The po ...
general toxicology
... A. Acute : single exposure Acute toxicity expressed as lethal dose – LD50 B. Subacute : less than 1 month C. Subchronic : 1 – 3 months D. Chronic : more than 3 months ...
... A. Acute : single exposure Acute toxicity expressed as lethal dose – LD50 B. Subacute : less than 1 month C. Subchronic : 1 – 3 months D. Chronic : more than 3 months ...
Review Notes Chapter 24: Alcohol, Tobacco, and Other Drug
... A. Depressants reduce a person’s energy level and sensitivity to outside stimulation. In low doses, they may produce a feeling of stimulation caused by initial sedation of the inhibitory centers of the brain. In higher doses, they lead to coma and, if vital organs shut down, death. 1. Alcohol. Alcoh ...
... A. Depressants reduce a person’s energy level and sensitivity to outside stimulation. In low doses, they may produce a feeling of stimulation caused by initial sedation of the inhibitory centers of the brain. In higher doses, they lead to coma and, if vital organs shut down, death. 1. Alcohol. Alcoh ...
rohypnol – flunitrazepam – (roofies)
... judgment and impaired motor skills and can make a victim unable to resist a sexual attack. The combination of alcohol and Rohypnol is also particularly hazardous because together, their effects on memory and judgment are greater than the effects resulting from either taken alone. Effects begin withi ...
... judgment and impaired motor skills and can make a victim unable to resist a sexual attack. The combination of alcohol and Rohypnol is also particularly hazardous because together, their effects on memory and judgment are greater than the effects resulting from either taken alone. Effects begin withi ...
Arrest Referral - Scottish Drugs Forum
... ► Real and Practical ► Full Drug Action Team support ► Police commitment across all levels (commander to turnkey) ► Good reporting on progress. ...
... ► Real and Practical ► Full Drug Action Team support ► Police commitment across all levels (commander to turnkey) ► Good reporting on progress. ...
Barbiturates
... • Benzodiazepines (drugs ending in “lam” or “pam” such as Diazepam)** • Benzodiazepine “Like” (zolpidem & zaleplon) • 5-HT1A partial agonist (buspirone丁螺环酮) ...
... • Benzodiazepines (drugs ending in “lam” or “pam” such as Diazepam)** • Benzodiazepine “Like” (zolpidem & zaleplon) • 5-HT1A partial agonist (buspirone丁螺环酮) ...
Weighing up the costs of switching AEDs
... the potential to produce a toxic effect. If the generic has 20% less absorption, it has the potential to affect seizure control and the patient may experience breakthrough seizures. Respected neuropharmacologist and epileptologist Professor Frank Vajda explains this concern. ‘Antiepileptic drugs are ...
... the potential to produce a toxic effect. If the generic has 20% less absorption, it has the potential to affect seizure control and the patient may experience breakthrough seizures. Respected neuropharmacologist and epileptologist Professor Frank Vajda explains this concern. ‘Antiepileptic drugs are ...
Age and Pharmacokinetics Pediatric and Geriatric
... “Polypharmacy” Multiple medications for multiple chronic diseases Multiple physicians Self-medication 12% of population receive 30% of all prescriptions. 2/3 use 1 or more drugs daily. • Ave 5 - 12 drugs daily • < 5% use no drugs. • 1/3 use 1 or more psychotropic drugs each year. ...
... “Polypharmacy” Multiple medications for multiple chronic diseases Multiple physicians Self-medication 12% of population receive 30% of all prescriptions. 2/3 use 1 or more drugs daily. • Ave 5 - 12 drugs daily • < 5% use no drugs. • 1/3 use 1 or more psychotropic drugs each year. ...
Nuplazid ™ - Pimavanserin Manufacturer
... • Drug Interactions – Object Drugs: None • Drug Interactions – Precipitant Drugs: • Strong CYP3A4 inhibitors: Cmax150%, ...
... • Drug Interactions – Object Drugs: None • Drug Interactions – Precipitant Drugs: • Strong CYP3A4 inhibitors: Cmax150%, ...
Causes of anaphylaxis
... Well distributed (including CNS) Extensive metabolism (rapid & slow acetylation) Average half-lives are less than 1h (rapid) & 3h (slow) ...
... Well distributed (including CNS) Extensive metabolism (rapid & slow acetylation) Average half-lives are less than 1h (rapid) & 3h (slow) ...
1.-Pain-Management
... **Lack of efficacy due to failure to produce active metabolite; †Increased risk of adverse events due to diminished drug clearance. ...
... **Lack of efficacy due to failure to produce active metabolite; †Increased risk of adverse events due to diminished drug clearance. ...
