Is cannabis addictive?
... The signs and symptoms experienced by cannabis users illustrate just how addictive the drug can become. Often, the extent of the addiction will correlate with the frequency of use. However, this may not always be the case and it can depend on the effects that the drug has on each individual. Common ...
... The signs and symptoms experienced by cannabis users illustrate just how addictive the drug can become. Often, the extent of the addiction will correlate with the frequency of use. However, this may not always be the case and it can depend on the effects that the drug has on each individual. Common ...
Product Monograph - Paladin Labs Inc.
... inhibitory neurotransmitter. The sedative-hypnotic action of phenobarbital may be due to an inhibition of conduction in the reticular formation resulting in a decrease in the number of impulses reaching the cerebral cortex. Phenobarbital also lowers the serum bilirubin concentrations by inducing glu ...
... inhibitory neurotransmitter. The sedative-hypnotic action of phenobarbital may be due to an inhibition of conduction in the reticular formation resulting in a decrease in the number of impulses reaching the cerebral cortex. Phenobarbital also lowers the serum bilirubin concentrations by inducing glu ...
11.02 Community Acquired Pneumonia
... Azithromycin(Zithromax) is preferred in view of no major drug interaction 9 ...
... Azithromycin(Zithromax) is preferred in view of no major drug interaction 9 ...
TED
... Drugs that inhibit this enzyme (e.g., amiodarone, cotrimoxazole, metronidazole and fluvoxamine) potentiate the effect of warfarin Other drugs that induce CYP 2C9 activity (e.g., rifampin) will do the converse ...
... Drugs that inhibit this enzyme (e.g., amiodarone, cotrimoxazole, metronidazole and fluvoxamine) potentiate the effect of warfarin Other drugs that induce CYP 2C9 activity (e.g., rifampin) will do the converse ...
Sedation and antipsychotics
... After sedation has been achieved (acutely disturbed and -ve adverse effects) pt may need to be: monitored closely (+ Calm and supportive) ...
... After sedation has been achieved (acutely disturbed and -ve adverse effects) pt may need to be: monitored closely (+ Calm and supportive) ...
et al. TRANSDERMAL DRUG DELIVERY SYSTEM (TDDS): AN OVERVIEW
... of skin is of prime concern for the success of a transdermal patch. A product development scientist often uses permeation enhancer(s) that increase the rate of transfer of drug(s) across the skin. In addition, adequate adhesiveness seems to be essential to ensure intimate contact of the formulation ...
... of skin is of prime concern for the success of a transdermal patch. A product development scientist often uses permeation enhancer(s) that increase the rate of transfer of drug(s) across the skin. In addition, adequate adhesiveness seems to be essential to ensure intimate contact of the formulation ...
grapefruit interactions
... Urinary tract agents e.g. darifenacin (Enablex), Solifenacin (Vesicare), tamsulosin (Flomaxtra) ...
... Urinary tract agents e.g. darifenacin (Enablex), Solifenacin (Vesicare), tamsulosin (Flomaxtra) ...
Manuscript "Fast-track drug approval in inflammatory bowel diseases"
... criteria for fast track review and what would the outcome have been if they had been subject to this process This is a very interesting question. The following statement was added in our manuscript. “An interesting question would be whether the currently -or soon to be- approved IBD drugs would have ...
... criteria for fast track review and what would the outcome have been if they had been subject to this process This is a very interesting question. The following statement was added in our manuscript. “An interesting question would be whether the currently -or soon to be- approved IBD drugs would have ...
Prediction of pharmacokinetic properties using experimental
... The best estimate for drug elimination can be obtained by determining the ‘total clearance’ (Cl) of the drug. Organ clearance is defined as the volume of blood that must be cleared of drug in a unit of time in order to account for the rate of drug elimination. Thus, clearance is the ratio of elimina ...
... The best estimate for drug elimination can be obtained by determining the ‘total clearance’ (Cl) of the drug. Organ clearance is defined as the volume of blood that must be cleared of drug in a unit of time in order to account for the rate of drug elimination. Thus, clearance is the ratio of elimina ...
C O L
... and infections) whereby high local concentration can be achieved Minimizes side effects that occur because of release of drugs in the upper GIT or unnecessary systemic absorption. The colon is rich in lymphoid tissue, uptake of antigens into the mast cells of the colonic mucosa produces rapid lo ...
... and infections) whereby high local concentration can be achieved Minimizes side effects that occur because of release of drugs in the upper GIT or unnecessary systemic absorption. The colon is rich in lymphoid tissue, uptake of antigens into the mast cells of the colonic mucosa produces rapid lo ...
PRELIMINARY SCREENING AND DEVELOPMENT OF FORMULATION DESIGN SPACE FOR Research Article
... Received: 11 Oct 2011, Revised and Accepted: 6 Jan 2012 ABSTRACT The drugs which are susceptible to acid hydrolysis in the stomach or extensively metabolized in the liver can be protected successfully by getting absorbed directly into systemic circulation through buccal route. Isradipine is used to ...
