EIR 18 - Universitätsklinikum Tübingen
... macrophages in muscle repair by inducing oxidative damage to muscle cell membranes and by removing cellular debris along with macrophages through phagocytosis (143). NK cells may function to maintain continued recruitment of monocytes and neutrophils into the circulation through cytokine cross-talk. ...
aureus Staphylococcus MyD88-Dependent Responses to Are
... assembly of signaling complexes (7). Supporting this possibility,
we recently identified components of numerous signaling pathways
associated with these organelles (6); our data suggest that the signals that emanate from the phagosome are likely to include defense
pathways that are able to signal vi ...
Reciprocal regulation of IL-23 and IL-12 following co
... (data not shown). We could also demonstrate that IL-12 downregulation in DC was mediated through Dectin-1, as this response
was lost in Dectin-1-deficient cells (Fig. 4D). As before, inhibition
of ERK with U0126 had no effect on IL-12 down-regulation;
however, and in contrast to macrophages, the inh ...
Cytokine-inducing glycolipids in the lipoteichoic acid fraction from
... by Fischer and which served as our synthetic target.
The second alternative seems to be supported by our
findings that the cytokine-inducing
potency considerably fluctuated among LTA preparations which were
obtained by the standard extraction procedure from
the same stock of E. hirue ATCC 9790 cells ...
Full Text - The Journal of Immunology
... response to E. coli
IL-6 is a pleiotropic cytokine that has among its functions the
amplification of neutrophil recruitment and the activation and differentiation of T and B cells (21–25). The rapid up-regulation of
IL-6 during UTIs in humans and mice make this molecule an ideal
read-out for epithel ...
ykl-40 as a novel factor associated with inflammation and
... like OA and RA? Is it just a biomarker reflecting inflammation
or is it an active molecule in the pathogenesis of these
diseases? Despite the growing interest and studies in recent
years, the role of YKL-40 in OA has remained unclear .
We report here over 10 fold greater levels of YKL-40 in
the s ...
Interleukin-6 Gene Expression in Multiple Myeloma: A Characteristic
... differentiation of early B cells in the bone marrow (BM) and
blood from myeloma patients into myeloma plasma
cells. ',I2 Apparently, granulocyte-macrophagecolony-stimulating factor (GM-CSF) and IL- l a modulate the proliferative response of myeloma cells to IL-6.'3,'4 Tumor necrosis
factor a (TNF-a) ...
20. Exercise in heat increases BDNF levels APL
... without influence of citalopram. Serum BDNF was found to be lower under citalopram
treatment, while basal cortisol levels were increased (p<0.05). Exercise triggered an
increase in both BDNF and cortisol (p<0.001). BDNF followed the same pattern as core
temperature during exercise, with higher level ...
Bradykinin stimulates IL-6 and IL-8 production by human lung
... Western blot analysis.
BK at nanomolar concentrations stimulated lung fibroblasts to produce IL-6 and
IL-8 along with increased ERK 1/2 and p38 MAPK phosphorylation. BK-induced IL6 and IL-8 synthesis was inhibited by a B2-type BK receptor antagonist. Furthermore,
PD98059 or SB203580 significantly su ...
Herpes simplex virus type 1 alters transcript levels of tumor
... the capacity of Miiller cells to produce immunologically important cytokines has not been investigated in
Cytokine production and release have been shown
to play a vital role in the initiation, regulation, and
subsequent resolution of immune and/or inflammatory responses to a variety of pat ...
... activation of mediators and cytokines. Studies were designed to identify and exploit the measurement of those
cytokines in search for culprit drugs. These tests have
measured de novo synthesized molecules from cultivated cells’ supernatants [2,5,6].
IL-6 a 22–27 kDa peptide is involved in numerous c ...
Interleukin-6 in Sepsis and Capillary Leakage Syndrome - Labor
... Is there a link between IL-6 and vascular leakage during
sepsis? In a visionary paper published in 1997, Ciliberto and
coworkers showed that vascular endothelial cells express
gp130 but not IL-6R and respond to trans-signaling by IL6/
sIL-6R (Romano and others 1997). In sepsis, considerable
Serum levels of tumor necrosis factor-alpha and interleukin-6
... the nature and possible consequences of this study was
obtained from all participants. Sera were collected
from patients with OCP (n = 35), uveitis (n = 8), other
extraocular inflammatory diseases (n = 9), and normal
(control) individuals (n = 29) and stored at -70°C
until assayed. The diagnosis of ...
Differential stimulation of IL-6 secretion following apical and
... ression of II,- 1 mRNA in epithelial cells may be
explained b d x e n t antigenic stimuli 3,4]. Its role has not yet
been fuuy (retermined in epithelial cell iology. A key feature of
the ro lnflammato effects of IL-1 is the induction of other
C y t O L i including% -6. In addition to its importance ...
Supplemental Materials and Methods Cell Lines and Cell Culture
... μg/ml for overnight incubation at 4°C. The slides were washed followed by addition of
biotinylated secondary (1:1000) or fluorescent conjugated antibody (1:10,000) for 1 hour
at room temperature. Post secondary washing was followed by peroxidase substrate
(Vector NovaRed) for 5-8 minutes. Slides wer ...
Interleukin 6 (IL-6) is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine. In humans, it is encoded by the IL6 gene.IL-6 is secreted by T cells and macrophages to stimulate immune response, e.g. during infection and after trauma, especially burns or other tissue damage leading to inflammation. IL-6 also plays a role in fighting infection, as IL-6 has been shown in mice to be required for resistance against bacterium Streptococcus pneumoniae.In addition, osteoblasts secrete IL-6 to stimulate osteoclast formation. Smooth muscle cells in the tunica media of many blood vessels also produce IL-6 as a pro-inflammatory cytokine. IL-6's role as an anti-inflammatory cytokine is mediated through its inhibitory effects on TNF-alpha and IL-1, and activation of IL-1ra and IL-10.