NURS 1011-Pharmacology I Online Syllabus
... What assessments do you need before administering? Was it given at a certain time because of drug/food interaction? (e.g. cholesterol medication; antacids?) What labs will need to be monitored? Any teaching for the patient? ...
... What assessments do you need before administering? Was it given at a certain time because of drug/food interaction? (e.g. cholesterol medication; antacids?) What labs will need to be monitored? Any teaching for the patient? ...
ED Toxicology
... Activated charcoal given in repeated doses also enhances the elimination of some drugs even after they have been absorbed such as carbamazepine, phenobarbitone, quinine, theophylline and dapsone. Alkalinisation of the urine for salicylate poisoning. Haemodialysis for ethylene glycol, lithium, ...
... Activated charcoal given in repeated doses also enhances the elimination of some drugs even after they have been absorbed such as carbamazepine, phenobarbitone, quinine, theophylline and dapsone. Alkalinisation of the urine for salicylate poisoning. Haemodialysis for ethylene glycol, lithium, ...
Antimalarial Drugs
... a. ↓ absorption when taken with dairy products and antacids 4. At stomach and upper intestine Distribution 1. Wide distribution in numerous parts of body a. Reticuloendothelial ...
... a. ↓ absorption when taken with dairy products and antacids 4. At stomach and upper intestine Distribution 1. Wide distribution in numerous parts of body a. Reticuloendothelial ...
Drug Development Process
... • Combination Chemistry – Make many possible compounds at one time. – Focus on quantity of possible compounds, not purity of each. ...
... • Combination Chemistry – Make many possible compounds at one time. – Focus on quantity of possible compounds, not purity of each. ...
Drug Interactions
... Increase the amount or ability of the isozyme(s) or transporter to metabolize or transport substrates May also be substrates ...
... Increase the amount or ability of the isozyme(s) or transporter to metabolize or transport substrates May also be substrates ...
Drug interaction
A drug interaction is a situation in which a substance (usually another drug) affects the activity of a drug when both are administered together. This action can be synergistic (when the drug's effect is increased) or antagonistic (when the drug's effect is decreased) or a new effect can be produced that neither produces on its own. Typically, interactions between drugs come to mind (drug-drug interaction). However, interactions may also exist between drugs and foods (drug-food interactions), as well as drugs and medicinal plants or herbs (drug-plant interactions). People taking antidepressant drugs such as monoamine oxidase inhibitors should not take food containing tyramine as hypertensive crisis may occur (an example of a drug-food interaction). These interactions may occur out of accidental misuse or due to lack of knowledge about the active ingredients involved in the relevant substances.It is therefore easy to see the importance of these pharmacological interactions in the practice of medicine. If a patient is taking two drugs and one of them increases the effect of the other it is possible that an overdose may occur. The interaction of the two drugs may also increase the risk that side effects will occur. On the other hand, if the action of a drug is reduced it may cease to have any therapeutic use because of under dosage. Notwithstanding the above, on occasion these interactions may be sought in order to obtain an improved therapeutic effect. Examples of this include the use of codeine with paracetamol to increase its analgesic effect. Or the combination of clavulanic acid with amoxicillin in order to overcome bacterial resistance to the antibiotic. It should also be remembered that there are interactions that, from a theoretical standpoint, may occur but in clinical practice have no important repercussions.The pharmaceutical interactions that are of special interest to the practice of medicine are primarily those that have negative effects for an organism. The risk that a pharmacological interaction will appear increases as a function of the number of drugs administered to a patient at the same time.It is possible that an interaction will occur between a drug and another substance present in the organism (i.e. foods or alcohol). Or in certain specific situations a drug may even react with itself, such as occurs with dehydration. In other situations, the interaction does not involve any effect on the drug. In certain cases, the presence of a drug in an individual's blood may affect certain types of laboratory analysis (analytical interference).It is also possible for interactions to occur outside an organism before administration of the drugs has taken place. This can occur when two drugs are mixed, for example, in a saline solution prior to intravenous injection. Some classic examples of this type of interaction include that Thiopentone and Suxamethonium should not be placed in the same syringe and same is true for Benzylpenicillin and Heparin. These situations will all be discussed under the same heading due to their conceptual similarity.Drug interactions may be the result of various processes. These processes may include alterations in the pharmacokinetics of the drug, such as alterations in the absorption, distribution, metabolism, and excretion (ADME) of a drug. Alternatively, drug interactions may be the result of the pharmacodynamic properties of the drug, e.g. the co-administration of a receptor antagonist and an agonist for the same receptor.