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Pharmacodynamics
Pharmacodynamics

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Adverse Drug Reactions
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... In 1922, there was an enquiry into the JAUNDICE associated with the use of SALVARSAN, an organic arsenical used in the treatment of Syphillis. In 1961, it was reported in West Germany that there was an outbreak of PHOCOMELIA (hypoplastic and aplastic limb deformities) in the new born babies. It was ...
Chapter 14 Marijuana
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... Mephedrone is a euphoric drug somewhere between ecstasy and cocaine. The first few occasions of use, the mephedrone user feels an intense rushing high. There is a sense of well-being and contentment; if you are on high doses or a long session you may also hallucinate. People on mephedrone report fee ...
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Synthetic Drugs of Abuse

... opioid receptors, with mitragynine having an effect at alpha-adrenergic receptors in lower doses. • The drug has limited effect on respiratory drive, making it relatively safe in pure form. • Kratom is often used in Southeast Asia to mediate the severity of heroin withdrawal. ...
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Polysubstance dependence



A person with polysubstance dependence is psychologically addicted to being in an intoxicated state without a preference for one particular substance. Although any combination of three drugs can be used, studies have shown that alcohol is commonly used with another substance. This is supported by one study on polysubstance use that separated participants who used multiple substances into groups based on their preferred drug. The three substances were cocaine, alcohol, and heroin, which implies that those three are very popular. Other studies have found that opiates, cannabis, amphetamines, hallucinogens, inhalants and benzodiazepines are often used in combination as well. The results of a long-term or longitudinal study on substance use led the researchers to observe that excessively using or relying on one drug increased the probability of excessively using or relying on another drug.
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