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File - Riske Science
File - Riske Science

... or alleviates the symptoms of disease – they have a therapeutic action. • Medicine are usually compound preparations, which means that they contain a number of ingredients – the active drug itself plus nonactive substances that improve the preparation in some way such as taste, consistency or admini ...
Full Text in PDF
Full Text in PDF

... current, Na+-Ca2+ exchanger and is propagated from the atria to the ventricles to maintain the normal rhythm and contractility of the heart10, 28-31. Any of these ion channels might act as a target for various drugs causing arrhythmia. However most of the drugs block the delayed rectifier repolarizi ...
Ch. 15 The Nervous System
Ch. 15 The Nervous System

... 2. Is the following sentence true or false? The central nervous system is the control center of the body. 3. The part of the central nervous system that controls most functions in the body is the ...
Pharmacology/Therapeutics II Block II Lectures
Pharmacology/Therapeutics II Block II Lectures

... Injection of the conjunctiva (“red eyes”) – due to decreased pressure in the eyes and increased blood pressure ...
Hypertension
Hypertension

... storage vesicles and replaces NE ...
PHENDIMETRAZINE TARTRATE TABLETS, USP 35 Mg
PHENDIMETRAZINE TARTRATE TABLETS, USP 35 Mg

... Phendimetrazine tartrate should not be used in combination with other anorectic agents, including prescribed drugs, over-the-counter preparations and herbal products. In a case-control epidemiological study, the use of anorectic agents, including phendimetrazine tartrate, was associated with an incr ...
Kinetics and dynamics HW exercise
Kinetics and dynamics HW exercise

... tissue. Only unbound drug is available to have its effects on the body. The amount of albumin in the blood can modify the availability of a drug in the body. Metabolism: Is the body’s way to get rid of lipid soluble compounds, so they can be eliminated through the kidneys in urine. Enzymes in the li ...
4• GI effects
4• GI effects

... Doses of 75-150 mg/day used to prevent thrombotic vascular occlusion; 300 mg as immediate treatment for myocardial infarction; 300-900 mg every 4-6 h for analgesia. ...
A. Glucocorticoid drugs
A. Glucocorticoid drugs

... (3) Long-term therapy: oral prednisone or prednisolone morning single dose ...
CYP2D6 - PGXL Laboratories
CYP2D6 - PGXL Laboratories

... CYP2C19 Poor Metabolizer (PM): This patient’s genotype is consistent with significantly reduced CYP2C19 enzymatic activity. PMs are at increased risk of drug-induced side effects due to diminished drug elimination of active drugs. Patients with no CYP2C19 function (PMs) taking clopidogrel lack adequ ...
(vortioxetine) sNDA
(vortioxetine) sNDA

... In clinical studies, Brintellix had no significant effect on body weight as measured by the mean change from baseline in 68 week placebo-controlled studies. In the 6-month, double-blind, placebo-controlled phase of a long-term study in patients who had responded to Brintellix during the initial 12-w ...
CLIA-WAIVED One Step Multi-Drug, Multi
CLIA-WAIVED One Step Multi-Drug, Multi

... Amphetamine is a Schedule II controlled substance available by prescription (Dexedrine®) and is also available on the illicit market. Amphetamines are a class of potent sympathomimetic agents with therapeutic applications. They are chemically related to the human body’s natural catecholamines: epine ...
Bontril - MedConnections
Bontril - MedConnections

... Phendimetrazine tartrate is a sympathomimetic amine with pharmacological activity similar to the prototype drugs of this class used in obesity, the amphetamines. Actions include central nervous system stimulation and elevation of blood pressure. Tachyphylaxis and tolerance have been demonstrated wit ...
CRYSTAL MYTHS œ The BIG LIE drug!!
CRYSTAL MYTHS œ The BIG LIE drug!!

