product monograph
... Fluconazole hepatotoxicity has usually, but not always, been reversible on discontinuation of therapy. Hypersensitivity In rare cases, anaphylaxis and angioedema have been reported in patients using fluconazole. Special Populations Pregnant Women: There are no adequate and well-controlled studies in ...
... Fluconazole hepatotoxicity has usually, but not always, been reversible on discontinuation of therapy. Hypersensitivity In rare cases, anaphylaxis and angioedema have been reported in patients using fluconazole. Special Populations Pregnant Women: There are no adequate and well-controlled studies in ...
Full US Prescribing Information including boxed warning
... stable dosage of medication who are making progress toward their treatment objectives. Continuation or modification of pharmacotherapy should be based on the physician’s evaluation of treatment outcomes and objectives such as: 1. Absence of medication toxicity 2. Absence of medical or behavioral adv ...
... stable dosage of medication who are making progress toward their treatment objectives. Continuation or modification of pharmacotherapy should be based on the physician’s evaluation of treatment outcomes and objectives such as: 1. Absence of medication toxicity 2. Absence of medical or behavioral adv ...
Pharmacological and Pharmaceutical Profile of Valsartan: A Review
... general classification system that categorises drugs with respect to their biopharmaceutical and absorption properties.In the biopharmaceutical classification system, valsartan has been classified as Class III drug with low permeability, poor metabolism and high solubility (Saydam et al., 2007). The ...
... general classification system that categorises drugs with respect to their biopharmaceutical and absorption properties.In the biopharmaceutical classification system, valsartan has been classified as Class III drug with low permeability, poor metabolism and high solubility (Saydam et al., 2007). The ...
Drugs The Straight Facts, Sleep Aids
... process and store information it received during the day and may even help make some memories more permanent. But the true function(s) of sleep are still largely unknown. One thing is for certain, though, sleep is absolutely necessary. The more someone is deprived of sleep, the stronger is the drive ...
... process and store information it received during the day and may even help make some memories more permanent. But the true function(s) of sleep are still largely unknown. One thing is for certain, though, sleep is absolutely necessary. The more someone is deprived of sleep, the stronger is the drive ...
The safety of hydroquinone
... Over 60 years, this amounts to 61 g of hydroquinone in the urine, which presumably found its way there after systemic exposure, such as from food.2,11,13 The mean background plasma level of hydroquinone in humans after an 8-hour fast is 0.038 !g/g.11 To compare, after a high-arbutin meal, the plasma ...
... Over 60 years, this amounts to 61 g of hydroquinone in the urine, which presumably found its way there after systemic exposure, such as from food.2,11,13 The mean background plasma level of hydroquinone in humans after an 8-hour fast is 0.038 !g/g.11 To compare, after a high-arbutin meal, the plasma ...
Australian public assessment report for Dolutegravir (as sodium)
... 2.5 million new infections and 1.7 million deaths annually. The epidemic has stabilised in most developed countries but the prevalence continues to rise in Central Europe, Asia and Sub-Saharan Africa. Progression to acquired immunodeficiency syndrome (AIDS) has been significantly reduced by combinat ...
... 2.5 million new infections and 1.7 million deaths annually. The epidemic has stabilised in most developed countries but the prevalence continues to rise in Central Europe, Asia and Sub-Saharan Africa. Progression to acquired immunodeficiency syndrome (AIDS) has been significantly reduced by combinat ...
Rx Only Cyclobenzaprine Hydrochloride Extended
... As a result of a two-fold higher cyclobenzaprine plasma levels in subjects with mild hepatic impairment, as compared to healthy subjects, following administration of immediate-release cyclobenzaprine and because there is limited dosing flexibility with cyclobenzaprine hydrochloride extended-release ...
... As a result of a two-fold higher cyclobenzaprine plasma levels in subjects with mild hepatic impairment, as compared to healthy subjects, following administration of immediate-release cyclobenzaprine and because there is limited dosing flexibility with cyclobenzaprine hydrochloride extended-release ...
Aminophylline
... this condition who are also suffering from obstructive airways disease. Aminophylline is usually preferred to theophylline when greater solubility in water is required, particularly in intravenous formulations. Aminophylline may be given in the anhydrous form or as the hydrate, and doses may be expr ...
... this condition who are also suffering from obstructive airways disease. Aminophylline is usually preferred to theophylline when greater solubility in water is required, particularly in intravenous formulations. Aminophylline may be given in the anhydrous form or as the hydrate, and doses may be expr ...
biodegradable implants with different drug release - diss.fu
... when drug candidates have poor absorption by other routes of administration and short halflives, such as when peptides and proteins are used. Additionally, they offer benefits for patients who have difficulty with oral drug administration or are unconscious. The advantages of parenteral controlled-r ...
