EIR 18 - Universitätsklinikum Tübingen
... macrophages in muscle repair by inducing oxidative damage to muscle cell membranes and by removing cellular debris along with macrophages through phagocytosis (143). NK cells may function to maintain continued recruitment of monocytes and neutrophils into the circulation through cytokine cross-talk. ...
... macrophages in muscle repair by inducing oxidative damage to muscle cell membranes and by removing cellular debris along with macrophages through phagocytosis (143). NK cells may function to maintain continued recruitment of monocytes and neutrophils into the circulation through cytokine cross-talk. ...
aureus Staphylococcus MyD88-Dependent Responses to Are
... assembly of signaling complexes (7). Supporting this possibility, we recently identified components of numerous signaling pathways associated with these organelles (6); our data suggest that the signals that emanate from the phagosome are likely to include defense pathways that are able to signal vi ...
... assembly of signaling complexes (7). Supporting this possibility, we recently identified components of numerous signaling pathways associated with these organelles (6); our data suggest that the signals that emanate from the phagosome are likely to include defense pathways that are able to signal vi ...
Reciprocal regulation of IL-23 and IL-12 following co
... (data not shown). We could also demonstrate that IL-12 downregulation in DC was mediated through Dectin-1, as this response was lost in Dectin-1-deficient cells (Fig. 4D). As before, inhibition of ERK with U0126 had no effect on IL-12 down-regulation; however, and in contrast to macrophages, the inh ...
... (data not shown). We could also demonstrate that IL-12 downregulation in DC was mediated through Dectin-1, as this response was lost in Dectin-1-deficient cells (Fig. 4D). As before, inhibition of ERK with U0126 had no effect on IL-12 down-regulation; however, and in contrast to macrophages, the inh ...
Cytokine-inducing glycolipids in the lipoteichoic acid fraction from
... by Fischer and which served as our synthetic target. The second alternative seems to be supported by our findings that the cytokine-inducing potency considerably fluctuated among LTA preparations which were obtained by the standard extraction procedure from the same stock of E. hirue ATCC 9790 cells ...
... by Fischer and which served as our synthetic target. The second alternative seems to be supported by our findings that the cytokine-inducing potency considerably fluctuated among LTA preparations which were obtained by the standard extraction procedure from the same stock of E. hirue ATCC 9790 cells ...
Full Text - The Journal of Immunology
... response to E. coli IL-6 is a pleiotropic cytokine that has among its functions the amplification of neutrophil recruitment and the activation and differentiation of T and B cells (21–25). The rapid up-regulation of IL-6 during UTIs in humans and mice make this molecule an ideal read-out for epithel ...
... response to E. coli IL-6 is a pleiotropic cytokine that has among its functions the amplification of neutrophil recruitment and the activation and differentiation of T and B cells (21–25). The rapid up-regulation of IL-6 during UTIs in humans and mice make this molecule an ideal read-out for epithel ...
ykl-40 as a novel factor associated with inflammation and
... like OA and RA? Is it just a biomarker reflecting inflammation or is it an active molecule in the pathogenesis of these diseases? Despite the growing interest and studies in recent years, the role of YKL-40 in OA has remained unclear [8]. We report here over 10 fold greater levels of YKL-40 in the s ...
... like OA and RA? Is it just a biomarker reflecting inflammation or is it an active molecule in the pathogenesis of these diseases? Despite the growing interest and studies in recent years, the role of YKL-40 in OA has remained unclear [8]. We report here over 10 fold greater levels of YKL-40 in the s ...
Interleukin-6 Gene Expression in Multiple Myeloma: A Characteristic
... differentiation of early B cells in the bone marrow (BM) and blood from myeloma patients into myeloma plasma cells. ',I2 Apparently, granulocyte-macrophagecolony-stimulating factor (GM-CSF) and IL- l a modulate the proliferative response of myeloma cells to IL-6.'3,'4 Tumor necrosis factor a (TNF-a) ...
... differentiation of early B cells in the bone marrow (BM) and blood from myeloma patients into myeloma plasma cells. ',I2 Apparently, granulocyte-macrophagecolony-stimulating factor (GM-CSF) and IL- l a modulate the proliferative response of myeloma cells to IL-6.'3,'4 Tumor necrosis factor a (TNF-a) ...
20. Exercise in heat increases BDNF levels APL
... without influence of citalopram. Serum BDNF was found to be lower under citalopram treatment, while basal cortisol levels were increased (p<0.05). Exercise triggered an increase in both BDNF and cortisol (p<0.001). BDNF followed the same pattern as core temperature during exercise, with higher level ...
... without influence of citalopram. Serum BDNF was found to be lower under citalopram treatment, while basal cortisol levels were increased (p<0.05). Exercise triggered an increase in both BDNF and cortisol (p<0.001). BDNF followed the same pattern as core temperature during exercise, with higher level ...
