How to determine personal use in drug legislation
... such a radical shift, the Minister of Justice issued a decree to abolish mandatory provisional arrest and imprisonment in case of possession of drug amounts slightly above the “daily average dose”. Two years later, after the fall of Craxi government, the law was again changed by the Amato government ...
... such a radical shift, the Minister of Justice issued a decree to abolish mandatory provisional arrest and imprisonment in case of possession of drug amounts slightly above the “daily average dose”. Two years later, after the fall of Craxi government, the law was again changed by the Amato government ...
ramadan and cardiovascular drug use
... Aldouni A, Ghamil N, Sail R, et al: Beneficial effect on serum APO B and LPAT levels of Ramadan fasting. Clin ...
... Aldouni A, Ghamil N, Sail R, et al: Beneficial effect on serum APO B and LPAT levels of Ramadan fasting. Clin ...
Antiepileptic drugs induced fatigue: a multidisciplinary management.
... patients develop fatigue differs from drug to drug, with incidence for some AEDs up to 30% [6]. Fatigue is classified as “peripheral” or “central” depending on which processes and systems are involved [7]. A depression of the central nervous system (CNS) and/or changes in peripheral processes may be ...
... patients develop fatigue differs from drug to drug, with incidence for some AEDs up to 30% [6]. Fatigue is classified as “peripheral” or “central” depending on which processes and systems are involved [7]. A depression of the central nervous system (CNS) and/or changes in peripheral processes may be ...
Depressants
... are absorbed by the sample depending on the bands present (such as C–H and O–H) and the rest of the radiation is transmitted. The recorder then produces the IR spectrum as % ...
... are absorbed by the sample depending on the bands present (such as C–H and O–H) and the rest of the radiation is transmitted. The recorder then produces the IR spectrum as % ...
CHIRALITY (AS PREFORMULATION ASPECTS)
... the therapeutic standpoint. In the sulindac the Z isomer is the more potent anti-inflammatory agent and is used in pharmaceutical formulations. Although not availab commercially, E-sulindac has greater theoretical utility for the treatment of preeclampsia because of its selective effects on NAD-link ...
... the therapeutic standpoint. In the sulindac the Z isomer is the more potent anti-inflammatory agent and is used in pharmaceutical formulations. Although not availab commercially, E-sulindac has greater theoretical utility for the treatment of preeclampsia because of its selective effects on NAD-link ...
IN-SILICO PROTEIN LIGAND INTERACTION STUDY OF TYPICAL ANTIPSYCHOTIC DRUGS
... Prochlorperazine can occur and there is cross-reactivity with other drugs in the phenothiazine class. Symptoms of a reaction include dyskinesia (unusual, uncontrollable body or face movements, including abnormal movements of the tongue, also known as tardive dyskinesia), seizures and seizure-like sy ...
... Prochlorperazine can occur and there is cross-reactivity with other drugs in the phenothiazine class. Symptoms of a reaction include dyskinesia (unusual, uncontrollable body or face movements, including abnormal movements of the tongue, also known as tardive dyskinesia), seizures and seizure-like sy ...
A reprint from - American Scientist
... substances the use of more than 900 mice to assess the lethality of, among other things, cocaine. As he and others have since found, a substance that is tolerated or even beneficial in small quantities often has harmful effects at higher levels. The amount of a substance that produces a beneficial e ...
... substances the use of more than 900 mice to assess the lethality of, among other things, cocaine. As he and others have since found, a substance that is tolerated or even beneficial in small quantities often has harmful effects at higher levels. The amount of a substance that produces a beneficial e ...
What is schizophrenia
... activity aggravates schizophrenia D2 receptor blockade alleviation of schizophrenia ...
... activity aggravates schizophrenia D2 receptor blockade alleviation of schizophrenia ...
FORMULATION AND EVALUATION OF GUAR GUM BASED COLON TARGETED TABLETS... SECNIDAZOLE AND ITS β-CYCLODEXTRIN COMPLEX TO TREAT AMOEBIASIS
... devoted to the development of the site specific drug delivery systems which offer several benefits over the traditional drug therapies. The therapeutic advantages of targeting the drug to the diseased organ include delivery of the drug in its intact form as close as possible to the target site, redu ...
... devoted to the development of the site specific drug delivery systems which offer several benefits over the traditional drug therapies. The therapeutic advantages of targeting the drug to the diseased organ include delivery of the drug in its intact form as close as possible to the target site, redu ...
Users Guide - AHFS Drug Information
... subsections that are specifically divided by body system affected (e.g., GI, CNS, Hematologic) or by type of effect (e.g., Sensitivity Reactions). The Precautions and Contraindications subsection includes any special care to be taken by practitioners and/or patients for safe and effective use of the ...
