Medications Development Research for Treatment of Amphetamine and Methamphetamine Addiction
... violent behavior, anxiety, depression, confusion, and insomnia; and heavy users may show progressive social and occupational deterioration. Methamphetamine abusers can also display a number of psychotic features, including paranoia, auditory hallucinations and delusions. ...
... violent behavior, anxiety, depression, confusion, and insomnia; and heavy users may show progressive social and occupational deterioration. Methamphetamine abusers can also display a number of psychotic features, including paranoia, auditory hallucinations and delusions. ...
FORMULATION AND EVALUATION OF FLOATING MATRIX TABLET OF ATENOLOL FOR
... Atenolol is a cardioselective β-blocker widely prescribed for asymptomatic condition such as hypertension. It is poorly absorbed from the lower gastrointestinal tract. The oral bioavailability of atenolol was reported to be 50%1. The human jejunal permeability and extent of absorption is low2. Thus, ...
... Atenolol is a cardioselective β-blocker widely prescribed for asymptomatic condition such as hypertension. It is poorly absorbed from the lower gastrointestinal tract. The oral bioavailability of atenolol was reported to be 50%1. The human jejunal permeability and extent of absorption is low2. Thus, ...
Alcohol Hangover
... Hangovers are a frequent, though unpleasant, experience among people who drink to intoxication. Despite the prevalence of hangovers, however, this condition is not well understood scientifically. Multiple possible contributors to the hangover state have been investigated, and researchers have produc ...
... Hangovers are a frequent, though unpleasant, experience among people who drink to intoxication. Despite the prevalence of hangovers, however, this condition is not well understood scientifically. Multiple possible contributors to the hangover state have been investigated, and researchers have produc ...
Epilepsy in elderly: Neelima Thakur, M.D.
... Only one third of the patients with NCSE had a history of epilepsy. High mortality of about 50%. Veterans Affairs studies found that 65% of the patients with NCSE died within 30 days of an episode compared to 27% of patients with ...
... Only one third of the patients with NCSE had a history of epilepsy. High mortality of about 50%. Veterans Affairs studies found that 65% of the patients with NCSE died within 30 days of an episode compared to 27% of patients with ...
Jemds.com
... Apart from the saliva/serum ratios, pharmacokinetics of rifampicin in saliva is evaluated for group I and group II subjects. Rifampicin metabolites 25-o-desacetyl rifampicin and rifampicin quinone were found to have small amounts of antimicrobial activity. Some of the studies done on the basis of mi ...
... Apart from the saliva/serum ratios, pharmacokinetics of rifampicin in saliva is evaluated for group I and group II subjects. Rifampicin metabolites 25-o-desacetyl rifampicin and rifampicin quinone were found to have small amounts of antimicrobial activity. Some of the studies done on the basis of mi ...
Benzodiazepine Overdose and Withdrawal
... Benzodiazepines are extremely safe when compared to other sedatives such as ethanol and barbiturates. Benzodiazepines do not cause classical addiction, whereas ethanol and barbiturates do. Benzodiazepines are essentially never fatal in overdose, whereas ethanol and barbiturates are extremely dangero ...
... Benzodiazepines are extremely safe when compared to other sedatives such as ethanol and barbiturates. Benzodiazepines do not cause classical addiction, whereas ethanol and barbiturates do. Benzodiazepines are essentially never fatal in overdose, whereas ethanol and barbiturates are extremely dangero ...
relpax® utilization management criteria
... CRITERIA FOR EXCEEDING QL: 1. Convey to physician the amount of the drug that the patient has already received (refer to QL criteria) and ask if the patient needs more than that amount. AND 2. Patient must have diagnosis of moderate to severe migraine headache. (Tension type and chronic daily headac ...
... CRITERIA FOR EXCEEDING QL: 1. Convey to physician the amount of the drug that the patient has already received (refer to QL criteria) and ask if the patient needs more than that amount. AND 2. Patient must have diagnosis of moderate to severe migraine headache. (Tension type and chronic daily headac ...
Alcohol Hangover - JBS Science Department
... Hangovers are a frequent, though unpleasant, experience among people who drink to intoxication. Despite the prevalence of hangovers, however, this condition is not well understood scientifically. Multiple possible contributors to the hangover state have been investigated, and researchers have produc ...
... Hangovers are a frequent, though unpleasant, experience among people who drink to intoxication. Despite the prevalence of hangovers, however, this condition is not well understood scientifically. Multiple possible contributors to the hangover state have been investigated, and researchers have produc ...
