Highly impulsive rats: modelling an endophenotype to determine the
... neurobiological mechanisms of impulsivity, as well as the genetic and environmental influences that govern the expression of this behaviour. Tests used on rodent models of impulsivity share strong parallels with tasks used to assess this trait in humans, and studies in both suggest a crucial role of ...
... neurobiological mechanisms of impulsivity, as well as the genetic and environmental influences that govern the expression of this behaviour. Tests used on rodent models of impulsivity share strong parallels with tasks used to assess this trait in humans, and studies in both suggest a crucial role of ...
COMPARATIVE EVALUATION OF NATURAL AND SYNTHETIC SUPERDISINTEGRANT FOR PROMOTING NIMESULIDE DISSOLUTION FOR FAST DISSOLVING TECHNOLOGY
... uses have been found in the preparation of cosmetics, textiles, and paint paper. Mucilage of natural origin is preferred over synthetic and semisynthetic agent because they are cheaper, abundantly available, nontoxic and nonirritating in nature. Lepidium sativum ...
... uses have been found in the preparation of cosmetics, textiles, and paint paper. Mucilage of natural origin is preferred over synthetic and semisynthetic agent because they are cheaper, abundantly available, nontoxic and nonirritating in nature. Lepidium sativum ...
Evaluation of 22 SIN List 2.0 substances according to the Danish
... effects at 10 mg/kg bw/day and below (STOT-RE Cat 1) lead to a classification as an endocrine disrupter of very high regulatory concern. Thus, the overall LOAEL for each substance was assessed, if possible, and evaluated in relation to this cut-off level of 10 mg/kg/day. In some cases, there was eff ...
... effects at 10 mg/kg bw/day and below (STOT-RE Cat 1) lead to a classification as an endocrine disrupter of very high regulatory concern. Thus, the overall LOAEL for each substance was assessed, if possible, and evaluated in relation to this cut-off level of 10 mg/kg/day. In some cases, there was eff ...
psychoactive substances
... export of a controlled drug both inside the State and elsewhere. The Act requires that a mandatory minimum sentence of 10 years imprisonment be imposed on individuals found guilty of an offence under Section 15 of the Misuse of Drugs Act where the offence is considered to be drug dealing and the val ...
... export of a controlled drug both inside the State and elsewhere. The Act requires that a mandatory minimum sentence of 10 years imprisonment be imposed on individuals found guilty of an offence under Section 15 of the Misuse of Drugs Act where the offence is considered to be drug dealing and the val ...
Evaluation of 22 SIN List 2.0 substances according to
... test information such as read across, chemical categorisation and QSAR predictions) Category 2b – Substances with indications of ED properties (indicated ED) Substances are placed in category 2b when there is in vitro/in silico evidence indicating potential for endocrine disruption in intact organis ...
... test information such as read across, chemical categorisation and QSAR predictions) Category 2b – Substances with indications of ED properties (indicated ED) Substances are placed in category 2b when there is in vitro/in silico evidence indicating potential for endocrine disruption in intact organis ...
Submission Guidelines for the CADTH Common Drug Review
... Common Drug Review (CDR) process. The Submission Guidelines for the CADTH Common Drug Review is a companion document to the Procedure for the CADTH Common Drug Review, a document that describes CDR procedures to be followed by all participants involved in the CDR process. The Submission Guidelines f ...
... Common Drug Review (CDR) process. The Submission Guidelines for the CADTH Common Drug Review is a companion document to the Procedure for the CADTH Common Drug Review, a document that describes CDR procedures to be followed by all participants involved in the CDR process. The Submission Guidelines f ...
acetaminophen and codeine phosphate tablets
... and conditions. Risks are increased in patients with a personal or family history of substance abuse (including drug or alcohol abuse or addiction) or mental illness (e.g., major depression). The potential for these risks should not, however, prevent the proper management of pain in any given patien ...
... and conditions. Risks are increased in patients with a personal or family history of substance abuse (including drug or alcohol abuse or addiction) or mental illness (e.g., major depression). The potential for these risks should not, however, prevent the proper management of pain in any given patien ...
Dopamine-Serotonin System Stabilizer
... Aripiprazole, a novel antipsychotic agent, is assumed to be a “dopamine-serotonin system stabilizer”. According to preclinical studies, aripiprazole exerts partial agonistic action on D2 and 5-HT1A receptors. Thus, it may block a receptor if it is overstimulated and stimulate a receptor when activit ...
... Aripiprazole, a novel antipsychotic agent, is assumed to be a “dopamine-serotonin system stabilizer”. According to preclinical studies, aripiprazole exerts partial agonistic action on D2 and 5-HT1A receptors. Thus, it may block a receptor if it is overstimulated and stimulate a receptor when activit ...
Special Contribution Acetaminophen-Induced Hepatotoxicity: Still an
... Acetaminophen (APAP), the most commonly sold over-the-counter antipyretic analgesic, is generally considered harmless at therapeutic doses. However, APAP overdose causes severe and sometimes fatal hepatic damage in humans and experimental animals. In the United States and Europe, the incidence of li ...