... when drug candidates have poor absorption by other routes of administration and short halflives, such as when peptides and proteins are used. Additionally, they offer benefits for patients who have difficulty with oral drug administration or are unconscious. The advantages of parenteral controlled-r ...
Third Amended Master Consolidated Class Action Complaint
... Abbott’s AWP Manipulation Benefited Providers at the Expense of the Class.................................................................................................................64 ...
... Abbott’s AWP Manipulation Benefited Providers at the Expense of the Class.................................................................................................................64 ...
Polyethylene Glycol: A Game-Changer Laxative for Children
... unctional constipation with or without encopresis is a common problem in children and is diagnosed by using Rome III criteria (1). The scope of the problem is worldwide, with the pediatric prevalence ranging from 0.7% to 29.6% (2). Constipation is estimated to account for 3% of visits to general ped ...
... unctional constipation with or without encopresis is a common problem in children and is diagnosed by using Rome III criteria (1). The scope of the problem is worldwide, with the pediatric prevalence ranging from 0.7% to 29.6% (2). Constipation is estimated to account for 3% of visits to general ped ...
Report on the Deliberation Results August 25, 2009 Evaluation and
... As the stability studies of the drug product, long-term testing (30°C/65%RH, 36 months), accelerated testing (40°C/75%RH, 6 months), and photostability testing (25°C/ambient humidity, open system, cool white fluorescent lamp and near ultraviolet lamp, an overall illumination of 1.2 million lux·h and ...
... As the stability studies of the drug product, long-term testing (30°C/65%RH, 36 months), accelerated testing (40°C/75%RH, 6 months), and photostability testing (25°C/ambient humidity, open system, cool white fluorescent lamp and near ultraviolet lamp, an overall illumination of 1.2 million lux·h and ...
Tartrazine: a potentially hazardous dye in Canadian drugs.
... dairy products, juices, pickles, candies and cake mixes, as do most home food-colouring kits.6 Cosmetics and toiletries, such as shampoos, after-shave lotions, colognes, toothpastes and soaps, may all contain tartrazine. Pharmaceutical manufacturers use this dye in many types of drug products. Table ...
... dairy products, juices, pickles, candies and cake mixes, as do most home food-colouring kits.6 Cosmetics and toiletries, such as shampoos, after-shave lotions, colognes, toothpastes and soaps, may all contain tartrazine. Pharmaceutical manufacturers use this dye in many types of drug products. Table ...
Glucosamine sulfate.fm
... the USA and Europe. For this and other reasons, the guidelines may soon need further updates. Both guidelines suggest that acetaminophen (paracetamol) should be the oral analgesic used initially and, if successful, the preferred longterm symptomatic agent [6–8]. Nevertheless, this pure analgesic is ...
... the USA and Europe. For this and other reasons, the guidelines may soon need further updates. Both guidelines suggest that acetaminophen (paracetamol) should be the oral analgesic used initially and, if successful, the preferred longterm symptomatic agent [6–8]. Nevertheless, this pure analgesic is ...
Position Paper: Ipecac Syrup
... In a controlled crossover study (5), six fasting adults ingested acetaminophen (paracetamol) 1 g, tetracycline 500 mg, and a long-acting aminophylline preparation 350 mg. Ipecac 20 mL and water 300 mL were given either 5 minutes or 30 minutes later and timed blood samples were collected for 24 hours ...
... In a controlled crossover study (5), six fasting adults ingested acetaminophen (paracetamol) 1 g, tetracycline 500 mg, and a long-acting aminophylline preparation 350 mg. Ipecac 20 mL and water 300 mL were given either 5 minutes or 30 minutes later and timed blood samples were collected for 24 hours ...
Safety and Efficacy of Ranibizumab and Bevacizumab for the
... neovascular age-related macular degeneration (nvAMD). The anti-VEGF agents, ranibizumab and bevacizumab, are both widely used in the treatment of nvAMD although bevacizumab has not yet received regulatory approval for intraocular use. Bevacizumab costs considerably less than ranibizumab when adminis ...
... neovascular age-related macular degeneration (nvAMD). The anti-VEGF agents, ranibizumab and bevacizumab, are both widely used in the treatment of nvAMD although bevacizumab has not yet received regulatory approval for intraocular use. Bevacizumab costs considerably less than ranibizumab when adminis ...
Discriminative Stimulus Properties of MDMA
... drug on the highest schedule of controlled substances in 1985 citing animal studies that suggested neurotoxicity. In New Zealand, MDMA was initially scheduled under part 2 of Class B in the Misuse of Drugs act in 1975 but this status was recently elevated to part 1 in 2005 ("Misuse of Drugs Act," 19 ...