Bradykinin stimulates IL-6 and IL-8 production by human lung
... Western blot analysis. BK at nanomolar concentrations stimulated lung fibroblasts to produce IL-6 and IL-8 along with increased ERK 1/2 and p38 MAPK phosphorylation. BK-induced IL6 and IL-8 synthesis was inhibited by a B2-type BK receptor antagonist. Furthermore, PD98059 or SB203580 significantly su ...
... Western blot analysis. BK at nanomolar concentrations stimulated lung fibroblasts to produce IL-6 and IL-8 along with increased ERK 1/2 and p38 MAPK phosphorylation. BK-induced IL6 and IL-8 synthesis was inhibited by a B2-type BK receptor antagonist. Furthermore, PD98059 or SB203580 significantly su ...
Herpes simplex virus type 1 alters transcript levels of tumor
... the capacity of Miiller cells to produce immunologically important cytokines has not been investigated in detail.9 Cytokine production and release have been shown to play a vital role in the initiation, regulation, and subsequent resolution of immune and/or inflammatory responses to a variety of pat ...
... the capacity of Miiller cells to produce immunologically important cytokines has not been investigated in detail.9 Cytokine production and release have been shown to play a vital role in the initiation, regulation, and subsequent resolution of immune and/or inflammatory responses to a variety of pat ...
journal
... activation of mediators and cytokines. Studies were designed to identify and exploit the measurement of those cytokines in search for culprit drugs. These tests have measured de novo synthesized molecules from cultivated cells’ supernatants [2,5,6]. IL-6 a 22–27 kDa peptide is involved in numerous c ...
... activation of mediators and cytokines. Studies were designed to identify and exploit the measurement of those cytokines in search for culprit drugs. These tests have measured de novo synthesized molecules from cultivated cells’ supernatants [2,5,6]. IL-6 a 22–27 kDa peptide is involved in numerous c ...
Interleukin-6 in Sepsis and Capillary Leakage Syndrome - Labor
... Is there a link between IL-6 and vascular leakage during sepsis? In a visionary paper published in 1997, Ciliberto and coworkers showed that vascular endothelial cells express gp130 but not IL-6R and respond to trans-signaling by IL6/ sIL-6R (Romano and others 1997). In sepsis, considerable amounts ...
... Is there a link between IL-6 and vascular leakage during sepsis? In a visionary paper published in 1997, Ciliberto and coworkers showed that vascular endothelial cells express gp130 but not IL-6R and respond to trans-signaling by IL6/ sIL-6R (Romano and others 1997). In sepsis, considerable amounts ...
The Immune System - University of Arizona
... • Tumor Necrosis Factor (TNF), • Interferon a,b,g (INF a,b,g) ...
... • Tumor Necrosis Factor (TNF), • Interferon a,b,g (INF a,b,g) ...
Serum levels of tumor necrosis factor-alpha and interleukin-6
... the nature and possible consequences of this study was obtained from all participants. Sera were collected from patients with OCP (n = 35), uveitis (n = 8), other extraocular inflammatory diseases (n = 9), and normal (control) individuals (n = 29) and stored at -70°C until assayed. The diagnosis of ...
... the nature and possible consequences of this study was obtained from all participants. Sera were collected from patients with OCP (n = 35), uveitis (n = 8), other extraocular inflammatory diseases (n = 9), and normal (control) individuals (n = 29) and stored at -70°C until assayed. The diagnosis of ...
Differential stimulation of IL-6 secretion following apical and
... ression of II,- 1 mRNA in epithelial cells may be explained b d x e n t antigenic stimuli 3,4]. Its role has not yet been fuuy (retermined in epithelial cell iology. A key feature of the ro lnflammato effects of IL-1 is the induction of other C y t O L i including% -6. In addition to its importance ...
... ression of II,- 1 mRNA in epithelial cells may be explained b d x e n t antigenic stimuli 3,4]. Its role has not yet been fuuy (retermined in epithelial cell iology. A key feature of the ro lnflammato effects of IL-1 is the induction of other C y t O L i including% -6. In addition to its importance ...
Supplemental Materials and Methods Cell Lines and Cell Culture
... μg/ml for overnight incubation at 4°C. The slides were washed followed by addition of biotinylated secondary (1:1000) or fluorescent conjugated antibody (1:10,000) for 1 hour at room temperature. Post secondary washing was followed by peroxidase substrate (Vector NovaRed) for 5-8 minutes. Slides wer ...
... μg/ml for overnight incubation at 4°C. The slides were washed followed by addition of biotinylated secondary (1:1000) or fluorescent conjugated antibody (1:10,000) for 1 hour at room temperature. Post secondary washing was followed by peroxidase substrate (Vector NovaRed) for 5-8 minutes. Slides wer ...