CHEWING GUM - International Journal of Pharmaceutical Sciences
... chewing gum for ease of compression. The alkaline earth metal phosphates and alkali metal phosphates prevent caking and balling of High” i.e. 2 to 8% moisture‐ containing chewing gum compositions during grinding. Additionally, it has been discovered that maltodextrin e ...
... chewing gum for ease of compression. The alkaline earth metal phosphates and alkali metal phosphates prevent caking and balling of High” i.e. 2 to 8% moisture‐ containing chewing gum compositions during grinding. Additionally, it has been discovered that maltodextrin e ...
1 Hepatoprotective effect of silymarin (Silybum marianum) on
... The liver is involved in detoxification and elimination of drugs and a liver injury could affects pharmacokinetics parameters of drugs, and increases the risk of adverse drug-effects. Liver injuries induced by APAP is one of the best characterized system of xenobiotic-induced hepatotoxicity. It is c ...
... The liver is involved in detoxification and elimination of drugs and a liver injury could affects pharmacokinetics parameters of drugs, and increases the risk of adverse drug-effects. Liver injuries induced by APAP is one of the best characterized system of xenobiotic-induced hepatotoxicity. It is c ...
Opposite effects of MDMA
... through an interaction with the corresponding presynaptic monoamine uptake transporter. 5HT transport inhibitors block MDMA-induced 5-HT release in vitro or in animals and also attenuate the subjective and cardiovascular response to MDMA in humans. NE transport inhibitors similarly prevent the MDMA- ...
... through an interaction with the corresponding presynaptic monoamine uptake transporter. 5HT transport inhibitors block MDMA-induced 5-HT release in vitro or in animals and also attenuate the subjective and cardiovascular response to MDMA in humans. NE transport inhibitors similarly prevent the MDMA- ...
Uses
... Side effects: (1) GIT problems. (2) Cholestatic jaundice: especially with Erythromycin Estolate [result from hypersensitivity reaction bile becomes granular in bile duct its flow back up into circulation]. (3) Ototoxicity: transient deafness [especially at doses]. (4) Erythromycin level ...
... Side effects: (1) GIT problems. (2) Cholestatic jaundice: especially with Erythromycin Estolate [result from hypersensitivity reaction bile becomes granular in bile duct its flow back up into circulation]. (3) Ototoxicity: transient deafness [especially at doses]. (4) Erythromycin level ...
article in press
... the search for new atypical antipsychotics presenting low cost and the understanding of the mechanism of action leading to atypical antipsychotic profile. The results obtained are presented in two distinct parts based on their nature, namely, experimental (first part) or theoretical (second part). F ...
... the search for new atypical antipsychotics presenting low cost and the understanding of the mechanism of action leading to atypical antipsychotic profile. The results obtained are presented in two distinct parts based on their nature, namely, experimental (first part) or theoretical (second part). F ...
LSD-25 as a Discriminative Stimulus for Response
... finally was maintained on 50 #g/kg of LSD. The dose resulting in50%LSD appropriate responding (ED_o)was 18/_g/kgand the median time-interval for the decay of the LSD stimulus (40 #g/kg) was 84 min. Tests with psilocybin (ED50=0.55 mg/kg) and N,N-dimethyltryptamine (ED50=5.7mg/kg) resulted in respond ...
... finally was maintained on 50 #g/kg of LSD. The dose resulting in50%LSD appropriate responding (ED_o)was 18/_g/kgand the median time-interval for the decay of the LSD stimulus (40 #g/kg) was 84 min. Tests with psilocybin (ED50=0.55 mg/kg) and N,N-dimethyltryptamine (ED50=5.7mg/kg) resulted in respond ...
Product Monograph ZANTAC Histamine H
... Accumulation of ZANTAC® with resulting elevated plasma concentrations will occur in patients with renal impairment (creatinine clearance less than 50 ml/min); a recommended daily dose of oral ranitidine in such patients should be 150 mg. ...
... Accumulation of ZANTAC® with resulting elevated plasma concentrations will occur in patients with renal impairment (creatinine clearance less than 50 ml/min); a recommended daily dose of oral ranitidine in such patients should be 150 mg. ...
THESIS FILESObesity is a medical condition in
... 1.1.1.6. Phytosterols: It may be found naturally in plants. Similar to ezetimibe, phytosterols reduce the absorption of cholesterol in the gut. Hence, they are most effective when consumed with meals. However, the precise mechanism of action of phytosterols differs from ezetimibe. ...
... 1.1.1.6. Phytosterols: It may be found naturally in plants. Similar to ezetimibe, phytosterols reduce the absorption of cholesterol in the gut. Hence, they are most effective when consumed with meals. However, the precise mechanism of action of phytosterols differs from ezetimibe. ...
Model-based Analysis of the Effects of Thioridazine Enantiomers on the... Papillary Action Potential
... by ICaL inhibition. Using the inverse method, the levels of IKr inhibition determined at higher doses were very similar to those found using the forward method. However, the shortening observed at 0.1 mg L-1 meant that zero IKr inhibition was determined. In addition, even attributing ICaL inhibition ...