... Acetaminophen (APAP), the most commonly sold over-the-counter antipyretic analgesic, is generally considered harmless at therapeutic doses. However, APAP overdose causes severe and sometimes fatal hepatic damage in humans and experimental animals. In the United States and Europe, the incidence of li ...
An Updated Review of the Research on the Risks and Harms
... Because marijuana is the most commonly used illicit drug in the world, with reports of approximately 125 to 203 million people having used the drug in the last year (United Nations Office on Drugs and Crime, 2011), there has been a great deal of research conducted on its effects on users. The use of ...
... Because marijuana is the most commonly used illicit drug in the world, with reports of approximately 125 to 203 million people having used the drug in the last year (United Nations Office on Drugs and Crime, 2011), there has been a great deal of research conducted on its effects on users. The use of ...
Effects of Long Acting Methylphenidate on Ghrelin Levels in Male
... obesity treatment and may suppress the motivation for consumption of sucrose and sweet foods28. Ghrelin is also involved in more complex cognitive-behavioral processes like learning, memory, reward, addiction and depressive and anxious symptoms14,29. In addition, it has been suggested that ghrelin ...
... obesity treatment and may suppress the motivation for consumption of sucrose and sweet foods28. Ghrelin is also involved in more complex cognitive-behavioral processes like learning, memory, reward, addiction and depressive and anxious symptoms14,29. In addition, it has been suggested that ghrelin ...
KEY and EXPLANATION for SET-A
... All the given microscopic characteristics: Anomocytic stomata, lignified parenchyma, absence of trichomes and presence of rosette crystals of calcium oxalate are related to Fennel. Hence, option A is the CORRECT answer. Senna consists of rubiaceous/ paracytic stomata, rectangular cells containing cl ...
... All the given microscopic characteristics: Anomocytic stomata, lignified parenchyma, absence of trichomes and presence of rosette crystals of calcium oxalate are related to Fennel. Hence, option A is the CORRECT answer. Senna consists of rubiaceous/ paracytic stomata, rectangular cells containing cl ...
Toxicity of Nutmeg (Myristicin): A Review
... measures are usually unnecessary because of the presence of vomiting or delayed contact (ie, > 1 to 2 hours after ingestion) by the health care facility. There are no clinical data to guide the treatment of nutmeg intoxication. The use of standard antiemetic (prochlorperazine, trimethobenzamide, oda ...
... measures are usually unnecessary because of the presence of vomiting or delayed contact (ie, > 1 to 2 hours after ingestion) by the health care facility. There are no clinical data to guide the treatment of nutmeg intoxication. The use of standard antiemetic (prochlorperazine, trimethobenzamide, oda ...
IN THE UNITED STATES DISTRICT COURT WESTERN DISTRICT
... Nov. 1, 2004, p. A1. Merck’s public statements (and specifically to prescribing doctors, through literature and sales rep visits, such as Mr. Hodge’s prescribing physician, M.D.) continued to reject any link between Vioxx and increased cardiac risk. Plaintiff avers that had Merck truthfully disclose ...
... Nov. 1, 2004, p. A1. Merck’s public statements (and specifically to prescribing doctors, through literature and sales rep visits, such as Mr. Hodge’s prescribing physician, M.D.) continued to reject any link between Vioxx and increased cardiac risk. Plaintiff avers that had Merck truthfully disclose ...
Elicited hippocampal theta rhythm: a screen for anxiolytic and
... and will argue that their action on the ascending systems that elicit and control theta makes a significant contribution to their behavioural and clinical profile. From this, we suggest that reticular-elicited theta can be used to detect both anxiolytic and, perhaps also, procognitive drugs. The hip ...
... and will argue that their action on the ascending systems that elicit and control theta makes a significant contribution to their behavioural and clinical profile. From this, we suggest that reticular-elicited theta can be used to detect both anxiolytic and, perhaps also, procognitive drugs. The hip ...
Disclosure Migraine Associated Vertigo (MAV) Case (patient DA)
... No sedation – great drug for this reason Hypotension rarely a problem Constipation main side effect – increase dose if not constipated after 2 weeks. • Cheap ($19/month). Pregnancy category C, interacts with statins (increases level). Solomon, G. D., et al. (1983). "Verapamil prophylaxis of migraine ...
... No sedation – great drug for this reason Hypotension rarely a problem Constipation main side effect – increase dose if not constipated after 2 weeks. • Cheap ($19/month). Pregnancy category C, interacts with statins (increases level). Solomon, G. D., et al. (1983). "Verapamil prophylaxis of migraine ...
5.02 atazanavir + cobicistat
... a Virologic success was defined as HIV-1 RNA < 50 copies/mL at 48 weeks. b Calculated based on baseline HIV-1 RNA stratum adjusted Mantel-Haenszel proportion; reported for Study 114 was a 95.2% confidence interval. c Modified intention-to-treat analysis, including those patients who received at leas ...
