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Nerve activates contraction
Nerve activates contraction

... • Axon endings are called synaptic terminals. • They contain neurotransmitters which conduct a signal across a synapse. • A synapse is the junction between a presynaptic and postsynaptic neuron. Synapses can be electrical or chemical. Ions carry information in electrical synapses. In chemical synap ...
Slide 1 - Elsevier Store
Slide 1 - Elsevier Store

... FIGURE 24.11 The medial path taken by spinothalamic neurons in lamina I (driven by C fibers) differs from the lateral path taken by neurons in laminae IV and V (driven by C and Aδ nociceptors and Aβ mechanoreceptors). Anterior spinothalamic tract axons are given off by the deeper neurons and termin ...
Chapter Two Line Title Here and Chapter Title Here and Here
Chapter Two Line Title Here and Chapter Title Here and Here

... A. Thirty-one pairs of mixed spinal nerves arise from the spinal cord and serve the entire body except the head and neck (pp. 501–503; Figs. 13.7–13.8). 1. Each spinal nerve connects to the spinal cord by a ventral root, containing motor fibers, and a dorsal root, containing sensory fibers. B. Inner ...
The kinaesthetic senses
The kinaesthetic senses

... contribution. In addition, receptors from skin and signals of central origin associated with the sense of effort or will and derived from the motor command, have become recognised as playing important roles. The principal muscle receptor in kinaesthesia is the muscle spindle. It includes both the pr ...
Lecture notes for Chapter 13
Lecture notes for Chapter 13

Slide 1
Slide 1

... •  A single neuron may receive input from many synapses. •  Neurons “decide” whether to generate an action potential by adding up excitatory and inhibitory input. ...
Dropped Questions Power Point - Fort Thomas Independent Schools
Dropped Questions Power Point - Fort Thomas Independent Schools

... Opiate drugs occupy the same receptor sites as what neurotransmitter? A. acetylcholine B. serotonin C. endorphins D. dopamine E. epinephrine ...
CranialN11
CranialN11

... IV. Trochlear n.  superior oblique muscle (Fig. 123). In Fig. 12-4 (not shown here), note that in the dorsal brainstem, all axons decussate. VI. Abducens n.  lateral rectus muscle. ...
01-Spinal Reflexes Student`s Copy
01-Spinal Reflexes Student`s Copy

... fringe zones and raises the excitability of the neurons (within the subliminal zones) to discharge. ...
Central nervous system
Central nervous system

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How to get on the right track

... imaging capabilities and a relative lack of genetic redundancy. They started from the ground up, identifying several unc-33 alleles in a screen for altered localization of presynaptic proteins. In most of their experiments, the authors focused on the PVD sensory neuron, which produces a characterist ...
Leap 2 - Teacher - Teacher Enrichment Initiatives
Leap 2 - Teacher - Teacher Enrichment Initiatives

... either cause an effect or feeling (excitatory) or prevent an effect or feeling (inhibitory). These chemical compounds exist in a delicate balance (equilibrium). The type of neurotransmitter activated, either inhibitory or excitatory, is dependent on the activity and the part of the brain involved. P ...
Spinal Cord and Spinal Nerves
Spinal Cord and Spinal Nerves

... Peripheral Nervous System • Peripheral nerves contain both motor and sensory neurons • Among the motor neurons, some of these are somatic and innervate skeletal muscles while some are autonomic and innervate smooth muscle, cardiac muscle, and glands • Sensory neurons are not subdivided into somatic ...
Accessory muscle in the hypothenar region: a functional approach
Accessory muscle in the hypothenar region: a functional approach

Reflexes - Sinoe Medical Association
Reflexes - Sinoe Medical Association

... • Soft cloth is placed over the babies eyes and nose • Baby arches head and turns head side to side • Brings both hands to face to swipe cloth away ...
Chapter 9 - Nervous System
Chapter 9 - Nervous System

... Nerve impulses travel from neuron to neuron along complex nerve pathways. B. The junction between two communicating neurons is called a synapse; there exists a synaptic cleft between them across which the impulse must be conveyed. ...
Chapter 13 - PNS
Chapter 13 - PNS

... • Step 1: Arrival of stimulus, activation of receptor – physical or chemical changes ...
Chapter 13 Student Guide
Chapter 13 Student Guide

