A Multimodal Data Analysis Approach for Targeted Drug Discovery
... silico drug discovery, or as some refer to it, computer-aided drug design (CADD), has had numerous successes, such as aiding in the discovery of drugs against human immunodeficiency virus (HIV) including ritonavir and indinavir, as well as captopril, an angiotensin-converting enzyme (ACE) inhibitor f ...
... silico drug discovery, or as some refer to it, computer-aided drug design (CADD), has had numerous successes, such as aiding in the discovery of drugs against human immunodeficiency virus (HIV) including ritonavir and indinavir, as well as captopril, an angiotensin-converting enzyme (ACE) inhibitor f ...
Tybost - Gilead Sciences, Inc.
... interactions. TYBOST and ritonavir when administered with either atazanavir or darunavir may result in different drug interactions when used with concomitant medications. (5.3, 7, 12.3). ------------------------DOSAGE AND ADMINISTRATION --------------------- TYBOST must be coadministered with ataza ...
... interactions. TYBOST and ritonavir when administered with either atazanavir or darunavir may result in different drug interactions when used with concomitant medications. (5.3, 7, 12.3). ------------------------DOSAGE AND ADMINISTRATION --------------------- TYBOST must be coadministered with ataza ...
MIFLONIDE
... (hypothalamic-pituitary-adrenal) axis function should be monitored regularly. Some patients need an extra supply of corticosteroids under these circumstances; they are advised to carry a warning card with them drawing attention to their potentially serious condition. Substitution of systemic cortico ...
... (hypothalamic-pituitary-adrenal) axis function should be monitored regularly. Some patients need an extra supply of corticosteroids under these circumstances; they are advised to carry a warning card with them drawing attention to their potentially serious condition. Substitution of systemic cortico ...
IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) e-ISSN: 2278-3008, p-ISSN:2319-7676.
... The result of the analgesic activity evaluated using hot plate method revealed that the reaction time for mice was significantly increased in a dose dependent manner after one hour of oral administration. It was found that both KVC and Aspirin caused an inhibition on the writhing response induced by ...
... The result of the analgesic activity evaluated using hot plate method revealed that the reaction time for mice was significantly increased in a dose dependent manner after one hour of oral administration. It was found that both KVC and Aspirin caused an inhibition on the writhing response induced by ...
Session 9: Central Nervous System Depressants
... There are six major subcategories of CNS Depressants other than alcohol. Barbiturates More than 250 different barbiturates have been produced; of these, about 50 have been accepted for medical use. • Derivatives of Barbituric Acid • First produced in 1864 • Very common in use and abuse today Non-Bar ...
... There are six major subcategories of CNS Depressants other than alcohol. Barbiturates More than 250 different barbiturates have been produced; of these, about 50 have been accepted for medical use. • Derivatives of Barbituric Acid • First produced in 1864 • Very common in use and abuse today Non-Bar ...
IN SITU Research Article SANTHOSH KUMAR.J*
... The present study deals with the formulation and evaluation of cytarabine in situ implants. Cytarabine is a synthetic pyrimidine nucleoside. Cytarabine is most commonly used to treat acute myeloid leukaemia.The purpose of this research is to minimize the frequency of doses and toxicity and to improv ...
... The present study deals with the formulation and evaluation of cytarabine in situ implants. Cytarabine is a synthetic pyrimidine nucleoside. Cytarabine is most commonly used to treat acute myeloid leukaemia.The purpose of this research is to minimize the frequency of doses and toxicity and to improv ...
Pharmaceuticals and the Elderly - WHO archives
... the elderly, the increasing prevalence of diseases (including co-morbidities) and the large numbers of drugs used per patient have a major impact on the health systems.3, 4 The rate of adverse drug reactions in elderly is higher than in other parts of the society, 5 whereas about between 27.6 and 51 ...
