preparation and in-vitro characterization of sustained release
... tramadol hydrochloride. From the study it was concluded that matrix tablets prepared by melt granulation technique were far superior to those prepared by direct compression of the physical mixture.12 Chakrahari et al., have investigated sustained release matrix tablets of losartan potassium using H ...
... tramadol hydrochloride. From the study it was concluded that matrix tablets prepared by melt granulation technique were far superior to those prepared by direct compression of the physical mixture.12 Chakrahari et al., have investigated sustained release matrix tablets of losartan potassium using H ...
Demystifying FDA`s 505(b)(2) Drug Registration Process
... previous findings of safety and efficacy for an approved product, a scientific bridge (BA/BE) to the RLD is required. This study compares the systemic levels of the proposed product with that of the RLD. The new product must be as bioavailable as the RLD (unless it has some other advantage, e.g., a ...
... previous findings of safety and efficacy for an approved product, a scientific bridge (BA/BE) to the RLD is required. This study compares the systemic levels of the proposed product with that of the RLD. The new product must be as bioavailable as the RLD (unless it has some other advantage, e.g., a ...
Effects of terbutaline and atenolol ... airways in asthmatic patients J.W.J. Lammers, Folgering,
... smaU airways. Inhalation of terbutaline to a cumulative dose of 2.0 mg induced a stepwise improvement in expiratory airflow parameters for large and small airways function when breathing air. Doubling the dose of inhaled terbutaline to 4 mg did not result in any further improvement of lung function. ...
... smaU airways. Inhalation of terbutaline to a cumulative dose of 2.0 mg induced a stepwise improvement in expiratory airflow parameters for large and small airways function when breathing air. Doubling the dose of inhaled terbutaline to 4 mg did not result in any further improvement of lung function. ...
Dextromethorphan – DXM – Triple C By Cardwell C. Nuckols, PhD
... over-the-counter (OTC) “high.” Look around and see how many possibilities you can find. The medicine aisle of your pharmacy or grocery store is becoming a favorite aisle for some. This affinity is not because they are sick but because they are looking to become intoxicated. The favored intoxicants a ...
... over-the-counter (OTC) “high.” Look around and see how many possibilities you can find. The medicine aisle of your pharmacy or grocery store is becoming a favorite aisle for some. This affinity is not because they are sick but because they are looking to become intoxicated. The favored intoxicants a ...
False Positive Urine Screens for Phencyclidine
... False Positive Urine Screens for Phencyclidine Antibody-based enzyme-mediated immunoassays are used in the emergency department for screening of the urine for substances of abuse. These immunoassays have become the prevailing technology despite limitations such as the weak specificity for phencyclid ...
... False Positive Urine Screens for Phencyclidine Antibody-based enzyme-mediated immunoassays are used in the emergency department for screening of the urine for substances of abuse. These immunoassays have become the prevailing technology despite limitations such as the weak specificity for phencyclid ...
The role of adherence in tuberculosis HIV-positive patients treated in
... HIV and Mycobacterium tuberculosis co-infection is associated with a higher mortality [1, 11, 15, 16], although most deaths in those who receive an effective therapy are due to complications of HIV infection rather than tuberculosis [11]. In the current study, almost one-quarter of patients do not r ...
... HIV and Mycobacterium tuberculosis co-infection is associated with a higher mortality [1, 11, 15, 16], although most deaths in those who receive an effective therapy are due to complications of HIV infection rather than tuberculosis [11]. In the current study, almost one-quarter of patients do not r ...
Adverse reactions to drugs, BMJ 1998
... and for which a lower dose was found to be both safe and effective. Elderly people and patients with diseases such as renal failure which affect drug handling are more likely to have type A reactions. The likelihood of developing an adverse interaction also increases with the number of drugs prescri ...
... and for which a lower dose was found to be both safe and effective. Elderly people and patients with diseases such as renal failure which affect drug handling are more likely to have type A reactions. The likelihood of developing an adverse interaction also increases with the number of drugs prescri ...