... 4. The cervical plexus is formed by the ventral rami of the first four cervical nerves. 5. The brachial plexus is situated partly in the neck and partly in the axilla and gives rise to virtually all the nerves that innervate the upper limb. 6. The sacral and lumbar plexuses overlap and because many ...
Calcium Influx and Protein Phosphorylation Mediate the Metabolic
Calcium Influx and Protein Phosphorylation Mediate the Metabolic

... Reiness and Weinberg, 198 1; Salpeter, 1987). The aim of the present study was to analyze the signaling mechanisms by which the motor nerve regulates metabolic stabilization of the synaptic AChRs in rat muscle. The nerve-induced metabolic stability of synaptic AChRs is a remarkably persistent phenom ...
Document
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... • Postsynaptic potentials fall into two categories – Excitatory postsynaptic potentials (EPSPs) are depolarizations that bring the membrane potential toward threshold – Inhibitory postsynaptic potentials (IPSPs) are hyperpolarizations that move the membrane potential farther from threshold ...
Inquiry into Life Twelfth Edition
Inquiry into Life Twelfth Edition

... • A single neuron may receive many signals, both excitatory and inhibitory • Synaptic integration is the summing up of excitatory and inhibitory signals – This determines if an action potential will travel along an axon ...
Ultrastructure and Function of Cephalopod Chromatophores
Ultrastructure and Function of Cephalopod Chromatophores

... muscles are completely relaxed and the chromatophores are retracted. Stimulation of the skin nerves with single pulses causes twitch-contractions; repetitive stimulation above 6-10 pulses/sec gives rise to a tetanus. Not. all the muscle fibers of a given chromatophore are activated by the same nerve ...
CHAPTER 39 NEURONS AND NERVOUS SYSTEMS
CHAPTER 39 NEURONS AND NERVOUS SYSTEMS

... a. Synaptic vesicles store neurotransmitters that diffuse across the synapse. b. When the action potential arrives at the presynaptic axon bulb, synaptic vesicles merge with the presynaptic membrane. c. When vesicles merge with the membrane, neurotransmitters are discharged into the synaptic cleft. ...
Purkinje cells
Purkinje cells

... lower motor neurons refer to alpha motor neurons in the spinal cord and brain stem arises from certain diseases that selectively affect alpha motor neurons (such as polio) Muscle atrophy. (decrease in the mass of the muscle) Weakness. Fasciculation. spontaneous action potentials, visible twitch (cal ...
Changing Channels
Changing Channels

... modular structure of ligand-gated ion channels. In these channels, the ion pore domain (IPD) is tethered to an independently functioning ligand-binding domain (LBD). Scientists had previously engineered “chimeric” ion channels by genetically splicing the LBD from one type of channel to the IPD from ...
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Neuromuscular junction



A neuromuscular junction (sometimes called a myoneural junction) is a junction between nerve and muscle; it is a chemical synapse formed by the contact between the presynaptic terminal of a motor neuron and the postsynaptic membrane of a muscle fiber. It is at the neuromuscular junction that a motor neuron is able to transmit a signal to the muscle fiber, causing muscle contraction.Muscles require innervation to function—and even just to maintain muscle tone, avoiding atrophy. Synaptic transmission at the neuromuscular junction begins when an action potential reaches the presynaptic terminal of a motor neuron, which activates voltage-dependent calcium channels to allow calcium ions to enter the neuron. Calcium ions bind to sensor proteins (synaptotagmin) on synaptic vesicles, triggering vesicle fusion with the cell membrane and subsequent neurotransmitter release from the motor neuron into the synaptic cleft. In vertebrates, motor neurons release acetylcholine (ACh), a small molecule neurotransmitter, which diffuses across the synaptic cleft and binds to nicotinic acetylcholine receptors (nAChRs) on the cell membrane of the muscle fiber, also known as the sarcolemma. nAChRs are ionotropic receptors, meaning they serve as ligand-gated ion channels. The binding of ACh to the receptor can depolarize the muscle fiber, causing a cascade that eventually results in muscle contraction.Neuromuscular junction diseases can be of genetic and autoimmune origin. Genetic disorders, such as Duchenne muscular dystrophy, can arise from mutated structural proteins that comprise the neuromuscular junction, whereas autoimmune diseases, such as myasthenia gravis, occur when antibodies are produced against nicotinic acetylcholine receptors on the sarcolemma.
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