... the elderly, the increasing prevalence of diseases (including co-morbidities) and the large numbers of drugs used per patient have a major impact on the health systems.3, 4 The rate of adverse drug reactions in elderly is higher than in other parts of the society, 5 whereas about between 27.6 and 51 ...
Popular Depression Medications
... A medication that is used for treating depression (an antidepressant). It works by affecting neurotransmitters in the brain, the chemical messengers that nerves use to communicate with one another. Neurotransmitters are made and released by nerves and then travel to other nearby nerves where they at ...
... A medication that is used for treating depression (an antidepressant). It works by affecting neurotransmitters in the brain, the chemical messengers that nerves use to communicate with one another. Neurotransmitters are made and released by nerves and then travel to other nearby nerves where they at ...
Biomarkers and surrogate endpoints: How and when might they
... are thought to reflect a given molecule’s mechanism of action and/or its pharmacodynamic activity. The hope is that such biomarkers could be used to direct key development decisions such as selection of agents for further development, selection of dose and/or schedule and selection of patients. Unfo ...
... are thought to reflect a given molecule’s mechanism of action and/or its pharmacodynamic activity. The hope is that such biomarkers could be used to direct key development decisions such as selection of agents for further development, selection of dose and/or schedule and selection of patients. Unfo ...
Pharmacology/Therapeutics I Block 2 Lectures 12. Drug Actions in
... up into the cell. If they are not rapidly transported into the synaptic vesicle they become subject to rapid degradation by monoamine oxidase (MAO). MAO inhibitors lead to increased catecholamines in the cytoplasm. As norepinephrine accumulates in the cytoplasm, the transporter protein reverses dire ...
... up into the cell. If they are not rapidly transported into the synaptic vesicle they become subject to rapid degradation by monoamine oxidase (MAO). MAO inhibitors lead to increased catecholamines in the cytoplasm. As norepinephrine accumulates in the cytoplasm, the transporter protein reverses dire ...
a review on technologies, recent trends and regulatory aspects
... In conclusion, “bad taste” is going to be an ongoing pediatric drug formulation problem because of the diverse number of receptors, the multiple transduction pathways, and age-related sensitivity based on genotype. Infants and children live in different sensory worlds, and there is a need for valida ...
... In conclusion, “bad taste” is going to be an ongoing pediatric drug formulation problem because of the diverse number of receptors, the multiple transduction pathways, and age-related sensitivity based on genotype. Infants and children live in different sensory worlds, and there is a need for valida ...
Where to purchase Diane no rx
... of whether or not such. Where to purchase Diane no rx Neuropsychiatric Symptoms and Suicide Risk in Smoking or prior diagnosis of bulimia or anorexia the benefits and risks associated with treatment see CLINICAL PHARMACOLOGY, WARNINGS, and DOSAGE AND. The emergence of such symptoms on a supine blood ...
... of whether or not such. Where to purchase Diane no rx Neuropsychiatric Symptoms and Suicide Risk in Smoking or prior diagnosis of bulimia or anorexia the benefits and risks associated with treatment see CLINICAL PHARMACOLOGY, WARNINGS, and DOSAGE AND. The emergence of such symptoms on a supine blood ...
FORMULATION AND EVALUATION OF FAST DISSOLVING TABLET CONTAINING AMLODIPINE Research Article
... The purpose of the present investigation was to increase the solubility and dissolution rate of amlodipine besylate by the preparation of its solid dispersion with PEG 4000, PVP K-30 using kneading process. Drug polymer interactions were investigated using differential scanning calorimetry (DSC) and ...
... The purpose of the present investigation was to increase the solubility and dissolution rate of amlodipine besylate by the preparation of its solid dispersion with PEG 4000, PVP K-30 using kneading process. Drug polymer interactions were investigated using differential scanning calorimetry (DSC) and ...
JB-D - Pharmaceutical Press
... using sprays, it is not only the dose but also the concentration that is of importance, and the same applies for drugs administered on the skin. If a small amount of a drug is given at an extremely high concentration, the drug may have a strong effect locally (causing, for example, severe erythema), ...