... Received: 11 Oct 2011, Revised and Accepted: 6 Jan 2012 ABSTRACT The drugs which are susceptible to acid hydrolysis in the stomach or extensively metabolized in the liver can be protected successfully by getting absorbed directly into systemic circulation through buccal route. Isradipine is used to ...
DOXAZOSIN MESYLATE - The Filipino Doctor
... The usual maintenance dose is 4 mg daily; daily doses of 8 mg should not be exceeded. The optimal effect of doxazosin may take up to 4 weeks. If necessary, the dosage may be increased following this period to 8 mg once daily according to patient response. Doxazosin Mesylate (Alfadil XL) can be taken ...
... The usual maintenance dose is 4 mg daily; daily doses of 8 mg should not be exceeded. The optimal effect of doxazosin may take up to 4 weeks. If necessary, the dosage may be increased following this period to 8 mg once daily according to patient response. Doxazosin Mesylate (Alfadil XL) can be taken ...
FORMULATION DEVELOPMENT, OPTIMIZATION AND IN-VITRO RELEAS KINETIC STUDY ON
... diseases [1] of colon like colon cancer, diarrhea, inflammation, constipation, crohn’s disease etc where by high local concentration can be achieved while minimizing side effects. The colon is attracting interest as a site where poorly absorbed drug molecule may have an improved bioavailability [2]. ...
... diseases [1] of colon like colon cancer, diarrhea, inflammation, constipation, crohn’s disease etc where by high local concentration can be achieved while minimizing side effects. The colon is attracting interest as a site where poorly absorbed drug molecule may have an improved bioavailability [2]. ...
Cook-Waite Carbocaine Prescribing Information
... Pregnacy: Teratogenic Effects: Pregnancy Category C: Animal reproduction studies have not been conducted with this solution. It is also not known whether this solution can cause fetal harm when administered to a pregnant woman or can effect reproductive capacity. This solution should be given to a p ...
... Pregnacy: Teratogenic Effects: Pregnancy Category C: Animal reproduction studies have not been conducted with this solution. It is also not known whether this solution can cause fetal harm when administered to a pregnant woman or can effect reproductive capacity. This solution should be given to a p ...
Center for the Development of Human Services
... pose a significant risk to children. Most illicit and prescription drugs are toxic when orally ingested, especially by a small child. The effect on a small child could be fatal. Needles, syringes, and razor blades are types of drug paraphernalia that pose another danger to children. Households invol ...
... pose a significant risk to children. Most illicit and prescription drugs are toxic when orally ingested, especially by a small child. The effect on a small child could be fatal. Needles, syringes, and razor blades are types of drug paraphernalia that pose another danger to children. Households invol ...
to Print Topic Help File ,
... Non-prescription drugs are also referred to as over the counter (OTC) drugs. These are medications that the FDA has determined to be safe and effective for consumers to self-medicate when used as directed by the product labeling. An OTC (over the counter) Drug is a drug that does not require any for ...
... Non-prescription drugs are also referred to as over the counter (OTC) drugs. These are medications that the FDA has determined to be safe and effective for consumers to self-medicate when used as directed by the product labeling. An OTC (over the counter) Drug is a drug that does not require any for ...
Antipyretic-analgesic and antiinflammatory drugs
... thus accounting for its analgesic and antipyretic activity. • It is much less effective than aspirin as an inhibitor of the peripherally located PG biosynthetic enzyme system that plays such an important role in inflammation. ...
... thus accounting for its analgesic and antipyretic activity. • It is much less effective than aspirin as an inhibitor of the peripherally located PG biosynthetic enzyme system that plays such an important role in inflammation. ...
MACROLIDES Macrolide antibiotics contain a many membered
... • Macrolides are incompletely but adequately absorbed from the GI tract. • Erythromycin base is inactivated by stomach acid. • Made in various acid resistant forms. ...
... • Macrolides are incompletely but adequately absorbed from the GI tract. • Erythromycin base is inactivated by stomach acid. • Made in various acid resistant forms. ...
Drug-Drug Interactions Among Hepatitis C Virus (HCV) and Human
... 1A2 activity and intestinal CYP 3A4 activity, ...
... 1A2 activity and intestinal CYP 3A4 activity, ...
Suggestion from clinicians
... Hydrochlorothiazide in its usual dose of 12.5 to 25 mg per day has never been shown to reduce the risk of myocardial infarction, stroke, or death.4 In fact, higher doses have been shown to increase the risk of sudden cardiac death in a dose-dependent fashion.8 3. Even in combination with an angioten ...
... Hydrochlorothiazide in its usual dose of 12.5 to 25 mg per day has never been shown to reduce the risk of myocardial infarction, stroke, or death.4 In fact, higher doses have been shown to increase the risk of sudden cardiac death in a dose-dependent fashion.8 3. Even in combination with an angioten ...