Guideline for Safe Chronic Opioid Therapy Prescribing For Patients
... i. The Brief Pain Inventory (S hort Form) will help with this history Perform a complete physical exam including evaluation of the neurologic and musculoskeletal systems E valuate mental health and substance abuse history E valuate for reversible causes of pain and work up as appropriate E valuate f ...
... i. The Brief Pain Inventory (S hort Form) will help with this history Perform a complete physical exam including evaluation of the neurologic and musculoskeletal systems E valuate mental health and substance abuse history E valuate for reversible causes of pain and work up as appropriate E valuate f ...
Intracarotid Etomidate is a Safe Alternative to w y
... been disrupted worldwide and has led to exploration of other possible agents. Pentobarbital, methohexital, secobarbital, etomidate, and propofol have all been investigated as substitutes.3–9 The summary of anesthetic agents used for the Wada procedure is shown in Table 2. The use of propofol as an a ...
... been disrupted worldwide and has led to exploration of other possible agents. Pentobarbital, methohexital, secobarbital, etomidate, and propofol have all been investigated as substitutes.3–9 The summary of anesthetic agents used for the Wada procedure is shown in Table 2. The use of propofol as an a ...
Clinical Research Protocol
... The introduction should open with remarks that state that this document is a clinical research protocol and the described study will be conducted in compliance with the protocol, Good Clinical Practices standards and associated Federal regulations, and all applicable Dartmouth research requirements. ...
... The introduction should open with remarks that state that this document is a clinical research protocol and the described study will be conducted in compliance with the protocol, Good Clinical Practices standards and associated Federal regulations, and all applicable Dartmouth research requirements. ...
The rationale for recommending fixed
... same effect. Multiple interruptions of treatment have been shown to be the predominant cause of drug resistance (21, 22). When using single-drug formulations, patients are more prone to continue their treatment with one drug while interrupting the others, thereby creating a risk of monotherapy and s ...
... same effect. Multiple interruptions of treatment have been shown to be the predominant cause of drug resistance (21, 22). When using single-drug formulations, patients are more prone to continue their treatment with one drug while interrupting the others, thereby creating a risk of monotherapy and s ...
The Effects of Nabilone on Sleep in Fibromyalgia: Results of a
... evaluated the safety and efficacy of nabilone, a synthetic cannabinoid, on sleep disturbance in fibromyalgia (FM), a disease characterized by widespread chronic pain and insomnia. METHODS: We conducted a randomized, double-blind, active-control, equivalency crossover trial to compare nabilone (0.5–1 ...
... evaluated the safety and efficacy of nabilone, a synthetic cannabinoid, on sleep disturbance in fibromyalgia (FM), a disease characterized by widespread chronic pain and insomnia. METHODS: We conducted a randomized, double-blind, active-control, equivalency crossover trial to compare nabilone (0.5–1 ...
Definition of artemisinin resistance
... Corresponding MPAC questions Which implications does the identification of the K13 mutation have on the response to artemisinin resistance? There is ‘spreading and popping’. The “firewall approach” remains necessary for tier 1 and 2 areas but additional measures are necessary, which includes an eff ...
... Corresponding MPAC questions Which implications does the identification of the K13 mutation have on the response to artemisinin resistance? There is ‘spreading and popping’. The “firewall approach” remains necessary for tier 1 and 2 areas but additional measures are necessary, which includes an eff ...
oral bioavailability and first-pass effects
... Historically, the concept of bioavailability is closely, if not exclusively, associated with dosage form performance. This is because the drug entity has been defined and its absorption and disposition characteristics per se are fixed. Recently, the application of bioavailability principles and tech ...
... Historically, the concept of bioavailability is closely, if not exclusively, associated with dosage form performance. This is because the drug entity has been defined and its absorption and disposition characteristics per se are fixed. Recently, the application of bioavailability principles and tech ...
BioInvent Financial Statement
... to BioInvent's in-house pre-clinical capacities in selecting antibody candidates for development. During the second quarter BioInvent initiated collaboration with Cancer Research Technology (CRT), a commercially targeted section of Cancer Research UK, and Queen Mary’s University Hospital, for identi ...
... to BioInvent's in-house pre-clinical capacities in selecting antibody candidates for development. During the second quarter BioInvent initiated collaboration with Cancer Research Technology (CRT), a commercially targeted section of Cancer Research UK, and Queen Mary’s University Hospital, for identi ...
