Division of Clinical Pharmacology Department of Medicine and Health Sciences Linköping University
... Methods: All six studies included in this thesis are based on ICSRs available in VigiBase. Two studies aimed to characterise drug interactions reported in VigiBase. In the first study we examined if contraindicated drug combinations (given in a reference source of drug interactions) were reported on ...
... Methods: All six studies included in this thesis are based on ICSRs available in VigiBase. Two studies aimed to characterise drug interactions reported in VigiBase. In the first study we examined if contraindicated drug combinations (given in a reference source of drug interactions) were reported on ...
ANTIDEPRESSANTS: MAOIs (p.1) 1. Mono
... MAOB – found in DA axox terminals, GI tract, liver MAOIs block both enzymes --- beneficial main effects & neg. SEs 4. Non-Selective & Irreversible MAOIs non-selective = block both MAOA and B enzymes irreversible = the MAOI enzyme is permanently blocked only when new molecules of MAO (A/B) are synthe ...
... MAOB – found in DA axox terminals, GI tract, liver MAOIs block both enzymes --- beneficial main effects & neg. SEs 4. Non-Selective & Irreversible MAOIs non-selective = block both MAOA and B enzymes irreversible = the MAOI enzyme is permanently blocked only when new molecules of MAO (A/B) are synthe ...
The Most Dangerous Drug
... surprisingly healthy, and seem totally shocked they—of all people—could have heart disease. Oh, and all of them were given aspirin. In the US, the average age for a first heart attack is 66 for men, and 70 for women. Men carry a far greater lifetime risk of having a heart attack than do women. As f ...
... surprisingly healthy, and seem totally shocked they—of all people—could have heart disease. Oh, and all of them were given aspirin. In the US, the average age for a first heart attack is 66 for men, and 70 for women. Men carry a far greater lifetime risk of having a heart attack than do women. As f ...
other drugs - Australian Indigenous HealthInfoNet
... There is no routinely used medicine for GHB detox: • Benzos (e.g. diazepam) are often used to manage some of the symptoms of GHB withdrawal, anti-psychotic or anti-convulsant medicines are also used. • If delirium occurs the client may need supervised care in a hospital or clinic. GHB overdose • ...
... There is no routinely used medicine for GHB detox: • Benzos (e.g. diazepam) are often used to manage some of the symptoms of GHB withdrawal, anti-psychotic or anti-convulsant medicines are also used. • If delirium occurs the client may need supervised care in a hospital or clinic. GHB overdose • ...
Unifying Bioinformatics and Chemoinformatics for
... GPCR ligands may be broadly classified into agonists which increase the amount of signalling that occurs after binding, or antagonists which nullify the effect of agonists and return a cell to normal signalling levels. GPCRs are involved in an amazing number of cellular processes, including vision, s ...
... GPCR ligands may be broadly classified into agonists which increase the amount of signalling that occurs after binding, or antagonists which nullify the effect of agonists and return a cell to normal signalling levels. GPCRs are involved in an amazing number of cellular processes, including vision, s ...
PHARMACOLOGY STUDY GUIDE FOR LESSON 3 QU
... Agonist- a drug that can combine with a receptor on a cell to produce a physiological reaction Antagonist- a drug that neutralizes or counteracts the effects of another drug 17) What is the paralytic of choice in almost all cases of rapid sequence induction (RSI) in adults? 18) What type of agent is ...
... Agonist- a drug that can combine with a receptor on a cell to produce a physiological reaction Antagonist- a drug that neutralizes or counteracts the effects of another drug 17) What is the paralytic of choice in almost all cases of rapid sequence induction (RSI) in adults? 18) What type of agent is ...
Investigational Drugs
... actions of the drug in humans, the side effects associated with increasing doses, and if possible, to gain early evidence on effectiveness. During Phase 1, sufficient information about the drug’s pharmacokinetics and pharmacological effects should be obtained to permit the design of wellcontrolled, ...
... actions of the drug in humans, the side effects associated with increasing doses, and if possible, to gain early evidence on effectiveness. During Phase 1, sufficient information about the drug’s pharmacokinetics and pharmacological effects should be obtained to permit the design of wellcontrolled, ...
Coumadin - Pinky S. Tiwari, MD, PA
... immediately. You will be switched over to another anticoagulant (e.g., heparin-type) during pregnancy. Consult your doctor for more information. This medication does not pass into breast milk. While there have been no reports of harm to nursing infants, consult your doctor before breast-feeding. DRU ...