Clinical Pharmacology of Drugs Acting on the Respiratory Organs
... reversible injury to the liver. Patients taking these medications should have liver function tests prior to initiating therapy and periodically thereafter. They should not be used in the presence of preexisting liver disease. Churge-Strauss Syndrome has been reported in some patients with severe ast ...
... reversible injury to the liver. Patients taking these medications should have liver function tests prior to initiating therapy and periodically thereafter. They should not be used in the presence of preexisting liver disease. Churge-Strauss Syndrome has been reported in some patients with severe ast ...
Formulation and in-vitro bioequivalence evaluation of verapamil
... the site of action to produce desired pharmacological action and also to achieve the effective drug concentration over the preferred period of time. Oral drug delivery system is the most commonly used route of administration when compared to all other routes for various pharmaceutical products of di ...
... the site of action to produce desired pharmacological action and also to achieve the effective drug concentration over the preferred period of time. Oral drug delivery system is the most commonly used route of administration when compared to all other routes for various pharmaceutical products of di ...
9Noval Drug Delivery System
... Container is flushed with nitrogen sealed and allowed to freezed by shaking in a bath of liquid nitrogen. After complete freezing the container is allowed to thaw by standing in the room temperature. Re-sonicated for 30 seconds and the entrapped material is separated by column ...
... Container is flushed with nitrogen sealed and allowed to freezed by shaking in a bath of liquid nitrogen. After complete freezing the container is allowed to thaw by standing in the room temperature. Re-sonicated for 30 seconds and the entrapped material is separated by column ...
Urine Drug Testing Clinical Practice in The Art
... illegal drugs. Many of these test systems are waived under the Clinical Laboratory Improvement Amendments of 1988 (CLIA), and can be performed without routine regulatory oversight under a Certificate of Waiver* from the Centers for Medicare & Medicaid Services.12;13 Providers who elect to use POC te ...
... illegal drugs. Many of these test systems are waived under the Clinical Laboratory Improvement Amendments of 1988 (CLIA), and can be performed without routine regulatory oversight under a Certificate of Waiver* from the Centers for Medicare & Medicaid Services.12;13 Providers who elect to use POC te ...
Omnicare Diabetes Health Management Program
... events. Most errors occur in the prescribing and monitoring phases of medication use. Other studies indicate that from 30 – 64% of nursing home residents experience an adverse drug event. Risk factors for developing adverse drug events have been identified and some are modifiable Gurwitz JH, Fie ...
... events. Most errors occur in the prescribing and monitoring phases of medication use. Other studies indicate that from 30 – 64% of nursing home residents experience an adverse drug event. Risk factors for developing adverse drug events have been identified and some are modifiable Gurwitz JH, Fie ...
Understanding Key Determinants of Drug Activity
... Drug transporters and metabolizing enzymes show significant differences based on gender, age, race/ethnicity, genetics (polymorphisms) and a variety of external factors (such as diet and lifestyle). It is important to understand these variations not only during drug development but they also form an ...
... Drug transporters and metabolizing enzymes show significant differences based on gender, age, race/ethnicity, genetics (polymorphisms) and a variety of external factors (such as diet and lifestyle). It is important to understand these variations not only during drug development but they also form an ...
Document
... A. Always start by choosing any available first-line drug that the isolate remains susceptible to B. Aim for a total of four to six drugs that the isolate is known to be sensitive to (preferably not drugs used previously by the patient) C. Second-line agents (like cycloserine, ethionimide, and PAS) ...
... A. Always start by choosing any available first-line drug that the isolate remains susceptible to B. Aim for a total of four to six drugs that the isolate is known to be sensitive to (preferably not drugs used previously by the patient) C. Second-line agents (like cycloserine, ethionimide, and PAS) ...
Alcohol P.P.
... Alcoholism Treatment with Disulfiram Inhibits acetaldehyde dehydrogenase (ALDH) Elevated acetaldehyde cause increased flushing, tachycardia (elevated heart rate), nausea, vomiting & hyperventilation. ...
