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Chapter 10
Chapter 10

... 10.3 DNA is a double-stranded helix • James Watson and Francis Crick worked out the three-dimensional structure of DNA, based on X-ray crystallography by Rosalind Franklin • DNA consists of two polynucleotide strands wrapped around each other in a double helix – Sugar-phosphate backbones are on the ...
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< 1 ... 34 35 36 37 38 39 40 41 42 ... 148 >

Helicase



Helicases are a class of enzymes vital to all living organisms. Their main function is to unpackage an organism's genes. They are motor proteins that move directionally along a nucleic acid phosphodiester backbone, separating two annealed nucleic acid strands (i.e., DNA, RNA, or RNA-DNA hybrid) using energy derived from ATP hydrolysis. There are many helicases resulting from the great variety of processes in which strand separation must be catalyzed. Approximately 1% of eukaryotic genes code for helicases. The human genome codes for 95 non-redundant helicases: 64 RNA helicases and 31 DNA helicases. Many cellular processes, such as DNA replication, transcription, translation, recombination, DNA repair, and ribosome biogenesis involve the separation of nucleic acid strands that necessitates the use of helicases.
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