... by ICaL inhibition. Using the inverse method, the levels of IKr inhibition determined at higher doses were very similar to those found using the forward method. However, the shortening observed at 0.1 mg L-1 meant that zero IKr inhibition was determined. In addition, even attributing ICaL inhibition ...
Volume 48 Number 4
... Our membership is also growing; this year we’ve recruited almost 500 new members, 350 of which are new student members. Next year, we hope to continue this growth and encourage more interest in pharmacology and the Society. Centennial Celebration: This year we have also begun preparations for ASPET’ ...
... Our membership is also growing; this year we’ve recruited almost 500 new members, 350 of which are new student members. Next year, we hope to continue this growth and encourage more interest in pharmacology and the Society. Centennial Celebration: This year we have also begun preparations for ASPET’ ...
09107sgp04
... Approval has been granted to market salmeterol in over 100 countries. Salmeterol was first approved as a CFC-MDI (chlorofluorocarbon-containing metered dose inhaler) in the United Kingdom (UK) in 1990 and in the United States (US) in 1994. Salmeterol was later developed as SEREVENT® DISKUS®† (salmet ...
... Approval has been granted to market salmeterol in over 100 countries. Salmeterol was first approved as a CFC-MDI (chlorofluorocarbon-containing metered dose inhaler) in the United Kingdom (UK) in 1990 and in the United States (US) in 1994. Salmeterol was later developed as SEREVENT® DISKUS®† (salmet ...
Dyslipidemia update by Dr Sarma
... Dr.Sarma RVSN, M.D., M.Sc (Canada) Consultant in Medicine and Chest, ...
... Dr.Sarma RVSN, M.D., M.Sc (Canada) Consultant in Medicine and Chest, ...
COMPARATIVE EVALUATION OF NATURAL AND SYNTHETIC SUPERDISINTEGRANT FOR PROMOTING NIMESULIDE DISSOLUTION FOR FAST DISSOLVING TECHNOLOGY
... Now a days fast dissolving technology has a nice applicability in case of patient care. Because this type of formulation can disintegrate within few seconds and release their active ingredient very fast and onset of action can be achieved in few minutes. Mostly superdisintegran ...
... Now a days fast dissolving technology has a nice applicability in case of patient care. Because this type of formulation can disintegrate within few seconds and release their active ingredient very fast and onset of action can be achieved in few minutes. Mostly superdisintegran ...
Development of Fast Dispersible Aceclofenac Tablets: Effect of
... drug (NSAID) has been indicated for various painful indications1 and proved as effective as other NSAIDs with lower indications of gastro-intestinal adverse effects and thus, resulted in a greater compliance with treatment2. Aceclofenac is practically insoluble. For poorly soluble orally administere ...
... drug (NSAID) has been indicated for various painful indications1 and proved as effective as other NSAIDs with lower indications of gastro-intestinal adverse effects and thus, resulted in a greater compliance with treatment2. Aceclofenac is practically insoluble. For poorly soluble orally administere ...
- Boehringer Ingelheim (Canada)
... Aptivus contains up to 50.4 mg sorbitol per maximum recommended daily dose. Patients with the rare hereditary condition of fructose intolerance should not take this medicine. APTIVUS® capsules contain ethanol 7 % (v/v). This should be taken into account in pregnant or breast-feeding women, children, ...
... Aptivus contains up to 50.4 mg sorbitol per maximum recommended daily dose. Patients with the rare hereditary condition of fructose intolerance should not take this medicine. APTIVUS® capsules contain ethanol 7 % (v/v). This should be taken into account in pregnant or breast-feeding women, children, ...
Warfarin and acetaminophen interaction: a summary
... carboxylase and vitamin K-epoxide reductase (VKOR), in washed microsomal preparations. Acetaminophen did not affect activities of either enzyme. However, NAPQI oxidized vitamin K-hydroquinone (KH2), the “active” form of the vitamin. In addition, NAPQI directly inhibited vitamin K-dependent carboxyla ...
... carboxylase and vitamin K-epoxide reductase (VKOR), in washed microsomal preparations. Acetaminophen did not affect activities of either enzyme. However, NAPQI oxidized vitamin K-hydroquinone (KH2), the “active” form of the vitamin. In addition, NAPQI directly inhibited vitamin K-dependent carboxyla ...
WELLBUTRIN SR
... number was not sufficient to reach any conclusion about drug effect on suicide. It is unknown whether the suicidality risk extends to longer-term use, i.e., beyond several months. However, there is substantial evidence from placebo-controlled maintenance trials in adults with depression that the use ...
... number was not sufficient to reach any conclusion about drug effect on suicide. It is unknown whether the suicidality risk extends to longer-term use, i.e., beyond several months. However, there is substantial evidence from placebo-controlled maintenance trials in adults with depression that the use ...
S0735109711027628_mmc1
... statin, and assigned half of the reduction in risk based on a full dose given to a non-user. The same holds for an individual using anti-hypertensives at baseline and SBP >140, >140, >130 mm Hg respectively. ...
... statin, and assigned half of the reduction in risk based on a full dose given to a non-user. The same holds for an individual using anti-hypertensives at baseline and SBP >140, >140, >130 mm Hg respectively. ...
