Syed Mohsin Ahmed 1 - journal of evidence based medicine and
... of diazoxide in type 2 diabetic patients who are on oral hypoglycemic drugs.3 Like diazoxide the novel potassium channel opener (nicorandil) also activates ATP sensitive potassium channels, which are present both on vascular smooth muscles and membrane of beta cells of pancreas. Hence nicorandil in ...
... of diazoxide in type 2 diabetic patients who are on oral hypoglycemic drugs.3 Like diazoxide the novel potassium channel opener (nicorandil) also activates ATP sensitive potassium channels, which are present both on vascular smooth muscles and membrane of beta cells of pancreas. Hence nicorandil in ...
Cardiovascular Drugs and Therapies HMG CoAa REDUCTASE
... hyperlinks) to which references are made in the Handbook. In no event shall UHN be liable for direct, indirect, consequential, special, exemplary, or other damages related to your use of the Handbook, regardless of how arising or the theory of liability whether arising in contract, tort, negligence ...
... hyperlinks) to which references are made in the Handbook. In no event shall UHN be liable for direct, indirect, consequential, special, exemplary, or other damages related to your use of the Handbook, regardless of how arising or the theory of liability whether arising in contract, tort, negligence ...
medicinal - American Chemical Society
... equipotent, while 3 was significantly less potent than either drug. The reasons for this are not clear, although this may indicate that factors other than 5-HT2and 5-HTlA interactions are involved. For instance, it is possible that, compared to the hallucinogenic phenethylamines, lysergamides may pr ...
... equipotent, while 3 was significantly less potent than either drug. The reasons for this are not clear, although this may indicate that factors other than 5-HT2and 5-HTlA interactions are involved. For instance, it is possible that, compared to the hallucinogenic phenethylamines, lysergamides may pr ...
INSITU GELLING OPHTHALMIC DRUG DELIVERY SYSTEM: AN OVERVIEW Review Article
... sustained release of the drug over six hours period, but Gelrite formulation showing long duration of release followed by combination of carbopol, HPMC and pluronic F‐127 and HPMC. The developed system is thus a viable alternative to conventional eye drops15. WenDi Ma ...
... sustained release of the drug over six hours period, but Gelrite formulation showing long duration of release followed by combination of carbopol, HPMC and pluronic F‐127 and HPMC. The developed system is thus a viable alternative to conventional eye drops15. WenDi Ma ...
Modeling and Simulation of Biochemical Processes
... equilibrium of the reactions responsible for their symptoms. There are several defining characteristics of drugs that are considered when modeling their behavior. Drugs can generally be classified as either stimulants or inhibitors, which respectively increase or decrease reaction rates. The efficacy of ...
... equilibrium of the reactions responsible for their symptoms. There are several defining characteristics of drugs that are considered when modeling their behavior. Drugs can generally be classified as either stimulants or inhibitors, which respectively increase or decrease reaction rates. The efficacy of ...
Drug Fact Sheet - Drug Free Business
... connects to specific sites called cannabinoid receptors on nerve cells and influences the activity of those cells. Many of these receptors are found in the parts of the brain that influence pleasure, memory, thought, concentration, sensory and time perception, and coordinated movement. The short-ter ...
... connects to specific sites called cannabinoid receptors on nerve cells and influences the activity of those cells. Many of these receptors are found in the parts of the brain that influence pleasure, memory, thought, concentration, sensory and time perception, and coordinated movement. The short-ter ...
Egg residue considerations during the treatment of backyard poultry
... residues were detected in the yolks of the eggs laid by those hens for up to 6 days after drug administration.7 Because ampicillin is quickly eliminated from plasma, it appears that ampicillin is transported by the circulation to developing follicles (eggs) immediately or shortly after administratio ...
... residues were detected in the yolks of the eggs laid by those hens for up to 6 days after drug administration.7 Because ampicillin is quickly eliminated from plasma, it appears that ampicillin is transported by the circulation to developing follicles (eggs) immediately or shortly after administratio ...
Marijuana
... Addiction can occur to THC, but only at dose and use levels far above what is now used recreationally. ...
... Addiction can occur to THC, but only at dose and use levels far above what is now used recreationally. ...
