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Midterm review - February 26, 2004
Midterm review - February 26, 2004

DEVELOPMENT AND VALIDATION OF A REVERSE PHASE HIGH PERFORMANCE LIQUID
DEVELOPMENT AND VALIDATION OF A REVERSE PHASE HIGH PERFORMANCE LIQUID

... Selection of mobile phase The method development for the determination of Tirofiban was tried with different solvent systems. Different mobile phases containing methanol, acetonitrile, water and 1 – Octane sulfonic acid Buffer (pH 3.0) in various compositions were tried and finally 1 – Octane sulfon ...
Sustained Release Formulations
Sustained Release Formulations

...  GI retention for drugs with poor absorption can be increased by enhancers.  Bioadhesive materials is made which has high affinity to the mucin coat.  A drug that is slowly absorbed is poor candidate for SRDF eg.,Gentamycin, Hexamethonium ...
Problem 1 Consider the Euler equation t x
Problem 1 Consider the Euler equation t x

... to the original Euler equation in this case. We see that, as t → ∞, a generic solution will go to infinity/a constant/zero if r+ is positive/zero/negative. Similarly, if ∆ = 0, so r+ = r− , we obtain the general solution C1 tr+ + C2 tr+ log t and as t → ∞, a generic solution will go to infinity/zero ...
Applications of the Derivative
Applications of the Derivative

... -- If f’(x) is positive, f(x) is increasing -- If f’(x) is negative, f(x) is decreasing 3. If f’(x) changes from positive to negative, the CV is a local max. If f’(x) changes from negative to positive, the CV is a local min. ...
AP Calculus AB Notebook
AP Calculus AB Notebook

...  State the definition of the integral as a limit of Riemann sums over equal subdivisions.  State the basic properties of definite integrals  State and use the Fundamental Theorem of Calculus Parts I and II  Apply integration techniques for determining antiderivatives:(do an example for each). In ...
PennState-jun06-unfolding
PennState-jun06-unfolding

...  actually, both methods are basically the same, with only differences in issues not directly related with the unfolding but with the regularization and so on ...
File - Siby Sebastian
File - Siby Sebastian

... the first tile is pushed, all the tiles will fall. To be absolutely sure that the tiles will fall, it is optimum to know that the first tile falls and the event that any tile falls, its successor necessarily falls. This is the major principle of mathematical induction. ...
Exercise session 3
Exercise session 3

... Problem 1 Charles’ utility function is u(x; y) = xy. Anne’s utility function is u(x; y) = 100xy. Diana’s utility function is u(x; y) = xy. Elizabeth’s utility function is u(x; y) = 1= (xy + 1). Fergie’s utility function is u(x; y) = xy 10; 000. Margaret’s utility function is u(x; y) = x=y. Philip’s ...
Pharmacology Exam for Grade 2007 Oversea Students (A)
Pharmacology Exam for Grade 2007 Oversea Students (A)

... Points ...
Supplementary Material
Supplementary Material

... Thurber et al (5). (For this paper, the Biot number = 0.0225 for the average diameter of vessels found in our human ovarian tumors (Table 1). This is similar to the value 0.024 calculated in (5)). This number concurs with a reflection coefficient of 0.95-0.98 for antibodies inside of vessels (9), a ...
1-Introduction,Nomeclature & ROA(1,2&3)
1-Introduction,Nomeclature & ROA(1,2&3)

... A mode of endocytosis used for extracellular fluids Small particles coming into the cells by forming an invagination The formed vesicles will fuse with lysosymes and the enzymes release their contents The hydrolysis needs energy through ATP but at the end due the usage of energy from engulfed liquid ...
mathematics of dimensional analysis and problem solving in physics
mathematics of dimensional analysis and problem solving in physics

... physical systems prior to their complete mathematical or experimental study [1-3]. In problem solving, the qualitative methods enable us to deduce useful information about the dependence of a physical quantity (the unknown) on other relevant quantities (the data) [4-8]. The complete description of a ...
A simple mathematical model for Batesian mimicry
A simple mathematical model for Batesian mimicry

... this fixed point. In this case, the graph of f over [0,ZR ] has the same shape of the graph of f over [0,1] in Figure 2.1. In general, f may have many fixed points, but we may assume that f has the shape given in Figure 2.1, since otherwise we may restrict f to a domain [Z1 ,Z2 ] (where 0 ≤ Z1 ≤ Z2 ...
Protocol for Fibromyalgia
Protocol for Fibromyalgia