... a Virologic success was defined as HIV-1 RNA < 50 copies/mL at 48 weeks. b Calculated based on baseline HIV-1 RNA stratum adjusted Mantel-Haenszel proportion; reported for Study 114 was a 95.2% confidence interval. c Modified intention-to-treat analysis, including those patients who received at leas ...
- International Journal of Pharmaceutical Sciences and
... way of dosing medications, not only for special population groups with swallowing difficulties such as children and the elderly, but also for the general population, including the young generation. Today, medicated chewing gum meets the same high quality standards as tablets. ...
... way of dosing medications, not only for special population groups with swallowing difficulties such as children and the elderly, but also for the general population, including the young generation. Today, medicated chewing gum meets the same high quality standards as tablets. ...
Emerging Drug Trends- Salvia Divinorum
... slurred speech, chills, nausea, decreased heart rate, and a lack of coordination. Though the Mazatecs have been using Salvia for centuries, the long-term effects of the herb remain unknown and have not been fully investigated. ...
... slurred speech, chills, nausea, decreased heart rate, and a lack of coordination. Though the Mazatecs have been using Salvia for centuries, the long-term effects of the herb remain unknown and have not been fully investigated. ...
FDA Regulation: 21 – CFR – 314 New Drug Application
... understanding of the data and information in the application, including an understanding of the quantitative aspects of the data. The summary is not required for supplements under Sec. 314.70. Resubmissions of an application should contain an updated summary, as appropriate. The summary should discu ...
... understanding of the data and information in the application, including an understanding of the quantitative aspects of the data. The summary is not required for supplements under Sec. 314.70. Resubmissions of an application should contain an updated summary, as appropriate. The summary should discu ...
Hair Pigmentation Literature Review James A. Bourland, Ph.D., DABFT
... Hair specimens were analyzed for cocaine, BE, CE, NCOC by LC/MS/MS. Results were compared to drug-users hair and subjects in a controlled dosing study. Findings/Conclusion(s): The effect of hair color was not evaluated. But the discussion stated “With these limited preliminary data, it appea ...
... Hair specimens were analyzed for cocaine, BE, CE, NCOC by LC/MS/MS. Results were compared to drug-users hair and subjects in a controlled dosing study. Findings/Conclusion(s): The effect of hair color was not evaluated. But the discussion stated “With these limited preliminary data, it appea ...
Pharmacokinetic Interaction Between Prasugrel and Ritonavir
... tablets; consumed alcohol regularly; had concomitant disease; or used any drug or food such as grapefruit in the month prior to the study that can either affect or be metabolized by CYP3A, 2C19, 2B6 and 2C9. Volunteers who used drugs associated with an increased risk of bleeding in the 10 days prece ...
... tablets; consumed alcohol regularly; had concomitant disease; or used any drug or food such as grapefruit in the month prior to the study that can either affect or be metabolized by CYP3A, 2C19, 2B6 and 2C9. Volunteers who used drugs associated with an increased risk of bleeding in the 10 days prece ...
A Prospective Experimental Study on the Protective Effect of
... Ototoxicity is a general term used for damage of the cochlear and/or vestibular organs; it results from exposure to several therapeutic agents and chemical substances [1]. Tinnitus is usually the first symptom of ototoxicity. Other symptoms include imbalance, hearing loss, and vertigo [2]. Aminoglyc ...
... Ototoxicity is a general term used for damage of the cochlear and/or vestibular organs; it results from exposure to several therapeutic agents and chemical substances [1]. Tinnitus is usually the first symptom of ototoxicity. Other symptoms include imbalance, hearing loss, and vertigo [2]. Aminoglyc ...
effect of piperine, a major component of black pepper, on the
... instead of increasing plasma levels of fexofenadine, a Pglycoprotein substrate, it decreased its plasma levels (29). On the other hand, it appears that there is a discrepancy between the finding of the present study and a previous report which had showed that pretreatment of rats with grapefruit jui ...
... instead of increasing plasma levels of fexofenadine, a Pglycoprotein substrate, it decreased its plasma levels (29). On the other hand, it appears that there is a discrepancy between the finding of the present study and a previous report which had showed that pretreatment of rats with grapefruit jui ...
Polysubstance dependence
A person with polysubstance dependence is psychologically addicted to being in an intoxicated state without a preference for one particular substance. Although any combination of three drugs can be used, studies have shown that alcohol is commonly used with another substance. This is supported by one study on polysubstance use that separated participants who used multiple substances into groups based on their preferred drug. The three substances were cocaine, alcohol, and heroin, which implies that those three are very popular. Other studies have found that opiates, cannabis, amphetamines, hallucinogens, inhalants and benzodiazepines are often used in combination as well. The results of a long-term or longitudinal study on substance use led the researchers to observe that excessively using or relying on one drug increased the probability of excessively using or relying on another drug.