... subsections that are specifically divided by body system affected (e.g., GI, CNS, Hematologic) or by type of effect (e.g., Sensitivity Reactions). The Precautions and Contraindications subsection includes any special care to be taken by practitioners and/or patients for safe and effective use of the ...
querying parse tree database of medline text to
... a team of scientists, aided by automated extractors or provided by external contributors in some cases. While interaction data from these databases are highly useful as a concise resource for biologists, the level of detail about the interactions is a priori defined by the databases. The interactio ...
... a team of scientists, aided by automated extractors or provided by external contributors in some cases. While interaction data from these databases are highly useful as a concise resource for biologists, the level of detail about the interactions is a priori defined by the databases. The interactio ...
Regulatory challenges of developing a combination product in a
... • Combination product regulations are a relatively recent, and specific regulations only exist in certain markets • No specific regulatory submission formats exist for combination products – all markets use existing drug, device or biologic application / submission procedures ...
... • Combination product regulations are a relatively recent, and specific regulations only exist in certain markets • No specific regulatory submission formats exist for combination products – all markets use existing drug, device or biologic application / submission procedures ...
Triptans For Migraine Headaches
... All triptans can cause unpleasant side effects. Usually they are mild and get better over time. The most common are dizziness, numbness, tingling, flushing, sleepiness, and tiredness. Severe side effects are rare. For many people, the most worrisome side effect is chest tightness, pain, or pressure. ...
... All triptans can cause unpleasant side effects. Usually they are mild and get better over time. The most common are dizziness, numbness, tingling, flushing, sleepiness, and tiredness. Severe side effects are rare. For many people, the most worrisome side effect is chest tightness, pain, or pressure. ...
drugs of abuse
... • Effect :IV: 7-8sec,IMI-5-8min,Smoked/sniffed-1015 min. • It comes as a white powder in its pure forms but with mixing with glucose, talcum and brick dust it ends up as a brownish powder. • The threshold for development withdrawal symptoms on discontinuation or toxicity depends on the tolerance of ...
... • Effect :IV: 7-8sec,IMI-5-8min,Smoked/sniffed-1015 min. • It comes as a white powder in its pure forms but with mixing with glucose, talcum and brick dust it ends up as a brownish powder. • The threshold for development withdrawal symptoms on discontinuation or toxicity depends on the tolerance of ...
Drug withdrawal syndromes cs
... Substitute abused drug with same/ similar class (a cross tolerant agonist is less likely to be abused, has longer ½ life) Substitute abused drug with one that blocks its reinforcing effects (antagonist) PREFERRED DRUG CLASS/ DRUG (where appropriate) with INTERACTIONS, DOSING SUGGESTIONS etc. Alcohol ...
... Substitute abused drug with same/ similar class (a cross tolerant agonist is less likely to be abused, has longer ½ life) Substitute abused drug with one that blocks its reinforcing effects (antagonist) PREFERRED DRUG CLASS/ DRUG (where appropriate) with INTERACTIONS, DOSING SUGGESTIONS etc. Alcohol ...
... therapies are considered beneficial, but more often than not their adverse effects and potential interaction with other drugs are not appreciated. Surveys in many developed countries have shown that the incidence of herbal medicine use ranges from 12% of the population in Australia2 to 37% in the US ...
Hydrocodone - Heads Up
... medication, in this amount, for this length of time. When the medication is taken on purpose for any other reason, by any other person, including the patient, that is ...
... medication, in this amount, for this length of time. When the medication is taken on purpose for any other reason, by any other person, including the patient, that is ...
A9581 - Injection, gadoxetate disodium, 1 mL
... information is essential and not available with non-contrast enhanced magnetic resonance imaging (MRI). NSF may result in fatal or debilitating systemic fibrosis affecting the skin, muscle and internal organs. Screen all patients for renal dysfunction by obtaining a history and/or laboratory tests. ...
... information is essential and not available with non-contrast enhanced magnetic resonance imaging (MRI). NSF may result in fatal or debilitating systemic fibrosis affecting the skin, muscle and internal organs. Screen all patients for renal dysfunction by obtaining a history and/or laboratory tests. ...
Recognizing Drug Use in Adolescents
... “plateaus,” associated with increased dosages. Symptoms and dangers of each are outlined below: 1st — A feeling similar to alcohol or marijuana intoxication, as well as the ability to operate in social situations (associated with drinking the equivalent of 2–3oz of maximum strength cough syrup) 2nd ...
... “plateaus,” associated with increased dosages. Symptoms and dangers of each are outlined below: 1st — A feeling similar to alcohol or marijuana intoxication, as well as the ability to operate in social situations (associated with drinking the equivalent of 2–3oz of maximum strength cough syrup) 2nd ...