Stable drug encapsulation in micelles and microemulsions
... surfactants are not preferred due to toxicological concerns. Microemulsions often include a cosurfactant. A cosurfactant is an amphiphilic molecule that substantially accumulates with the surfactant at the interfacial layer. Usually a very low HLB cosurfactant is used with a high HLB surfactant to m ...
... surfactants are not preferred due to toxicological concerns. Microemulsions often include a cosurfactant. A cosurfactant is an amphiphilic molecule that substantially accumulates with the surfactant at the interfacial layer. Usually a very low HLB cosurfactant is used with a high HLB surfactant to m ...
10.4103_0975-1483.63169
... drugs (statins) are prescribed in patients of diabetes for the prevention of complications of diabetes like cardiovascular diseases or diabetic dyslipidemia.[4,5] The greatest effects are seen with the most potent statins such as simvastatin, atorvastatin, and rosuvastatin in higher doses.[6] One st ...
... drugs (statins) are prescribed in patients of diabetes for the prevention of complications of diabetes like cardiovascular diseases or diabetic dyslipidemia.[4,5] The greatest effects are seen with the most potent statins such as simvastatin, atorvastatin, and rosuvastatin in higher doses.[6] One st ...
Ina AIHA
... splenectomy only benefit for pt wt Ig G cold agglutinin plasma pheresis severe hemolysis ...
... splenectomy only benefit for pt wt Ig G cold agglutinin plasma pheresis severe hemolysis ...
FinMedChem2011
... development? Another question concerns the role of the untypical H-bond: are those common in small-molecular-protein interactions and if so, are those interactions really contributing to binding affinity? 3. Experimental All cases were retrieved using the MOAD database [1] and www.pdb.org [2]. 4. Re ...
... development? Another question concerns the role of the untypical H-bond: are those common in small-molecular-protein interactions and if so, are those interactions really contributing to binding affinity? 3. Experimental All cases were retrieved using the MOAD database [1] and www.pdb.org [2]. 4. Re ...
Master Thesis 2016 - 2017 - Department of Drug Design and
... Aim: To study how drugs compounds are metabolized by or inhibit cytochromes P450 (CYP) enzymes. Background: In humans, CYP enzymes are involved in several different transformations, e.g. the elimination of drug compounds and the synthesis of hormones. The main function of CYP enzymes is to oxidize c ...
... Aim: To study how drugs compounds are metabolized by or inhibit cytochromes P450 (CYP) enzymes. Background: In humans, CYP enzymes are involved in several different transformations, e.g. the elimination of drug compounds and the synthesis of hormones. The main function of CYP enzymes is to oxidize c ...
sustained and controlled drug delivery system - as a part
... comparison with the frequency required by a conventional dosage form. It is designed to maintain constant levels of a drug in the patient's bloodstream by releasing the drug over an extended period. Maintaining constant blood levels of the drug in the bloodstream increases the therapeutic effectiven ...
... comparison with the frequency required by a conventional dosage form. It is designed to maintain constant levels of a drug in the patient's bloodstream by releasing the drug over an extended period. Maintaining constant blood levels of the drug in the bloodstream increases the therapeutic effectiven ...
The importance of residence and recognition time of drug
... coagulation process and converts fibrinogen into clottable fibrin. ...
... coagulation process and converts fibrinogen into clottable fibrin. ...
Anticoagulants, Thrombolytics Agents and Antiplatelet Drugs
... How does gamma-carboxylation affect the vitamin K dependent proteins ? –gamma-carboxylation gives the proteins the ability to bind CALCIUM IONS ...
... How does gamma-carboxylation affect the vitamin K dependent proteins ? –gamma-carboxylation gives the proteins the ability to bind CALCIUM IONS ...
ANTI-ARRHYTHMIC DRUGS
... They lower blood pressure by decreasing vascular resistance and appear to depress C.O.P or HR less than other β blockers Significantly greater agonist than antagonist effects at β2 receptors Beneficial for patients with bradyarrhythmias or peripheral vascular ...
... They lower blood pressure by decreasing vascular resistance and appear to depress C.O.P or HR less than other β blockers Significantly greater agonist than antagonist effects at β2 receptors Beneficial for patients with bradyarrhythmias or peripheral vascular ...