OVERVIEW
... This observation suggests that other factors, in addition to affinity and receptor occupancy, determine the strength of response. Accordingly, an additional modifier termed intrinsic activity was proposed. This use of the word "efficacy" was introduced by Stephenson (1956) to describe the way in whi ...
... This observation suggests that other factors, in addition to affinity and receptor occupancy, determine the strength of response. Accordingly, an additional modifier termed intrinsic activity was proposed. This use of the word "efficacy" was introduced by Stephenson (1956) to describe the way in whi ...
File
... 12 and older have tried marijuana at least once, according to the 2003 National Survey on Drug Use and Health (NSDUH). In 2004, 14.6 million Americans age 12 and older used marijuana at least once in the month prior to being surveyed. About 6,000 people a day in 2004 used marijuana for the first tim ...
... 12 and older have tried marijuana at least once, according to the 2003 National Survey on Drug Use and Health (NSDUH). In 2004, 14.6 million Americans age 12 and older used marijuana at least once in the month prior to being surveyed. About 6,000 people a day in 2004 used marijuana for the first tim ...
How fast and how often: The pharmacokinetics of drug use are
... profile of a drug can produce different effects even when the same amount of drug reaches the brain. In other words, “how fast” and “how often” can be more important than “how much” in determining functional outcome. This principle is at the core of the present review. The general principles that wi ...
... profile of a drug can produce different effects even when the same amount of drug reaches the brain. In other words, “how fast” and “how often” can be more important than “how much” in determining functional outcome. This principle is at the core of the present review. The general principles that wi ...
The use of benzodiazepines within the Traveller community
... gather these figures, they do not highlight the real extent of the problem within the entire community i.e. Travellers who are most likely to fall between the gaps of support services and who may not consider their benzodiazepine use a problem. The Report of the Benzodiazepine Committee acknowledge ...
... gather these figures, they do not highlight the real extent of the problem within the entire community i.e. Travellers who are most likely to fall between the gaps of support services and who may not consider their benzodiazepine use a problem. The Report of the Benzodiazepine Committee acknowledge ...
iScreen DX Multi-Drugs of Abuse Dip Test Quick Reference Guide
... Dip Test after the expiration date printed on the pouch. Be careful when handling urine because it may contain infectious agents. Always wear gloves and wash hands with soap and water after handling urine. To ensure that the test will work properly the testing instructions must be followed. Failure ...
... Dip Test after the expiration date printed on the pouch. Be careful when handling urine because it may contain infectious agents. Always wear gloves and wash hands with soap and water after handling urine. To ensure that the test will work properly the testing instructions must be followed. Failure ...
Cyclooxygenase inhibition: between the devil and the deep blue sea
... enrolled in the trial, there was an increased incidence of myocardial infarction compared to naproxen. Whether this indicates that COX-2 inhibitors promote myocardial infarction or that (some) NSAIDs have an aspirin like effect in preventing it, is currently uncertain. However, it is worth noting th ...
... enrolled in the trial, there was an increased incidence of myocardial infarction compared to naproxen. Whether this indicates that COX-2 inhibitors promote myocardial infarction or that (some) NSAIDs have an aspirin like effect in preventing it, is currently uncertain. However, it is worth noting th ...
Acute Hallucinations
... Eighty two year old male with a past medical history significant for diastolic CHF, syncopal episode vs. vertiginous fall with transient confusion 4/2011, very small left occipital CVA 4/2011, seizure disorder (Grand Mal seizure in his 60’s, Dilantin therapy in the past, but not currently being trea ...
... Eighty two year old male with a past medical history significant for diastolic CHF, syncopal episode vs. vertiginous fall with transient confusion 4/2011, very small left occipital CVA 4/2011, seizure disorder (Grand Mal seizure in his 60’s, Dilantin therapy in the past, but not currently being trea ...
Polysubstance dependence
A person with polysubstance dependence is psychologically addicted to being in an intoxicated state without a preference for one particular substance. Although any combination of three drugs can be used, studies have shown that alcohol is commonly used with another substance. This is supported by one study on polysubstance use that separated participants who used multiple substances into groups based on their preferred drug. The three substances were cocaine, alcohol, and heroin, which implies that those three are very popular. Other studies have found that opiates, cannabis, amphetamines, hallucinogens, inhalants and benzodiazepines are often used in combination as well. The results of a long-term or longitudinal study on substance use led the researchers to observe that excessively using or relying on one drug increased the probability of excessively using or relying on another drug.