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DNA Sequence Analysis of Genes Related to Functional
DNA Sequence Analysis of Genes Related to Functional

... A functional disorder is a medical condition that impairs the normal function of a bodily process, but where the body or associated organs appear normal under examination, imaging, laboratory values, or other standard studies. The occurrence of multiple functional symptoms in one individual suggests ...
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Human Genome Case Study
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Topics in Computational Biology

... The genome contained within a human cell is very large and complex. It holds all of the genetic information necessary for its creation and function encoded with a total of six feet of DNA. The goals of the Human Genome Initiative (HGI), as framed by the National Institutes of Health and the Departme ...
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Whole genome sequencing



Whole genome sequencing (also known as full genome sequencing, complete genome sequencing, or entire genome sequencing) is a laboratory process that determines the complete DNA sequence of an organism's genome at a single time. This entails sequencing all of an organism's chromosomal DNA as well as DNA contained in the mitochondria and, for plants, in the chloroplast.Whole genome sequencing should not be confused with DNA profiling, which only determines the likelihood that genetic material came from a particular individual or group, and does not contain additional information on genetic relationships, origin or susceptibility to specific diseases. Also unlike full genome sequencing, SNP genotyping covers less than 0.1% of the genome. Almost all truly complete genomes are of microbes; the term ""full genome"" is thus sometimes used loosely to mean ""greater than 95%"". The remainder of this article focuses on nearly complete human genomes.High-throughput genome sequencing technologies have largely been used as a research tool and are currently being introduced in the clinics. In the future of personalized medicine, whole genome sequence data will be an important tool to guide therapeutic intervention. The tool of gene sequencing at SNP level is also used to pinpoint functional variants from association studies and improve the knowledge available to researchers interested in evolutionary biology, and hence may lay the foundation for predicting disease susceptibility and drug response.
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