IOSR Journal of Applied Chemistry (IOSR-JAC) ISSN: 2278-5736.
... Abstract: Cardiovascular disease remains the major cause of morbidity and death in developed countries, claiming 17.1 million lives a year. Tobacco use, an unhealthy diet, physical inactivity and harmful use of alcohol increase the risk of heart attacks and strokes .Atherosclerosis (also known as ar ...
... Abstract: Cardiovascular disease remains the major cause of morbidity and death in developed countries, claiming 17.1 million lives a year. Tobacco use, an unhealthy diet, physical inactivity and harmful use of alcohol increase the risk of heart attacks and strokes .Atherosclerosis (also known as ar ...
Lithium sulfate
... Passage of blood-brain barrier is restricted [7]. Distribution of Li to the brain can be delayed up to 24 h [8]. Li passes freely through the placenta membrane [9]. Metabolism and excretion Li is not metabolized. Because Li chemical similarity to sodium (Na+) and potassium (K+), it may interact or i ...
... Passage of blood-brain barrier is restricted [7]. Distribution of Li to the brain can be delayed up to 24 h [8]. Li passes freely through the placenta membrane [9]. Metabolism and excretion Li is not metabolized. Because Li chemical similarity to sodium (Na+) and potassium (K+), it may interact or i ...
PART III: CONSUMER INFORMATION Pr ADALAT® XL® Nifedipine
... valproic acid blood pressure lowering drugs including beta blockers benzodiazepines cisapride coumarin anticoagulants warfarin imipramine propafenone terfenadine ...
... valproic acid blood pressure lowering drugs including beta blockers benzodiazepines cisapride coumarin anticoagulants warfarin imipramine propafenone terfenadine ...
Oxcarbazepine (TrileptalTM)
... mandatory substitution of generic antiepileptic drugs without prior approval of the patient and treating physician. Because changing from one formulation of an AED to another can usually be accomplished, and risks minimized, if physicians and patients monitor blood levels, seizures and toxicity, the ...
... mandatory substitution of generic antiepileptic drugs without prior approval of the patient and treating physician. Because changing from one formulation of an AED to another can usually be accomplished, and risks minimized, if physicians and patients monitor blood levels, seizures and toxicity, the ...
Drug interaction
A drug interaction is a situation in which a substance (usually another drug) affects the activity of a drug when both are administered together. This action can be synergistic (when the drug's effect is increased) or antagonistic (when the drug's effect is decreased) or a new effect can be produced that neither produces on its own. Typically, interactions between drugs come to mind (drug-drug interaction). However, interactions may also exist between drugs and foods (drug-food interactions), as well as drugs and medicinal plants or herbs (drug-plant interactions). People taking antidepressant drugs such as monoamine oxidase inhibitors should not take food containing tyramine as hypertensive crisis may occur (an example of a drug-food interaction). These interactions may occur out of accidental misuse or due to lack of knowledge about the active ingredients involved in the relevant substances.It is therefore easy to see the importance of these pharmacological interactions in the practice of medicine. If a patient is taking two drugs and one of them increases the effect of the other it is possible that an overdose may occur. The interaction of the two drugs may also increase the risk that side effects will occur. On the other hand, if the action of a drug is reduced it may cease to have any therapeutic use because of under dosage. Notwithstanding the above, on occasion these interactions may be sought in order to obtain an improved therapeutic effect. Examples of this include the use of codeine with paracetamol to increase its analgesic effect. Or the combination of clavulanic acid with amoxicillin in order to overcome bacterial resistance to the antibiotic. It should also be remembered that there are interactions that, from a theoretical standpoint, may occur but in clinical practice have no important repercussions.The pharmaceutical interactions that are of special interest to the practice of medicine are primarily those that have negative effects for an organism. The risk that a pharmacological interaction will appear increases as a function of the number of drugs administered to a patient at the same time.It is possible that an interaction will occur between a drug and another substance present in the organism (i.e. foods or alcohol). Or in certain specific situations a drug may even react with itself, such as occurs with dehydration. In other situations, the interaction does not involve any effect on the drug. In certain cases, the presence of a drug in an individual's blood may affect certain types of laboratory analysis (analytical interference).It is also possible for interactions to occur outside an organism before administration of the drugs has taken place. This can occur when two drugs are mixed, for example, in a saline solution prior to intravenous injection. Some classic examples of this type of interaction include that Thiopentone and Suxamethonium should not be placed in the same syringe and same is true for Benzylpenicillin and Heparin. These situations will all be discussed under the same heading due to their conceptual similarity.Drug interactions may be the result of various processes. These processes may include alterations in the pharmacokinetics of the drug, such as alterations in the absorption, distribution, metabolism, and excretion (ADME) of a drug. Alternatively, drug interactions may be the result of the pharmacodynamic properties of the drug, e.g. the co-administration of a receptor antagonist and an agonist for the same receptor.