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PERSPECTIVES
PERSPECTIVES

... But what determines the probability of is, in fact, a 10-fold variation in the amplisynapse. The release probability of a given neurotransmitter release for each particular tudes of Ca2+ signals in the boutons from a synaptic contact depends on the concentra- nerve terminal? Because of their small s ...
File
File

Brain and Behaviour
Brain and Behaviour

...  Axon – passes information to other neurons  Dendrites – receive information from other neurons  For a neural impulse to “FIRE” the combined impulses that reach the dendrite must reach a certain level of intensity or THRESHOLD – this is an all of nothing response to neurons either reaching the th ...
Synapses and neurotransmitters
Synapses and neurotransmitters

... One neuron (usually) has only one type of receptor • Great place for drug interaction ...
Document
Document

... afferents to reduce motor neuron firing, to soften the touch -- used by descending input to fine tune the muscle output ...
File
File

... neurotransmitters bound to them, the signal is transmitted… ...
MTC42: control of smooth muscle 11/10/07
MTC42: control of smooth muscle 11/10/07

8.2 Structure of skeletal muscle
8.2 Structure of skeletal muscle

... - Muscle cells are called fibers because they are much longer than they are wide - These cells are usually as long as the whole muscle ...
Unit M - Notes #1 Neurons - Mr. Lesiuk
Unit M - Notes #1 Neurons - Mr. Lesiuk

Synapses and Neurotransmitters
Synapses and Neurotransmitters

... the dendrites, axon, or cell body of the postsynaptic neuron. This binding of neurotransmitters creates a depolarization of the postsynaptic neuron stimulating an action potential and allowing the message to move on. ...
Neurons
Neurons

... Myelin sheath • Dendrites transmit impulses into the cell body ...
Central nervous system
Central nervous system

... Conductivity: the property of neurons that give them the ability to transmit nerve impulses  Electrical impulses (action potentials) are “all-or-none” responses ...
Diagrams - whsanatomy
Diagrams - whsanatomy

... of the sole of the foot causes toes to have downward flexion  Babinki’s sign- if toes fan out, common in infants. In adults indicates corticospinal or motor cortex damage ...
Function
Function

... synaptic cleft: the extracellular space between the presynaptic membrane and the postsynaptic membrane, 15-30nm postsynaptic element: • postsynaptic membrane: the plasmalemma at the contract point of the receiving neurons, -specific receptor molecules ...
Nervous System
Nervous System

... membrane. Na+ rushes in following its concentration gradient.  5. potassium channels in the membrane open.  6. potassium ions diffuse outward, repolarizing the membrane. ...
[j26]Chapter 7#
[j26]Chapter 7#

... This chapter begins a four-chapter unit (chapters 7 through 10) on the basic structure and function of neurons and synapses in the nervous system. The electrical membrane potential of a neuron at rest that was introduced in the last chapter, now “comes to life” as appropriate stimuli alter the perme ...
Modeling Synaptic Plasticity
Modeling Synaptic Plasticity

... have documented the phenomenology of synaptic plasticity in the last four decades, but the precise ‘learning rule’ used by synapses and the mechanisms of plasticity still elude us. In this talk, I will first review the relevant experimental data. I will then present a model of synaptic plasticity wh ...
[j26]Chapter 7#
[j26]Chapter 7#

... next cell in the sequence via electrical synapses or gap junctions, or indirectly are responsible for activating the release of specialized neurotransmitter chemicals. Released from vesicles into the synaptic space, these neurotransmitters diffuse a short distance, bind to specialized receptors inte ...
Acetylcholine
Acetylcholine

Lecture #19 - Suraj @ LUMS
Lecture #19 - Suraj @ LUMS

Readings to Accompany “Nerves” Worksheet (adapted from France
Readings to Accompany “Nerves” Worksheet (adapted from France

Biopsychology and the Foundations of Neuroscience Chapter 3
Biopsychology and the Foundations of Neuroscience Chapter 3

... receives info from thousands of other neurons-some excitatory (like pushing the gas pedal). Others are inhibitory (like pushing the breaks). If the excitatory signals, minus the inhibitory signals exceed a minimum intensity, called the absolute threshold, then action potential is realized or crossed ...
1. Cell body - greinerudsd
1. Cell body - greinerudsd

... contain neurotransmitters  chemical signals • Impulse triggers release of neurotransmitters into the synaptic cleft (via exocytosis) – Neurotransmitters diffuse across gap & bind to receptors on the adjacent neuron – Cause the impulse to continue (if threshold is reached) • Neurotransmitters are ei ...
Neuron Unit 3A
Neuron Unit 3A

... • Terminal buttons turns electrical charge into chemical (neurotransmitter) and shoots message to next neuron across the synapse. ...
Unit 3A Notes
Unit 3A Notes

< 1 ... 169 170 171 172 173 174 175 176 177 ... 209 >

Neuromuscular junction



A neuromuscular junction (sometimes called a myoneural junction) is a junction between nerve and muscle; it is a chemical synapse formed by the contact between the presynaptic terminal of a motor neuron and the postsynaptic membrane of a muscle fiber. It is at the neuromuscular junction that a motor neuron is able to transmit a signal to the muscle fiber, causing muscle contraction.Muscles require innervation to function—and even just to maintain muscle tone, avoiding atrophy. Synaptic transmission at the neuromuscular junction begins when an action potential reaches the presynaptic terminal of a motor neuron, which activates voltage-dependent calcium channels to allow calcium ions to enter the neuron. Calcium ions bind to sensor proteins (synaptotagmin) on synaptic vesicles, triggering vesicle fusion with the cell membrane and subsequent neurotransmitter release from the motor neuron into the synaptic cleft. In vertebrates, motor neurons release acetylcholine (ACh), a small molecule neurotransmitter, which diffuses across the synaptic cleft and binds to nicotinic acetylcholine receptors (nAChRs) on the cell membrane of the muscle fiber, also known as the sarcolemma. nAChRs are ionotropic receptors, meaning they serve as ligand-gated ion channels. The binding of ACh to the receptor can depolarize the muscle fiber, causing a cascade that eventually results in muscle contraction.Neuromuscular junction diseases can be of genetic and autoimmune origin. Genetic disorders, such as Duchenne muscular dystrophy, can arise from mutated structural proteins that comprise the neuromuscular junction, whereas autoimmune diseases, such as myasthenia gravis, occur when antibodies are produced against nicotinic acetylcholine receptors on the sarcolemma.
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