... using sprays, it is not only the dose but also the concentration that is of importance, and the same applies for drugs administered on the skin. If a small amount of a drug is given at an extremely high concentration, the drug may have a strong effect locally (causing, for example, severe erythema), ...
Luvox (fluvoxamine)
... Antidepressants known as monoamine oxidase inhibitors (MAOIs) should not be taken together with Luvox, because the combination may potentially produce a toxic reaction that includes elevated temperature, high blood pressure, and extreme excitation and agitation. Patients should consult their physici ...
... Antidepressants known as monoamine oxidase inhibitors (MAOIs) should not be taken together with Luvox, because the combination may potentially produce a toxic reaction that includes elevated temperature, high blood pressure, and extreme excitation and agitation. Patients should consult their physici ...
influence of oxcarbazepine on the antinociceptive action of
... Analgesics are combined with drugs belonging to other therapeutic groups, including, more and more frequently, antiepileptic agents. The influence of oxcarbazepine (10 mg/kg) on the antinociceptive effect of morphine (10 mg/kg) and metamizole (500 mg/kg) was investigated in mice using the hot-plate ...
... Analgesics are combined with drugs belonging to other therapeutic groups, including, more and more frequently, antiepileptic agents. The influence of oxcarbazepine (10 mg/kg) on the antinociceptive effect of morphine (10 mg/kg) and metamizole (500 mg/kg) was investigated in mice using the hot-plate ...
Attention-Deficit Hyperactivity Disorder (ADHD) Drug
... How should patients be monitored? (See also chart) • Regular documentation of the progress of symptoms and impairment should be made through the appropriate use of rating scales, such as SNAP-IV Swanson, Nolan and Pelham Questionnaire, CGI Clinical Global Impression Scale and Conners’ rating scale, ...
... How should patients be monitored? (See also chart) • Regular documentation of the progress of symptoms and impairment should be made through the appropriate use of rating scales, such as SNAP-IV Swanson, Nolan and Pelham Questionnaire, CGI Clinical Global Impression Scale and Conners’ rating scale, ...
CINERARIA LINN AGAINST CARBON TETRACHLORIDE INDUCED HEPATOTOXICITY Research Article VELMURUGAN V
... exogenous xenobiotic, drugs, viral infection and chronic alcoholism. The liver is involved with almost all the biochemical pathways to growth, fight against disease, nutrient supply, energy provision and reproduction [1]. The major functions of the liver are carbohydrate, protein and fat metabolism, ...
... exogenous xenobiotic, drugs, viral infection and chronic alcoholism. The liver is involved with almost all the biochemical pathways to growth, fight against disease, nutrient supply, energy provision and reproduction [1]. The major functions of the liver are carbohydrate, protein and fat metabolism, ...
Sebastiania chamaelea Research Article N.YASODAMMA*, K.S.SHANTHI SREE, C.ALEKHYA
... Objective: There is an immense need in the herbal remedies still in the treatment of diarrhea. The juice of the Sebastiania chamealea is used as astringent and used as a remedy for diarrhea by the herbalists. Hence antidiarrhoel activity of leaf extracts was carried out. Methods: Acute toxicity stud ...
... Objective: There is an immense need in the herbal remedies still in the treatment of diarrhea. The juice of the Sebastiania chamealea is used as astringent and used as a remedy for diarrhea by the herbalists. Hence antidiarrhoel activity of leaf extracts was carried out. Methods: Acute toxicity stud ...
Drug Resistance
... Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. ...
... Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. ...
Management of Graves` Disease in Children and Adolescents
... depending on gland size re-Px rate = 24.3% large goitre + stopping ATD 3 days before I- 131 re-Px one thyroid storm – the patient stopped ATD 13 days before I-131 one year hypo T = 31% ...
