Substance Related Disorders
... play a key role in the development and maintenance of substance abuse ...
... play a key role in the development and maintenance of substance abuse ...
Medication Supported Recovery
... treating the pain with buprenorphine alone. The total daily dose of buprenorphine can be increased (to a maximum of 32 mg sublingual/day); it should be given in divided doses every 6-8 hours. • Another option is to continue buprenorphine and use short-acting opioid agonists at high enough doses to o ...
... treating the pain with buprenorphine alone. The total daily dose of buprenorphine can be increased (to a maximum of 32 mg sublingual/day); it should be given in divided doses every 6-8 hours. • Another option is to continue buprenorphine and use short-acting opioid agonists at high enough doses to o ...
USP Overview and Some Current Activities
... on the Specification Limits for Residues of Metal Catalysts (CPMP/SWP/4446/00) lists 14 catalysts used in pharmaceutical synthesis – Exclude zinc and iron, which are not toxic at levels relevant in pharmaceuticals ...
... on the Specification Limits for Residues of Metal Catalysts (CPMP/SWP/4446/00) lists 14 catalysts used in pharmaceutical synthesis – Exclude zinc and iron, which are not toxic at levels relevant in pharmaceuticals ...
LSD Music final accepted - Spiral
... for many centuries (Nettl 1956), was a staple component in psychedelic-assisted psychotherapy in the 1950s and 60s (Bonny and Pahnke 1972; Grof 1980) and remains so today (Bogenschutz et al 2015; Johnson et al 2014; Gasser et al 2014a; Gasser et al 2014b; Grob et al 2011). It has been proposed that ...
... for many centuries (Nettl 1956), was a staple component in psychedelic-assisted psychotherapy in the 1950s and 60s (Bonny and Pahnke 1972; Grof 1980) and remains so today (Bogenschutz et al 2015; Johnson et al 2014; Gasser et al 2014a; Gasser et al 2014b; Grob et al 2011). It has been proposed that ...
PRODUCT MONOGRAPH PrMatulane® Procarbazine
... hypotensive agents, phenothiazines, momoamine oxidase (MAO) inhibitors, or catechol-Omthyltransferase (COMT) inhibitors. Matulane can interfere with the absorption of digoxin. The effects of antidiabetics and levodopa may be enhanced by Matulane use. Sensitivity to Matulane can be increased when use ...
... hypotensive agents, phenothiazines, momoamine oxidase (MAO) inhibitors, or catechol-Omthyltransferase (COMT) inhibitors. Matulane can interfere with the absorption of digoxin. The effects of antidiabetics and levodopa may be enhanced by Matulane use. Sensitivity to Matulane can be increased when use ...
Iboga - Scientific Information
... Ibogaine (12-methoxyibogamine) is the main alkaloid of at least 12 alkaloids found in the Tabernanthe iboga plant. After ingestion, ibogaine is metabolized by the cytochrome P450 2D6 (CYP2D6) into also active metabolite noribogaine (12hydroxyibogamine) (6). Since it has been shown that noribogaine p ...
... Ibogaine (12-methoxyibogamine) is the main alkaloid of at least 12 alkaloids found in the Tabernanthe iboga plant. After ingestion, ibogaine is metabolized by the cytochrome P450 2D6 (CYP2D6) into also active metabolite noribogaine (12hydroxyibogamine) (6). Since it has been shown that noribogaine p ...
FSC402H Forensic Toxicology of Common Pharmaceuticals
... Tolerance needs to be considered Often information on dose, not plasma (blood) concentration is available No means through law to obtain a blood sample from an individual – seized hospital samples from motor vehicle collisions ...
... Tolerance needs to be considered Often information on dose, not plasma (blood) concentration is available No means through law to obtain a blood sample from an individual – seized hospital samples from motor vehicle collisions ...
DEVELOPMENT AND CHARACTERIZATION OF FLUTAMIDE CONTAINING SELF-MICROEMULSIFYING DRUG DELIVERY SYSTEM (SMEDDS)
... antiandrogen that acts by inhibiting the uptake and/or binding of ...
... antiandrogen that acts by inhibiting the uptake and/or binding of ...
ANTIINFLAMMATORY AND ANTIBACTERIAL ACTIVITIES OF DIFFERENT EXTRACTS OF GYNANDROPSIS GYNANDRA
... The inflammation has long been recognized; the tissues become red, swollen, tender, or painful, there is local heat and the patient may be febrile. Inflammation can be categorized mainly as Chronic and Acute inflammatory disease. Acute and chronic inflammatory diseases are still one of the most impo ...
... The inflammation has long been recognized; the tissues become red, swollen, tender, or painful, there is local heat and the patient may be febrile. Inflammation can be categorized mainly as Chronic and Acute inflammatory disease. Acute and chronic inflammatory diseases are still one of the most impo ...