FORMULATION, CHARACTERIZATION AND IN
... developed in order to increase the gastric residence time of dosage forms. [1,2,3] The multiple unit system has been developed to identify the merit over a single unit dosage form because the single unit floating systems are more popular. The multiple unit dosage forms may be better suited because t ...
... developed in order to increase the gastric residence time of dosage forms. [1,2,3] The multiple unit system has been developed to identify the merit over a single unit dosage form because the single unit floating systems are more popular. The multiple unit dosage forms may be better suited because t ...
co-guide
... discontinue ART within the first year of treatment due to side effects2. Immune dysregulation, altered drug metabolism and polypharmacy in these patients result in the presence of some degree of ADRs in about 80% of HIV-infected patients3. Among these ADRs some are clinically presented and the other ...
... discontinue ART within the first year of treatment due to side effects2. Immune dysregulation, altered drug metabolism and polypharmacy in these patients result in the presence of some degree of ADRs in about 80% of HIV-infected patients3. Among these ADRs some are clinically presented and the other ...
Cohort and Case Control Studies
... • Process of bringing a new drug or device to the market. It includes drug discovery and product development, pre-clinical research (microorganisms/animals) and clinical trials (on humans). New Chemical Entities (NCEs), also called New Molecular Entities (NMEs), are compounds which emerge from the p ...
... • Process of bringing a new drug or device to the market. It includes drug discovery and product development, pre-clinical research (microorganisms/animals) and clinical trials (on humans). New Chemical Entities (NCEs), also called New Molecular Entities (NMEs), are compounds which emerge from the p ...
Derive Version
... We will now look at a simple model for drug administration. We will consider a drug that is administered intravenously. In this situation, we are able to assume that the drug reaches its maximum concentration in the bloodstream as soon as it is injected. We will also assume that the drug a metaboliz ...
... We will now look at a simple model for drug administration. We will consider a drug that is administered intravenously. In this situation, we are able to assume that the drug reaches its maximum concentration in the bloodstream as soon as it is injected. We will also assume that the drug a metaboliz ...
Drug interaction
A drug interaction is a situation in which a substance (usually another drug) affects the activity of a drug when both are administered together. This action can be synergistic (when the drug's effect is increased) or antagonistic (when the drug's effect is decreased) or a new effect can be produced that neither produces on its own. Typically, interactions between drugs come to mind (drug-drug interaction). However, interactions may also exist between drugs and foods (drug-food interactions), as well as drugs and medicinal plants or herbs (drug-plant interactions). People taking antidepressant drugs such as monoamine oxidase inhibitors should not take food containing tyramine as hypertensive crisis may occur (an example of a drug-food interaction). These interactions may occur out of accidental misuse or due to lack of knowledge about the active ingredients involved in the relevant substances.It is therefore easy to see the importance of these pharmacological interactions in the practice of medicine. If a patient is taking two drugs and one of them increases the effect of the other it is possible that an overdose may occur. The interaction of the two drugs may also increase the risk that side effects will occur. On the other hand, if the action of a drug is reduced it may cease to have any therapeutic use because of under dosage. Notwithstanding the above, on occasion these interactions may be sought in order to obtain an improved therapeutic effect. Examples of this include the use of codeine with paracetamol to increase its analgesic effect. Or the combination of clavulanic acid with amoxicillin in order to overcome bacterial resistance to the antibiotic. It should also be remembered that there are interactions that, from a theoretical standpoint, may occur but in clinical practice have no important repercussions.The pharmaceutical interactions that are of special interest to the practice of medicine are primarily those that have negative effects for an organism. The risk that a pharmacological interaction will appear increases as a function of the number of drugs administered to a patient at the same time.It is possible that an interaction will occur between a drug and another substance present in the organism (i.e. foods or alcohol). Or in certain specific situations a drug may even react with itself, such as occurs with dehydration. In other situations, the interaction does not involve any effect on the drug. In certain cases, the presence of a drug in an individual's blood may affect certain types of laboratory analysis (analytical interference).It is also possible for interactions to occur outside an organism before administration of the drugs has taken place. This can occur when two drugs are mixed, for example, in a saline solution prior to intravenous injection. Some classic examples of this type of interaction include that Thiopentone and Suxamethonium should not be placed in the same syringe and same is true for Benzylpenicillin and Heparin. These situations will all be discussed under the same heading due to their conceptual similarity.Drug interactions may be the result of various processes. These processes may include alterations in the pharmacokinetics of the drug, such as alterations in the absorption, distribution, metabolism, and excretion (ADME) of a drug. Alternatively, drug interactions may be the result of the pharmacodynamic properties of the drug, e.g. the co-administration of a receptor antagonist and an agonist for the same receptor.