... immediately. You will be switched over to another anticoagulant (e.g., heparin-type) during pregnancy. Consult your doctor for more information. This medication does not pass into breast milk. While there have been no reports of harm to nursing infants, consult your doctor before breast-feeding. DRU ...
Temperature and pH Responsive Microfibers for Controllable and
... improved efficacy.[3-5] However, there are still two major challenges to overcome 1) reducing initial burst effects and 2) realizing a programmable drug delivery.[6, 7] In the past decade, multiple technologies have been proposed and developed, purposing to solve or partially relieve the above menti ...
... improved efficacy.[3-5] However, there are still two major challenges to overcome 1) reducing initial burst effects and 2) realizing a programmable drug delivery.[6, 7] In the past decade, multiple technologies have been proposed and developed, purposing to solve or partially relieve the above menti ...
... inflammatory bowel disease (Crohn’s disease and ulcerative colitis), irritable bowel syndrome, and colon cancer. Other potential applications of colonic delivery include chronotherapy, prophylaxis of colon cancer and treatment of nicotine addiction1,2. It has also gained increased importance not jus ...
Oral Fluid Drug Screen Device
... compounds such as morphine and codeine and semi-synthetic drugs such as heroin. Opiates act to control pain by depressing the central nervous system. The drugs demonstrate addictive properties when used for sustained periods of time; symptoms of withdrawal may include sweating, shaking, nausea and i ...
... compounds such as morphine and codeine and semi-synthetic drugs such as heroin. Opiates act to control pain by depressing the central nervous system. The drugs demonstrate addictive properties when used for sustained periods of time; symptoms of withdrawal may include sweating, shaking, nausea and i ...
Omalizumab in ABPA - Stanford University
... – Frequent toxicities (vori>itra). Absorption, metabolism, drug interactions mandate drug level monitoring; resistance 4-8% ...
... – Frequent toxicities (vori>itra). Absorption, metabolism, drug interactions mandate drug level monitoring; resistance 4-8% ...
Kaytwo
... the remaining neonate. Thrombotest and hepaplastintest values also improved significantly after administration of KAYTWO3). ...
... the remaining neonate. Thrombotest and hepaplastintest values also improved significantly after administration of KAYTWO3). ...
R Sams - National Thoroughbred Racing Association
... • Decreases reabsorption of electrolytes and water • Produces mild metabolic alkalosis • Greater diuretic effect after IM administration ...
... • Decreases reabsorption of electrolytes and water • Produces mild metabolic alkalosis • Greater diuretic effect after IM administration ...
Coronary Artery Disease, Angina and MI
... – Lipid packages absorbed from intestine – Transported to liver ...
... – Lipid packages absorbed from intestine – Transported to liver ...
Steroids (Anabolic-Androgenic)
... receptors on the surface of a cell. This AAS–receptor complex can then shuttle into the cell nucleus to influence patterns of gene expression. Because of this, the acute effects of AAS in the brain are substantially different from those of other drugs of abuse. The most important difference is that ...
... receptors on the surface of a cell. This AAS–receptor complex can then shuttle into the cell nucleus to influence patterns of gene expression. Because of this, the acute effects of AAS in the brain are substantially different from those of other drugs of abuse. The most important difference is that ...
109 KB
... The effects of the medicines or groups of substances below may be affected by concomitant treatment with acetylsalicylic acid. Enhanced effects ranging up to an increased risk of side effects: Anticoagulants (e.g. coumarin, heparin) and thrombolytic drugs: acetylsalicylic acid can increase the risk ...
... The effects of the medicines or groups of substances below may be affected by concomitant treatment with acetylsalicylic acid. Enhanced effects ranging up to an increased risk of side effects: Anticoagulants (e.g. coumarin, heparin) and thrombolytic drugs: acetylsalicylic acid can increase the risk ...
DrugFacts MDMA 2013
... ing, and anxiety—that may occur soon after taking the drug or during the days or even weeks thereafter. ...
... ing, and anxiety—that may occur soon after taking the drug or during the days or even weeks thereafter. ...
Reversal_Agents_in_Sedation_and_Anesthesia-A Review
... occasionally requiring pharmacologic or mechanical support of vital functions postoperatively. An ideal solution to these situations would be the availability of drugs to reverse the effects of the therapeutic drug (anesthetic) when the anesthetic effect is no longer needed (ie, an "anesthetic antid ...