Effects of Social Interaction and Warm Ambient
... but such elevations are less than those induced by MDMA. MDPV is reported to cause hyperthermia in mice (3–30 mg/kg, i.p.) but only at elevated ambient temperature (Fantegrossi et al, 2013). In rats, acute MDPV (1.0–5.6 mg/kg, s.c.) has no effect on core temperature (Aarde et al, 2013). Thus, it rem ...
... but such elevations are less than those induced by MDMA. MDPV is reported to cause hyperthermia in mice (3–30 mg/kg, i.p.) but only at elevated ambient temperature (Fantegrossi et al, 2013). In rats, acute MDPV (1.0–5.6 mg/kg, s.c.) has no effect on core temperature (Aarde et al, 2013). Thus, it rem ...
DGL - bioclinicnaturals
... Drug Interactions: No known drug interactions. Licorice influences the activity of several cytochrome enzymes, and reduces warfarin activity in animal models, likely due to glycyrrhizic acid activity. Thus DGL use should be carefully monitored in these ...
... Drug Interactions: No known drug interactions. Licorice influences the activity of several cytochrome enzymes, and reduces warfarin activity in animal models, likely due to glycyrrhizic acid activity. Thus DGL use should be carefully monitored in these ...
Formulation and evaluation of fluconazole and ichthammol ointment
... Ointment was removed from each tube and each empty tube was washed with methanol. The empty tubes were dried and their weight was taken. The difference between two weights was calculated as net weight of the ointment of tube. The average of net weight of ointment of ten tubes was noted. ...
... Ointment was removed from each tube and each empty tube was washed with methanol. The empty tubes were dried and their weight was taken. The difference between two weights was calculated as net weight of the ointment of tube. The average of net weight of ointment of ten tubes was noted. ...
Sections 18 to 27
... All plasma fractions should comply with the WHO Requirements for the Collection, Processing and Quality Control of Blood, Blood Components and Plasma Derivatives (Revised 1992). WHO Expert Committee on Biological Standardization Forty-third report, WHO Technical Report Series, No. 840, 1994, Annex 2 ...
... All plasma fractions should comply with the WHO Requirements for the Collection, Processing and Quality Control of Blood, Blood Components and Plasma Derivatives (Revised 1992). WHO Expert Committee on Biological Standardization Forty-third report, WHO Technical Report Series, No. 840, 1994, Annex 2 ...
Fluvoxamine as a cause of stimulation, mania and
... in a Manic Episode may be due to the direct effects of antidepressant medication. . .” (1994, p. 329). Similarly, it observes that “Symptoms like those seen in a Manic Episode may also be precipitated by antidepressant treatment such as medication. . .” (1994, p. 331). References to antidepressant-i ...
... in a Manic Episode may be due to the direct effects of antidepressant medication. . .” (1994, p. 329). Similarly, it observes that “Symptoms like those seen in a Manic Episode may also be precipitated by antidepressant treatment such as medication. . .” (1994, p. 331). References to antidepressant-i ...
Committee on Law Enforcement/Legislation
... The Task Force was successful in preparing model regulations for patient counseling and prospective DUR that could be used by the state boards of pharmacy. The packet was reviewed and enforced by the Committee for states to utilize when developing regulations to implement the patient counseling and ...
... The Task Force was successful in preparing model regulations for patient counseling and prospective DUR that could be used by the state boards of pharmacy. The packet was reviewed and enforced by the Committee for states to utilize when developing regulations to implement the patient counseling and ...
International Journal of Experimental pharmacology
... Luffa acutangula (Family: Cucurbitaceae) is commonly known as Ridge gourd. It is a widely growing vegetative climber. In the present study we evaluated the anticataleptic efficacy of ethanol extract of Luffa acutangula in haloperidol induced catalepsy in rats. Scientific evaluation of this claim usi ...
... Luffa acutangula (Family: Cucurbitaceae) is commonly known as Ridge gourd. It is a widely growing vegetative climber. In the present study we evaluated the anticataleptic efficacy of ethanol extract of Luffa acutangula in haloperidol induced catalepsy in rats. Scientific evaluation of this claim usi ...
3. ACHIEVEment of policy goals
... considering them in the context of the broader policy and market environment in which they operate, and investigating their role in contributing to Canada’s achievements in meeting a range of objectives relating to the pharmaceutical policy. The federal government regulates prices of patented pharma ...
... considering them in the context of the broader policy and market environment in which they operate, and investigating their role in contributing to Canada’s achievements in meeting a range of objectives relating to the pharmaceutical policy. The federal government regulates prices of patented pharma ...
Unit 4
... thoughts, feelings, and sensations are clear, organized, and the person feels alert. Altered state of consciousness - state in which there is a shift in the quality or pattern of mental activity as compared to waking ...