... drug on the highest schedule of controlled substances in 1985 citing animal studies that suggested neurotoxicity. In New Zealand, MDMA was initially scheduled under part 2 of Class B in the Misuse of Drugs act in 1975 but this status was recently elevated to part 1 in 2005 ("Misuse of Drugs Act," 19 ...
aspartate Antagonists on a Multiple Schedule of Ethanol and
... Many studies have examined drug effects on ethanol selfadministration behavior; however, relatively few experiments have attempted to assess the selectivity of pretreatment drug effects for ethanol self-administration, compared with other reinforcers. Clearly, pharmacologically useful treatment drug ...
... Many studies have examined drug effects on ethanol selfadministration behavior; however, relatively few experiments have attempted to assess the selectivity of pretreatment drug effects for ethanol self-administration, compared with other reinforcers. Clearly, pharmacologically useful treatment drug ...
ibogaine: a review
... mechanism of action that differs from other existing pharmacotherapies of addiction, and its mechanism of action does not appear to be readily explained on the basis of existing pharmacologic approaches to addiction. Ibogaine’s effects may result from complex interactions between multiple neurotrans ...
... mechanism of action that differs from other existing pharmacotherapies of addiction, and its mechanism of action does not appear to be readily explained on the basis of existing pharmacologic approaches to addiction. Ibogaine’s effects may result from complex interactions between multiple neurotrans ...
KHAT (CATHA EDULIS) A CONTROVERSIAL PLANT: BLESSING
... research was undertaken in Ethiopia in early 1998, confirming that the cultivation of khat is financially attractive and is spreading into new areas, apparently at the expense of traditional staple and cash crops, and there is an increasing trend in cultivation and and consumption of khat, which is ...
... research was undertaken in Ethiopia in early 1998, confirming that the cultivation of khat is financially attractive and is spreading into new areas, apparently at the expense of traditional staple and cash crops, and there is an increasing trend in cultivation and and consumption of khat, which is ...
Assessment report on hamamelis virginiana l - EMA
... Hamamelis virginiana L. and the documentation provided by the European Medicines Agency completed by additional searches in biomedical databases and the available articles from references included in monographs on Hamamelis virginiana L. (Commission E Monographs, 2001; ESCOP, 2003; WHO, 2002), as we ...
... Hamamelis virginiana L. and the documentation provided by the European Medicines Agency completed by additional searches in biomedical databases and the available articles from references included in monographs on Hamamelis virginiana L. (Commission E Monographs, 2001; ESCOP, 2003; WHO, 2002), as we ...
Investigating the efficacy and safety of over-the
... Combination codeine medicines are widely available over-the-counter and concerns over misuse have risen. Common indications for use include headache, back pain, dental pain and post-surgical pain. The aim of this systematic review was to determine the efficacy and safety of over-the-counter codeine ...
... Combination codeine medicines are widely available over-the-counter and concerns over misuse have risen. Common indications for use include headache, back pain, dental pain and post-surgical pain. The aim of this systematic review was to determine the efficacy and safety of over-the-counter codeine ...
PACIFIC BUSPIRONE Presentation NEW ZEALAND DATA SHEET
... psychomotor impairment. However, its CNS effects in any individual patient may not be predictable. Therefore, patients should be cautioned about driving a vehicle or using complex machinery until they are certain that buspirone treatment does not affect them adversely. While formal studies of the in ...
... psychomotor impairment. However, its CNS effects in any individual patient may not be predictable. Therefore, patients should be cautioned about driving a vehicle or using complex machinery until they are certain that buspirone treatment does not affect them adversely. While formal studies of the in ...
Clearing of Metabolic Waste via Enterohepatic Recirculation Table
... University of Wisconsin-Eau Claire, Warren Gallagher, Ph.D. Enterohepatic Recirculation Hormones Hormones are one such set of recycled substances. These endogenous (internally derived) signal molecules are secreted by endocrine glands. Hormones are filtered from the bloodstream by the liver and plac ...
... University of Wisconsin-Eau Claire, Warren Gallagher, Ph.D. Enterohepatic Recirculation Hormones Hormones are one such set of recycled substances. These endogenous (internally derived) signal molecules are secreted by endocrine glands. Hormones are filtered from the bloodstream by the liver and plac ...
Polysubstance dependence
A person with polysubstance dependence is psychologically addicted to being in an intoxicated state without a preference for one particular substance. Although any combination of three drugs can be used, studies have shown that alcohol is commonly used with another substance. This is supported by one study on polysubstance use that separated participants who used multiple substances into groups based on their preferred drug. The three substances were cocaine, alcohol, and heroin, which implies that those three are very popular. Other studies have found that opiates, cannabis, amphetamines, hallucinogens, inhalants and benzodiazepines are often used in combination as well. The results of a long-term or longitudinal study on substance use led the researchers to observe that excessively using or relying on one drug increased the probability of excessively using or relying on another drug.