... depending on gland size re-Px rate = 24.3% large goitre + stopping ATD 3 days before I- 131 re-Px one thyroid storm – the patient stopped ATD 13 days before I-131 one year hypo T = 31% ...
Marijuana - City of Green River
... merely accumulates in fat tissue, which has a high affinity for THC. Some of the THC is partially degraded, but it remains a cannabinol residue. Cannabinol residues and THC are excreted largely by the bile, but only at a very slow rate. The implication of this type finding for humans is that progres ...
... merely accumulates in fat tissue, which has a high affinity for THC. Some of the THC is partially degraded, but it remains a cannabinol residue. Cannabinol residues and THC are excreted largely by the bile, but only at a very slow rate. The implication of this type finding for humans is that progres ...
448-452 - Cairo University Scholars
... produced with Selenium combination with the same drug. However, the use of each antioxidant alone didn’t induce any considerable effect. Synergistic effect of antioxidants with specific antiparasitic drug may occur as a result of the ability of the antioxidant to improve the immune and general healt ...
... produced with Selenium combination with the same drug. However, the use of each antioxidant alone didn’t induce any considerable effect. Synergistic effect of antioxidants with specific antiparasitic drug may occur as a result of the ability of the antioxidant to improve the immune and general healt ...
Drug interaction
A drug interaction is a situation in which a substance (usually another drug) affects the activity of a drug when both are administered together. This action can be synergistic (when the drug's effect is increased) or antagonistic (when the drug's effect is decreased) or a new effect can be produced that neither produces on its own. Typically, interactions between drugs come to mind (drug-drug interaction). However, interactions may also exist between drugs and foods (drug-food interactions), as well as drugs and medicinal plants or herbs (drug-plant interactions). People taking antidepressant drugs such as monoamine oxidase inhibitors should not take food containing tyramine as hypertensive crisis may occur (an example of a drug-food interaction). These interactions may occur out of accidental misuse or due to lack of knowledge about the active ingredients involved in the relevant substances.It is therefore easy to see the importance of these pharmacological interactions in the practice of medicine. If a patient is taking two drugs and one of them increases the effect of the other it is possible that an overdose may occur. The interaction of the two drugs may also increase the risk that side effects will occur. On the other hand, if the action of a drug is reduced it may cease to have any therapeutic use because of under dosage. Notwithstanding the above, on occasion these interactions may be sought in order to obtain an improved therapeutic effect. Examples of this include the use of codeine with paracetamol to increase its analgesic effect. Or the combination of clavulanic acid with amoxicillin in order to overcome bacterial resistance to the antibiotic. It should also be remembered that there are interactions that, from a theoretical standpoint, may occur but in clinical practice have no important repercussions.The pharmaceutical interactions that are of special interest to the practice of medicine are primarily those that have negative effects for an organism. The risk that a pharmacological interaction will appear increases as a function of the number of drugs administered to a patient at the same time.It is possible that an interaction will occur between a drug and another substance present in the organism (i.e. foods or alcohol). Or in certain specific situations a drug may even react with itself, such as occurs with dehydration. In other situations, the interaction does not involve any effect on the drug. In certain cases, the presence of a drug in an individual's blood may affect certain types of laboratory analysis (analytical interference).It is also possible for interactions to occur outside an organism before administration of the drugs has taken place. This can occur when two drugs are mixed, for example, in a saline solution prior to intravenous injection. Some classic examples of this type of interaction include that Thiopentone and Suxamethonium should not be placed in the same syringe and same is true for Benzylpenicillin and Heparin. These situations will all be discussed under the same heading due to their conceptual similarity.Drug interactions may be the result of various processes. These processes may include alterations in the pharmacokinetics of the drug, such as alterations in the absorption, distribution, metabolism, and excretion (ADME) of a drug. Alternatively, drug interactions may be the result of the pharmacodynamic properties of the drug, e.g. the co-administration of a receptor antagonist and an agonist for the same receptor.