Americas
... 409. The extent of the increase in criminal activities related to drug trafficking in Central American countries was confirmed by the release of the so-called “Panama papers”. The revelations contained in those leaked financial documents led to various operations, including the discovery, in an oper ...
... 409. The extent of the increase in criminal activities related to drug trafficking in Central American countries was confirmed by the release of the so-called “Panama papers”. The revelations contained in those leaked financial documents led to various operations, including the discovery, in an oper ...
N Gokal Counting the Costs
... These costs are difficult to measure accurately. However, they need to be taken into account in order to make reliable comparisons between one drug or technique with another. These costs can be broadly classified as direct and indirect costs. Direct costs include the price of the anaesthetic drugs t ...
... These costs are difficult to measure accurately. However, they need to be taken into account in order to make reliable comparisons between one drug or technique with another. These costs can be broadly classified as direct and indirect costs. Direct costs include the price of the anaesthetic drugs t ...
Short Bowel Syndrome in Adults - University of Virginia School of
... either from genetics or drug interactions (e.g., CYP2D6 inhibitors such as citalopram, fluoxetine, paroxetine), the antidiarrheal effect of codeine could be reduced compared with patients having normal CYP2D6 activity.8 Conversely, DNA variations also occurs in a subgroup of patients resulting in mo ...
... either from genetics or drug interactions (e.g., CYP2D6 inhibitors such as citalopram, fluoxetine, paroxetine), the antidiarrheal effect of codeine could be reduced compared with patients having normal CYP2D6 activity.8 Conversely, DNA variations also occurs in a subgroup of patients resulting in mo ...
Drug interaction
A drug interaction is a situation in which a substance (usually another drug) affects the activity of a drug when both are administered together. This action can be synergistic (when the drug's effect is increased) or antagonistic (when the drug's effect is decreased) or a new effect can be produced that neither produces on its own. Typically, interactions between drugs come to mind (drug-drug interaction). However, interactions may also exist between drugs and foods (drug-food interactions), as well as drugs and medicinal plants or herbs (drug-plant interactions). People taking antidepressant drugs such as monoamine oxidase inhibitors should not take food containing tyramine as hypertensive crisis may occur (an example of a drug-food interaction). These interactions may occur out of accidental misuse or due to lack of knowledge about the active ingredients involved in the relevant substances.It is therefore easy to see the importance of these pharmacological interactions in the practice of medicine. If a patient is taking two drugs and one of them increases the effect of the other it is possible that an overdose may occur. The interaction of the two drugs may also increase the risk that side effects will occur. On the other hand, if the action of a drug is reduced it may cease to have any therapeutic use because of under dosage. Notwithstanding the above, on occasion these interactions may be sought in order to obtain an improved therapeutic effect. Examples of this include the use of codeine with paracetamol to increase its analgesic effect. Or the combination of clavulanic acid with amoxicillin in order to overcome bacterial resistance to the antibiotic. It should also be remembered that there are interactions that, from a theoretical standpoint, may occur but in clinical practice have no important repercussions.The pharmaceutical interactions that are of special interest to the practice of medicine are primarily those that have negative effects for an organism. The risk that a pharmacological interaction will appear increases as a function of the number of drugs administered to a patient at the same time.It is possible that an interaction will occur between a drug and another substance present in the organism (i.e. foods or alcohol). Or in certain specific situations a drug may even react with itself, such as occurs with dehydration. In other situations, the interaction does not involve any effect on the drug. In certain cases, the presence of a drug in an individual's blood may affect certain types of laboratory analysis (analytical interference).It is also possible for interactions to occur outside an organism before administration of the drugs has taken place. This can occur when two drugs are mixed, for example, in a saline solution prior to intravenous injection. Some classic examples of this type of interaction include that Thiopentone and Suxamethonium should not be placed in the same syringe and same is true for Benzylpenicillin and Heparin. These situations will all be discussed under the same heading due to their conceptual similarity.Drug interactions may be the result of various processes. These processes may include alterations in the pharmacokinetics of the drug, such as alterations in the absorption, distribution, metabolism, and excretion (ADME) of a drug. Alternatively, drug interactions may be the result of the pharmacodynamic properties of the drug, e.g. the co-administration of a receptor antagonist and an agonist for the same receptor.