... Start with one capsule twice per day (or if using liquid, one serving twice per day), and increase dosage by one capsule per day, until magnesium causes a laxative effect. Subtract one capsule to determine your individual daily dosage. If you do not want to take Magnesium tablets, then consider, Liq ...
Physical Science Unit Test
Physical Science Unit Test

... 3. __________________ Anything that has mass and take up space. 4. __________________ The amount of matter in an object. 5. __________________ The smallest particle of matter. 6. __________________ A change in matter that produces new kinds of matter. 7. __________________ A change in the size, shap ...
02-Lecture_2 doc2008-10-31 07:3483 KB
02-Lecture_2 doc2008-10-31 07:3483 KB

IB Math Studies Problem Set: Sequences/Series/Interest Name: 1
IB Math Studies Problem Set: Sequences/Series/Interest Name: 1

... (Total 12 marks) ...
1 Lecture 10: Math 285 (Bronski) Existence
1 Lecture 10: Math 285 (Bronski) Existence

... solve for the coefficients. By the first theorem this must be the ONLY solution, since solutions are unique. The same thing holds in general. We’ll state this as a “guiding principle”. Guiding Principle: If we can find two different solutions to a second order linear homogeneous differential equatio ...
Ch. 6-Basic Pharmacology - NAC / CNA Certification Spokane
Ch. 6-Basic Pharmacology - NAC / CNA Certification Spokane

... – Urine and feces are the primary routes – Other routes of elimination include: • Evaporation from skin • Exhalation from lungs • Secretion into saliva & breast milk ...
The Effect Of Diabetes Mellitus On Exposure To Tuberculosis Drugs
The Effect Of Diabetes Mellitus On Exposure To Tuberculosis Drugs

... Since increasing the dose of TB drugs may result in increased plasma concentrations of the drugs and improved treatment outcome; —Individualization of the dosages and therapeutic drug monitoring in diabetic TB patients are necessary —Or in developing countriesincreasing the doses of TB drugs (espec ...
biotransformation - USU OCW - Universitas Sumatera Utara
biotransformation - USU OCW - Universitas Sumatera Utara

... – cimetidine inhibits CYP450s, therefore doubles oral propranolol bioavailability – phenytoin induces enzymes, therefore decreases felodipine bioavailability – acute alcohol intake inhibits a CYP CYP, therefore amitrptiline bioavailability is higher ...
Teeter-totter Geometry and Adding Areas
Teeter-totter Geometry and Adding Areas

Elimination
Elimination

... In the proximal tubule there is re-absorption of water and active secretion of some weak electrolyte but especially weak acids. As this process is an active secretion it requires a carrier and a supply of energy. This may be a significant pathway for some compounds such as penicillins. Because tubul ...
Autonomic Nervous System
Autonomic Nervous System

... Norepinephrine varies according to the amount of stress present and will cause transient changes in heart rate and systemic arteries and veins. Epinephrine is a constant in regulating heart rate, vasoconstriction in systemic arteries and veins and vasodilation of muscles and liver. ...
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Plateau principle

The plateau principle is a mathematical model or scientific law originally developed to explain the time course of drug action The principle has wide applicability in pharmacology, physiology, nutrition, biochemistry and system dynamics. It applies whenever a drug or nutrient is infused or ingested at a relatively constant rate and when a constant fraction is eliminated during each time interval. Under these conditions, any change in the rate of infusion leads to an exponential increase or decrease until a new level is achieved. This behavior is also called an approach to steady state because rather than causing an indefinite increase or decrease, a natural balance is achieved when the rate of infusion or production is balanced by the rate of loss.An especially important use of the plateau principle is to study the renewal of tissue constituents in the human and animal body. In adults, daily synthesis of tissue constituents is nearly constant, and most constituents are removed with a first order reaction rate. Applicability of the plateau principle was recognized during radiotracer studies of protein turnover in the 1940s by Rudolph Schoenheimer and David Rittenberg. Unlike the case with drugs, the initial amount of tissue or tissue protein is not zero because daily synthesis offsets daily elimination. In this case, the model is also said to approach a steady state with exponential or logarithmic kinetics. Constituents that change in this manner are said to have a biological half-life.A practical application of the plateau principle is that most people have experienced ""plateauing"" during regimens for weight management or training for sports. After a few weeks of progress, one seems unable to continue gaining in ability or losing weight. This outcome results from the same underlying quantitative model. This entry will describe the popular concepts as well as development of the plateau principle as a scientific, mathematical model.In the sciences, the broadest application of the plateau principle is creating realistic time signatures for change in kinetic models (see Mathematical model). One example of this principle is the long time required to effectively change human body composition. Theoretical studies have shown that many months of consistent physical training and food restriction are needed to bring about permanent weight stability in people who were previously overweight.
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