... Still, just because the drugs are legal doesn’t mean they’re safe. They’re not – not always, anyway. Most contain giga-jolts of caffeine and ephedrine, which can cause problems (even stroke or cardiac arrest) when overused, or when used at all by people who are hypersensitive to individual ingredien ...
Neuroscience Letters Withdrawal-like behavior
Neuroscience Letters Withdrawal-like behavior

... withdrawal from opioids, cannabinoids, stimulants and benzodiazepines. This suggests that planarians display a withdrawal-like behavior that can be quantified as a reduction in locomotor activity. Because withdrawal-like behavior in previous studies has been quantified only following the cessation of ...
The ideal sedative agent
The ideal sedative agent

... more negative. This makes it even more difficult to fire an action potential so reducing: polysynaptic transmission depressing the uptake of sensory information ...
Benzodiazepines
Benzodiazepines

... more negative. This makes it even more difficult to fire an action potential so reducing: polysynaptic transmission depressing the uptake of sensory information ...
chronopharmacology - International Research Journal of Pharmacy
chronopharmacology - International Research Journal of Pharmacy

... The Chronopharmacology is useful to solve problems of drugs optimization means to enhance the desired efficiency or to reduce its undesired effects. The chronopharmacologic approach involves a lesser risk of errors or false information than the conventional homeostatic approach. Many seasonal psycho ...
Withdrawing Drugs in the US Versus Other Countries
Withdrawing Drugs in the US Versus Other Countries

... before they were also banned by the rest of the world. For the remaining 43%, differences were not detected. This shows that the U.S. may no longer be leader in observing, reporting and removing dangerous drugs from the market. This might be because the drug might have been introduced first internat ...
Tranquilizer drug forensics - Neuroscience Consulting, Inc
Tranquilizer drug forensics - Neuroscience Consulting, Inc

... History and prevalence of the GABA A agonist drugs: Current problems of forensic concern caused by tranquilizing drug action are merely the leading edge of an historical wave. In seeking to understand the present context and future direction of this wave it helps to have an historical understanding ...
Phenobarbitone Elixir 15mg/5mL
Phenobarbitone Elixir 15mg/5mL

... advisable if phenobarbitone is given on a regular basis. Antidepressants Phenobarbitone may increase the metabolism of tricyclic antidepressants and selective serotonin reuptake inhibitor through the possible induction of CYP2D6, resulting in a lack of effect. Plasma TCA or SSRI levels should be mon ...
General Principles - My Illinois State
General Principles - My Illinois State

... Additive effect: two or more drugs administered to a patient can produce effects equivalent to the sum of the effects of either drug administered alone in higher doses. (Example: acetaminophen 325 mg. and codeine 30 mg are equal in analgesic effect. When combined, as in Codeine #3, their analgesic e ...
Drugs with narrow therapeutic index as indicators in the risk
Drugs with narrow therapeutic index as indicators in the risk

... Drug risk ratio= Number of DRPs for a given drug Number of times the drug is used A drug might cause one or more DRPs. Most often only one DRP was identified for each prescribed drug. Sometimes more than one DRP was found to be linked to the drug and often these DRPs were interdependent. For example ...
Fundamentals of Drug Testing
Fundamentals of Drug Testing

... Are not significantly affected by brief periods of abstinence from drugs.  Can sometimes be used to determine when use occurred and if it has  been discontinued. Drugs, such as opiates (codeine, morphine, heroin) lay  down on the hair shaft very tightly and are shown not to migrate along the  shaft, ...
Hallucinogens Hallucinogens are drugs that distort one`s
Hallucinogens Hallucinogens are drugs that distort one`s

... Mescaline is a natural hallucinogen that is derived from the fleshy parts or buttons of the peyote cactus which is smoked or taken orally. These drugs cause unpredictable reactions including erratic behavior and violence. Users hallucinating on these drugs can have a bad experience, or “trip”, and c ...
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Stimulant



Stimulants (also referred to as psychostimulants) are psychoactive drugs that induce temporary improvements in either mental or physical functions or both. Examples of these kinds of effects may include enhanced alertness, wakefulness, and locomotion, among others. Due to their rendering a characteristic ""up"" feeling, stimulants are also occasionally referred to as ""uppers"". Depressants or ""downers"", which decrease mental and/or physical function, are in stark contrast to stimulants and are considered to be their functional opposites. Stimulants are widely used throughout the world as prescription medicines and without prescription both as legal substances and illicit substances of recreational use or abuse.
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