... occasionally requiring pharmacologic or mechanical support of vital functions postoperatively. An ideal solution to these situations would be the availability of drugs to reverse the effects of the therapeutic drug (anesthetic) when the anesthetic effect is no longer needed (ie, an "anesthetic antid ...
Misuse of Prescription Drugs
... single large dose of an opioid can cause severe respiratory depression (slowing or stopping of breathing), which can be fatal; taking opioids with alcohol or sedatives increases this risk.5,24 When properly managed, short-term medical use of opioid pain relievers— taken for a few days following oral ...
... single large dose of an opioid can cause severe respiratory depression (slowing or stopping of breathing), which can be fatal; taking opioids with alcohol or sedatives increases this risk.5,24 When properly managed, short-term medical use of opioid pain relievers— taken for a few days following oral ...
NIDA InfoFacts- Steroids (Anabolic-Androgenic)
... receptors on the surface of a cell. This AAS–receptor complex can then shuttle into the cell nucleus to influence patterns of gene expression. Because of this, the acute effects of AAS in the brain are substantially different from those of other drugs of abuse. The most important difference is that ...
... receptors on the surface of a cell. This AAS–receptor complex can then shuttle into the cell nucleus to influence patterns of gene expression. Because of this, the acute effects of AAS in the brain are substantially different from those of other drugs of abuse. The most important difference is that ...
Print / Save PDF - Pennsylvania Patient Safety Authority
... of the terms for the many different kinds of longacting formulations. As a result, there are many inconsistencies, allowing different suffixes to be used for an identical formulation by two different manufacturers or even similar suffixes for dissimilar formulations. In short, the nomenclature used ...
... of the terms for the many different kinds of longacting formulations. As a result, there are many inconsistencies, allowing different suffixes to be used for an identical formulation by two different manufacturers or even similar suffixes for dissimilar formulations. In short, the nomenclature used ...
Drug interaction
A drug interaction is a situation in which a substance (usually another drug) affects the activity of a drug when both are administered together. This action can be synergistic (when the drug's effect is increased) or antagonistic (when the drug's effect is decreased) or a new effect can be produced that neither produces on its own. Typically, interactions between drugs come to mind (drug-drug interaction). However, interactions may also exist between drugs and foods (drug-food interactions), as well as drugs and medicinal plants or herbs (drug-plant interactions). People taking antidepressant drugs such as monoamine oxidase inhibitors should not take food containing tyramine as hypertensive crisis may occur (an example of a drug-food interaction). These interactions may occur out of accidental misuse or due to lack of knowledge about the active ingredients involved in the relevant substances.It is therefore easy to see the importance of these pharmacological interactions in the practice of medicine. If a patient is taking two drugs and one of them increases the effect of the other it is possible that an overdose may occur. The interaction of the two drugs may also increase the risk that side effects will occur. On the other hand, if the action of a drug is reduced it may cease to have any therapeutic use because of under dosage. Notwithstanding the above, on occasion these interactions may be sought in order to obtain an improved therapeutic effect. Examples of this include the use of codeine with paracetamol to increase its analgesic effect. Or the combination of clavulanic acid with amoxicillin in order to overcome bacterial resistance to the antibiotic. It should also be remembered that there are interactions that, from a theoretical standpoint, may occur but in clinical practice have no important repercussions.The pharmaceutical interactions that are of special interest to the practice of medicine are primarily those that have negative effects for an organism. The risk that a pharmacological interaction will appear increases as a function of the number of drugs administered to a patient at the same time.It is possible that an interaction will occur between a drug and another substance present in the organism (i.e. foods or alcohol). Or in certain specific situations a drug may even react with itself, such as occurs with dehydration. In other situations, the interaction does not involve any effect on the drug. In certain cases, the presence of a drug in an individual's blood may affect certain types of laboratory analysis (analytical interference).It is also possible for interactions to occur outside an organism before administration of the drugs has taken place. This can occur when two drugs are mixed, for example, in a saline solution prior to intravenous injection. Some classic examples of this type of interaction include that Thiopentone and Suxamethonium should not be placed in the same syringe and same is true for Benzylpenicillin and Heparin. These situations will all be discussed under the same heading due to their conceptual similarity.Drug interactions may be the result of various processes. These processes may include alterations in the pharmacokinetics of the drug, such as alterations in the absorption, distribution, metabolism, and excretion (ADME) of a drug. Alternatively, drug interactions may be the result of the pharmacodynamic properties of the drug, e.g. the co-administration of a receptor antagonist and an agonist for the same receptor.