... Alcoholism Treatment with Disulfiram Inhibits acetaldehyde dehydrogenase (ALDH) Elevated acetaldehyde cause increased flushing, tachycardia (elevated heart rate), nausea, vomiting & hyperventilation. ...
Selective serotonin reuptake inhibitors in the treatment of
... European primary care settings was 4.8% for GAD without other comorbid depressive or anxiety disorders and 3.7% for GAD with depression: a further 4.1% had ‘subthreshold’ GAD [6]. Comorbid GAD is associated with more severe symptoms, greater functional impairment, a more prolonged course, decreased ...
... European primary care settings was 4.8% for GAD without other comorbid depressive or anxiety disorders and 3.7% for GAD with depression: a further 4.1% had ‘subthreshold’ GAD [6]. Comorbid GAD is associated with more severe symptoms, greater functional impairment, a more prolonged course, decreased ...
557-1648-1-SP - Journal of Drug Delivery and Therapeutics
... 1.1.Nanosuspension:More than 40% of the new chemical entities being generated through drug discovery programmes are poorly water‐soluble or lipophilic compounds.Formulating a poorly water soluble drug has always been a challenging problem confronted by the pharmaceutical scientist.The formulation of ...
... 1.1.Nanosuspension:More than 40% of the new chemical entities being generated through drug discovery programmes are poorly water‐soluble or lipophilic compounds.Formulating a poorly water soluble drug has always been a challenging problem confronted by the pharmaceutical scientist.The formulation of ...
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... To rebel and establish an identity Because some drugs are taboo and illegal, their use bas been a vehicle in expressing rebellion and in establishing an identity. To go along with peer pressure Many people do not seek out drugs, but get involved because the "group" uses them.. This is particularly p ...
... To rebel and establish an identity Because some drugs are taboo and illegal, their use bas been a vehicle in expressing rebellion and in establishing an identity. To go along with peer pressure Many people do not seek out drugs, but get involved because the "group" uses them.. This is particularly p ...
11_Bioequivalence
... • Therefore, the studies should normally be performed with healthy volunteers. Subjects could belong to either sex; however, the risk to women of childbearing potential should be considered on an individual basis. • In general, subjects should be between 18–55 years old, of weight within the normal ...
... • Therefore, the studies should normally be performed with healthy volunteers. Subjects could belong to either sex; however, the risk to women of childbearing potential should be considered on an individual basis. • In general, subjects should be between 18–55 years old, of weight within the normal ...
Predictors of relapse among pulmonary tuberculosis patients treated
... However, the relapse rate, which is also an important indicator of the success of any treatment regimen, has not been measured under programme conditions. We undertook a study in a newly introduced DOTS programme in South India to examine the rate of relapse and predictors of relapse among a cohort ...
... However, the relapse rate, which is also an important indicator of the success of any treatment regimen, has not been measured under programme conditions. We undertook a study in a newly introduced DOTS programme in South India to examine the rate of relapse and predictors of relapse among a cohort ...
Current Status and Perspectives of Placebo
... result of not receiving the best proven intervention.” The Council for International Organizations of Medical Science (CIOMS) established similar conditions in the “International Ethical Guidelines for Biomedical Research Involving Human Subjects” ...
... result of not receiving the best proven intervention.” The Council for International Organizations of Medical Science (CIOMS) established similar conditions in the “International Ethical Guidelines for Biomedical Research Involving Human Subjects” ...
Polysubstance dependence
A person with polysubstance dependence is psychologically addicted to being in an intoxicated state without a preference for one particular substance. Although any combination of three drugs can be used, studies have shown that alcohol is commonly used with another substance. This is supported by one study on polysubstance use that separated participants who used multiple substances into groups based on their preferred drug. The three substances were cocaine, alcohol, and heroin, which implies that those three are very popular. Other studies have found that opiates, cannabis, amphetamines, hallucinogens, inhalants and benzodiazepines are often used in combination as well. The results of a long-term or longitudinal study on substance use led the researchers to observe that excessively using or relying on one drug increased the probability of excessively using or relying on another drug.