... thoughts, feelings, and sensations are clear, organized, and the person feels alert. Altered state of consciousness - state in which there is a shift in the quality or pattern of mental activity as compared to waking ...
Initial Severity and Antidepressant Benefits: A Meta-Analysis
... drug and placebo groups’ arithmetic mean (weighted for the inverse of the variance) as the meta-analytic ‘‘effect size’’ [11]. The first analysis permitted a determination of the absolute magnitude of change in both the placebo and treatment groups. Results permitted a determination of overall trends ...
... drug and placebo groups’ arithmetic mean (weighted for the inverse of the variance) as the meta-analytic ‘‘effect size’’ [11]. The first analysis permitted a determination of the absolute magnitude of change in both the placebo and treatment groups. Results permitted a determination of overall trends ...
Management of Status Epilepticus (SE)
... Duration: variable 45-70% protein-bound Hepatic metabolism ...
... Duration: variable 45-70% protein-bound Hepatic metabolism ...
Lidocaine Hydrochloride and Epinephrine
... with caution in patients with hepatic disease. Patients with severe hepatic disease because of their inability to metabolize local anesthetics normally, are a greater risk of developing toxic plasma concentrations. Lidocaine should also be used with caution in patients with impaired cardiovascular f ...
... with caution in patients with hepatic disease. Patients with severe hepatic disease because of their inability to metabolize local anesthetics normally, are a greater risk of developing toxic plasma concentrations. Lidocaine should also be used with caution in patients with impaired cardiovascular f ...
DESEANSIBILIZACION A ASA
... administration of a drug in order to diagnose hypersensitivity reactions The challenge test should be done under medical supervision for an alternative drug, structurally or pharmacologically related to the suspect medicine. The provocation test drug is also known as challenge or controlled re-chall ...
... administration of a drug in order to diagnose hypersensitivity reactions The challenge test should be done under medical supervision for an alternative drug, structurally or pharmacologically related to the suspect medicine. The provocation test drug is also known as challenge or controlled re-chall ...
Drug interaction
A drug interaction is a situation in which a substance (usually another drug) affects the activity of a drug when both are administered together. This action can be synergistic (when the drug's effect is increased) or antagonistic (when the drug's effect is decreased) or a new effect can be produced that neither produces on its own. Typically, interactions between drugs come to mind (drug-drug interaction). However, interactions may also exist between drugs and foods (drug-food interactions), as well as drugs and medicinal plants or herbs (drug-plant interactions). People taking antidepressant drugs such as monoamine oxidase inhibitors should not take food containing tyramine as hypertensive crisis may occur (an example of a drug-food interaction). These interactions may occur out of accidental misuse or due to lack of knowledge about the active ingredients involved in the relevant substances.It is therefore easy to see the importance of these pharmacological interactions in the practice of medicine. If a patient is taking two drugs and one of them increases the effect of the other it is possible that an overdose may occur. The interaction of the two drugs may also increase the risk that side effects will occur. On the other hand, if the action of a drug is reduced it may cease to have any therapeutic use because of under dosage. Notwithstanding the above, on occasion these interactions may be sought in order to obtain an improved therapeutic effect. Examples of this include the use of codeine with paracetamol to increase its analgesic effect. Or the combination of clavulanic acid with amoxicillin in order to overcome bacterial resistance to the antibiotic. It should also be remembered that there are interactions that, from a theoretical standpoint, may occur but in clinical practice have no important repercussions.The pharmaceutical interactions that are of special interest to the practice of medicine are primarily those that have negative effects for an organism. The risk that a pharmacological interaction will appear increases as a function of the number of drugs administered to a patient at the same time.It is possible that an interaction will occur between a drug and another substance present in the organism (i.e. foods or alcohol). Or in certain specific situations a drug may even react with itself, such as occurs with dehydration. In other situations, the interaction does not involve any effect on the drug. In certain cases, the presence of a drug in an individual's blood may affect certain types of laboratory analysis (analytical interference).It is also possible for interactions to occur outside an organism before administration of the drugs has taken place. This can occur when two drugs are mixed, for example, in a saline solution prior to intravenous injection. Some classic examples of this type of interaction include that Thiopentone and Suxamethonium should not be placed in the same syringe and same is true for Benzylpenicillin and Heparin. These situations will all be discussed under the same heading due to their conceptual similarity.Drug interactions may be the result of various processes. These processes may include alterations in the pharmacokinetics of the drug, such as alterations in the absorption, distribution, metabolism, and excretion (ADME) of a drug. Alternatively, drug interactions may be the result of the pharmacodynamic properties of the drug, e.g. the co-administration of a receptor antagonist and an agonist for the same receptor.