METRONIDAZOLE INTRAVENOUS INFUSION
... dosage of lithium has been reported to increase serum lithium concentrations, resulting in signs of lithium toxicity in several patients. Serum lithium and serum creatinine levels should be obtained several days after commencing metronidazole therapy to detect any increase that may precede clinical ...
... dosage of lithium has been reported to increase serum lithium concentrations, resulting in signs of lithium toxicity in several patients. Serum lithium and serum creatinine levels should be obtained several days after commencing metronidazole therapy to detect any increase that may precede clinical ...
Serum albumin, the most abundant protein in the
... Serum albumin, the most abundant protein in the circulatory system, has been one of the most extensively studied of all proteins 1. Serum albumins are prone to bind effectively many small organic molecules. Bovine serum albumin (BSA), a large globular protein (65,000 Daltons), consists of a single c ...
... Serum albumin, the most abundant protein in the circulatory system, has been one of the most extensively studied of all proteins 1. Serum albumins are prone to bind effectively many small organic molecules. Bovine serum albumin (BSA), a large globular protein (65,000 Daltons), consists of a single c ...
Epinefrina. Adrenalina. Monografia del farmaco.
... Patients with long-standing bronchial asthma and emphysema who have developed degenerative heart disease should be administered the drug with extreme caution. Overdosage or inadvertent intravenous injection of epinephrine may cause cerebrovascular hemorrhage resulting from the sharp rise in blood pr ...
... Patients with long-standing bronchial asthma and emphysema who have developed degenerative heart disease should be administered the drug with extreme caution. Overdosage or inadvertent intravenous injection of epinephrine may cause cerebrovascular hemorrhage resulting from the sharp rise in blood pr ...
Prescribing Framework for Phenelzine (MAOI) in the treatment of
... avoidance of bupropion for 2 weeks after stopping MAOIs advised by manufacturer of bupropion avoidance of MAOIs advised by manufacturer of buspirone enhanced hypotensive effect when MAOIs given with calcium-channel blockers avoidance for 2 weeks after stopping MAOIs advised by manufacturer of carbam ...
... avoidance of bupropion for 2 weeks after stopping MAOIs advised by manufacturer of bupropion avoidance of MAOIs advised by manufacturer of buspirone enhanced hypotensive effect when MAOIs given with calcium-channel blockers avoidance for 2 weeks after stopping MAOIs advised by manufacturer of carbam ...
Drug interaction
A drug interaction is a situation in which a substance (usually another drug) affects the activity of a drug when both are administered together. This action can be synergistic (when the drug's effect is increased) or antagonistic (when the drug's effect is decreased) or a new effect can be produced that neither produces on its own. Typically, interactions between drugs come to mind (drug-drug interaction). However, interactions may also exist between drugs and foods (drug-food interactions), as well as drugs and medicinal plants or herbs (drug-plant interactions). People taking antidepressant drugs such as monoamine oxidase inhibitors should not take food containing tyramine as hypertensive crisis may occur (an example of a drug-food interaction). These interactions may occur out of accidental misuse or due to lack of knowledge about the active ingredients involved in the relevant substances.It is therefore easy to see the importance of these pharmacological interactions in the practice of medicine. If a patient is taking two drugs and one of them increases the effect of the other it is possible that an overdose may occur. The interaction of the two drugs may also increase the risk that side effects will occur. On the other hand, if the action of a drug is reduced it may cease to have any therapeutic use because of under dosage. Notwithstanding the above, on occasion these interactions may be sought in order to obtain an improved therapeutic effect. Examples of this include the use of codeine with paracetamol to increase its analgesic effect. Or the combination of clavulanic acid with amoxicillin in order to overcome bacterial resistance to the antibiotic. It should also be remembered that there are interactions that, from a theoretical standpoint, may occur but in clinical practice have no important repercussions.The pharmaceutical interactions that are of special interest to the practice of medicine are primarily those that have negative effects for an organism. The risk that a pharmacological interaction will appear increases as a function of the number of drugs administered to a patient at the same time.It is possible that an interaction will occur between a drug and another substance present in the organism (i.e. foods or alcohol). Or in certain specific situations a drug may even react with itself, such as occurs with dehydration. In other situations, the interaction does not involve any effect on the drug. In certain cases, the presence of a drug in an individual's blood may affect certain types of laboratory analysis (analytical interference).It is also possible for interactions to occur outside an organism before administration of the drugs has taken place. This can occur when two drugs are mixed, for example, in a saline solution prior to intravenous injection. Some classic examples of this type of interaction include that Thiopentone and Suxamethonium should not be placed in the same syringe and same is true for Benzylpenicillin and Heparin. These situations will all be discussed under the same heading due to their conceptual similarity.Drug interactions may be the result of various processes. These processes may include alterations in the pharmacokinetics of the drug, such as alterations in the absorption, distribution, metabolism, and excretion (ADME) of a drug. Alternatively, drug interactions may be the result of the pharmacodynamic properties of the drug, e.g. the co-administration of a receptor antagonist and an agonist for the same receptor.